GREMLIN Database
YOPP - SPBc2 prophage-derived probable integrase/recombinase YopP
UniProt: O34336 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 358 (283)
Sequences: 29101 (23393)
Seq/√Len: 1390.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
275_I293_G5.0071.00
187_W227_K3.4051.00
78_S81_E3.3591.00
211_V294_N3.2661.00
266_V269_S2.9241.00
274_G292_Q2.7171.00
179_V268_H2.7031.00
172_A267_L2.6171.00
89_L102_K2.5771.00
176_S274_G2.5631.00
186_R240_G2.4401.00
199_Y220_Y2.4231.00
272_G306_S2.3001.00
172_A182_I2.2761.00
186_R236_L2.1671.00
202_T212_S2.0841.00
143_T146_E2.0821.00
186_R235_E2.0781.00
167_L226_L2.0561.00
52_E56_K2.0421.00
285_D288_A1.9681.00
295_H301_T1.9631.00
191_Q194_E1.9621.00
181_A211_V1.9541.00
279_Y289_A1.9281.00
220_Y224_L1.9261.00
54_D101_R1.9101.00
86_V103_M1.8791.00
209_Q296_K1.8451.00
33_S55_I1.8051.00
214_G292_Q1.7891.00
82_L126_F1.7881.00
174_R216_N1.7651.00
77_V110_Y1.7411.00
287_L290_K1.7201.00
54_D105_S1.7081.00
177_F182_I1.7041.00
187_W237_V1.7031.00
274_G278_V1.6931.00
200_I212_S1.6931.00
33_S109_L1.6861.00
47_T51_Y1.6471.00
57_Q102_K1.6291.00
215_I220_Y1.6271.00
112_Y118_K1.6131.00
293_G301_T1.5791.00
280_E311_I1.5451.00
32_N113_L1.5341.00
192_L224_L1.5121.00
179_V183_L1.4721.00
278_V284_H1.4711.00
168_F246_L1.4511.00
279_Y305_M1.4511.00
97_N101_R1.4471.00
278_V289_A1.4371.00
146_E149_R1.4361.00
109_L113_L1.4301.00
188_K235_E1.4261.00
100_N132_L1.4251.00
286_L302_E1.4201.00
30_S34_N1.3991.00
186_R189_D1.3971.00
189_D204_I1.3811.00
154_M253_S1.3731.00
167_L225_Q1.3721.00
168_F182_I1.3691.00
58_F61_V1.3661.00
165_K249_S1.3551.00
142_T273_V1.3481.00
191_Q200_I1.3391.00
174_R219_F1.3371.00
177_F203_V1.3301.00
144_Q277_Y1.3291.00
199_Y202_T1.3261.00
173_I277_Y1.3241.00
32_N112_Y1.3211.00
147_A173_I1.3031.00
287_L291_E1.2991.00
166_K170_K1.2931.00
290_K301_T1.2851.00
45_S49_K1.2761.00
37_M52_E1.2751.00
114_E121_I1.2701.00
90_Q99_I1.2651.00
314_S318_T1.2571.00
216_N219_F1.2511.00
111_T127_N1.2511.00
275_I289_A1.2511.00
204_I210_V1.2511.00
167_L222_E1.2471.00
37_M48_R1.2441.00
46_N49_K1.2441.00
119_D123_L1.2381.00
85_Y102_K1.2341.00
290_K298_T1.2341.00
85_Y89_L1.2301.00
276_D306_S1.2271.00
148_E152_Q1.2241.00
103_M107_K1.2041.00
242_S245_S1.2031.00
142_T265_L1.1971.00
236_L240_G1.1901.00
180_S184_R1.1851.00
179_V243_E1.1711.00
147_A277_Y1.1621.00
245_S248_H1.1541.00
217_Q221_E1.1521.00
192_L199_Y1.1471.00
280_E308_K1.1451.00
49_K53_G1.1451.00
98_S102_K1.1431.00
199_Y203_V1.1321.00
142_T150_I1.1311.00
300_T303_R1.1311.00
86_V90_Q1.1281.00
144_Q281_N1.1201.00
51_Y105_S1.1201.00
170_K222_E1.1121.00
297_N300_T1.1041.00
44_V47_T1.1031.00
243_E247_R1.1021.00
61_V84_N1.1021.00
251_K264_E1.0981.00
83_S87_K1.0951.00
273_V277_Y1.0911.00
173_I270_F1.0861.00
110_Y125_V1.0851.00
153_D257_L1.0811.00
95_V98_S1.0801.00
250_L254_K1.0681.00
192_L220_Y1.0621.00
299_L302_E1.0541.00
43_R48_R1.0491.00
297_N303_R1.0471.00
171_F219_F1.0471.00
48_R52_E1.0431.00
171_F201_V1.0401.00
201_V204_I1.0391.00
249_S252_R1.0371.00
50_N53_G1.0351.00
28_S31_G1.0341.00
