GREMLIN Database
ASSY - Argininosuccinate synthase
UniProt: O34347 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 403 (391)
Sequences: 2295 (862)
Seq/√Len: 43.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
221_A229_S5.1281.00
248_A279_T5.0831.00
330_E333_K4.8211.00
107_E136_N4.6371.00
216_E251_H4.0271.00
58_N109_E3.8831.00
336_T357_Y3.4711.00
216_E250_A3.3961.00
233_V243_K3.3161.00
78_Q329_K3.3061.00
216_E231_D3.1581.00
76_S93_L3.1291.00
219_E338_I3.1191.00
217_V351_E2.8661.00
101_K104_E2.8521.00
221_A338_I2.7791.00
66_E70_Q2.7631.00
194_W354_K2.7401.00
37_D65_K2.7381.00
338_I354_K2.7161.00
8_V111_A2.6681.00
196_A217_V2.6341.00
243_K246_E2.6181.00
5_K112_Q2.5981.00
49_Q53_E2.5771.00
224_Q333_K2.5121.00
102_L132_I2.5081.00
230_I243_K2.4801.00
209_E342_K2.4601.00
107_E138_D2.3601.00
114_I132_I2.3581.00
284_H332_Q2.3231.00
36_L64_A2.3221.00
62_I101_K2.3221.00
321_K325_H2.2461.00
202_Y271_V2.1981.00
157_E161_S2.1911.00
26_E162_R2.1741.00
307_M325_H2.1100.99
298_H309_E2.0590.99
22_K25_Q2.0420.99
263_L315_L2.0310.99
65_K242_L2.0210.99
66_E236_S2.0180.99
69_A241_I2.0160.99
208_L211_T1.9810.99
60_Y108_K1.9700.99
236_S239_E1.9700.99
43_D46_F1.9080.99
199_E207_P1.8980.99
86_K286_E1.8900.99
32_I58_N1.8870.99
84_E261_N1.8810.99
299_F303_I1.8780.99
74_L237_L1.8720.99
199_E210_K1.8560.99
102_L114_I1.7960.98
192_D362_E1.7840.98
221_A336_T1.7630.98
220_I227_P1.7360.98
78_Q226_V1.6770.97
217_V342_K1.6610.97
70_Q237_L1.6550.97
206_A250_A1.6500.97
7_V29_Y1.6290.97
5_K140_E1.6280.97
91_S94_S1.6150.97
33_A59_S1.6020.96
103_V139_L1.5770.96
207_P210_K1.5750.96
340_R352_G1.5730.96
244_L279_T1.5730.96
211_T344_F1.5630.96
206_A211_T1.5580.96
30_N57_T1.5580.96
235_Y243_K1.5450.96
180_L241_I1.5450.96
196_A342_K1.5420.96
72_Y317_F1.5380.96
130_V386_G1.5200.95
45_A48_Q1.5090.95
323_A331_T1.4850.95
223_E228_V1.4820.95
196_A351_E1.4800.94
60_Y109_E1.4660.94
187_C367_Y1.4660.94
284_H331_T1.4610.94
114_I139_L1.4460.94
364_L391_V1.4450.94
205_T255_R1.4190.93
26_E158_Y1.4170.93
90_V182_G1.4140.93
227_P240_L1.4110.93
43_D178_Q1.4070.93
303_I324_L1.4010.93
66_E238_S1.3940.92
323_A327_F1.3880.92
64_A101_K1.3750.92
48_Q52_L1.3740.92
287_L339_V1.3680.92
213_D345_K1.3620.92
206_A210_K1.3560.91
299_F320_L1.3520.91
209_E215_P1.3510.91
246_E250_A1.3340.91
60_Y105_I1.3300.91
306_K309_E1.3290.91
219_E340_R1.3140.90
72_Y97_L1.3130.90
194_W340_R1.3090.90
29_Y112_Q1.3080.90
223_E234_S1.3030.90
67_E100_K1.2890.89
