GREMLIN Database
YOAK - UPF0700 transmembrane protein YoaK
UniProt: O34343 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 225 (199)
Sequences: 2339 (1828)
Seq/√Len: 129.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_I124_I3.6351.00
41_I185_C3.5081.00
97_A214_M3.3531.00
130_T144_T3.3351.00
67_I154_L3.2181.00
71_I158_S3.1831.00
16_L190_I2.9411.00
12_S183_L2.8731.00
104_A204_W2.8401.00
44_L56_V2.6231.00
129_Q143_S2.5961.00
97_A211_F2.5371.00
65_G120_I2.4281.00
47_A52_I2.2811.00
71_I157_I2.2521.00
24_I202_I2.1941.00
67_I150_L2.1191.00
153_L174_T2.1101.00
101_F207_I2.0661.00
153_L178_A1.9771.00
198_F205_V1.9701.00
107_S111_A1.9161.00
65_G69_G1.8211.00
37_M150_L1.8041.00
145_V148_G1.7991.00
142_S145_V1.7681.00
23_V191_V1.6961.00
96_E100_L1.6821.00
61_T120_I1.6701.00
130_T148_G1.6601.00
60_L64_I1.6521.00
22_D42_V1.6491.00
27_L195_E1.6281.00
100_L122_M1.6171.00
11_L15_C1.6111.00
144_T148_G1.6101.00
69_G127_G1.5881.00
50_K196_P1.5591.00
41_I146_L1.5561.00
93_L96_E1.5131.00
97_A207_I1.5061.00
25_G34_T1.4841.00
96_E129_Q1.4801.00
36_N151_A1.4801.00
36_N142_S1.4521.00
37_M40_N1.4341.00
33_F43_L1.3861.00
201_F204_W1.3801.00
34_T126_M1.3691.00
130_T145_V1.3671.00
150_L181_I1.3651.00
20_I191_V1.3551.00
45_G188_A1.3231.00
171_L175_V1.3201.00
142_S152_S1.2951.00
202_I205_V1.2931.00
148_G180_A1.2621.00
209_L212_G1.2551.00
37_M62_A1.2451.00
91_K95_L1.2321.00
182_I186_V1.2291.00
67_I153_L1.2191.00
130_T142_S1.2171.00
37_M146_L1.2140.99
39_G66_F1.2010.99
149_T181_I1.2000.99
186_V190_I1.1820.99
17_T210_I1.1820.99
22_D33_F1.1800.99
35_A38_T1.1700.99
35_A126_M1.1700.99
96_E210_I1.1580.99
47_A56_V1.1530.99
106_L114_P1.1500.99
73_A131_T1.1470.99
73_A132_A1.1470.99
203_I206_P1.1450.99
28_S195_E1.1450.99
34_T129_Q1.1410.99
58_N123_S1.1320.99
94_A98_F1.1200.99
45_G189_I1.1080.99
36_N130_T1.1070.99
36_N143_S1.1050.99
94_A211_F1.1000.99
99_I103_F1.1000.99
106_L208_V1.0990.99
64_I83_T1.0880.99
194_A205_V1.0870.99
145_V152_S1.0730.99
146_L149_T1.0700.99
44_L185_C1.0670.99
25_G122_M1.0640.99
69_G124_I1.0580.99
15_C43_L1.0500.99
35_A144_T1.0460.98
12_S179_L1.0080.98
89_V96_E1.0010.98
63_L185_C1.0000.98
202_I206_P0.9970.98
129_Q132_A0.9960.98
70_V131_T0.9920.98
20_I194_A0.9790.98
73_A128_I0.9720.98
101_F204_W0.9700.98
33_F40_N0.9700.98
21_V206_P0.9660.97
96_E154_L0.9640.97
70_V155_E0.9620.97
10_L213_I0.9390.97
146_L181_I0.9390.97
145_V151_A0.9390.97
106_L186_V0.9350.97
15_C180_A0.9300.97
21_V147_T0.9280.97
73_A127_G0.9280.97
35_A130_T0.9260.97
17_T209_L0.9250.97
182_I194_A0.9100.96
143_S151_A0.9070.96
156_D177_R0.9070.96
69_G123_S0.8950.96
68_C124_I0.8950.96
36_N145_V0.8890.96
71_I161_L0.8870.96
139_A176_L0.8870.96
22_D145_V0.8850.96
16_L186_V0.8840.96
78_G162_F0.8840.96
134_K142_S0.8820.96
37_M126_M0.8820.96
35_A119_I0.8810.96
36_N43_L0.8730.95
34_T62_A0.8710.95
68_C164_K0.8680.95
113_V117_I0.8640.95
111_A208_V0.8600.95
116_H120_I0.8530.95
21_V100_L0.8520.95
98_F215_M0.8370.94
22_D89_V0.8340.94
10_L141_I0.8300.94
13_L209_L0.8250.94
36_N66_F0.8220.94
102_V197_D0.8180.93
149_T177_R0.8180.93
142_S151_A0.8160.93
64_I68_C0.8140.93
38_T42_V0.8080.93
54_V102_V0.8070.93
35_A213_I0.8050.93
27_L34_T0.8040.93
52_I55_T0.8010.93
175_V179_L0.8010.93
76_M91_K0.7980.93
33_F134_K0.7960.93
26_Y146_L0.7960.93
