GREMLIN Database
YEBC - Uncharacterized protein YebC
UniProt: O34341 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 267 (226)
Sequences: 220 (190)
Seq/√Len: 12.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
61_A64_W4.3661.00
70_Y99_S3.7980.99
112_W132_F3.2430.98
154_I171_A2.8250.95
136_F140_L2.7940.94
97_L101_L2.6940.93
73_F77_I2.6190.92
77_I180_V2.5890.92
149_V156_A2.5420.91
188_L240_A2.4210.89
108_S136_F2.3490.87
173_A180_V2.2690.85
60_L70_Y2.2400.84
110_G186_S2.1680.82
173_A176_G2.1320.81
167_T205_T2.0410.78
33_A37_S2.0300.78
102_I183_I2.0210.77
64_W67_I1.9300.74
174_V219_Y1.8640.71
132_F139_V1.8360.70
195_V207_L1.7840.68
101_L153_A1.7810.68
75_F108_S1.7670.67
168_F212_I1.7330.65
34_S37_S1.7270.65
145_I202_V1.7220.65
96_G218_L1.7180.65
41_Q168_F1.6800.63
81_P96_G1.6690.62
159_R250_A1.6670.62
65_A68_N1.6610.62
96_G173_A1.6540.62
169_R184_A1.6150.60
102_I163_K1.6090.60
194_I209_L1.6040.59
168_F260_I1.5560.57
70_Y102_I1.5450.56
141_V194_I1.5240.55
106_I187_I1.5230.55
156_A194_I1.5040.54
73_F103_F1.4920.54
34_S191_I1.4890.53
118_S243_A1.4760.53
39_Q42_K1.4760.53
90_F258_E1.4730.53
73_F186_S1.4720.53
108_S180_V1.4710.53
248_F252_T1.4620.52
99_S183_I1.4610.52
81_P233_D1.4610.52
73_F117_A1.4460.51
67_I168_F1.4350.51
188_L213_F1.4310.50
37_S170_E1.4220.50
200_L217_A1.3910.48
143_L256_I1.3880.48
198_P209_L1.3850.48
77_I171_A1.3730.47
143_L239_F1.3210.45
137_L251_V1.3200.45
192_F262_A1.3010.44
170_E174_V1.2970.44
31_R34_S1.2800.43
49_Q247_L1.2650.42
188_L251_V1.2570.42
137_L151_V1.2550.41
138_V174_V1.2410.41
151_V218_L1.2390.41
34_S43_Q1.2210.40
177_S235_I1.2120.39
204_F215_I1.1920.38
234_Y244_I1.1900.38
175_L218_L1.1820.38
35_R44_K1.1740.37
78_L184_A1.1710.37
73_F131_A1.1670.37
182_V217_A1.1670.37
70_Y93_Y1.1620.37
31_R46_K1.1600.37
73_F179_L1.1550.37
119_W205_T1.1530.36
246_L261_T1.1440.36
156_A201_T1.1430.36
171_A204_F1.1380.36
185_V190_L1.1380.36
123_L204_F1.1240.35
33_A36_Q1.1170.35
226_A260_I1.1160.35
155_W180_V1.1150.35
79_K182_V1.1110.34
122_P128_R1.1100.34
112_W162_M1.1000.34
122_P197_I1.0990.34
44_K137_L1.0870.33
106_I133_Y1.0810.33
37_S40_K1.0790.33
122_P152_F1.0760.33
188_L262_A1.0720.33
56_V248_F1.0700.33
82_A176_G1.0700.33
60_L185_V1.0700.33
94_K173_A1.0690.33
106_I219_Y1.0660.32
159_R252_T1.0650.32
56_V243_A1.0620.32
152_F210_F1.0580.32
146_F188_L1.0530.32
58_D62_S1.0480.32
150_M180_V1.0470.32
73_F154_I1.0420.31
101_L248_F1.0260.31
146_F155_W1.0240.31
43_Q229_D1.0210.30
