GREMLIN Database
RAPJ - Response regulator aspartate phosphatase J
UniProt: O34327 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 373 (305)
Sequences: 1780 (1582)
Seq/√Len: 90.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
195_H198_K4.9361.00
187_A203_L4.4361.00
235_D238_E4.3921.00
274_K277_K4.0681.00
227_G243_F3.9951.00
349_H352_S3.9821.00
142_L161_Y3.7021.00
114_N117_L3.6031.00
154_Q157_F3.6001.00
106_G122_Y3.5321.00
146_A162_A3.4871.00
266_T282_Y3.2681.00
230_K238_E2.9941.00
223_Y242_Y2.6541.00
149_Y157_F2.6161.00
244_K265_L2.3921.00
227_G242_Y2.3571.00
243_F264_S2.3361.00
200_L226_V2.2861.00
340_T344_F2.2391.00
240_E269_Y2.1861.00
159_M189_N2.1761.00
223_Y245_T2.1501.00
183_E202_H2.1091.00
145_V149_Y2.1041.00
341_A357_Y2.1011.00
159_M186_I2.0871.00
105_R109_E2.0721.00
240_E265_L2.0711.00
317_L320_C2.0641.00
240_E268_I2.0621.00
277_K280_E2.0241.00
198_K201_T1.9711.00
162_A185_I1.9111.00
262_V281_A1.9031.00
119_I149_Y1.8991.00
190_L198_K1.8761.00
186_I190_L1.8471.00
226_V242_Y1.8131.00
220_A246_A1.8131.00
240_E272_E1.7651.00
143_F185_I1.7381.00
122_Y144_K1.7341.00
142_L164_Q1.7161.00
164_Q167_D1.7081.00
247_A262_V1.7041.00
352_S355_F1.6841.00
227_G239_A1.6781.00
109_E117_L1.6761.00
200_L233_L1.6431.00
184_F225_N1.5881.00
238_E241_G1.5761.00
204_C226_V1.5681.00
265_L281_A1.5621.00
344_F349_H1.5351.00
226_V230_K1.5111.00
145_V161_Y1.5061.00
191_T203_L1.5021.00
223_Y246_A1.4991.00
207_L226_V1.4761.00
102_Y124_H1.4490.99
187_A206_A1.4440.99
180_V206_A1.4390.99
227_G246_A1.4320.99
210_A219_I1.4130.99
269_Y274_K1.4130.99
76_K80_S1.4050.99
242_Y246_A1.3980.99
250_F258_A1.3900.99
244_K277_K1.3830.99
110_F122_Y1.3790.99
187_A202_H1.3700.99
188_G203_L1.3680.99
300_K304_I1.3660.99
37_E40_L1.3590.99
354_A358_R1.3520.99
163_S186_I1.3470.99
82_M85_E1.3340.99
223_Y262_V1.3300.99
237_K272_E1.3100.99
240_E244_K1.3030.99
38_Y42_D1.2830.99
102_Y121_H1.2820.99
99_Y125_A1.2800.99
103_Y144_K1.2650.99
150_Y162_A1.2590.98
200_L204_C1.2590.98
36_I43_M1.2580.98
190_L195_H1.2550.98
309_L313_D1.2540.98
344_F352_S1.2520.98
126_E142_L1.2490.98
341_A360_L1.2360.98
325_E359_R1.2360.98
200_L230_K1.2320.98
183_E205_S1.2220.98
34_Q37_E1.2190.98
308_Y313_D1.2180.98
224_Y227_G1.2010.98
223_Y227_G1.1960.98
119_I152_I1.1880.98
353_A361_M1.1870.98
264_S267_H1.1840.98
34_Q38_Y1.1750.98
200_L229_C1.1690.98
139_A165_A1.1340.97
247_A261_A1.1230.97
355_F359_R1.1220.97
301_F308_Y1.1070.97
106_G125_A1.1050.97
47_Q53_F1.1030.97
341_A353_A1.1010.96
149_Y154_Q1.0910.96
49_L53_F1.0860.96
142_L223_Y1.0830.96
159_M190_L1.0810.96
158_S189_N1.0800.96
65_D70_V1.0760.96
49_L52_Y1.0710.96
296_M303_L1.0700.96
41_E44_E1.0650.96
188_G225_N1.0610.96
304_I308_Y1.0550.96
281_A284_R1.0500.95
147_E162_A1.0480.95
146_A187_A1.0410.95
350_Y353_A1.0370.95
337_L359_R1.0350.95
57_E61_R1.0320.95
266_T281_A1.0290.95
309_L312_G1.0290.95
35_E41_E1.0190.95
183_E262_V1.0180.95
305_H309_L1.0100.94
316_V319_E1.0100.94
50_L53_F1.0100.94
216_A219_I1.0080.94
322_D325_E1.0070.94
61_R67_L1.0010.94
