GREMLIN Database
FABF - 3-oxoacyl-[acyl-carrier-protein] synthase 2
UniProt: O34340 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 413 (396)
Sequences: 21132 (13797)
Seq/√Len: 693.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
280_A320_T3.2041.00
258_V409_K3.1001.00
20_D23_T2.8621.00
353_S392_V2.8171.00
100_R184_D2.7171.00
26_N30_N2.7071.00
172_G260_Y2.6961.00
255_G354_I2.6931.00
224_K370_T2.6461.00
224_K373_E2.5491.00
391_Y409_K2.5441.00
361_V384_A2.4511.00
4_K244_E2.4201.00
254_Y358_K2.3571.00
88_D254_Y2.2961.00
85_A239_V2.2891.00
242_E245_H2.2311.00
29_I361_V2.2281.00
27_N34_G2.2101.00
222_F302_A2.2081.00
81_A235_A2.1421.00
27_N32_V2.1061.00
19_N23_T2.0801.00
221_P336_S2.0721.00
356_A363_P2.0671.00
296_E391_Y2.0641.00
178_I242_E2.0591.00
350_A408_F2.0561.00
104_W177_V2.0521.00
171_I350_A2.0361.00
241_E251_A2.0061.00
5_R258_V1.9621.00
361_V386_R1.9591.00
225_N370_T1.9581.00
280_A284_Q1.9561.00
176_K180_R1.9451.00
364_P384_A1.9381.00
107_S143_A1.9161.00
330_A385_R1.9101.00
293_A296_E1.8571.00
241_E249_R1.8161.00
83_K87_E1.8141.00
82_A147_I1.8131.00
216_K227_D1.8091.00
82_A187_V1.7961.00
63_M71_M1.7941.00
102_G186_M1.7911.00
100_R285_E1.7811.00
390_N410_K1.7731.00
35_I52_A1.7551.00
292_I391_Y1.7541.00
379_Y385_R1.7361.00
15_S348_I1.7331.00
105_V237_I1.7241.00
243_L247_L1.7141.00
362_I381_P1.6971.00
355_L358_K1.6921.00
245_H248_A1.6911.00
236_G347_G1.6861.00
225_N369_Q1.6641.00
355_L359_E1.6631.00
37_P50_V1.6531.00
280_A321_V1.6501.00
175_F257_I1.6441.00
8_V350_A1.6331.00
189_G237_I1.6241.00
24_S334_T1.6241.00
37_P49_K1.6131.00
36_G55_K1.6051.00
183_A186_M1.6051.00
232_G341_L1.5801.00
252_K358_K1.5751.00
12_G81_A1.5731.00
175_F179_Q1.5731.00
33_S218_A1.5671.00
350_A394_S1.5671.00
8_V354_I1.5651.00
106_G166_T1.5591.00
238_I350_A1.5571.00
148_S157_N1.5551.00
334_T348_I1.5461.00
177_V183_A1.5451.00
300_I318_I1.5201.00
78_A147_I1.5181.00
187_V239_V1.5121.00
176_K182_D1.5121.00
4_K242_E1.5071.00
58_N61_D1.5051.00
81_A237_I1.4941.00
223_D368_I1.4881.00
330_A379_Y1.4841.00
263_T403_N1.4831.00
258_V391_Y1.4831.00
78_A105_V1.4791.00
11_L21_V1.4691.00
92_N95_D1.4591.00
236_G351_I1.4521.00
169_N404_A1.4471.00
47_P204_S1.4391.00
73_R77_Y1.4381.00
29_I384_A1.4301.00
101_V185_V1.4261.00
24_S352_F1.4251.00
162_T165_A1.4231.00
83_K150_A1.3981.00
42_D45_E1.3981.00
88_D252_K1.3921.00
185_V239_V1.3901.00
260_Y406_L1.3861.00
360_G390_N1.3831.00
78_A237_I1.3801.00
234_G341_L1.3631.00
158_S173_D1.3621.00
176_K179_Q1.3621.00