18_A145_V0.7920.92
102_V106_L0.7730.91
17_T21_V0.7730.91
130_T154_L0.7650.91
22_D148_G0.7600.91
103_F125_S0.7550.90
68_C208_V0.7540.90
131_T142_S0.7540.90
47_A55_T0.7540.90
22_D152_S0.7530.90
11_L180_A0.7490.90
41_I150_L0.7460.90
136_L176_L0.7440.90
17_T206_P0.7440.90
22_D142_S0.7430.90
131_T144_T0.7350.89
133_A180_A0.7340.89
81_E87_S0.7300.89
11_L141_I0.7300.89
130_T151_A0.7210.88
126_M130_T0.7180.88
112_F115_V0.7170.88
164_K171_L0.7160.88
26_Y135_K0.7140.88
194_A197_D0.7120.88
134_K156_D0.7030.87
103_F203_I0.6990.87
21_V122_M0.6980.87
9_T211_F0.6950.86
104_A207_I0.6940.86
27_L46_L0.6930.86
42_V127_G0.6930.86
160_R164_K0.6910.86
127_G144_T0.6900.86
145_V180_A0.6860.86
102_V190_I0.6840.86
42_V181_I0.6830.85
54_V57_F0.6800.85
74_T159_G0.6790.85
68_C71_I0.6760.85
64_I67_I0.6760.85
147_T150_L0.6690.84
156_D173_D0.6650.84
190_I194_A0.6640.84
131_T151_A0.6640.84
15_C33_F0.6610.84
148_G184_Y0.6550.83
160_R174_T0.6550.83
133_A151_A0.6470.82
102_V171_L0.6470.82
139_A152_S0.6440.82
104_A201_F0.6420.82
48_I190_I0.6400.82
9_T137_G0.6390.81
117_I197_D0.6380.81
51_S56_V0.6380.81
26_Y58_N0.6320.81
38_T43_L0.6320.81
137_G176_L0.6300.81
134_K145_V0.6290.80
68_C178_A0.6250.80
194_A198_F0.6250.80
47_A54_V0.6240.80
129_Q136_L0.6220.80
154_L178_A0.6220.80
127_G143_S0.6200.80
138_I151_A0.6200.80
29_L118_L0.6190.79
126_M144_T0.6190.79
57_F157_I0.6190.79
51_S196_P0.6180.79
190_I212_G0.6180.79
143_S155_E0.6130.79
198_F202_I0.6110.79
147_T209_L0.6100.78
133_A177_R0.6060.78
11_L148_G0.6050.78
55_T59_S0.6040.78
65_G123_S0.6040.78
148_G152_S0.6030.78
143_S191_V0.5990.77
90_T214_M0.5960.77
17_T20_I0.5940.77
134_K152_S0.5900.76
18_A36_N0.5900.76
151_A181_I0.5880.76
24_I203_I0.5880.76
25_G42_V0.5840.75
102_V212_G0.5820.75
134_K184_Y0.5800.75
45_G49_G0.5800.75
159_G173_D0.5790.75
29_L146_L0.5790.75
60_L107_S0.5770.75
199_Y205_V0.5760.74
186_V194_A0.5750.74
16_L183_L0.5740.74
151_A155_E0.5740.74
55_T98_F0.5720.74
207_I214_M0.5710.74
71_I154_L0.5680.73
13_L213_I0.5670.73
44_L63_L0.5660.73
104_A203_I0.5650.73
99_I125_S0.5570.72
80_A88_A0.5560.72
54_V186_V0.5560.72
124_I210_I0.5560.72
35_A147_T0.5550.72
38_T181_I0.5510.71
137_G140_G0.5510.71
70_V74_T0.5500.71
172_R215_M0.5490.71
21_V203_I0.5480.71
11_L183_L0.5470.71
21_V126_M0.5470.71
178_A182_I0.5410.70
78_G173_D0.5380.69
83_T212_G0.5370.69
21_V176_L0.5330.69
92_A123_S0.5330.69
130_T152_S0.5320.68
9_T84_L0.5280.68
152_S155_E0.5260.68
38_T142_S0.5260.68
40_N123_S0.5240.67
42_V83_T0.5240.67
13_L193_L0.5230.67
40_N63_L0.5230.67
61_T116_H0.5220.67
12_S16_L0.5200.67
103_F121_L0.5150.66
34_T103_F0.5140.66
70_V154_L0.5130.66
30_G59_S0.5080.65
102_V113_V0.5070.65
17_T213_I0.5060.65
28_S93_L0.5040.64
49_G193_L0.5020.64
60_L128_I0.5010.64
48_I165_K0.5000.64
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ldsA 2 0.7956 90.3 0.893 Contact Map
4j05A 3 0.8044 90.1 0.893 Contact Map
1pw4A 1 0.8489 87.9 0.898 Contact Map
4zw9A 1 0.88 85.8 0.901 Contact Map
2cfqA 1 0.8444 84.5 0.903 Contact Map
3wdoA 1 0.8178 82.2 0.905 Contact Map
3o7qA 1 0.8267 82 0.905 Contact Map
4pypA 1 0.8489 79.1 0.908 Contact Map
4tphA 2 0.8178 75.2 0.911 Contact Map
4xnjA 1 0.8533 74 0.912 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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