GREMLIN Database
MSME - Putative binding protein MsmE
UniProt: O34335 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 426 (390)
Sequences: 30471 (24705)
Seq/√Len: 1251.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
32_T65_S3.7231.00
398_A401_D3.2961.00
105_A318_L3.2751.00
227_T400_Q3.1871.00
148_N284_K3.1101.00
234_K238_K3.1041.00
32_T63_H2.9291.00
34_T65_S2.9221.00
106_D130_K2.8931.00
147_R286_G2.8761.00
165_I235_Q2.7401.00
231_E235_Q2.5001.00
160_T163_D2.4341.00
147_R151_D2.4251.00
62_I320_E2.3821.00
49_R53_A2.3471.00
169_R239_E2.3091.00
235_Q239_E2.2801.00
224_S228_Y2.2721.00
54_A57_K2.2431.00
145_Y286_G2.2401.00
404_Q408_R2.2291.00
400_Q404_Q2.2271.00
56_E63_H2.1961.00
72_D75_N2.1811.00
108_R130_K2.1391.00
323_D326_A2.1341.00
330_R333_N2.1221.00
125_K131_V2.1131.00
407_G411_K2.0631.00
54_A327_F2.0441.00
397_L405_K2.0431.00
55_F323_D2.0431.00
155_I167_A2.0381.00
166_K170_T2.0361.00
50_K53_A2.0311.00
231_E399_P2.0181.00
34_T67_H2.0031.00
118_P122_S2.0021.00
150_L265_F2.0011.00
169_R173_E1.9521.00
391_E397_L1.9511.00
317_Q320_E1.9281.00
408_R412_R1.9121.00
148_N152_R1.9031.00
163_D166_K1.8901.00
250_K253_Q1.8891.00
122_S125_K1.8411.00
228_Y231_E1.8301.00
36_Y80_R1.8281.00
53_A57_K1.8241.00
222_Q404_Q1.8201.00
104_T310_A1.8201.00
54_A58_E1.8161.00
391_E396_I1.7941.00
88_D317_Q1.7941.00
115_D349_N1.7641.00
319_K323_D1.7381.00
11_L14_L1.7221.00
166_K169_R1.7181.00
315_S318_L1.7181.00
170_T174_K1.7131.00
405_K409_E1.7051.00
56_E60_S1.7041.00
54_A336_Q1.6901.00
335_K339_E1.6761.00
401_D405_K1.6561.00
52_A56_E1.6471.00
231_E400_Q1.6231.00
12_I15_V1.6201.00
45_R49_R1.6111.00
227_T231_E1.6071.00
162_D165_I1.6021.00
133_A308_T1.6001.00
384_V409_E1.5991.00
213_K217_I1.5861.00
383_D387_T1.5861.00
53_A56_E1.5801.00
165_I169_R1.5661.00
165_I239_E1.5641.00
392_L402_I1.5631.00
183_W263_I1.5581.00
124_L308_T1.5491.00
52_A324_F1.5281.00
90_F312_W1.5231.00
162_D166_K1.5091.00
354_I358_N1.5031.00
143_L288_I1.4961.00
227_T399_P1.4961.00
214_K218_N1.4901.00
401_D404_Q1.4881.00
331_P335_K1.4851.00
149_I264_A1.4811.00
397_L402_I1.4781.00
213_K216_L1.4751.00
169_R241_L1.4711.00
333_N336_Q1.4651.00
165_I236_M1.4641.00
210_H213_K1.4591.00
145_Y288_I1.4591.00
234_K392_L1.4411.00
232_I235_Q1.4401.00
159_E163_D1.4361.00
50_K54_A1.4351.00
171_I264_A1.4301.00
405_K408_R1.4221.00
106_D109_D1.4181.00
404_Q407_G1.4161.00
257_L262_K1.4131.00
388_V405_K1.4121.00
147_R284_K1.4101.00
81_M86_L1.4051.00