102_G183_A1.3611.00
216_K220_R1.3531.00
336_S366_I1.3531.00
299_Y362_I1.3531.00
281_R285_E1.3511.00
297_I391_Y1.3491.00
6_V240_L1.3431.00
223_D370_T1.3391.00
154_K281_R1.3211.00
393_L407_I1.3181.00
330_A362_I1.3171.00
220_R225_N1.3101.00
102_G156_V1.3061.00
6_V175_F1.3061.00
5_R256_E1.3051.00
169_N402_H1.3001.00
78_A143_A1.3001.00
177_V182_D1.2981.00
365_T368_I1.2961.00
330_A381_P1.2881.00
26_N32_V1.2871.00
97_I152_G1.2861.00
144_T159_C1.2701.00
17_L34_G1.2701.00
315_T331_V1.2701.00
4_K7_V1.2681.00
223_D369_Q1.2641.00
263_T282_A1.2531.00
23_T26_N1.2531.00
299_Y332_S1.2441.00
393_L405_T1.2431.00
336_S365_T1.2381.00
238_I347_G1.2361.00
254_Y354_I1.2321.00
368_I371_P1.2311.00
11_L351_I1.2211.00
362_I387_Q1.2211.00
184_D245_H1.2201.00
26_N29_I1.2161.00
387_Q390_N1.2151.00
357_I408_F1.2141.00
360_G410_K1.2141.00
210_S227_D1.2051.00
338_T348_I1.1971.00
145_G400_G1.1911.00
395_N405_T1.1881.00
284_Q288_K1.1801.00
13_A21_V1.1791.00
169_N262_S1.1761.00
105_V189_G1.1671.00
299_Y353_S1.1651.00
261_G282_A1.1641.00
261_G286_A1.1641.00
171_I240_L1.1511.00
341_L348_I1.1501.00
15_S236_G1.1441.00
318_I331_V1.1411.00
82_A237_I1.1401.00
282_A286_A1.1381.00
238_I351_I1.1331.00
85_A237_I1.1321.00
372_D375_C1.1281.00
215_P227_D1.1281.00
220_R227_D1.1191.00
259_G289_D1.1171.00
176_K289_D1.1161.00
10_G88_D1.1041.00
157_N264_G1.1031.00
298_D387_Q1.0991.00
190_G347_G1.0981.00
168_T404_A1.0911.00
11_L254_Y1.0891.00
243_L256_E1.0891.00
39_T53_E1.0871.00
22_D88_D1.0801.00
28_A352_F1.0781.00
285_E289_D1.0781.00
334_T338_T1.0721.00
5_R243_L1.0711.00
298_D390_N1.0691.00
360_G388_E1.0661.00
315_T375_C1.0641.00
283_M321_V1.0621.00
369_Q382_D1.0621.00
25_W359_E1.0591.00
337_M366_I1.0581.00
52_A232_G1.0581.00
33_S367_N1.0571.00
292_I296_E1.0541.00
13_A351_I1.0531.00
19_N55_K1.0521.00
174_A188_T1.0481.00
179_Q289_D1.0461.00
35_I50_V1.0451.00
287_I297_I1.0421.00
148_S264_G1.0381.00
287_I294_P1.0361.00
353_S357_I1.0341.00
368_I380_V1.0341.00
316_M320_T1.0331.00
83_K151_L1.0301.00
381_P385_R1.0291.00
61_D83_K1.0261.00
13_A24_S1.0221.00
85_A187_V1.0151.00
200_F231_M1.0061.00
295_E325_H0.9991.00
142_M271_A0.9961.00
217_T369_Q0.9951.00
168_T406_L0.9861.00
81_A84_M0.9851.00
171_I406_L0.9851.00
160_T173_D0.9831.00
86_V151_L0.9821.00
322_F393_L0.9811.00
178_I240_L0.9811.00
353_S394_S0.9791.00
283_M393_L0.9761.00
308_Y374_E0.9741.00
283_M395_N0.9731.00
9_T241_E0.9671.00
184_D242_E0.9661.00
256_E409_K0.9641.00
25_W363_P0.9611.00
171_I188_T0.9581.00