336_L340_T0.9940.94
37_E41_E0.9930.94
43_M53_F0.9920.94
107_M122_Y0.9910.94
47_Q50_L0.9890.94
149_Y161_Y0.9880.94
156_Y193_V0.9790.93
268_I272_E0.9770.93
226_V265_L0.9720.93
236_Y240_E0.9690.93
50_L56_M0.9680.93
342_E357_Y0.9670.93
194_Y348_E0.9660.93
205_S208_E0.9660.93
144_K147_E0.9660.93
316_V320_C0.9650.93
265_L269_Y0.9640.93
236_Y268_I0.9590.93
60_H63_M0.9580.93
244_K269_Y0.9550.92
262_V284_R0.9540.92
186_I202_H0.9520.92
138_K142_L0.9500.92
63_M69_P0.9470.92
270_C282_Y0.9440.92
339_D342_E0.9430.92
250_F261_A0.9360.92
210_A218_M0.9360.92
184_F188_G0.9340.92
142_L165_A0.9330.92
116_I152_I0.9290.91
110_F115_F0.9280.91
206_A222_A0.9250.91
315_N319_E0.9230.91
224_Y264_S0.9220.91
148_V152_I0.9220.91
58_F65_D0.9220.91
39_D42_D0.9190.91
37_E43_M0.9170.91
102_Y125_A0.9150.91
48_D51_L0.9130.91
191_T229_C0.9110.91
130_E138_K0.9060.90
337_L356_F0.8970.90
357_Y361_M0.8920.90
48_D55_L0.8910.90
181_Q184_F0.8910.90
312_G316_V0.8910.90
49_L54_S0.8910.90
247_A265_L0.8880.89
61_R70_V0.8880.89
161_Y165_A0.8830.89
34_Q44_E0.8800.89
51_L55_L0.8730.89
166_L183_E0.8690.88
57_E62_I0.8670.88
229_C233_L0.8670.88
333_A337_L0.8660.88
122_Y148_V0.8650.88
230_K235_D0.8650.88
146_A189_N0.8630.88
229_C268_I0.8620.88
110_F148_V0.8600.88
39_D43_M0.8600.88
266_T285_G0.8580.88
65_D68_M0.8580.88
44_E47_Q0.8580.88
331_A335_D0.8530.87
203_L225_N0.8530.87
38_Y41_E0.8440.87
231_Y236_Y0.8410.87
308_Y314_L0.8370.86
269_Y281_A0.8340.86
297_Y300_K0.8330.86
302_R305_H0.8310.86
311_S322_D0.8310.86
163_S208_E0.8300.86
146_A165_A0.8290.86
340_T356_F0.8240.86
354_A357_Y0.8210.85
106_G110_F0.8180.85
183_E206_A0.8150.85
159_M240_E0.8140.85
278_A282_Y0.8100.85
66_K72_D0.8090.85
109_E121_H0.8090.85
258_A261_A0.8020.84
62_I66_K0.8000.84
58_F63_M0.7970.84
207_L223_Y0.7950.83
48_D52_Y0.7880.83
309_L316_V0.7850.83
58_F62_I0.7840.83
34_Q42_D0.7830.83
36_I39_D0.7770.82
40_L43_M0.7770.82
119_I145_V0.7720.82
240_E274_K0.7710.82
225_N228_H0.7690.81
35_E44_E0.7660.81
155_T158_S0.7630.81
234_G271_K0.7630.81
142_L262_V0.7630.81
98_E102_Y0.7610.81
228_H243_F0.7590.81
40_L50_L0.7560.80
35_E43_M0.7550.80
185_I188_G0.7550.80
64_L77_P0.7530.80
43_M47_Q0.7480.80
307_L310_G0.7480.80
111_K115_F0.7450.79
317_L324_L0.7410.79
283_D287_K0.7410.79
303_L307_L0.7410.79
269_Y277_K0.7390.79
216_A249_I0.7390.79
345_N358_R0.7380.79
39_D44_E0.7370.79
140_E144_K0.7360.79
119_I148_V0.7350.78
103_Y122_Y0.7330.78
124_H127_E0.7290.78
265_L284_R0.7280.78
280_E284_R0.7280.78
225_N231_Y0.7280.78
79_F82_M0.7240.77
99_Y129_L0.7230.77
38_Y61_R0.7170.77
234_G312_G0.7140.76
245_T249_I0.7120.76
39_D49_L0.7110.76
35_E38_Y0.7090.76
299_T306_E0.7090.76
338_H342_E0.7080.76
303_L308_Y0.7060.76
298_L302_R0.7050.75
205_S209_H0.7040.75
103_Y141_F0.7040.75
142_L183_E0.7030.75
190_L269_Y0.6980.75
55_L58_F0.6980.75
195_H282_Y0.6970.75
37_E67_L0.6960.75
159_M163_S0.6960.75
199_A229_C0.6950.74
304_I307_L0.6950.74
125_A141_F0.6950.74
35_E39_D0.6940.74
275_Y279_V0.6940.74
105_R121_H0.6930.74
61_R71_K0.6910.74
203_L226_V0.6900.74
103_Y125_A0.6860.73
