GREMLIN Database
YFMC - Fe(3+)-citrate-binding protein YfmC
UniProt: O34348 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 315 (283)
Sequences: 14161 (11154)
Seq/√Len: 663.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
161_T174_K4.1551.00
164_A173_G4.0481.00
249_D277_K4.0431.00
157_I181_K3.9161.00
169_K172_E3.5111.00
165_K170_E3.2301.00
277_K281_N3.1101.00
46_H51_K3.0131.00
63_V69_L2.9641.00
161_T177_L2.7911.00
172_E175_E2.6491.00
44_V51_K2.6431.00
185_N189_A2.6141.00
222_F227_F2.6131.00
174_K178_A2.5751.00
183_V306_K2.5351.00
183_V302_E2.5121.00
114_V117_S2.5091.00
178_A182_K2.5061.00
244_Q247_K2.3681.00
47_D52_T2.2511.00
62_V115_I2.2481.00
198_N228_T2.1571.00
72_V167_L2.1471.00
61_V167_L2.1131.00
219_G223_K2.0851.00
181_K185_N2.0811.00
77_I167_L2.0241.00
182_K186_D2.0151.00
251_D277_K1.9841.00
136_Q139_K1.9781.00
268_K282_G1.9671.00
186_D190_E1.9231.00
265_D269_T1.9161.00
142_P147_K1.9021.00
71_A160_F1.8771.00
77_I169_K1.8611.00
134_Y138_K1.8461.00
175_E179_E1.8361.00
252_I285_Y1.7791.00
124_I163_I1.7671.00
42_S53_T1.7631.00
155_E158_D1.7601.00
276_L279_V1.7431.00
44_V53_T1.7221.00
171_D175_E1.7111.00
252_I283_Q1.6811.00
264_V268_K1.6561.00
179_E183_V1.6371.00
185_N188_K1.6071.00
277_K280_K1.6071.00
43_R165_K1.6011.00
158_D161_T1.5831.00
110_P115_I1.5491.00
102_T114_V1.5491.00
275_N280_K1.5481.00
135_K139_K1.5341.00
62_V118_L1.5231.00
172_E176_K1.5201.00
111_N114_V1.4691.00
158_D162_T1.4561.00
199_I227_F1.4331.00
265_D268_K1.4321.00
307_D310_K1.4301.00
131_K135_K1.4191.00
116_S140_I1.4141.00
273_W279_V1.3931.00
197_R252_I1.3921.00
196_N228_T1.3781.00
261_K265_D1.3731.00
170_E174_K1.3611.00
189_A192_P1.3571.00
157_I177_L1.3541.00
63_V72_V1.3511.00
242_L270_N1.3451.00
113_E243_E1.3411.00
143_T147_K1.3361.00
253_L278_A1.3101.00
161_T181_K1.2971.00
176_K179_E1.2941.00
244_Q248_I1.2891.00
75_L169_K1.2891.00
178_A181_K1.2861.00
47_D50_G1.2861.00
183_V186_D1.2841.00
208_S239_E1.2791.00
60_R80_V1.2661.00
231_V248_I1.2591.00
233_S248_I1.2581.00
88_K91_I1.2541.00
135_K138_K1.2521.00
54_V57_T1.2481.00
182_K185_N1.2271.00
171_D174_K1.2251.00
59_K121_D1.2181.00
59_K80_V1.2111.00
18_A21_I1.2101.00
186_D189_A1.2081.00
130_H133_I1.2081.00
187_L305_A1.1961.00
72_V77_I1.1961.00
58_P121_D1.1771.00
230_A248_I1.1731.00
162_T165_K1.1681.00
200_V203_V1.1661.00
142_P145_E1.1581.00
160_F173_G1.1531.00
112_L136_Q1.1521.00
198_N251_D1.1421.00
60_R119_K1.1291.00
214_S223_K1.1241.00
302_E306_K1.1191.00
177_L181_K1.1181.00
188_K224_M1.1031.00
305_A309_L1.1011.00
73_H78_T1.0991.00
74_N176_K1.0981.00
262_T265_D1.0921.00
90_M93_K1.0851.00
179_E182_K1.0831.00
47_D134_Y1.0741.00
188_K192_P1.0691.00
42_S55_S1.0561.00
61_V122_L1.0551.00
187_L309_L1.0461.00
200_V250_P1.0431.00
81_G84_D1.0361.00
201_L222_F1.0351.00
42_S56_G1.0321.00
197_R283_Q1.0241.00
200_V211_L1.0221.00
123_I141_A1.0161.00
81_G118_L1.0071.00
125_A145_E0.9981.00
262_T266_E0.9921.00
133_I136_Q0.9901.00
306_K310_K0.9891.00
184_I188_K0.9871.00
89_D92_K0.9851.00
72_V124_I0.9831.00
273_W276_L0.9751.00
