GREMLIN Database
UXUA - Mannonate dehydratase
UniProt: O34346 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 359 (347)
Sequences: 997 (613)
Seq/√Len: 32.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
92_R198_A4.0251.00
197_E236_S3.9871.00
91_I102_I3.9711.00
177_D180_K3.8381.00
95_A199_Y3.7641.00
91_I201_V3.5401.00
185_L205_I3.4431.00
67_V90_T3.4251.00
44_K97_F3.2931.00
228_K262_T3.2931.00
35_Q46_E3.2651.00
224_E258_E3.1461.00
224_E262_T3.0721.00
88_K191_E3.0491.00
193_L203_M2.7731.00
16_T19_Y2.7621.00
4_T28_G2.7401.00
103_C242_T2.6681.00
270_S304_L2.5601.00
186_S190_Q2.4551.00
85_E88_K2.4100.99
345_L349_Y2.3710.99
245_T300_V2.3660.99
190_Q234_S2.3530.99
44_K96_G2.3370.99
298_Q345_L2.3120.99
52_E56_S2.2830.99
171_A174_R2.2710.99
2_N62_E2.2690.99
70_H83_Y2.2600.99
255_D258_E2.2520.99
182_W229_K2.2150.99
227_Y248_M2.1470.99
257_V299_G2.1320.99
287_S292_D2.0940.98
51_T55_Q2.0110.98
36_K43_E2.0030.98
260_A267_A2.0030.98
67_V94_L1.9960.98
192_I203_M1.9570.97
76_G80_R1.9320.97
200_G238_S1.9290.97
46_E49_A1.9080.97
222_T226_S1.8760.97
131_E282_D1.8490.96
41_V93_N1.8460.96
228_K232_A1.8340.96
227_Y241_I1.8310.96
47_I94_L1.8270.96
195_V198_A1.7980.96
240_C268_P1.7880.96
221_I230_L1.7840.96
345_L348_A1.7800.96
186_S233_I1.7770.96
193_L236_S1.7730.95
130_F212_W1.7710.95
44_K48_R1.7540.95
258_E262_T1.7520.95
295_I300_V1.7160.95
260_A264_A1.7030.94
92_R199_Y1.7020.94
48_R97_F1.6910.94
31_W54_I1.6350.93
2_N60_H1.6330.93
301_M342_L1.6170.93
41_V89_Q1.6070.92
261_K306_K1.5980.92
227_Y231_R1.5940.92
72_A79_E1.5900.92
243_L256_M1.5800.92
10_R53_Y1.5690.91
224_E263_Y1.5690.91
298_Q348_A1.5490.91
264_A307_Q1.5480.91
301_M345_L1.5390.91
167_K171_A1.5340.90
221_I227_Y1.5240.90
223_G251_N1.5160.90
81_G191_E1.5050.90
261_K299_G1.5030.90
92_R195_V1.4920.89
79_E82_R1.4470.88
278_Y282_D1.4310.87
48_R52_E1.4300.87
81_G187_F1.4210.87
276_K294_S1.4160.87
89_Q92_R1.4150.86
178_E213_P1.4010.86
211_P250_A1.3960.86
305_H349_Y1.3930.86
36_K46_E1.3770.85
204_A242_T1.3760.85
48_R51_T1.3720.85
272_I301_M1.3650.84
322_W332_L1.3540.84
67_V91_I1.3540.84
195_V199_Y1.3490.84
80_R187_F1.3480.84
257_V261_K1.3420.83
123_D337_L1.3400.83
179_E229_K1.3300.83
102_I201_V1.3270.83
250_A275_V1.3250.83
95_A201_V1.3240.83
261_K303_E1.3210.82
89_Q93_N1.3130.82
55_Q60_H1.3060.82
31_W61_A1.3040.82
120_P126_T1.2980.81
276_K292_D1.2970.81
298_Q351_A1.2870.81
77_N172_A1.2700.80
231_R235_D1.2560.79
64_V94_L1.2530.79
3_M346_W1.2440.78
298_Q349_Y1.2370.78
228_K263_Y1.2370.78
47_I93_N1.2360.78
243_L259_I1.2310.78
303_E306_K1.2290.77
140_P143_L1.2260.77
232_A235_D1.2230.77
289_L343_N1.2210.77
30_V63_V1.2140.77
224_E228_K1.2090.76
141_Q145_R1.2060.76
202_Q238_S1.1880.75
152_D327_R1.1730.74
333_Y336_A1.1720.74