6_K30_N1.2780.89
323_A330_E1.2690.88
99_A131_S1.2670.88
133_K383_E1.2570.88
364_L372_A1.2550.88
45_A49_Q1.2510.88
341_V348_A1.2510.88
173_P188_G1.2500.88
32_I109_E1.2390.87
7_V142_I1.2380.87
366_T372_A1.2220.86
103_V135_L1.2210.86
220_I280_L1.2180.86
133_K390_K1.2110.86
176_I183_R1.2100.86
153_E368_T1.2080.86
376_H379_I1.2070.86
372_A375_H1.1940.85
43_D47_V1.1860.85
223_E336_T1.1850.85
150_W155_E1.1820.85
67_E71_D1.1800.84
136_N139_L1.1770.84
373_F378_A1.1770.84
178_Q204_L1.1740.84
291_T335_V1.1730.84
208_L344_F1.1710.84
189_I198_P1.1680.84
32_I57_T1.1670.84
342_K351_E1.1640.84
239_E242_L1.1550.83
176_I185_N1.1520.83
274_C277_A1.1470.83
322_D330_E1.1410.82
67_E101_K1.1340.82
41_G178_Q1.1320.82
101_K105_I1.1310.82
37_D41_G1.1280.82
241_I276_G1.1280.82
72_Y100_K1.1200.81
243_K247_M1.1060.80
29_Y113_A1.1050.80
133_K386_G1.1040.80
292_L331_T1.1030.80
299_F302_I1.0970.80
235_Y240_L1.0920.79
80_H304_E1.0900.79
169_N188_G1.0880.79
303_I328_L1.0870.79
218_I244_L1.0830.79
233_V239_E1.0700.78
236_S240_L1.0700.78
211_T345_K1.0700.78
86_K282_K1.0670.78
172_S188_G1.0640.78
181_W277_A1.0630.78
192_D195_A1.0620.78
79_A328_L1.0590.77
229_S234_S1.0560.77
327_F331_T1.0470.77
385_W388_P1.0460.76
206_A252_G1.0460.76
253_V278_M1.0370.76
255_R353_R1.0350.76
247_M250_A1.0320.75
77_L280_L1.0290.75
215_P251_H1.0260.75
80_H281_I1.0240.75
212_P345_K1.0230.75
103_V132_I1.0230.75
202_Y255_R1.0210.75
70_Q226_V1.0180.74
377_A383_E1.0170.74
220_I240_L1.0150.74
74_L226_V1.0090.74
157_E170_L1.0000.73
221_A234_S0.9960.73
207_P211_T0.9880.72
378_A382_I0.9880.72
204_L249_G0.9870.72
328_L331_T0.9850.72
340_R354_K0.9820.72
185_N201_A0.9810.72
231_D243_K0.9800.72
326_A330_E0.9750.71
301_P305_Q0.9720.71
35_C59_S0.9690.71
68_F73_A0.9680.71
7_V31_V0.9660.71
80_H284_H0.9660.71
218_I230_I0.9620.70
228_V234_S0.9590.70
302_I306_K0.9580.70
244_L276_G0.9570.70
69_A237_L0.9560.70
199_E255_R0.9530.69
374_D379_I0.9530.69
178_Q203_D0.9520.69
217_V340_R0.9440.69
261_N298_H0.9430.69
21_I33_A0.9390.68
62_I108_K0.9390.68
74_L77_L0.9370.68
69_A73_A0.9350.68
105_I109_E0.9350.68
88_P270_E0.9330.68
364_L370_D0.9320.68
156_I168_I0.9250.67
328_L332_Q0.9170.66
296_V331_T0.9170.66
69_A74_L0.9160.66
221_A228_V0.9150.66
190_L193_P0.9090.66
174_Y200_G0.9040.65
91_S184_A0.9030.65
197_P352_G0.9020.65
292_L300_K0.8950.65
19_V159_A0.8930.64
180_L238_S0.8920.64
85_G301_P0.8910.64
307_M321_K0.8890.64
208_L251_H0.8840.64
230_I244_L0.8840.64
286_E350_V0.8840.64
