GREMLIN Database
KGUA - Guanylate kinase
UniProt: O34328 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 204 (180)
Sequences: 4949 (3215)
Seq/√Len: 239.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
130_E133_N3.5201.00
132_K136_V3.2701.00
64_Q68_D2.6911.00
28_Q180_K2.6641.00
59_R63_E2.4971.00
39_V57_K2.3641.00
87_D91_Q2.3421.00
136_V143_D2.3391.00
49_V52_V2.3141.00
61_E64_Q2.2971.00
65_M70_K2.2781.00
63_E81_Y2.2481.00
39_V85_P2.1491.00
76_E79_G2.0171.00
58_T61_E1.9991.00
174_T178_K1.9601.00
21_V123_L1.9431.00
34_E97_K1.9221.00
59_R81_Y1.9091.00
66_I74_W1.8861.00
78_V152_A1.8351.00
59_R76_E1.8281.00
86_V90_E1.8121.00
21_V179_I1.7951.00
167_V175_A1.7941.00
143_D147_E1.7921.00
24_A27_S1.7911.00
70_K87_D1.7311.00
75_A106_Q1.7211.00
24_A176_C1.7071.00
59_R80_N1.6921.00
11_S163_Y1.6881.00
88_Y91_Q1.6821.00
90_E94_Q1.6681.00
171_N174_T1.6471.00
77_Y104_E1.6401.00
132_K147_E1.6121.00
49_V53_D1.6051.00
29_E180_K1.5751.00
142_T145_L1.5541.00
109_L162_A1.5451.00
50_N55_F1.5351.00
91_Q95_D1.5201.00
20_T172_V1.5101.00
63_E67_A1.5101.00
112_R164_D1.4711.00
12_G16_V1.4701.00
55_F88_Y1.4671.00
24_A28_Q1.4641.00
63_E66_I1.4601.00
57_K65_M1.4511.00
19_G102_E1.4081.00
34_E92_T1.3991.00
165_Y182_I1.3831.00
21_V176_C1.3631.00
127_S130_E1.3271.00
39_V65_M1.3231.00
76_E81_Y1.3171.00
147_E151_K1.3081.00
29_E32_K1.2971.00
85_P88_Y1.2961.00
24_A173_E1.2791.00
124_A166_V1.2761.00
167_V179_I1.2731.00
35_Y102_E1.2711.00
88_Y92_T1.2531.00
10_L22_R1.2511.00
66_I81_Y1.2201.00
23_Q53_D1.2181.00
177_D180_K1.2131.00
92_T97_K1.2091.00
180_K184_L1.1841.00
103_I111_V1.1731.00
170_D174_T1.1731.00
57_K61_E1.1701.00
159_M162_A1.1651.00
22_R100_F1.1621.00
133_N137_T1.1471.00
8_I119_L1.1381.00
61_E65_M1.1371.00
172_V176_C1.1371.00
86_V114_A1.1351.00
64_Q67_A1.1141.00
23_Q27_S1.1121.00
112_R120_F1.1041.00
92_T99_V1.0871.00
178_K184_L1.0751.00
92_T95_D1.0711.00
101_L111_V1.0651.00
6_L119_L1.0491.00
181_A184_L1.0481.00
124_A157_I1.0471.00
148_N152_A1.0301.00
22_R102_E1.0231.00
28_Q176_C1.0231.00
105_V159_M1.0171.00
72_L89_V1.0161.00
60_D63_E1.0131.00
177_D181_A1.0011.00
155_A158_E0.9971.00
12_G19_G0.9961.00
50_N61_E0.9941.00
167_V182_I0.9921.00
108_A120_F0.9871.00
79_G148_N0.9861.00
152_A155_A0.9851.00
110_Q113_N0.9721.00
69_N114_A0.9651.00
181_A185_A0.9621.00
109_L159_M0.9621.00
165_Y178_K0.9611.00
74_W81_Y0.9541.00
39_V71_L0.9541.00
9_V120_F0.9531.00
128_L154_K0.9381.00
160_M166_V0.9371.00
141_E146_I0.9211.00
10_L179_I0.9151.00
65_M71_L0.9041.00
165_Y186_E0.9031.00
90_E115_F0.8991.00
28_Q177_D0.8891.00
8_I183_V0.8870.99
65_M85_P0.8700.99
78_V104_E0.8660.99
48_E53_D0.8560.99
151_K154_K0.8500.99
19_G53_D0.8500.99
44_P47_G0.8390.99
69_N86_V0.8320.99
39_V88_Y0.8320.99
57_K62_F0.8260.99
21_V172_V0.8230.99
132_K150_M0.8010.99
19_G22_R0.7940.99
119_L165_Y0.7930.99
109_L113_N0.7900.99
170_D175_A0.7720.99
62_F74_W0.7660.99
26_F35_Y0.7660.99
8_I98_D0.7650.98
75_A110_Q0.7620.98
72_L115_F0.7530.98