180_K183_D1.1630.73
248_M259_I1.1610.73
2_N27_K1.1550.73
76_G187_F1.1510.73
231_R241_I1.1480.72
298_Q302_E1.1450.72
241_I263_Y1.1450.72
76_G81_G1.1350.72
189_L234_S1.1250.71
85_E191_E1.1050.69
90_T94_L1.0990.69
8_Y128_L1.0940.69
23_I332_L1.0940.69
35_Q49_A1.0920.69
301_M349_Y1.0850.68
142_E146_T1.0810.68
182_W226_S1.0790.68
223_G226_S1.0790.68
258_E263_Y1.0790.68
88_K195_V1.0730.67
54_I61_A1.0620.66
196_A238_S1.0610.66
245_T304_L1.0600.66
4_T312_Y1.0540.66
223_G253_A1.0520.66
125_S321_L1.0460.65
186_S229_K1.0390.65
347_D351_A1.0350.64
5_F26_V1.0310.64
88_K92_R1.0300.64
193_L234_S1.0260.64
26_V339_I1.0260.64
205_I221_I1.0130.63
78_E81_G1.0090.62
305_H346_W1.0050.62
131_E134_K0.9980.61
49_A53_Y0.9970.61
248_M257_V0.9940.61
272_I297_I0.9920.61
62_E100_K0.9890.61
40_D82_R0.9860.61
72_A75_L0.9860.61
126_T320_H0.9830.60
204_A248_M0.9830.60
296_N299_G0.9820.60
332_L336_A0.9800.60
186_S234_S0.9780.60
116_D119_R0.9700.59
100_K200_G0.9650.59
125_S337_L0.9530.58
193_L196_A0.9480.57
47_I90_T0.9440.57
132_K136_E0.9410.57
197_E238_S0.9410.57
178_E229_K0.9360.56
305_H350_E0.9360.56
327_R331_G0.9340.56
165_R168_E0.9320.56
135_V215_F0.9290.56
260_A304_L0.9290.56
340_M343_N0.9260.56
75_L176_V0.9210.55
256_M259_I0.9210.55
75_L172_A0.9200.55
142_E145_R0.9180.55
62_E312_Y0.9160.55
71_E75_L0.9120.55
320_H331_G0.9120.55
47_I67_V0.9090.54
23_I336_A0.9070.54
320_H326_C0.9040.54
116_D131_E0.9030.54
101_V202_Q0.8990.53
15_V23_I0.8900.53
21_K122_E0.8880.53
182_W230_L0.8850.52
45_E198_A0.8840.52
61_A64_V0.8820.52
84_I88_K0.8810.52
286_T292_D0.8800.52
143_L146_T0.8790.52
28_G312_Y0.8770.52
30_V269_F0.8730.51
245_T249_G0.8650.51
264_A303_E0.8650.51
5_F23_I0.8610.50
101_V312_Y0.8590.50
129_F278_Y0.8580.50
32_A38_V0.8460.49
18_E57_Y0.8460.49
311_G331_G0.8450.49
162_K165_R0.8410.49
242_T268_P0.8410.49
321_L337_L0.8380.48
4_T62_E0.8380.48
100_K310_E0.8370.48
43_E90_T0.8360.48
1_M301_M0.8350.48
231_R266_I0.8350.48
67_V87_Y0.8310.48
204_A308_D0.8290.48
103_C269_F0.8270.47
256_M277_I0.8270.47
235_D266_I0.8250.47
132_K281_G0.8220.47
289_L292_D0.8210.47
38_V159_E0.8210.47
50_E61_A0.8200.47
103_C204_A0.8190.47
260_A303_E0.8160.47
88_K192_I0.8140.46
226_S230_L0.8100.46
256_M264_A0.8090.46
71_E173_Y0.8030.45
202_Q268_P0.8000.45
265_G307_Q0.7990.45
8_Y235_D0.7920.45
236_S266_I0.7890.44
34_H50_E0.7830.44
261_K307_Q0.7830.44
31_W50_E0.7820.44
252_P277_I0.7820.44
178_E225_A0.7790.44
183_D186_S0.7750.43
134_K137_S0.7700.43
10_R50_E0.7700.43
85_E89_Q0.7690.43
15_V332_L0.7680.43
276_K286_T0.7670.43
229_K233_I0.7650.42
152_D159_E0.7630.42
228_K258_E0.7620.42
234_S266_I0.7620.42
72_A83_Y0.7610.42
191_E195_V0.7540.41
25_G289_L0.7530.41
18_E323_G0.7510.41
38_V327_R0.7510.41
250_A274_N0.7510.41