227_P280_L0.8820.63
229_S338_I0.8810.63
36_L98_I0.8800.63
332_Q335_V0.8690.62
189_I200_G0.8670.62
133_K141_V0.8620.62
49_Q52_L0.8620.62
219_E232_G0.8580.61
230_I235_Y0.8570.61
309_E313_N0.8510.61
168_I188_G0.8490.60
157_E160_A0.8490.60
286_E289_D0.8440.60
159_A166_I0.8410.60
71_D100_K0.8400.60
320_L327_F0.8390.60
126_V264_V0.8340.59
176_I203_D0.8290.59
11_Y21_I0.8280.58
30_N112_Q0.8280.58
274_C278_M0.8260.58
70_Q74_L0.8240.58
34_C64_A0.8230.58
251_H345_K0.8230.58
300_K304_E0.8160.57
287_L336_T0.8150.57
193_P339_V0.8030.56
282_K348_A0.8020.56
288_E300_K0.8020.56
50_K164_I0.8010.56
103_V136_N0.8000.56
294_K313_N0.7960.55
26_E161_S0.7900.55
373_F377_A0.7900.55
183_R270_E0.7890.55
53_E165_P0.7880.55
74_L240_L0.7880.55
48_Q58_N0.7870.55
20_A23_W0.7870.55
209_E344_F0.7840.54
286_E353_R0.7840.54
284_H335_V0.7810.54
221_A230_I0.7810.54
47_V59_S0.7800.54
318_S389_T0.7770.54
266_I373_F0.7770.54
160_A170_L0.7760.54
35_C47_V0.7760.54
283_A341_V0.7750.54
366_T370_D0.7720.53
279_T341_V0.7680.53
90_V94_S0.7680.53
58_N105_I0.7600.52
82_M88_P0.7540.51
143_A146_R0.7540.51
133_K139_L0.7500.51
325_H329_K0.7500.51
248_A253_V0.7490.51
214_T251_H0.7470.51
153_E157_E0.7460.51
355_S358_S0.7460.51
88_P182_G0.7450.51
182_G367_Y0.7440.51
251_H344_F0.7440.51
150_W154_E0.7380.50
36_L62_I0.7370.50
34_C62_I0.7370.50
46_F49_Q0.7360.50
344_F347_H0.7350.50
173_P176_I0.7350.50
5_K29_Y0.7340.50
334_H357_Y0.7330.49
222_F280_L0.7330.49
85_G285_K0.7330.49
22_K26_E0.7320.49
145_V270_E0.7290.49
160_A163_G0.7290.49
99_A114_I0.7280.49
220_I282_K0.7260.49
261_N297_A0.7200.48
82_M281_I0.7200.48
73_A241_I0.7190.48
22_K27_Q0.7170.48
185_N270_E0.7170.48
350_V353_R0.7160.48
52_L59_S0.7130.48
22_K54_V0.7120.47
22_K164_I0.7110.47
77_L237_L0.7090.47
21_I163_G0.7090.47
218_I247_M0.7060.47
33_A56_A0.7050.47
250_A279_T0.7050.47
348_A351_E0.7050.47
245_N276_G0.7050.47
281_I285_K0.7040.47
336_T356_E0.7020.47
230_I240_L0.6970.46
177_D186_E0.6960.46
181_W241_I0.6940.46
86_K289_D0.6920.46
78_Q325_H0.6920.46
220_I230_I0.6890.45
296_V323_A0.6850.45
198_P201_A0.6840.45
76_S311_I0.6840.45
219_E354_K0.6830.45
383_E390_K0.6830.45
266_I364_L0.6820.45
253_V343_L0.6820.45
44_L61_V0.6820.45
103_V114_I0.6800.44
100_K104_E0.6800.44
320_L385_W0.6790.44
34_C102_L0.6770.44
173_P189_I0.6770.44
288_E335_V0.6750.44
25_Q57_T0.6730.44
206_A249_G0.6710.44
213_D251_H0.6700.43
310_I324_L0.6690.43
75_I325_H0.6690.43
21_I25_Q0.6680.43
367_Y375_H0.6680.43
276_G279_T0.6680.43
