GREMLIN Database
CTAG - Protein CtaG
UniProt: O34329 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 297 (255)
Sequences: 1458 (1087)
Seq/√Len: 68.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
25_T54_M7.0621.00
73_F253_G5.7971.00
29_L51_L5.6441.00
25_T51_L5.4441.00
100_W104_I3.5501.00
53_A94_G3.4141.00
57_L87_V3.4091.00
112_V116_F3.3631.00
32_Y47_M3.3541.00
45_K49_C3.3481.00
44_G48_V3.0411.00
131_S196_A2.9651.00
21_L54_M2.9141.00
33_R37_S2.8941.00
52_S90_L2.8461.00
42_I99_L2.7211.00
43_T46_E2.6441.00
27_L31_F2.6131.00
50_F94_G2.4281.00
42_I47_M2.4011.00
74_S249_D2.3461.00
22_L26_A2.2871.00
245_P248_E2.2581.00
77_M149_H2.2481.00
43_T48_V2.1751.00
125_L159_L2.0811.00
56_F87_V2.0711.00
111_P114_S2.0231.00
115_F121_I1.9551.00
21_L58_Y1.7961.00
19_C23_G1.7921.00
26_A30_Y1.7771.00
196_A257_M1.7411.00
72_M243_T1.7191.00
76_H80_M1.7121.00
28_Y94_G1.6700.99
72_M249_D1.6280.99
129_I155_L1.5910.99
15_P19_C1.5840.99
51_L54_M1.5830.99
91_L94_G1.5660.99
76_H149_H1.5300.99
95_I170_K1.5290.99
35_M38_K1.5160.99
177_L181_M1.5060.99
36_S41_R1.5030.99
197_C258_K1.4940.99
77_M257_M1.4670.99
59_A63_S1.4630.99
140_D209_A1.4610.99
32_Y99_L1.4410.98
280_E284_D1.4400.98
164_W268_F1.4340.98
141_T148_Y1.4330.98
53_A91_L1.4020.98
15_P18_F1.3950.98
140_D144_T1.3870.98
269_L273_F1.3660.98
136_P208_Y1.3610.98
60_A82_V1.3570.98
212_T215_A1.3410.97
197_C255_V1.3400.97
26_A33_R1.3210.97
88_P160_A1.3110.97
72_M75_A1.3060.97
77_M80_M1.2840.97
123_L189_D1.2810.97
129_I152_I1.2800.97
195_P264_V1.2740.96
127_N192_L1.2730.96
125_L128_G1.2720.96
58_Y62_G1.2690.96
118_T121_I1.2660.96
270_A273_F1.2580.96
11_A63_S1.2580.96
127_N189_D1.2370.96
271_V274_F1.2060.95
48_V52_S1.1970.95
198_A202_F1.1860.95
77_M85_L1.1850.95
142_V152_I1.1840.95
247_L251_Q1.1780.95
43_T99_L1.1710.94
80_M257_M1.1640.94
179_G279_K1.1630.94
24_I50_F1.1610.94
262_E276_W1.1400.93
79_Q184_G1.1370.93
201_M254_A1.1140.93
63_S79_Q1.1080.92
66_D79_Q1.1010.92
65_V75_A1.0980.92
209_A213_D1.0800.92
81_A261_Q1.0760.91
80_M149_H1.0750.91
132_L138_I1.0700.91
112_V115_F1.0600.91
201_M255_V1.0560.91
192_L196_A1.0510.90
81_A260_I1.0380.90
46_E49_C1.0320.90
53_A87_V1.0190.89
17_L71_I1.0080.88
27_L30_Y1.0060.88
23_G27_L1.0030.88
94_G166_P0.9950.88
166_P185_Y0.9860.87
149_H156_I0.9860.87
66_D211_Y0.9840.87
24_I54_M0.9800.87
45_K170_K0.9780.87
248_E251_Q0.9710.86
85_L193_L0.9680.86
206_P247_L0.9610.86
134_H193_L0.9610.86
75_A78_V0.9580.86
80_M156_I0.9580.86
77_M134_H0.9560.86
98_W171_V0.9550.86
266_G273_F0.9510.85
51_L55_L0.9480.85
28_Y119_P0.9460.85
136_P164_W0.9450.85
72_M242_N0.9450.85
72_M245_P0.9430.85
56_F82_V0.9390.85
30_Y34_R0.9380.85
94_G111_P0.9350.84
133_Y164_W0.9340.84
193_L262_E0.9320.84
33_R111_P0.9270.84