255_I286_D0.9711.00
42_S57_T0.9681.00
228_T232_K0.9641.00
144_I166_A0.9611.00
190_E309_L0.9601.00
60_R82_I0.9591.00
161_T165_K0.9451.00
285_Y311_K0.9411.00
81_G101_Y0.9381.00
254_F308_V0.9361.00
91_I94_L0.9351.00
80_V169_K0.9311.00
164_A177_L0.9301.00
41_D168_N0.9271.00
61_V72_V0.9261.00
271_P274_K0.9261.00
183_V187_L0.9241.00
49_E138_K0.9161.00
85_D88_K0.9161.00
151_A154_D0.9111.00
162_T166_A0.9101.00
277_K283_Q0.9051.00
231_V244_Q0.9051.00
199_I222_F0.9041.00
266_E269_T0.9041.00
305_A310_K0.8971.00
220_E223_K0.8931.00
180_H224_M0.8931.00
279_V284_V0.8901.00
75_L176_K0.8891.00
71_A163_I0.8831.00
57_T169_K0.8811.00
263_I266_E0.8781.00
47_D51_K0.8781.00
41_D56_G0.8761.00
288_D291_T0.8761.00
173_G177_L0.8761.00
20_L23_S0.8721.00
72_V81_G0.8611.00
84_D103_S0.8601.00
54_V58_P0.8581.00
77_I80_V0.8571.00
65_E126_D0.8561.00
300_S303_T0.8491.00
25_C28_S0.8481.00
211_L231_V0.8431.00
56_G59_K0.8401.00
73_H94_L0.8371.00
245_L276_L0.8361.00
58_P122_L0.8311.00
18_A22_V0.8311.00
214_S232_K0.8261.00
299_K303_T0.8261.00
163_I167_L0.8261.00
122_L166_A0.8231.00
43_R54_V0.8231.00
202_G270_N0.8211.00
124_I166_A0.8181.00
88_K92_K0.8161.00
159_S162_T0.8161.00
220_E224_M0.8141.00
70_D299_K0.8131.00
175_E178_A0.8081.00
80_V83_A0.8071.00
180_H184_I0.8061.00
68_F124_I0.8031.00
201_L256_S0.8031.00
246_S276_L0.7991.00
64_L123_I0.7951.00
268_K284_V0.7941.00
274_K279_V0.7871.00
255_I284_V0.7871.00
122_L144_I0.7841.00
120_P123_I0.7751.00
154_D158_D0.7751.00
191_L194_D0.7751.00
161_T164_A0.7721.00
41_D57_T0.7721.00
74_N299_K0.7701.00
19_C22_V0.7691.00
176_K180_H0.7681.00
123_I140_I0.7681.00
49_E145_E0.7671.00
174_K177_L0.7661.00
19_C23_S0.7661.00
57_T168_N0.7641.00
246_S275_N0.7611.00
184_I305_A0.7601.00
200_V245_L0.7591.00
163_I166_A0.7581.00
144_I162_T0.7571.00
254_F285_Y0.7541.00
73_H93_K0.7541.00
25_C29_Q0.7511.00
83_A118_L0.7471.00
98_S101_Y0.7451.00
187_L191_L0.7441.00
240_V248_I0.7421.00
205_R208_S0.7391.00
199_I203_V0.7381.00
84_D101_Y0.7341.00
63_V81_G0.7301.00
74_N160_F0.7251.00
86_N103_S0.7231.00
157_I161_T0.7201.00
75_L172_E0.7171.00
297_G300_S0.7171.00
200_V204_A0.7161.00
76_G172_E0.7141.00
106_T109_E0.7131.00
75_L167_L0.7131.00
303_T310_K0.7111.00
152_T155_E0.7111.00
78_T81_G0.7111.00
256_S287_A0.7081.00
154_D157_I0.7081.00
216_S219_G0.7041.00
79_P83_A0.7031.00
160_F176_K0.7001.00
296_R299_K0.7001.00
304_S308_V0.6971.00
23_S26_S0.6961.00
132_N135_K0.6961.00
212_H237_Y0.6961.00
212_H216_S0.6951.00
75_L164_A0.6921.00
156_T180_H0.6911.00
202_G253_L0.6901.00
62_V120_P0.6891.00
102_T105_G0.6881.00
270_N274_K0.6871.00
183_V309_L0.6841.00
199_I202_G0.6821.00
142_P146_L0.6801.00
82_I118_L0.6791.00
88_K94_L0.6761.00
184_I224_M0.6761.00
303_T306_K0.6751.00
199_I254_F0.6741.00
190_E193_K0.6731.00
261_K264_V0.6691.00
241_S244_Q0.6681.00
75_L160_F0.6671.00
197_R227_F0.6661.00
204_A207_D0.6661.00
127_A147_K0.6641.00
157_I184_I0.6641.00
297_G301_S0.6601.00
264_V286_D0.6601.00
25_C30_N0.6601.00
76_G169_K0.6591.00
90_M94_L0.6551.00
78_T100_D0.6551.00
76_G79_P0.6531.00
70_D297_G0.6521.00