320_L388_P0.6670.43
129_E141_V0.6660.43
282_K350_V0.6640.43
51_A55_G0.6630.43
169_N172_S0.6630.43
253_V341_V0.6610.43
263_L385_W0.6590.42
179_N186_E0.6590.42
88_P145_V0.6590.42
72_Y316_W0.6550.42
216_E247_M0.6530.42
366_T375_H0.6510.42
74_L78_Q0.6490.42
10_A102_L0.6470.41
48_Q59_S0.6460.41
30_N43_D0.6450.41
239_E246_E0.6440.41
264_V373_F0.6420.41
201_A258_H0.6410.41
231_D250_A0.6400.41
298_H306_K0.6390.41
216_E246_E0.6390.41
186_E190_L0.6380.41
18_S50_K0.6370.40
59_S62_I0.6370.40
130_V263_L0.6370.40
263_L313_N0.6360.40
156_I173_P0.6350.40
245_N275_P0.6350.40
110_D163_G0.6350.40
388_P391_V0.6330.40
88_P278_M0.6330.40
145_V182_G0.6300.40
94_S274_C0.6300.40
339_V355_S0.6300.40
181_W276_G0.6280.40
290_L358_S0.6280.40
159_A162_R0.6270.39
260_E272_Y0.6260.39
315_L385_W0.6250.39
5_K113_A0.6220.39
8_V32_I0.6210.39
239_E243_K0.6200.39
182_G270_E0.6200.39
156_I166_I0.6180.39
300_K331_T0.6160.38
259_V290_L0.6160.38
43_D48_Q0.6140.38
218_I343_L0.6130.38
334_H395_V0.6120.38
34_C101_K0.6120.38
256_I276_G0.6110.38
50_K166_I0.6100.38
213_D344_F0.6100.38
76_S307_M0.6090.38
12_S15_L0.6090.38
73_A181_W0.6080.38
136_N393_S0.6060.38
104_E108_K0.6040.37
131_S317_F0.6030.37
231_D384_L0.6010.37
219_E351_E0.6010.37
154_E369_K0.6000.37
81_T307_M0.5990.37
151_S370_D0.5980.37
272_Y312_Y0.5980.37
44_L178_Q0.5980.37
94_S182_G0.5980.37
163_G168_I0.5950.37
126_V381_F0.5940.37
264_V365_A0.5940.37
234_S243_K0.5930.36
206_A251_H0.5920.36
70_Q238_S0.5910.36
52_L56_A0.5900.36
107_E141_V0.5880.36
20_A293_V0.5880.36
220_I244_L0.5880.36
103_V153_E0.5880.36
185_N258_H0.5870.36
19_V155_E0.5870.36
311_I316_W0.5840.36
52_L233_V0.5840.36
77_L181_W0.5840.36
159_A169_N0.5830.36
108_K112_Q0.5830.36
12_S16_D0.5820.35
89_L92_A0.5810.35
169_N173_P0.5810.35
253_V347_H0.5800.35
24_L145_V0.5800.35
129_E146_R0.5800.35
293_V296_V0.5800.35
291_T334_H0.5780.35
270_E367_Y0.5780.35
222_F283_A0.5770.35
210_K250_A0.5770.35
310_I321_K0.5760.35
171_D200_G0.5760.35
156_I167_P0.5760.35
209_E217_V0.5750.35
229_S235_Y0.5750.35
97_L101_K0.5740.35
82_M285_K0.5720.35
201_A352_G0.5720.35
71_D237_L0.5710.35
248_A343_L0.5700.34
32_I60_Y0.5690.34
369_K372_A0.5690.34
151_S270_E0.5680.34
207_P255_R0.5680.34
253_V279_T0.5670.34
177_D260_E0.5670.34
211_T251_H0.5660.34
27_Q149_Q0.5660.34
282_K285_K0.5610.34
11_Y50_K0.5600.34
13_G16_D0.5600.34
88_P367_Y0.5600.34
151_S368_T0.5580.33
178_Q202_Y0.5580.33
9_L17_T0.5580.33
80_H328_L0.5570.33
64_A114_I0.5570.33