149_I171_I1.3991.00
76_M80_R1.3881.00
311_A325_I1.3851.00
222_Q407_G1.3831.00
55_F327_F1.3631.00
225_K228_Y1.3591.00
37_S66_L1.3581.00
388_V397_L1.3531.00
392_L399_P1.3271.00
105_A313_K1.3221.00
388_V391_E1.3001.00
361_E365_D1.2981.00
232_I236_M1.2971.00
55_F324_F1.2861.00
55_F62_I1.2841.00
111_K114_Q1.2801.00
397_L401_D1.2761.00
320_E323_D1.2751.00
168_L265_F1.2731.00
214_K217_I1.2681.00
165_I232_I1.2651.00
92_T310_A1.2471.00
354_I357_A1.2451.00
408_R411_K1.2421.00
158_P163_D1.2391.00
52_A66_L1.2351.00
336_Q340_A1.2261.00
151_D157_P1.2161.00
155_I170_T1.2151.00
213_K218_N1.2131.00
258_M285_V1.2071.00
143_L265_F1.2051.00
31_K320_E1.1931.00
62_I323_D1.1921.00
409_E412_R1.1831.00
153_Y171_I1.1831.00
46_D49_R1.1781.00
256_E260_Q1.1771.00
172_K181_P1.1691.00
142_G287_I1.1681.00
322_K326_A1.1661.00
89_L321_A1.1641.00
9_L13_L1.1591.00
99_R132_Y1.1581.00
315_S321_A1.1521.00
349_N352_A1.1491.00
167_A170_T1.1371.00
387_T409_E1.1361.00
19_C22_E1.1361.00
124_L131_V1.1351.00
327_F333_N1.1341.00
361_E364_Q1.1331.00
46_D50_K1.1331.00
168_L241_L1.1321.00
146_N149_I1.1301.00
388_V406_L1.1271.00
58_E330_R1.1131.00
162_D294_H1.1101.00
224_S227_T1.0971.00
88_D315_S1.0971.00
318_L322_K1.0931.00
150_L167_A1.0871.00
324_F328_M1.0841.00
391_E405_K1.0821.00
89_L325_I1.0821.00
150_L155_I1.0781.00
228_Y232_I1.0781.00
384_V387_T1.0741.00
235_Q238_K1.0711.00
8_F11_L1.0621.00
8_F14_L1.0601.00
336_Q339_E1.0561.00
121_N125_K1.0551.00
331_P349_N1.0541.00
227_T403_S1.0531.00
275_D278_Q1.0521.00
164_F168_L1.0511.00
55_F320_E1.0471.00
311_A322_K1.0461.00
280_N283_V1.0441.00
149_I179_I1.0421.00
324_F327_F1.0401.00
15_V18_G1.0401.00
149_I153_Y1.0391.00
172_K241_L1.0391.00
99_R127_K1.0361.00
8_F12_I1.0331.00
170_T173_E1.0331.00
179_I262_K1.0281.00
13_L16_L1.0271.00
113_T121_N1.0231.00
253_Q256_E1.0231.00
164_F265_F1.0201.00
211_N214_K1.0191.00
257_L263_I1.0171.00
19_C23_K1.0161.00
149_I152_R1.0141.00
151_D156_A1.0101.00
89_L324_F1.0101.00
231_E234_K1.0071.00
234_K399_P1.0061.00
112_W115_D1.0051.00
381_M410_Y1.0041.00
35_I309_L1.0031.00
313_K318_L1.0021.00
86_L312_W0.9911.00
50_K340_A0.9891.00
76_M79_V0.9871.00
167_A265_F0.9751.00
332_A335_K0.9741.00
12_I16_L0.9731.00
153_Y174_K0.9721.00
102_E313_K0.9691.00
312_W315_S0.9691.00
81_M103_Y0.9681.00
388_V409_E0.9631.00
33_L324_F0.9621.00
105_A315_S0.9541.00
311_A321_A0.9491.00
52_A64_V0.9461.00
148_N151_D0.9461.00
64_V324_F0.9441.00
77_M90_F0.9401.00
115_D347_L0.9361.00
51_L54_A0.9341.00