54_I64_V0.7470.41
230_L235_D0.7460.41
267_A304_L0.7450.41
221_I241_I0.7440.41
63_V101_V0.7440.41
95_A100_K0.7410.40
29_I59_F0.7390.40
29_I62_E0.7390.40
20_V26_V0.7380.40
80_R84_I0.7310.40
182_W221_I0.7280.39
230_L241_I0.7250.39
118_F126_T0.7240.39
130_F135_V0.7230.39
135_V150_A0.7220.39
133_A282_D0.7200.39
88_K198_A0.7200.39
184_N187_F0.7190.39
189_L193_L0.7180.39
119_R129_F0.7170.39
95_A102_I0.7100.38
319_R331_G0.7090.38
88_K199_Y0.7080.38
193_L221_I0.7070.38
77_N80_R0.7060.38
91_I199_Y0.7050.38
115_T135_V0.7040.38
72_A77_N0.7030.37
289_L340_M0.7020.37
159_E163_L0.6990.37
337_L341_Y0.6950.37
56_S142_E0.6920.37
144_I166_I0.6910.37
72_A78_E0.6900.36
274_N286_T0.6870.36
129_F282_D0.6870.36
241_I267_A0.6860.36
15_V35_Q0.6820.36
225_A229_K0.6800.36
234_S239_N0.6790.36
18_E120_P0.6790.36
245_T250_A0.6750.35
121_L284_I0.6720.35
8_Y214_I0.6720.35
26_V29_I0.6720.35
44_K93_N0.6710.35
193_L238_S0.6680.35
302_E349_Y0.6680.35
15_V20_V0.6650.35
287_S321_L0.6640.34
183_D187_F0.6630.34
182_W233_I0.6630.34
51_T61_A0.6620.34
148_E152_D0.6610.34
27_K60_H0.6600.34
168_E171_A0.6560.34
81_G84_I0.6560.34
118_F320_H0.6560.34
267_A270_S0.6540.34
231_R263_Y0.6540.34
6_R9_G0.6540.34
2_N310_E0.6530.34
76_G184_N0.6530.34
82_R86_N0.6510.33
50_E53_Y0.6500.33
274_N295_I0.6500.33
4_T8_Y0.6480.33
10_R49_A0.6460.33
132_K214_I0.6460.33
284_I287_S0.6440.33
274_N287_S0.6440.33
119_R284_I0.6430.33
274_N315_P0.6430.33
257_V264_A0.6430.33
12_N99_V0.6410.33
31_W64_V0.6400.33
84_I187_F0.6390.33
177_D183_D0.6380.33
89_Q96_G0.6350.32
41_V47_I0.6310.32
169_L227_Y0.6300.32
105_N111_D0.6290.32
260_A299_G0.6290.32
38_V166_I0.6270.32
242_T269_F0.6270.32
51_T97_F0.6260.32
319_R337_L0.6260.32
63_V312_Y0.6240.32
121_L127_A0.6230.31
334_D341_Y0.6230.31
113_T153_M0.6220.31
53_Y56_S0.6220.31
140_P144_I0.6220.31
182_W186_S0.6220.31
296_N351_A0.6210.31
189_L239_N0.6200.31
323_G333_Y0.6200.31
38_V153_M0.6200.31
185_L230_L0.6190.31
141_Q197_E0.6180.31
259_I277_I0.6180.31
87_Y192_I0.6150.31
37_P43_E0.6140.31
95_A195_V0.6120.31
146_T149_E0.6110.31
84_I87_Y0.6100.31
147_V155_L0.6090.30
346_W350_E0.6080.30
132_K282_D0.6080.30
38_V158_W0.6070.30
48_R96_G0.6050.30
14_T326_C0.6040.30
259_I263_Y0.6030.30
100_K202_Q0.6020.30
278_Y284_I0.6000.30
187_F191_E0.5990.30
91_I195_V0.5990.30
141_Q144_I0.5970.30
30_V101_V0.5970.30
87_Y203_M0.5970.30
44_K89_Q0.5970.30
138_L148_E0.5960.30
196_A277_I0.5940.29
143_L147_V0.5930.29
127_A326_C0.5930.29
313_V331_G0.5930.29
200_G237_P0.5920.29
26_V59_F0.5920.29
71_E110_F0.5910.29
47_I97_F0.5910.29
277_I294_S0.5870.29
27_K62_E0.5860.29
5_F8_Y0.5860.29
125_S298_Q0.5860.29
130_F179_E0.5850.29
259_I304_L0.5840.29
92_R122_E0.5840.29
321_L332_L0.5830.29
134_K287_S0.5820.29
297_I342_L0.5820.29