139_F153_T0.9270.84
248_E252_L0.9200.83
77_M156_I0.9200.83
84_Y159_L0.9190.83
123_L188_A0.9180.83
113_F117_T0.9140.83
182_K190_G0.9130.83
49_C52_S0.9080.83
134_H257_M0.9080.83
128_G163_M0.9080.83
21_L60_A0.9040.82
50_F91_L0.8960.82
134_H194_T0.8940.82
122_A166_P0.8790.80
85_L261_Q0.8770.80
130_F186_I0.8770.80
260_I269_L0.8730.80
134_H160_A0.8700.80
92_I165_W0.8690.80
42_I46_E0.8670.80
86_V264_V0.8650.79
281_R284_D0.8610.79
25_T29_L0.8580.79
64_P68_L0.8580.79
29_L33_R0.8510.78
190_G258_K0.8500.78
134_H152_I0.8470.78
84_Y193_L0.8450.78
80_M152_I0.8440.78
164_W260_I0.8410.77
274_F278_K0.8360.77
80_M155_L0.8360.77
203_S206_P0.8290.76
66_D208_Y0.8240.76
194_T262_E0.8200.76
69_G79_Q0.8200.76
79_Q153_T0.8180.75
33_R55_L0.8170.75
17_L150_T0.8160.75
271_V275_Q0.8130.75
282_E285_G0.8090.75
148_Y152_I0.8070.74
166_P269_L0.8050.74
281_R287_E0.8040.74
270_A274_F0.7980.74
78_V256_M0.7980.74
65_V79_Q0.7970.74
184_G188_A0.7970.74
175_R182_K0.7970.74
198_A201_M0.7940.73
139_F143_K0.7900.73
76_H134_H0.7900.73
283_K286_Q0.7810.72
283_K287_E0.7790.72
30_Y33_R0.7790.72
49_C90_L0.7760.72
126_F201_M0.7690.71
92_I118_T0.7690.71
68_L72_M0.7660.71
81_A156_I0.7660.71
165_W208_Y0.7560.70
242_N245_P0.7540.69
243_T246_L0.7500.69
80_M193_L0.7500.69
133_Y142_V0.7480.69
84_Y89_P0.7480.69
277_V281_R0.7460.69
171_V174_L0.7410.68
121_I167_L0.7390.68
79_Q89_P0.7380.68
69_G140_D0.7380.68
142_V145_D0.7330.67
202_F258_K0.7330.67
56_F60_A0.7320.67
81_A264_V0.7320.67
88_P184_G0.7310.67
76_H257_M0.7190.66
94_G135_V0.7160.65
119_P211_Y0.7160.65
34_R267_T0.7130.65
74_S193_L0.7070.64
48_V120_L0.7050.64
61_E83_L0.7050.64
168_V264_V0.7020.64
76_H189_D0.7010.64
159_L209_A0.7010.64
108_S111_P0.6980.63
251_Q261_Q0.6940.63
152_I193_L0.6940.63
71_I143_K0.6920.63
13_W18_F0.6910.63
66_D153_T0.6900.63
33_R36_S0.6890.62
216_L241_L0.6870.62
255_V259_I0.6860.62
254_A257_M0.6790.61
104_I183_L0.6770.61
80_M258_K0.6750.61
120_L190_G0.6740.61
114_S175_R0.6700.60
127_N177_L0.6690.60
57_L157_F0.6690.60
74_S252_L0.6680.60
44_G124_L0.6630.59
105_F109_I0.6610.59
127_N131_S0.6600.59
187_M283_K0.6590.59
26_A45_K0.6560.59
50_F79_Q0.6550.59
11_A58_Y0.6550.59
121_I125_L0.6510.58
192_L254_A0.6510.58
107_P110_K0.6500.58
182_K275_Q0.6460.57
202_F261_Q0.6460.57
84_Y156_I0.6460.57
57_L151_L0.6450.57
134_H171_V0.6440.57
18_F23_G0.6420.57
76_H186_I0.6400.57
78_V280_E0.6390.57
90_L266_G0.6320.56
68_L74_S0.6320.56
83_L167_L0.6310.56
189_D265_Y0.6290.55
266_G270_A0.6250.55
97_A116_F0.6240.55
206_P209_A0.6240.55
268_F272_I0.6240.55
105_F162_F0.6230.55
77_M81_A0.6190.54
26_A102_K0.6190.54
103_I282_E0.6160.54
133_Y260_I0.6150.54
174_L182_K0.6150.54
60_A281_R0.6150.54
165_W173_R0.6110.53
86_V206_P0.6100.53
76_H169_H0.6100.53