71_V76_V1.0341.00
199_Y217_Q1.0321.00
58_F63_K1.0301.00
254_K265_L1.0271.00
30_S60_S1.0261.00
111_T124_S1.0251.00
188_K234_T1.0221.00
311_I314_S1.0171.00
146_E263_R1.0161.00
288_A315_A1.0151.00
313_N317_V1.0141.00
61_V88_Y1.0091.00
151_A170_K1.0051.00
34_N52_E1.0041.00
187_W230_D1.0031.00
244_Q247_R1.0011.00
185_V190_I1.0001.00
141_K273_V0.9931.00
185_V201_V0.9931.00
317_V321_E0.9921.00
274_G293_G0.9911.00
110_Y121_I0.9881.00
89_L99_I0.9871.00
276_D305_M0.9831.00
115_H130_E0.9771.00
298_T302_E0.9751.00
36_M108_M0.9751.00
179_V247_R0.9741.00
149_R153_D0.9721.00
247_R251_K0.9681.00
40_S48_R0.9651.00
191_Q202_T0.9631.00
168_F238_F0.9621.00
110_Y126_F0.9591.00
153_D256_R0.9571.00
299_L303_R0.9561.00
144_Q280_E0.9551.00
53_G57_Q0.9541.00
79_K83_S0.9531.00
90_Q96_N0.9491.00
292_Q312_A0.9471.00
79_K115_H0.9461.00
142_T146_E0.9411.00
101_R104_T0.9361.00
68_K76_V0.9341.00
170_K218_V0.9321.00
284_H288_A0.9311.00
183_L243_E0.9271.00
275_I305_M0.9251.00
194_E200_I0.9251.00
252_R256_R0.9251.00
202_T210_V0.9201.00
166_K222_E0.9101.00
215_I219_F0.9091.00
291_E312_A0.9061.00
154_M169_V0.9041.00
94_L98_S0.9041.00
34_N38_P0.9011.00
113_L120_Y0.9001.00
43_R51_Y0.8971.00
284_H315_A0.8961.00
218_V221_E0.8941.00
50_N54_D0.8911.00
191_Q199_Y0.8901.00
171_F238_F0.8891.00
251_K255_K0.8851.00
219_F222_E0.8831.00
173_I273_V0.8831.00
226_L230_D0.8721.00
204_I208_S0.8681.00
61_V85_Y0.8681.00
46_N50_N0.8671.00
174_R218_V0.8671.00
178_R268_H0.8671.00
83_S118_K0.8551.00
94_L102_K0.8541.00
89_L94_L0.8521.00
141_K306_S0.8521.00
185_V237_V0.8471.00
30_S64_G0.8451.00
103_M126_F0.8451.00
275_I279_Y0.8391.00
277_Y280_E0.8351.00
183_L246_L0.8351.00
171_F182_I0.8341.00
167_L238_F0.8321.00
275_I301_T0.8321.00
114_E124_S0.8311.00
58_F110_Y0.8281.00
107_K111_T0.8251.00
227_K230_D0.8221.00
163_L225_Q0.8191.00
163_L229_E0.8081.00
284_H318_T0.8041.00
179_V267_L0.7961.00
225_Q229_E0.7911.00
144_Q148_E0.7901.00
56_K60_S0.7901.00
124_S127_N0.7891.00
115_H128_T0.7881.00
59_F63_K0.7801.00
32_N36_M0.7801.00
94_L99_I0.7791.00
279_Y308_K0.7761.00
217_Q317_V0.7751.00
55_I60_S0.7751.00
157_N162_P0.7741.00
54_D102_K0.7671.00
172_A179_V0.7661.00
50_N101_R0.7661.00
45_S48_R0.7601.00
179_V246_L0.7591.00
247_R267_L0.7541.00
58_F92_K0.7541.00
80_S118_K0.7531.00
163_L166_K0.7521.00
310_N313_N0.7501.00
32_N118_K0.7481.00
159_R162_P0.7431.00
310_N314_S0.7431.00
187_W223_L0.7421.00
84_N88_Y0.7371.00
113_L121_I0.7371.00
79_K119_D0.7351.00
140_D269_S0.7351.00
317_V320_D0.7341.00
150_I169_V0.7341.00
265_L269_S0.7331.00
280_E310_N0.7321.00
175_T213_T0.7301.00
169_V270_F0.7281.00
224_L228_E0.7281.00
224_L227_K0.7271.00
177_F201_V0.7261.00
218_V320_D0.7261.00
107_K126_F0.7221.00
60_S63_K0.7201.00
97_N100_N0.7191.00
110_Y114_E0.7161.00
163_L167_L0.7151.00
81_E84_N0.7141.00
33_S36_M0.7141.00
199_Y204_I0.7141.00
176_S293_G0.7141.00
29_S109_L0.7111.00
82_L106_L0.7111.00
154_M166_K0.7091.00
287_L302_E0.7051.00
245_S249_S0.7051.00
88_Y92_K0.7031.00
35_Y120_Y0.7001.00
153_D253_S0.6981.00
290_K302_E0.6971.00
77_V82_L0.6961.00