371_P377_L0.9541.00
104_W186_M0.9531.00
101_V153_A0.9531.00
378_D385_R0.9511.00
368_I382_D0.9501.00
357_I360_G0.9481.00
285_E288_K0.9461.00
12_G85_A0.9441.00
244_E247_L0.9441.00
172_G182_D0.9431.00
312_K316_M0.9421.00
11_L354_I0.9371.00
175_F289_D0.9271.00
173_D176_K0.9261.00
287_I322_F0.9181.00
167_G347_G0.9151.00
246_A253_I0.9141.00
231_M342_L0.9111.00
18_G27_N0.9091.00
354_I408_F0.9051.00
22_D26_N0.9041.00
7_V256_E0.9021.00
234_G348_I0.9001.00
29_I359_E0.8991.00
15_S351_I0.8981.00
276_G316_M0.8941.00
302_A331_V0.8921.00
349_E394_S0.8891.00
174_A186_M0.8881.00
172_G176_K0.8881.00
31_G364_P0.8871.00
77_Y235_A0.8861.00
377_L380_V0.8851.00
167_G190_G0.8851.00
287_I292_I0.8821.00
49_K52_A0.8801.00
301_N349_E0.8771.00
86_V187_V0.8751.00
78_A189_G0.8691.00
292_I407_I0.8681.00
54_L77_Y0.8641.00
300_I393_L0.8631.00
31_G383_E0.8621.00
7_V243_L0.8621.00
162_T169_N0.8591.00
277_E280_A0.8581.00
154_K277_E0.8551.00
12_G84_M0.8541.00
175_F260_Y0.8521.00
20_D84_M0.8461.00
357_I389_L0.8461.00
14_L84_M0.8451.00
103_V153_A0.8431.00
297_I322_F0.8411.00
304_G333_S0.8401.00
304_G310_N0.8371.00
110_G140_P0.8371.00
25_W29_I0.8331.00
24_S338_T0.8321.00
33_S366_I0.8311.00
263_T281_R0.8301.00
283_M317_A0.8301.00
245_H249_R0.8301.00
64_D67_E0.8261.00
315_T379_Y0.8251.00
297_I407_I0.8241.00
286_A290_A0.8231.00
210_S220_R0.8181.00
11_L88_D0.8171.00
51_A54_L0.8151.00
286_A407_I0.8151.00
242_E247_L0.8131.00
34_G52_A0.8081.00
11_L355_L0.8041.00
25_W355_L0.8031.00
107_S140_P0.8031.00
168_T346_G0.8031.00
35_I230_V0.7991.00
47_P207_K0.7981.00
281_R284_Q0.7971.00
185_V188_T0.7961.00
353_S356_A0.7901.00
283_M287_I0.7901.00
57_F80_V0.7891.00
243_L253_I0.7871.00
279_G397_L0.7871.00
22_D359_E0.7861.00
379_Y382_D0.7841.00
333_S365_T0.7831.00
82_A85_A0.7831.00
18_G34_G0.7821.00
258_V292_I0.7791.00
86_V239_V0.7781.00
14_L80_V0.7751.00
187_V237_I0.7741.00
17_L27_N0.7721.00
315_T319_K0.7701.00
284_Q320_T0.7651.00
284_Q321_V0.7651.00
341_L344_A0.7641.00
381_P384_A0.7641.00
145_G157_N0.7641.00
156_V183_A0.7631.00
322_F329_L0.7631.00
277_E281_R0.7611.00
323_G326_A0.7601.00
354_I357_I0.7581.00
108_G343_G0.7571.00
89_A239_V0.7491.00
188_T240_L0.7491.00
185_V245_H0.7481.00
72_D114_T0.7461.00
171_I347_G0.7461.00
104_W183_A0.7451.00
43_A49_K0.7421.00
303_H307_T0.7411.00
7_V253_I0.7411.00
191_T235_A0.7391.00
168_T394_S0.7371.00
107_S159_C0.7371.00
38_I41_V0.7361.00
135_V202_G0.7351.00
182_D289_D0.7351.00
27_N30_N0.7351.00
79_V150_A0.7341.00
270_T273_A0.7331.00