6_K110_D0.5570.33
293_V361_D0.5550.33
41_G46_F0.5550.33
292_L297_A0.5520.33
167_P203_D0.5520.33
166_I169_N0.5520.33
284_H288_E0.5510.33
220_I283_A0.5500.33
107_E347_H0.5490.33
33_A52_L0.5480.33
295_E306_K0.5460.32
278_M348_A0.5460.32
5_K30_N0.5460.32
251_H347_H0.5460.32
379_I383_E0.5440.32
256_I268_S0.5440.32
370_D375_H0.5440.32
327_F386_G0.5430.32
308_S343_L0.5420.32
196_A215_P0.5410.32
186_E260_E0.5410.32
285_K301_P0.5400.32
281_I304_E0.5400.32
297_A309_E0.5390.32
334_H392_N0.5390.32
156_I271_V0.5370.32
218_I253_V0.5360.32
201_A395_V0.5350.31
28_G326_A0.5340.31
341_V352_G0.5340.31
222_F287_L0.5330.31
222_F227_P0.5320.31
147_E366_T0.5320.31
6_K32_I0.5320.31
172_S300_K0.5320.31
208_L346_G0.5310.31
151_S367_Y0.5300.31
362_E368_T0.5300.31
315_L388_P0.5300.31
65_K101_K0.5280.31
154_E310_I0.5280.31
90_V278_M0.5270.31
299_F315_L0.5270.31
210_K216_E0.5260.31
5_K28_G0.5260.31
124_D312_Y0.5250.31
159_A165_P0.5250.31
176_I201_A0.5240.31
91_S270_E0.5230.30
315_L389_T0.5230.30
334_H356_E0.5220.30
364_L375_H0.5210.30
41_G48_Q0.5210.30
182_G274_C0.5210.30
194_W384_L0.5200.30
155_E181_W0.5190.30
240_L280_L0.5190.30
233_V236_S0.5180.30
190_L360_Y0.5180.30
297_A301_P0.5170.30
186_E191_E0.5170.30
145_V148_W0.5150.30
281_I300_K0.5140.30
41_G242_L0.5140.30
117_G124_D0.5130.30
361_D364_L0.5130.30
68_F93_L0.5120.30
318_S388_P0.5120.30
206_A344_F0.5110.30
151_S375_H0.5110.30
299_F324_L0.5110.30
363_K370_D0.5110.30
80_H332_Q0.5100.29
47_V61_V0.5100.29
38_V97_L0.5100.29
99_A132_I0.5100.29
247_M251_H0.5100.29
215_P342_K0.5100.29
279_T348_A0.5100.29
24_L59_S0.5080.29
187_C377_A0.5080.29
77_L194_W0.5080.29
148_W367_Y0.5080.29
145_V367_Y0.5070.29
156_I170_L0.5070.29
60_Y101_K0.5070.29
87_Y122_G0.5060.29
94_S184_A0.5060.29
263_L388_P0.5060.29
23_W27_Q0.5050.29
10_A13_G0.5050.29
195_A198_P0.5030.29
122_G125_Q0.5030.29
40_E258_H0.5020.29
266_I384_L0.5020.29
374_D383_E0.5020.29
224_Q357_Y0.5020.29
45_A239_E0.5010.29
35_C258_H0.5010.29
64_A97_L0.5000.29
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vl2A 4 0.9677 100 0.214 Contact Map
2nz2A 4 0.9727 100 0.229 Contact Map
4xfjA 4 0.9801 100 0.259 Contact Map
1korA 4 0.9529 100 0.274 Contact Map
1k92A 4 0.9901 100 0.274 Contact Map
4nzpA 4 0.9429 100 0.28 Contact Map
2hmaA 2 0.8139 100 0.829 Contact Map
3rjzA 2 0.5037 99.9 0.863 Contact Map
2derA 1 0.7891 99.8 0.872 Contact Map
3k32A 2 0.4789 99.8 0.88 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0123 seconds.