213_D216_L0.6070.53
200_I203_S0.6020.52
152_I155_L0.6010.52
179_G182_K0.6000.52
53_A160_A0.5990.52
15_P21_L0.5980.52
80_M261_Q0.5970.52
36_S39_P0.5970.52
14_S62_G0.5960.52
123_L166_P0.5960.52
152_I156_I0.5950.51
44_G205_A0.5940.51
60_A87_V0.5910.51
187_M190_G0.5910.51
45_K120_L0.5910.51
133_Y193_L0.5910.51
133_Y152_I0.5900.51
11_A14_S0.5900.51
195_P198_A0.5890.51
190_G265_Y0.5880.51
137_L148_Y0.5860.50
186_I272_I0.5840.50
12_M16_Y0.5820.50
49_C56_F0.5770.49
101_E173_R0.5770.49
208_Y212_T0.5760.49
15_P124_L0.5760.49
92_I169_H0.5760.49
131_S257_M0.5750.49
84_Y163_M0.5740.49
142_V253_G0.5740.49
123_L207_L0.5730.49
65_V82_V0.5720.49
29_L47_M0.5720.49
89_P164_W0.5710.49
12_M15_P0.5710.49
279_K283_K0.5700.48
128_G188_A0.5680.48
117_T121_I0.5680.48
69_G150_T0.5680.48
59_A65_V0.5670.48
142_V148_Y0.5670.48
73_F76_H0.5660.48
69_G186_I0.5660.48
86_V278_K0.5650.48
126_F164_W0.5630.48
167_L186_I0.5620.47
140_D199_L0.5590.47
186_I190_G0.5570.47
130_F269_L0.5570.47
197_C254_A0.5570.47
139_F152_I0.5570.47
52_S254_A0.5520.46
145_D270_A0.5500.46
35_M40_N0.5490.46
282_E286_Q0.5480.46
263_I274_F0.5480.46
183_L272_I0.5460.46
114_S285_G0.5460.46
99_L172_E0.5440.45
182_K185_Y0.5420.45
112_V158_V0.5420.45
82_V128_G0.5410.45
83_L100_W0.5400.45
64_P134_H0.5400.45
12_M62_G0.5390.45
87_V204_G0.5390.45
183_L269_L0.5390.45
74_S250_Q0.5380.45
210_T214_P0.5350.44
177_L185_Y0.5340.44
94_G165_W0.5330.44
48_V112_V0.5320.44
22_L287_E0.5320.44
104_I135_V0.5310.44
50_F161_F0.5300.44
189_D269_L0.5300.44
14_S58_Y0.5290.44
26_A51_L0.5280.43
241_L245_P0.5270.43
19_C115_F0.5230.43
73_F200_I0.5230.43
20_I157_F0.5230.43
167_L179_G0.5220.43
152_I195_P0.5220.43
155_L193_L0.5210.43
80_M196_A0.5210.43
196_A262_E0.5200.42
114_S174_L0.5190.42
163_M186_I0.5170.42
140_D211_Y0.5170.42
107_P136_P0.5150.42
114_S176_Q0.5140.42
197_C261_Q0.5130.42
262_E280_E0.5120.42
17_L153_T0.5120.42
189_D258_K0.5110.41
196_A264_V0.5100.41
95_I98_W0.5100.41
173_R177_L0.5100.41
265_Y268_F0.5090.41
83_L253_G0.5080.41
125_L162_F0.5080.41
167_L185_Y0.5080.41
123_L167_L0.5070.41
165_W265_Y0.5070.41
244_L248_E0.5060.41
145_D200_I0.5050.41
57_L149_H0.5030.41
123_L163_M0.5020.40
121_I181_M0.5020.40
15_P203_S0.5000.40
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2m20A 2 0.1582 30.8 0.958 Contact Map
3pjzA 2 0.5354 15 0.964 Contact Map
2mqdA 1 0.1448 14.7 0.964 Contact Map
4tphA 2 0.7138 8.5 0.967 Contact Map
1pw4A 1 0.7778 8.2 0.968 Contact Map
2lomA 1 0.2593 7.9 0.968 Contact Map
4j05A 3 0.7643 7.3 0.968 Contact Map
2kncB 1 0.1852 7.1 0.969 Contact Map
2l2tA 2 0.1448 6.9 0.969 Contact Map
3ayfA 2 0.8114 6.8 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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