GREMLIN Database
YLBH - Putative rRNA methyltransferase YlbH
UniProt: O34331 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 184 (177)
Sequences: 4198 (3075)
Seq/√Len: 231.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
56_G69_F3.2621.00
57_I84_L2.8381.00
14_K82_S2.7511.00
8_K89_L2.6161.00
3_V57_I2.5971.00
29_K54_G2.3041.00
32_I177_V2.2871.00
11_R86_T2.2831.00
151_H178_A2.2571.00
44_R66_H2.2391.00
74_F97_R2.1651.00
7_S92_H2.1531.00
68_I114_F2.1181.00
141_L145_G2.1151.00
84_L93_A2.0891.00
45_G55_L2.0741.00
50_A69_F1.9161.00
60_L93_A1.9041.00
66_H94_Q1.9011.00
115_R142_E1.8511.00
71_D77_I1.8451.00
30_E34_N1.8441.00
103_A107_A1.8191.00
35_M179_I1.8041.00
60_L67_C1.8041.00
68_I96_Y1.7791.00
77_I95_V1.7581.00
169_K176_G1.7571.00
166_M180_Y1.7461.00
31_S172_Y1.6941.00
46_L114_F1.6741.00
84_L95_V1.6661.00
28_V175_T1.6591.00
21_T76_A1.6491.00
78_Q82_S1.5841.00
48_L70_V1.5691.00
44_R112_T1.5641.00
171_T176_G1.5431.00
11_R88_E1.5181.00
117_I145_G1.5081.00
74_F78_Q1.4851.00
77_I97_R1.4641.00
8_K87_L1.4631.00
49_F131_L1.4421.00
2_R26_D1.4201.00
40_F43_G1.4161.00
56_G67_C1.3971.00
124_K152_D1.3941.00
70_V103_A1.3761.00
85_K90_T1.3591.00
98_N103_A1.3491.00
24_T150_E1.3411.00
166_M178_A1.3251.00
31_S34_N1.3231.00
35_M168_R1.3151.00
166_M169_K1.3111.00
82_S85_K1.3021.00
135_I145_G1.2881.00
127_K131_L1.2831.00
153_R171_T1.2781.00
55_L118_F1.2751.00
66_H112_T1.2741.00
142_E145_G1.2681.00
60_L69_F1.2631.00
45_G59_A1.2431.00
99_D102_R1.2201.00
32_I55_L1.2041.00
117_I135_I1.1981.00
78_Q81_K1.1691.00
127_K130_A1.1661.00
48_L100_A1.1631.00
69_F93_A1.1621.00
71_D76_A1.1611.00
75_K78_Q1.1551.00
133_T137_E1.1131.00
50_A80_V1.1041.00
42_G65_E1.0991.00
136_D163_D1.0951.00
146_F167_T1.0891.00
11_R87_L1.0891.00
107_A140_M1.0871.00
105_H134_L1.0741.00
136_D164_L1.0661.00
113_G139_Q1.0611.00
45_G64_F1.0581.00
40_F116_G1.0551.00
113_G142_E1.0531.00
169_K178_A1.0461.00
82_S86_T1.0341.00
45_G116_G1.0321.00
72_R99_D1.0291.00
7_S89_L1.0191.00
98_N102_R1.0081.00
152_D174_L1.0071.00
45_G67_C1.0071.00
129_K133_T1.0061.00
68_I103_A0.9871.00
4_I30_E0.9861.00
15_A18_G0.9851.00
15_A52_S0.9781.00
167_T181_K0.9781.00
13_L83_N0.9651.00
81_K97_R0.9641.00
134_L138_Y0.9581.00
44_R113_G0.9571.00
130_A133_T0.9561.00
28_V31_S0.9551.00
16_V79_T0.9511.00
50_A56_G0.9501.00
60_L84_L0.9481.00
45_G118_F0.9481.00
24_T120_D0.9461.00
40_F64_F0.9381.00
124_K154_E0.9311.00
119_L149_A0.9301.00
1_M15_A0.9291.00
4_I26_D0.9271.00
77_I80_V0.9171.00
31_S35_M0.9071.00
44_R114_F0.9061.00
68_I94_Q0.8920.99
70_V98_N0.8920.99
8_K11_R0.8830.99
165_V181_K0.8770.99
153_R176_G0.8770.99
128_L149_A0.8770.99
160_T180_Y0.8730.99
119_L147_I0.8720.99
98_N106_A0.8600.99
28_V177_V0.8590.99
35_M170_E0.8580.99
46_L117_I0.8520.99
44_R68_I0.8500.99
44_R142_E0.8470.99
33_F59_A0.8450.99
100_A131_L0.8440.99
17_A75_K0.8320.99
77_I81_K0.8240.99
151_H155_V0.8220.99
44_R65_E0.8150.99
70_V100_A0.8130.99