71_C75_F1.0180.30
73_F180_V1.0170.30
174_V238_V1.0150.30
95_Y176_G1.0140.30
154_I184_A1.0140.30
196_N244_I1.0100.30
146_F167_T1.0040.30
71_C103_F1.0020.30
106_I141_V1.0010.30
145_I235_I1.0000.29
142_Y248_F0.9990.29
163_K197_I0.9990.29
143_L168_F0.9940.29
41_Q45_Q0.9940.29
56_V61_A0.9910.29
77_I173_A0.9900.29
112_W191_I0.9890.29
93_Y169_R0.9890.29
175_L236_Y0.9810.29
89_G183_I0.9800.29
154_I158_S0.9800.29
185_V205_T0.9780.29
99_S162_M0.9770.29
181_P217_A0.9660.28
103_F176_G0.9660.28
156_A243_A0.9650.28
179_L186_S0.9620.28
152_F184_A0.9600.28
113_F254_P0.9570.28
57_K61_A0.9510.27
73_F177_S0.9460.27
175_L232_I0.9450.27
73_F162_M0.9440.27
132_F176_G0.9400.27
34_S247_L0.9380.27
39_Q99_S0.9350.27
99_S237_C0.9340.27
148_A218_L0.9250.26
222_R233_D0.9240.26
48_R203_L0.9230.26
171_A180_V0.9190.26
168_F193_A0.9170.26
69_R80_S0.9150.26
101_L172_A0.9090.26
173_A184_A0.9050.26
103_F177_S0.9000.25
32_K35_R0.8990.25
37_S141_V0.8930.25
108_S184_A0.8930.25
199_M206_V0.8890.25
57_K64_W0.8890.25
58_D247_L0.8890.25
80_S193_A0.8870.25
138_V144_L0.8860.25
204_F208_I0.8850.25
178_L237_C0.8780.25
62_S67_I0.8770.25
106_I201_T0.8700.24
72_G175_L0.8670.24
112_W176_G0.8650.24
105_I209_L0.8590.24
36_Q40_K0.8560.24
140_L244_I0.8560.24
31_R172_A0.8530.24
51_R244_I0.8500.23
108_S146_F0.8470.23
101_L235_I0.8450.23
34_S187_I0.8420.23
231_P238_V0.8400.23
202_V206_V0.8370.23
44_K138_V0.8320.23
137_L184_A0.8270.23
71_C233_D0.8250.23
50_E260_I0.8250.23
244_I251_V0.8160.22
77_I235_I0.8150.22
99_S236_Y0.8140.22
97_L236_Y0.8080.22
161_M237_C0.7970.22
152_F187_I0.7950.22
37_S45_Q0.7890.21
106_I243_A0.7880.21
145_I150_M0.7800.21
240_A249_T0.7730.21
103_F179_L0.7730.21
220_V239_F0.7710.21
108_S173_A0.7700.21
80_S157_V0.7690.21
158_S175_L0.7610.20
44_K185_V0.7600.20
57_K60_L0.7600.20
78_L206_V0.7550.20
191_I206_V0.7510.20
171_A234_Y0.7460.20
143_L190_L0.7440.20
137_L260_I0.7430.20
130_H137_L0.7380.20
85_V200_L0.7370.20
105_I234_Y0.7360.20
77_I184_A0.7360.20
176_G225_Q0.7350.19
100_M255_F0.7350.19
75_F79_K0.7340.19
182_V215_I0.7320.19
226_A232_I0.7310.19
97_L117_A0.7310.19
72_G187_I0.7200.19
108_S139_V0.7200.19
148_A232_I0.7170.19
93_Y96_G0.7150.19
58_D163_K0.7140.19
136_F183_I0.7100.19
100_M104_S0.7090.19
212_I244_I0.7060.19
74_A154_I0.7010.18
243_A251_V0.7010.18
152_F247_L0.7000.18
155_W171_A0.7000.18
47_P194_I0.6980.18
74_A157_V0.6940.18
63_V186_S0.6940.18
149_V161_M0.6890.18
70_Y177_S0.6880.18
68_N102_I0.6880.18
77_I177_S0.6820.18