48_A51_A0.7331.00
290_A407_I0.7311.00
201_A204_S0.7291.00
357_I410_K0.7271.00
99_P184_D0.7271.00
40_R73_R0.7271.00
262_S404_A0.7251.00
104_W158_S0.7241.00
307_T310_N0.7231.00
301_N352_F0.7231.00
287_I407_I0.7211.00
298_D391_Y0.7201.00
130_V201_A0.7191.00
283_M318_I0.7191.00
362_I389_L0.7191.00
23_T27_N0.7181.00
14_L81_A0.7181.00
99_P154_K0.7161.00
82_A151_L0.7101.00
371_P380_V0.7101.00
103_V147_I0.7091.00
284_Q324_E0.7081.00
21_V355_L0.7081.00
263_T285_E0.7041.00
247_L253_I0.7041.00
300_I329_L0.7031.00
171_I257_I0.7021.00
48_A204_S0.7011.00
269_I273_A0.7011.00
171_I238_I0.7011.00
208_A229_F0.7011.00
153_A187_V0.6991.00
255_G408_F0.6971.00
309_Y313_Y0.6971.00
365_T380_V0.6951.00
50_V53_E0.6941.00
312_K374_E0.6921.00
74_F191_T0.6921.00
299_Y392_V0.6911.00
276_G280_A0.6911.00
96_E101_V0.6861.00
282_A405_T0.6851.00
38_I53_E0.6831.00
36_G53_E0.6771.00
298_D389_L0.6771.00
325_H328_K0.6741.00
316_M374_E0.6741.00
19_N56_D0.6721.00
319_K323_G0.6721.00
141_D163_A0.6701.00
49_K53_E0.6691.00
354_I358_K0.6671.00
73_R76_Q0.6661.00
108_G111_G0.6651.00
38_I51_A0.6631.00
86_V96_E0.6631.00
168_T396_S0.6621.00
319_K376_D0.6621.00
276_G317_A0.6611.00
257_I406_L0.6611.00
259_G286_A0.6591.00
17_L36_G0.6581.00
38_I200_F0.6561.00
334_T352_F0.6561.00
319_K377_L0.6551.00
5_R179_Q0.6501.00
263_T278_G0.6501.00
185_V241_E0.6491.00
139_I142_M0.6481.00
360_G386_R0.6481.00
10_G85_A0.6481.00
219_S229_F0.6471.00
277_E320_T0.6471.00
75_T142_M0.6461.00
16_P341_L0.6441.00
21_V88_D0.6441.00
24_S348_I0.6441.00
273_A309_Y0.6431.00
98_A152_G0.6431.00
142_M399_F0.6391.00
203_F208_A0.6381.00
244_E248_A0.6371.00
75_T143_A0.6371.00
105_V144_T0.6361.00
315_T377_L0.6351.00
86_V153_A0.6351.00
28_A355_L0.6331.00
188_T238_I0.6311.00
42_D46_Y0.6311.00
177_V186_M0.6301.00
192_E342_L0.6281.00
158_S162_T0.6271.00
229_F342_L0.6261.00
362_I385_R0.6221.00
226_R372_D0.6221.00
78_A82_A0.6211.00
50_V218_A0.6181.00
241_E245_H0.6181.00
220_R369_Q0.6181.00
80_V84_M0.6181.00
180_R289_D0.6161.00
262_S402_H0.6151.00
276_G313_Y0.6151.00
203_F399_F0.6151.00
237_I347_G0.6141.00
84_M88_D0.6141.00
24_S28_A0.6131.00
330_A387_Q0.6131.00
357_I392_V0.6111.00
111_G115_L0.6111.00
338_T341_L0.6101.00
102_G177_V0.6091.00
51_A200_F0.6091.00
388_E410_K0.6081.00
356_A387_Q0.6071.00
8_V408_F0.6061.00
6_V178_I0.6041.00
280_A317_A0.6011.00
330_A380_V0.6011.00
328_K379_Y0.6001.00
292_I297_I0.5981.00
40_R43_A0.5981.00
188_T347_G0.5971.00
208_A399_F0.5971.00
173_D177_V0.5971.00
389_L409_K0.5971.00