18_G21_T0.8090.99
172_Y177_V0.8080.99
89_L92_H0.8050.99
152_D155_V0.8040.99
96_Y103_A0.8040.99
126_Q129_K0.7980.99
37_G62_R0.7960.99
117_I141_L0.7960.99
27_K30_E0.7950.99
81_K85_K0.7930.99
79_T83_N0.7900.99
128_L151_H0.7850.99
32_I148_V0.7790.98
68_I112_T0.7700.98
102_R105_H0.7590.98
170_E177_V0.7530.98
46_L68_I0.7490.98
3_V84_L0.7480.98
50_A71_D0.7470.98
151_H176_G0.7460.98
94_Q112_T0.7460.98
49_F127_K0.7400.98
20_S73_D0.7340.98
132_L147_I0.7300.98
25_T28_V0.7120.97
113_G140_M0.7110.97
33_F118_F0.7110.97
57_I93_A0.7030.97
37_G40_F0.7030.97
108_A138_Y0.7030.97
69_F84_L0.7010.97
25_T175_T0.6940.97
36_I148_V0.6930.97
148_V177_V0.6860.97
101_E130_A0.6790.96
71_D80_V0.6790.96
158_P161_V0.6780.96
13_L87_L0.6730.96
104_L134_L0.6720.96
14_K79_T0.6700.96
118_F148_V0.6650.96
3_V29_K0.6580.96
18_G76_A0.6570.96
108_A140_M0.6550.96
134_L137_E0.6510.95
43_G64_F0.6500.95
35_M177_V0.6480.95
55_L148_V0.6480.95
39_Y168_R0.6410.95
29_K55_L0.6340.95
154_E174_L0.6330.95
168_R179_I0.6300.95
38_P43_G0.6290.95
14_K86_T0.6280.95
74_F77_I0.6230.94
105_H138_Y0.6170.94
48_L119_L0.6150.94
25_T172_Y0.6140.94
31_S177_V0.6120.94
18_G73_D0.6080.94
144_D181_K0.6070.93
26_D30_E0.6060.93
5_S62_R0.6050.93
43_G115_R0.6030.93
119_L131_L0.6030.93
100_A104_L0.5990.93
101_E127_K0.5980.93
130_A134_L0.5960.93
5_S29_K0.5960.93
32_I118_F0.5910.93
125_E155_V0.5900.93
27_K31_S0.5860.92
15_A21_T0.5850.92
128_L155_V0.5840.92
24_T28_V0.5830.92
159_E166_M0.5830.92
104_L140_M0.5830.92
64_F116_G0.5820.92
57_I87_L0.5800.92
101_E134_L0.5800.92
131_L135_I0.5800.92
8_K60_L0.5720.91
101_E131_L0.5720.91
103_A140_M0.5720.91
38_P41_D0.5690.91
148_V179_I0.5680.91
24_T54_G0.5640.91
8_K92_H0.5630.91
21_T79_T0.5620.91
128_L152_D0.5580.90
136_D162_G0.5540.90
55_L179_I0.5490.90
158_P180_Y0.5490.90
161_V180_Y0.5470.89
48_L104_L0.5460.89
89_L93_A0.5450.89
57_I83_N0.5450.89
70_V96_Y0.5430.89
39_Y146_F0.5430.89
47_D56_G0.5400.89
73_D76_A0.5380.89
150_E175_T0.5350.88
107_A138_Y0.5340.88
72_R97_R0.5320.88
49_F100_A0.5320.88
83_N86_T0.5320.88
55_L116_G0.5300.88
96_Y106_A0.5280.88
1_M18_G0.5180.87
119_L128_L0.5150.86
107_A113_G0.5150.86
76_A83_N0.5150.86
136_D165_V0.5140.86
7_S63_G0.5130.86
60_L89_L0.5090.86
49_F99_D0.5090.86
128_L132_L0.5080.86
47_D53_G0.5050.85
32_I179_I0.5050.85
24_T30_E0.5030.85
10_G170_E0.5020.85
148_V172_Y0.5020.85
35_M148_V0.5020.85
129_K157_L0.5010.85
67_C93_A0.5000.85
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ws6A 1 0.9185 100 0.54 Contact Map
2fpoA 1 0.9783 100 0.571 Contact Map
2fhpA 1 0.9946 100 0.571 Contact Map
2iftA 1 0.9565 99.9 0.579 Contact Map
4bluA 2 0.9022 99.9 0.595 Contact Map
2oo3A 1 0.9293 99.9 0.601 Contact Map
3x0dA 1 0.8967 99.9 0.613 Contact Map
2esrA 2 0.837 99.9 0.617 Contact Map
3p9nA 1 0.9565 99.9 0.62 Contact Map
4dcmA 1 0.8696 99.8 0.666 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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