62_V83_A0.6521.00
62_V104_V0.6501.00
167_L170_E0.6491.00
60_R121_D0.6451.00
246_S250_P0.6441.00
69_L94_L0.6421.00
263_I267_W0.6421.00
131_K134_Y0.6411.00
94_L98_S0.6411.00
89_D93_K0.6371.00
138_K143_T0.6331.00
143_T146_L0.6321.00
54_V142_P0.6321.00
21_I24_G0.6311.00
102_T118_L0.6311.00
250_P253_L0.6291.00
112_L115_I0.6291.00
115_I137_L0.6281.00
222_F225_L0.6281.00
63_V68_F0.6271.00
75_L173_G0.6211.00
28_S31_N0.6211.00
252_I256_S0.6191.00
73_H81_G0.6171.00
215_S219_G0.6161.00
113_E116_S0.6081.00
62_V123_I0.6071.00
48_E162_T0.6071.00
41_D55_S0.6051.00
180_H183_V0.6051.00
270_N273_W0.6041.00
287_A292_W0.6041.00
97_S100_D0.6031.00
129_R133_I0.6031.00
189_A193_K0.6031.00
157_I180_H0.6011.00
43_R56_G0.5961.00
45_I54_V0.5961.00
25_C31_N0.5941.00
54_V122_L0.5901.00
72_V163_I0.5881.00
58_P167_L0.5871.00
225_L309_L0.5841.00
219_G232_K0.5841.00
304_S310_K0.5841.00
191_L309_L0.5801.00
177_L180_H0.5781.00
73_H101_Y0.5781.00
257_A286_D0.5771.00
300_S304_S0.5761.00
258_N289_R0.5741.00
188_K225_L0.5731.00
92_K99_I0.5731.00
242_L273_W0.5721.00
80_V167_L0.5721.00
214_S233_S0.5711.00
161_T170_E0.5701.00
146_L162_T0.5701.00
263_I268_K0.5691.00
160_F177_L0.5681.00
215_S235_N0.5661.00
133_I137_L0.5661.00
104_V118_L0.5661.00
299_K302_E0.5631.00
134_Y137_L0.5631.00
43_R57_T0.5601.00
307_D311_K0.5601.00
213_T219_G0.5581.00
214_S219_G0.5581.00
62_V81_G0.5571.00
68_F163_I0.5571.00
176_K298_I0.5541.00
219_G229_H0.5541.00
231_V240_V0.5541.00
227_F252_I0.5531.00
94_L97_S0.5531.00
296_R300_S0.5531.00
157_I224_M0.5521.00
89_D94_L0.5511.00
57_T121_D0.5501.00
200_V230_A0.5491.00
181_K184_I0.5491.00
234_D238_Q0.5491.00
112_L133_I0.5491.00
201_L218_D0.5471.00
180_H301_S0.5441.00
253_L273_W0.5431.00
114_V118_L0.5421.00
116_S243_E0.5421.00
132_N136_Q0.5411.00
212_H218_D0.5401.00
230_A233_S0.5391.00
216_S237_Y0.5341.00
198_N252_I0.5341.00
184_I301_S0.5301.00
240_V245_L0.5301.00
46_H49_E0.5291.00
24_G28_S0.5291.00
298_I302_E0.5280.99
267_W270_N0.5280.99
49_E131_K0.5280.99
187_L190_E0.5280.99
305_A311_K0.5260.99
71_A74_N0.5260.99
303_T307_D0.5230.99
69_L82_I0.5230.99
302_E305_A0.5210.99
52_T144_I0.5190.99
210_Q237_Y0.5170.99
113_E241_S0.5170.99
276_L280_K0.5150.99
197_R201_L0.5150.99
105_G110_P0.5140.99
41_D58_P0.5140.99
198_N230_A0.5120.99
112_L140_I0.5110.99
54_V166_A0.5100.99
301_S305_A0.5080.99
68_F71_A0.5070.99
42_S54_V0.5060.99
184_I187_L0.5060.99
246_S272_L0.5060.99
295_F300_S0.5050.99
264_V267_W0.5040.99
273_W284_V0.5030.99
188_K191_L0.5010.99
216_S236_A0.5000.99
210_Q239_E0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4n01A 1 0.873 100 0.199 Contact Map
3tnyA 1 0.8508 100 0.259 Contact Map
3lhsA 1 0.8698 100 0.263 Contact Map
4mlzA 1 0.873 100 0.263 Contact Map
3tlkA 1 0.8571 100 0.271 Contact Map
4hn9A 1 0.8794 100 0.274 Contact Map
3gfvA 1 0.8635 100 0.28 Contact Map
4mx8A 1 0.8698 100 0.281 Contact Map
3mwfA 1 0.8476 100 0.282 Contact Map
4mo9A 1 0.8698 100 0.284 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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