210_S216_K0.5961.00
6_V242_E0.5961.00
154_K278_G0.5961.00
21_V24_S0.5951.00
389_L410_K0.5941.00
4_K179_Q0.5941.00
85_A89_A0.5921.00
220_R367_N0.5901.00
301_N353_S0.5881.00
279_G317_A0.5861.00
100_R281_R0.5861.00
287_I405_T0.5841.00
9_T185_V0.5831.00
163_A399_F0.5831.00
17_L24_S0.5831.00
302_A318_I0.5821.00
104_W173_D0.5791.00
9_T251_A0.5791.00
98_A154_K0.5761.00
332_S363_P0.5741.00
387_Q392_V0.5731.00
219_S306_S0.5711.00
91_L185_V0.5701.00
257_I408_F0.5701.00
74_F143_A0.5681.00
302_A333_S0.5681.00
91_L239_V0.5671.00
18_G55_K0.5671.00
71_M146_Q0.5651.00
319_K327_H0.5651.00
94_T97_I0.5631.00
21_V351_I0.5621.00
84_M87_E0.5611.00
62_Y80_V0.5601.00
317_A321_V0.5561.00
356_A392_V0.5561.00
178_I245_H0.5561.00
18_G23_T0.5561.00
169_N173_D0.5531.00
236_G344_A0.5511.00
166_T170_S0.5481.00
275_D278_G0.5471.00
107_S110_G0.5471.00
47_P50_V0.5461.00
37_P43_A0.5461.00
350_A354_I0.5421.00
46_Y201_A0.5411.00
14_L77_Y0.5411.00
216_K230_V0.5381.00
132_P202_G0.5381.00
332_S362_I0.5371.00
181_G242_E0.5351.00
144_T157_N0.5351.00
174_A240_L0.5351.00
394_S408_F0.5351.00
40_R53_E0.5341.00
111_G195_L0.5331.00
219_S230_V0.5331.00
224_K372_D0.5321.00
93_I96_E0.5321.00
19_N84_M0.5321.00
310_N313_Y0.5311.00
75_T146_Q0.5311.00
172_G262_S0.5311.00
57_F62_Y0.5301.00
133_F136_P0.5291.00
221_P229_F0.5291.00
353_S408_F0.5291.00
16_P52_A0.5271.00
225_N368_I0.5251.00
308_Y312_K0.5251.00
273_A277_E0.5251.00
61_D87_E0.5251.00
91_L251_A0.5241.00
177_V180_R0.5211.00
394_S406_L0.5211.00
188_T237_I0.5211.00
265_D268_H0.5211.00
178_I181_G0.5201.00
272_P309_Y0.5201.00
299_Y356_A0.5201.00
15_S18_G0.5181.00
77_Y193_A0.5170.99
276_G320_T0.5170.99
41_V200_F0.5160.99
15_S341_L0.5160.99
337_M364_P0.5130.99
63_M80_V0.5130.99
156_V177_V0.5130.99
108_G140_P0.5120.99
10_G254_Y0.5110.99
287_I321_V0.5090.99
296_E390_N0.5090.99
15_S24_S0.5090.99
223_D367_N0.5070.99
50_V54_L0.5050.99
13_A348_I0.5050.99
347_G351_I0.5040.99
91_L241_E0.5030.99
10_G252_K0.5020.99
114_T198_M0.5020.99
5_R244_E0.5000.99
93_I97_I0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2vz8A 2 0.9588 100 0.04 Contact Map
4na1A 2 0.9709 100 0.104 Contact Map
4tktA 1 0.9685 100 0.123 Contact Map
4qyrA 2 0.9613 100 0.125 Contact Map
2hg4A 2 0.9709 100 0.126 Contact Map
4oqjA 2 0.9831 100 0.128 Contact Map
4mz0A 2 0.9709 100 0.129 Contact Map
4wkyA 2 0.9831 100 0.13 Contact Map
1ox0A 2 0.9903 100 0.13 Contact Map
4kc5A 2 0.9734 100 0.131 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0121 seconds.