183_D232_A0.5800.28
16_T21_K0.5800.28
163_L167_K0.5790.28
304_L310_E0.5770.28
106_F315_P0.5770.28
101_V201_V0.5760.28
14_T327_R0.5760.28
85_E184_N0.5730.28
272_I313_V0.5720.28
190_Q235_D0.5720.28
193_L197_E0.5720.28
3_M343_N0.5720.28
139_D215_F0.5710.28
320_H327_R0.5710.28
270_S311_G0.5700.28
76_G180_K0.5690.28
107_M111_D0.5690.28
67_V214_I0.5670.28
225_A263_Y0.5630.27
93_N211_P0.5620.27
322_W334_D0.5610.27
110_F158_W0.5590.27
43_E89_Q0.5590.27
202_Q237_P0.5590.27
192_I238_S0.5580.27
201_V238_S0.5560.27
52_E145_R0.5550.27
204_A268_P0.5530.27
68_N160_P0.5530.27
264_A277_I0.5520.27
245_T270_S0.5510.27
56_S96_G0.5510.27
179_E182_W0.5510.27
292_D347_D0.5510.27
14_T153_M0.5500.26
29_I233_I0.5490.26
302_E306_K0.5480.26
189_L197_E0.5470.26
3_M23_I0.5470.26
17_L21_K0.5460.26
128_L205_I0.5440.26
68_N155_L0.5440.26
158_W161_E0.5440.26
89_Q118_F0.5430.26
45_E49_A0.5430.26
90_T93_N0.5420.26
182_W196_A0.5390.26
304_L313_V0.5390.26
164_A167_K0.5390.26
178_E220_I0.5390.26
196_A199_Y0.5380.26
260_A270_S0.5380.26
183_D302_E0.5370.26
324_E333_Y0.5370.26
27_K294_S0.5360.26
181_L185_L0.5340.25
75_L196_A0.5330.25
121_L337_L0.5330.25
113_T154_T0.5290.25
237_P265_G0.5290.25
81_G88_K0.5280.25
190_Q233_I0.5270.25
93_N96_G0.5270.25
129_F284_I0.5250.25
314_R318_G0.5250.25
28_G58_G0.5250.25
26_V161_E0.5230.25
103_C161_E0.5220.25
18_E176_V0.5210.25
31_W34_H0.5210.25
147_V151_S0.5210.25
336_A341_Y0.5210.25
274_N293_G0.5200.25
13_D114_R0.5200.25
166_I170_F0.5200.25
38_V160_P0.5200.25
298_Q347_D0.5200.25
234_S241_I0.5200.25
102_I261_K0.5180.24
14_T325_Q0.5160.24
35_Q43_E0.5150.24
93_N97_F0.5140.24
182_W225_A0.5140.24
230_L233_I0.5130.24
243_L304_L0.5120.24
155_L161_E0.5110.24
37_P211_P0.5110.24
89_Q202_Q0.5110.24
132_K212_W0.5110.24
47_I51_T0.5100.24
141_Q279_E0.5100.24
286_T295_I0.5080.24
263_Y303_E0.5070.24
331_G334_D0.5070.24
128_L319_R0.5070.24
67_V204_A0.5070.24
176_V180_K0.5060.24
301_M348_A0.5060.24
75_L180_K0.5050.24
170_F175_T0.5050.24
175_T255_D0.5050.24
339_I343_N0.5050.24
6_R13_D0.5050.24
2_N243_L0.5050.24
32_A63_V0.5050.24
28_G235_D0.5030.24
71_E170_F0.5030.24
175_T258_E0.5020.23
297_I340_M0.5020.23
122_E201_V0.5010.23
108_P173_Y0.5010.23
67_V159_E0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4eacA 1 0.9777 100 0.468 Contact Map
3bdkA 2 0.9387 100 0.553 Contact Map
1tz9A 2 0.9526 100 0.643 Contact Map
3vniA 4 0.7493 99.9 0.855 Contact Map
1i60A 1 0.7577 99.9 0.858 Contact Map
2hk0A 3 0.7437 99.9 0.859 Contact Map
3cqjA 2 0.7382 99.9 0.861 Contact Map
3obeA 1 0.7242 99.9 0.862 Contact Map
2qulA 2 0.7437 99.9 0.863 Contact Map
3u0hA 3 0.7604 99.9 0.863 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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