315_A318_T0.6931.00
114_E123_L0.6931.00
80_S84_N0.6901.00
288_A292_Q0.6891.00
33_S37_M0.6831.00
314_S317_V0.6801.00
29_S33_S0.6771.00
297_N302_E0.6771.00
114_E127_N0.6761.00
65_K81_E0.6751.00
100_N104_T0.6751.00
109_L112_Y0.6751.00
30_S65_K0.6741.00
86_V99_I0.6731.00
53_G56_K0.6691.00
34_N60_S0.6681.00
253_S256_R0.6671.00
30_S33_S0.6651.00
103_M129_V0.6641.00
119_D128_T0.6641.00
251_K254_K0.6641.00
32_N70_L0.6611.00
145_T149_R0.6601.00
27_R31_G0.6591.00
316_G319_M0.6571.00
308_K311_I0.6571.00
223_L237_V0.6561.00
227_K231_D0.6561.00
248_H252_R0.6551.00
87_K90_Q0.6541.00
221_E224_L0.6521.00
249_S253_S0.6501.00
214_G312_A0.6461.00
244_Q251_K0.6421.00
177_F185_V0.6411.00
281_N284_H0.6401.00
85_Y88_Y0.6361.00
279_Y286_L0.6361.00
62_I88_Y0.6341.00
35_Y38_P0.6291.00
32_N109_L0.6281.00
171_F177_F0.6251.00
221_E225_Q0.6231.00
27_R35_Y0.6221.00
106_L126_F0.6171.00
88_Y91_E0.6161.00
66_D81_E0.6151.00
145_T148_E0.6151.00
55_I109_L0.6141.00
63_K66_D0.6141.00
107_K131_R0.6131.00
214_G313_N0.6121.00
58_F85_Y0.6081.00
201_V205_D0.6061.00
146_E260_P0.6031.00
250_L267_L0.5961.00
149_R152_Q0.5921.00
57_Q92_K0.5891.00
111_T114_E0.5861.00
286_L298_T0.5831.00
181_A203_V0.5811.00
192_L215_I0.5801.00
147_A273_V0.5791.00
107_K127_N0.5781.00
164_M226_L0.5771.00
27_R120_Y0.5751.00
110_Y124_S0.5751.00
246_L267_L0.5751.00
31_G34_N0.5731.00
216_N320_D0.5721.00
290_K293_G0.5711.00
284_H289_A0.5671.00
61_V64_G0.5661.00
182_I267_L0.5621.00
63_K85_Y0.5591.00
167_L171_F0.5561.00
269_S272_G0.5551.00
83_S86_V0.5541.00
286_L301_T0.5541.00
290_K300_T0.5521.00
36_M112_Y0.5521.00
260_P263_R0.5511.00
167_L219_F0.5511.00
89_L92_K0.5501.00
170_K219_F0.5481.00
165_K253_S0.5461.00
250_L270_F0.5441.00
58_F106_L0.5431.00
55_I105_S0.5431.00
187_W231_D0.5421.00
51_Y54_D0.5361.00
175_T216_N0.5361.00
207_G294_N0.5361.00
147_A151_A0.5351.00
55_I59_F0.5351.00
177_F181_A0.5331.00
139_W266_V0.5331.00
222_E225_Q0.5331.00
292_Q316_G0.5321.00
192_L237_V0.5311.00
164_M167_L0.5281.00
279_Y307_R0.5281.00
279_Y287_L0.5261.00
186_R234_T0.5221.00
35_Y118_K0.5211.00
302_E305_M0.5201.00
108_M111_T0.5191.00
100_N131_R0.5191.00
199_Y215_I0.5191.00
276_D307_R0.5171.00
141_K276_D0.5171.00
66_D76_V0.5171.00
142_T147_A0.5121.00
286_L290_K0.5121.00
275_I290_K0.5121.00
298_T301_T0.5121.00
85_Y106_L0.5101.00
31_G35_Y0.5101.00
190_I223_L0.5091.00
285_D311_I0.5091.00
217_Q320_D0.5081.00
309_I312_A0.5081.00
151_A166_K0.5081.00
172_A270_F0.5081.00
61_V65_K0.5061.00
115_H127_N0.5041.00
112_Y120_Y0.5031.00
169_V250_L0.5001.00
114_E128_T0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1a0pA 1 0.7179 100 0.28 Contact Map
2a3vA 3 0.757 100 0.295 Contact Map
1z1bA 3 0.824 100 0.318 Contact Map
1z19A 3 0.7514 100 0.323 Contact Map
1xo0A 3 0.7821 100 0.339 Contact Map
4a8eA 2 0.7123 100 0.348 Contact Map
3nkhA 2 0.5112 100 0.478 Contact Map
1ae9A 4 0.4413 100 0.543 Contact Map
1aihA 2 0.4749 100 0.546 Contact Map
4e0gA 2 0.7458 99.9 0.612 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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