292_A295_P0.9311.00
7_L11_L0.9271.00
332_A336_Q0.9271.00
268_Q272_L0.9271.00
50_K336_Q0.9261.00
19_C24_S0.9231.00
219_G411_K0.9221.00
47_T50_K0.9201.00
347_L350_V0.9141.00
117_D348_T0.9141.00
387_T391_E0.9141.00
155_I171_I0.9041.00
90_F310_A0.9031.00
212_E215_Q0.9011.00
144_A268_Q0.9001.00
11_L15_V0.8991.00
54_A332_A0.8971.00
384_V388_V0.8941.00
151_D284_K0.8911.00
311_A315_S0.8901.00
36_Y87_P0.8881.00
355_F358_N0.8831.00
7_L13_L0.8821.00
110_M114_Q0.8811.00
164_F182_F0.8771.00
10_S13_L0.8761.00
84_N314_D0.8741.00
383_D386_G0.8631.00
121_N131_V0.8621.00
293_I296_G0.8571.00
36_Y69_P0.8571.00
198_Q201_T0.8551.00
403_S407_G0.8541.00
221_F226_F0.8531.00
110_M113_T0.8521.00
7_L14_L0.8471.00
159_E292_A0.8471.00
79_V83_A0.8441.00
335_K350_V0.8401.00
402_I406_L0.8391.00
165_I241_L0.8361.00
230_S392_L0.8361.00
118_P121_N0.8331.00
321_A325_I0.8301.00
384_V406_L0.8261.00
33_L320_E0.8251.00
152_R179_I0.8241.00
145_Y157_P0.8231.00
178_S181_P0.8221.00
398_A402_I0.8211.00
9_L15_V0.8181.00
348_T352_A0.8161.00
105_A109_D0.8151.00
388_V402_I0.8131.00
210_H214_K0.8131.00
223_W226_F0.8121.00
319_K322_K0.8101.00
168_L181_P0.8091.00
370_P373_D0.8091.00
31_K317_Q0.8091.00
116_L329_A0.8081.00
314_D317_Q0.8041.00
118_P348_T0.8041.00
180_V244_I0.8011.00
236_M241_L0.8011.00
90_F104_T0.8001.00
369_E372_F0.8001.00
19_C25_S0.7991.00
133_A310_A0.7981.00
80_R85_D0.7971.00
56_E61_D0.7951.00
10_S14_L0.7911.00
136_I309_L0.7901.00
16_L19_C0.7861.00
153_Y170_T0.7841.00
61_D323_D0.7831.00
98_I104_T0.7831.00
69_P76_M0.7821.00
380_G383_D0.7821.00
220_T223_W0.7811.00
33_L317_Q0.7791.00
108_R131_V0.7781.00
54_A333_N0.7771.00
9_L12_I0.7751.00
104_T132_Y0.7751.00
172_K240_K0.7721.00
105_A311_A0.7691.00
7_L10_S0.7661.00
146_N284_K0.7651.00
385_L406_L0.7641.00
371_Y374_R0.7621.00
99_R104_T0.7611.00
156_A159_E0.7601.00
56_E64_V0.7581.00
230_S403_S0.7561.00
125_K129_G0.7531.00
51_L333_N0.7521.00
108_R125_K0.7501.00
167_A171_I0.7451.00
119_N122_S0.7451.00
209_A212_E0.7441.00
109_D322_K0.7431.00
8_F15_V0.7421.00
109_D130_K0.7421.00
150_L171_I0.7421.00
387_T390_Q0.7401.00
403_S406_L0.7401.00
240_K244_I0.7391.00
256_E259_A0.7381.00
190_S194_Q0.7341.00
106_D132_Y0.7331.00
58_E327_F0.7331.00
111_K326_A0.7291.00
356_Y360_Y0.7291.00
35_I89_L0.7281.00
194_Q198_Q0.7281.00
196_Y200_A0.7271.00
219_G407_G0.7271.00
362_Y365_D0.7271.00
36_Y67_H0.7161.00
363_Y366_V0.7151.00
230_S402_I0.7141.00
105_A312_W0.7141.00
372_F376_Y0.7121.00
165_I168_L0.7101.00