25_I33_F0.7510.98
145_L148_N0.7470.98
44_P50_N0.7450.98
16_V19_G0.7440.98
50_N56_F0.7390.98
169_N175_A0.7390.98
121_I179_I0.7350.98
6_L186_E0.7350.98
65_M68_D0.7330.98
22_R35_Y0.7290.98
16_V123_L0.7290.98
154_K158_E0.7270.98
91_Q94_Q0.7260.98
129_S132_K0.7210.98
29_E184_L0.7190.98
63_E76_E0.7180.98
7_L115_F0.7170.98
13_P16_V0.7060.97
22_R26_F0.6920.97
35_Y38_S0.6900.97
119_L186_E0.6880.97
178_K181_A0.6880.97
175_A178_K0.6870.97
124_A160_M0.6860.97
177_D184_L0.6840.97
24_A172_V0.6830.97
57_K85_P0.6830.97
50_N57_K0.6820.97
77_Y152_A0.6800.97
103_I110_Q0.6780.97
176_C180_K0.6760.97
13_P157_I0.6740.97
136_V146_I0.6700.97
26_F100_F0.6680.96
109_L120_F0.6670.96
25_I179_I0.6670.96
105_V152_A0.6660.96
42_R56_F0.6580.96
45_R138_R0.6490.96
7_L93_L0.6470.96
137_T140_T0.6470.96
119_L182_I0.6460.96
70_K86_V0.6450.96
77_Y106_Q0.6410.96
128_L132_K0.6410.96
25_I176_C0.6390.95
78_V148_N0.6390.95
62_F81_Y0.6370.95
38_S102_E0.6340.95
173_E177_D0.6300.95
11_S108_A0.6250.95
141_E145_L0.6240.95
155_A159_M0.6170.95
172_V175_A0.6160.95
5_G98_D0.6150.94
157_I160_M0.6130.94
37_I55_F0.6120.94
42_R48_E0.6120.94
154_K157_I0.6110.94
37_I51_G0.6110.94
87_D90_E0.6100.94
134_R138_R0.6090.94
14_S146_I0.6060.94
9_V118_G0.6030.94
174_T177_D0.6020.94
158_E161_D0.5950.93
34_E88_Y0.5950.93
103_I107_G0.5930.93
21_V175_A0.5910.93
46_E140_T0.5850.93
33_F98_D0.5830.93
29_E33_F0.5830.93
153_A156_E0.5830.93
105_V109_L0.5790.92
6_L98_D0.5750.92
13_P153_A0.5730.92
68_D71_L0.5710.92
36_S102_E0.5700.92
144_A147_E0.5690.92
34_E99_V0.5690.92
106_Q110_Q0.5670.92
60_D64_Q0.5650.92
39_V55_F0.5650.92
33_F100_F0.5620.91
14_S131_L0.5570.91
14_S149_R0.5560.91
25_I180_K0.5530.91
72_L86_V0.5520.91
138_R141_E0.5500.90
105_V156_E0.5500.90
20_T24_A0.5490.90
146_I150_M0.5480.90
110_Q114_A0.5460.90
66_I71_L0.5450.90
19_G35_Y0.5430.90
17_G169_N0.5430.90
128_L150_M0.5420.90
43_S58_T0.5380.90
72_L111_V0.5370.89
176_C179_I0.5360.89
34_E95_D0.5340.89
43_S80_N0.5330.89
51_G56_F0.5320.89
11_S120_F0.5310.89
8_I121_I0.5300.89
104_E152_A0.5300.89
12_G160_M0.5300.89
103_I156_E0.5270.89
93_L99_V0.5260.88
16_V78_V0.5260.88
41_T59_R0.5210.88
45_R149_R0.5210.88
38_S107_G0.5200.88
42_R45_R0.5180.88
8_I33_F0.5160.88
25_I29_E0.5140.87
71_L85_P0.5130.87
24_A171_N0.5090.87
36_S84_T0.5080.87
78_V105_V0.5080.87
48_E51_G0.5070.87
86_V115_F0.5060.86
36_S101_L0.5050.86
121_I182_I0.5050.86
93_L98_D0.5040.86
38_S84_T0.5030.86
104_E107_G0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2xkxA 2 0.9461 100 0.202 Contact Map
1kjwA 1 0.9461 100 0.21 Contact Map
3tvtA 1 0.9265 100 0.233 Contact Map
1s96A 4 0.9853 100 0.396 Contact Map
4deyA 1 0.7794 100 0.404 Contact Map
3tszA 1 0.7745 100 0.425 Contact Map
3shwA 1 0.7255 100 0.458 Contact Map
1lvgA 1 0.9167 100 0.477 Contact Map
3kfvA 1 0.7255 100 0.489 Contact Map
1z6gA 1 0.9167 100 0.492 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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