220_V248_F0.6790.18
180_V233_D0.6720.18
72_G207_L0.6700.17
103_F154_I0.6690.17
105_I168_F0.6670.17
71_C85_V0.6650.17
50_E205_T0.6630.17
82_A181_P0.6610.17
95_Y119_W0.6600.17
31_R35_R0.6600.17
42_K45_Q0.6580.17
70_Y181_P0.6560.17
243_A250_A0.6510.17
133_Y258_E0.6500.17
60_L95_Y0.6500.17
134_D145_I0.6490.17
203_L212_I0.6460.17
101_L113_F0.6460.17
53_E248_F0.6450.17
82_A233_D0.6430.17
100_M236_Y0.6310.16
73_F173_A0.6300.16
78_L215_I0.6240.16
105_I247_L0.6220.16
76_S95_Y0.6180.16
107_F125_F0.6140.16
155_W205_T0.6090.16
85_V231_P0.6090.16
98_I179_L0.6060.16
145_I239_F0.6050.16
111_N260_I0.6050.16
145_I205_T0.6040.16
173_A237_C0.6020.16
105_I206_V0.6010.16
101_L206_V0.6000.15
72_G104_S0.5960.15
32_K38_K0.5940.15
47_P53_E0.5920.15
58_D109_I0.5920.15
77_I255_F0.5910.15
50_E133_Y0.5900.15
63_V79_K0.5860.15
156_A185_V0.5860.15
210_F244_I0.5850.15
130_H214_F0.5850.15
85_V241_V0.5840.15
149_V214_F0.5830.15
126_G188_L0.5820.15
77_I95_Y0.5810.15
32_K240_A0.5770.15
140_L251_V0.5770.15
132_F179_L0.5750.15
60_L247_L0.5740.15
101_L185_V0.5740.15
72_G185_V0.5740.15
176_G233_D0.5720.15
67_I145_I0.5720.15
179_L215_I0.5710.15
145_I167_T0.5710.15
108_S174_V0.5690.15
186_S190_L0.5690.15
118_S150_M0.5670.15
63_V116_K0.5660.15
97_L213_F0.5620.14
195_V257_S0.5560.14
101_L188_L0.5540.14
141_V260_I0.5530.14
247_L251_V0.5510.14
41_Q140_L0.5470.14
181_P201_T0.5460.14
80_S145_I0.5460.14
77_I234_Y0.5450.14
195_V237_C0.5390.14
140_L191_I0.5360.14
117_A172_A0.5350.14
72_G237_C0.5350.14
89_G176_G0.5280.14
92_H170_E0.5270.14
191_I234_Y0.5270.14
168_F237_C0.5260.14
252_T260_I0.5260.14
63_V109_I0.5240.14
53_E167_T0.5230.14
214_F217_A0.5230.14
69_R108_S0.5230.14
146_F179_L0.5200.13
41_Q44_K0.5200.13
101_L109_I0.5150.13
107_F201_T0.5140.13
73_F255_F0.5140.13
39_Q83_K0.5140.13
59_K73_F0.5140.13
32_K106_I0.5100.13
35_R39_Q0.5060.13
103_F180_V0.5060.13
78_L180_V0.5050.13
97_L167_T0.5050.13
157_V219_Y0.5030.13
85_V215_I0.5020.13
149_V249_T0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4febA 3 0.0712 66.2 0.925 Contact Map
5a63B 1 0.3895 43.1 0.935 Contact Map
3wdoA 1 0.2547 36.2 0.938 Contact Map
4l3aA 1 0.0225 20.7 0.945 Contact Map
4ui9I 1 0.0449 20.2 0.945 Contact Map
3wqtA 2 0 11.3 0.951 Contact Map
3wu2Z 1 0.2247 8.8 0.953 Contact Map
4pj3A 1 0 7.9 0.954 Contact Map
3m0cC 1 0.0112 5.5 0.958 Contact Map
3syjA 2 0.015 5.4 0.958 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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