252_S255_I0.7101.00
194_Q200_A0.7081.00
362_Y366_V0.7071.00
10_S15_V0.7071.00
364_Q367_K0.7051.00
51_L327_F0.7001.00
402_I405_K0.7001.00
96_G100_Y0.6991.00
112_W326_A0.6991.00
382_W386_G0.6971.00
97_K101_G0.6961.00
197_D201_T0.6951.00
75_N79_V0.6931.00
331_P347_L0.6921.00
199_F203_L0.6921.00
161_M232_I0.6901.00
168_L172_K0.6901.00
198_Q202_P0.6891.00
113_T125_K0.6891.00
234_K237_Q0.6871.00
223_W227_T0.6861.00
153_Y167_A0.6851.00
233_L237_Q0.6801.00
116_L121_N0.6791.00
292_A296_G0.6791.00
274_Q278_Q0.6771.00
105_A322_K0.6771.00
161_M165_I0.6751.00
81_M312_W0.6731.00
169_R172_K0.6721.00
252_S256_E0.6711.00
23_K26_A0.6701.00
58_E332_A0.6681.00
14_L17_P0.6671.00
215_Q218_N0.6651.00
178_S262_K0.6651.00
22_E25_S0.6611.00
353_D357_A0.6601.00
156_A167_A0.6591.00
390_Q394_A0.6551.00
144_A287_I0.6511.00
279_I282_N0.6501.00
356_Y359_D0.6501.00
315_S319_K0.6451.00
278_Q281_P0.6441.00
51_L336_Q0.6441.00
212_E216_L0.6421.00
18_G21_A0.6361.00
95_W133_A0.6351.00
243_N257_L0.6341.00
254_L266_T0.6311.00
145_Y150_L0.6301.00
58_E323_D0.6291.00
314_D318_L0.6291.00
392_L397_L0.6291.00
179_I183_W0.6291.00
174_K179_I0.6281.00
124_L133_A0.6271.00
89_L309_L0.6261.00
172_K180_V0.6251.00
153_Y264_A0.6251.00
294_H297_D0.6241.00
27_D31_K0.6231.00
115_D331_P0.6231.00
33_L321_A0.6231.00
72_D76_M0.6221.00
56_E62_I0.6201.00
19_C26_A0.6191.00
174_K178_S0.6171.00
48_F51_L0.6151.00
399_P403_S0.6121.00
171_I174_K0.6121.00
153_Y179_I0.6111.00
67_H80_R0.6101.00
199_F202_P0.6091.00
171_I265_F0.6091.00
194_Q197_D0.6081.00
378_P382_W0.6071.00
249_A257_L0.6071.00
55_F60_S0.6071.00
78_R97_K0.6071.00
200_A203_L0.6061.00
257_L260_Q0.6041.00
180_V243_N0.6021.00
143_L267_M0.6021.00
355_F359_D0.6011.00
218_N411_K0.6011.00
228_Y293_I0.5981.00
318_L321_A0.5971.00
159_E164_F0.5951.00
223_W407_G0.5951.00
212_E217_I0.5941.00
58_E61_D0.5931.00
229_L233_L0.5931.00
211_N215_Q0.5921.00
99_R102_E0.5911.00
304_G308_T0.5901.00
372_F375_L0.5881.00
195_Y198_Q0.5871.00
73_Y77_M0.5851.00
259_A279_I0.5851.00
322_K325_I0.5831.00
221_F410_Y0.5821.00
368_V371_Y0.5821.00
368_V372_F0.5811.00
173_E178_S0.5811.00
95_W99_R0.5811.00
273_G277_A0.5811.00
168_L236_M0.5811.00
197_D200_A0.5811.00
326_A330_R0.5791.00
187_Y250_K0.5791.00
369_E373_D0.5771.00
209_A213_K0.5761.00
146_N261_N0.5751.00
35_I52_A0.5741.00
63_H66_L0.5741.00
60_S323_D0.5721.00
152_R174_K0.5721.00
67_H76_M0.5721.00
108_R322_K0.5721.00
31_K61_D0.5691.00
157_P167_A0.5691.00
225_K229_L0.5681.00
388_V392_L0.5671.00
307_Y310_A0.5671.00
151_D154_G0.5661.00
369_E374_R0.5651.00
107_L325_I0.5651.00
331_P334_A0.5641.00
238_K241_L0.5641.00
60_S320_E0.5631.00
74_E97_K0.5631.00
117_D351_K0.5621.00
120_L138_Q0.5621.00
9_L14_L0.5611.00
15_V19_C0.5601.00
308_T312_W0.5601.00
70_G74_E0.5601.00
144_A285_V0.5591.00
338_A341_T0.5571.00
169_R235_Q0.5571.00
371_Y375_L0.5551.00
35_I66_L0.5541.00
127_K130_K0.5521.00
234_K398_A0.5521.00
373_D376_Y0.5511.00
323_D327_F0.5481.00
112_W117_D0.5481.00
51_L328_M0.5451.00
86_L314_D0.5441.00
340_A343_L0.5421.00
75_N78_R0.5421.00
21_A24_S0.5411.00
348_T351_K0.5401.00
358_N361_E0.5391.00
309_L325_I0.5391.00
391_E402_I0.5371.00
211_N217_I0.5361.00
13_L17_P0.5361.00
144_A273_G0.5361.00
255_I259_A0.5351.00
17_P21_A0.5341.00
236_M242_I0.5341.00
255_I268_Q0.5341.00
157_P286_G0.5331.00
274_Q277_A0.5321.00
148_N261_N0.5321.00
237_Q242_I0.5311.00
34_T80_R0.5311.00
18_G22_E0.5311.00
49_R66_L0.5311.00
92_T98_I0.5301.00
309_L328_M0.5291.00
88_D321_A0.5291.00
362_Y367_K0.5281.00
158_P265_F0.5281.00
106_D131_V0.5261.00
110_M326_A0.5251.00
183_W257_L0.5251.00
399_P402_I0.5251.00
110_M322_K0.5241.00
163_D167_A0.5241.00
253_Q257_L0.5241.00
105_A314_D0.5231.00
157_P288_I0.5231.00
22_E26_A0.5211.00
192_F195_Y0.5201.00
193_A197_D0.5201.00
34_T88_D0.5201.00
171_I179_I0.5201.00
235_Q240_K0.5201.00
95_W104_T0.5191.00
183_W254_L0.5181.00
33_L89_L0.5181.00
74_E78_R0.5171.00
93_H307_Y0.5161.00
20_S23_K0.5161.00
308_T311_A0.5151.00
47_T51_L0.5141.00
67_H87_P0.5141.00
370_P374_R0.5131.00
211_N216_L0.5121.00
334_A346_G0.5121.00
227_T404_Q0.5121.00
155_I158_P0.5121.00
115_D348_T0.5111.00
195_Y200_A0.5101.00
277_A285_V0.5101.00
80_R87_P0.5101.00
357_A360_Y0.5081.00
111_K115_D0.5071.00
162_D293_I0.5071.00
117_D120_L0.5071.00
209_A214_K0.5061.00
400_Q403_S0.5061.00
33_L88_D0.5061.00
100_Y128_S0.5051.00
7_L12_I0.5041.00
357_A361_E0.5031.00
134_Y325_I0.5021.00
195_Y199_F0.5011.00
69_P73_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4r6hA 1 0.9249 100 0.168 Contact Map
4rk9A 1 0.9014 100 0.182 Contact Map
3uorA 1 0.8826 100 0.213 Contact Map
4mfiA 1 0.8826 100 0.215 Contact Map
4r9fA 1 0.8638 100 0.224 Contact Map
4r2fA 1 0.8662 100 0.224 Contact Map
3vxbA 1 0.8662 100 0.227 Contact Map
4c1uA 1 0.8803 100 0.228 Contact Map
4r6kA 1 0.8779 100 0.236 Contact Map
4g68A 1 0.8756 100 0.243 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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