99_Y106_G0.6840.73
204_C238_E0.6800.73
54_S67_L0.6800.73
60_H68_M0.6790.73
66_K83_L0.6790.73
355_F358_R0.6770.73
115_F148_V0.6770.73
40_L44_E0.6760.72
61_R69_P0.6750.72
52_Y55_L0.6730.72
142_L145_V0.6720.72
231_Y243_F0.6720.72
129_L141_F0.6690.72
61_R66_K0.6680.72
60_H64_L0.6680.72
86_I119_I0.6670.71
56_M61_R0.6610.71
106_G118_A0.6560.70
123_K166_L0.6550.70
150_Y189_N0.6550.70
190_L201_T0.6550.70
187_A199_A0.6530.70
207_L219_I0.6510.70
313_D317_L0.6510.70
334_E355_F0.6510.70
145_V164_Q0.6500.69
143_F165_A0.6490.69
351_E361_M0.6470.69
52_Y56_M0.6460.69
47_Q51_L0.6440.69
42_D49_L0.6440.69
137_E148_V0.6390.68
246_A261_A0.6390.68
297_Y304_I0.6370.68
339_D343_R0.6320.67
165_A206_A0.6320.67
227_G265_L0.6310.67
170_T179_R0.6310.67
150_Y155_T0.6310.67
35_E42_D0.6300.67
183_E223_Y0.6260.67
313_D316_V0.6250.66
312_G317_L0.6250.66
231_Y285_G0.6240.66
90_Q93_L0.6230.66
39_D51_L0.6220.66
188_G192_D0.6200.66
39_D50_L0.6190.66
308_Y312_G0.6180.66
62_I68_M0.6150.65
305_H311_S0.6150.65
51_L56_M0.6150.65
68_M71_K0.6150.65
279_V286_I0.6150.65
329_L332_D0.6140.65
49_L56_M0.6140.65
34_Q40_L0.6120.65
76_K79_F0.6110.65
157_F160_N0.6110.65
48_D56_M0.6100.65
163_S198_K0.6090.64
125_A128_K0.6090.64
228_H264_S0.6080.64
157_F269_Y0.6070.64
343_R347_L0.6050.64
37_E50_L0.6040.64
36_I41_E0.6020.64
168_I225_N0.6020.64
245_T248_A0.5980.63
321_F359_R0.5980.63
78_P82_M0.5970.63
35_E40_L0.5940.63
34_Q39_D0.5940.63
184_F222_A0.5940.63
301_F313_D0.5930.62
210_A217_Y0.5920.62
163_S190_L0.5920.62
43_M54_S0.5900.62
344_F350_Y0.5890.62
43_M63_M0.5880.62
265_L268_I0.5860.61
57_E70_V0.5860.61
182_C185_I0.5840.61
34_Q43_M0.5830.61
304_I324_L0.5820.61
335_D349_H0.5800.61
204_C208_E0.5780.60
320_C323_L0.5780.60
345_N349_H0.5770.60
44_E53_F0.5770.60
39_D48_D0.5750.60
94_T97_L0.5750.60
202_H205_S0.5740.60
36_I50_L0.5730.60
350_Y359_R0.5670.59
143_F184_F0.5650.59
59_R63_M0.5640.59
139_A169_Y0.5620.58
296_M299_T0.5610.58
103_Y148_V0.5590.58
273_G280_E0.5580.58
340_T343_R0.5550.57
96_L145_V0.5550.57
89_N92_K0.5550.57
203_L282_Y0.5540.57
36_I54_S0.5540.57
38_Y43_M0.5540.57
262_V285_G0.5540.57
104_F126_E0.5540.57
57_E69_P0.5530.57
335_D339_D0.5510.57
36_I40_L0.5480.56
324_L336_L0.5480.56
190_L202_H0.5470.56
348_E351_E0.5470.56
141_F144_K0.5470.56
315_N318_T0.5460.56
156_Y189_N0.5460.56
38_Y47_Q0.5440.56
53_F57_E0.5430.56
277_K281_A0.5390.55
61_R79_F0.5380.55
106_G121_H0.5380.55
64_L69_P0.5340.55
116_I360_L0.5340.55
169_Y210_A0.5300.54
49_L67_L0.5290.54
55_L63_M0.5290.54
182_C290_A0.5290.54
37_E53_F0.5270.54
305_H308_Y0.5260.53
350_Y354_A0.5260.53
37_E42_D0.5260.53
297_Y301_F0.5250.53
42_D84_N0.5240.53
283_D298_L0.5240.53
317_L322_D0.5240.53
107_M144_K0.5230.53
147_E185_I0.5220.53
197_E233_L0.5220.53
328_Q333_A0.5200.53
320_C327_R0.5200.53
63_M66_K0.5190.52
186_I290_A0.5190.52
100_Y112_Q0.5190.52
206_A241_G0.5180.52
323_L327_R0.5170.52
335_D341_A0.5160.52
234_G273_G0.5140.52
263_F267_H0.5130.52
52_Y70_V0.5120.51
165_A182_C0.5110.51
53_F64_L0.5100.51
165_A242_Y0.5090.51
314_L320_C0.5090.51
36_I51_L0.5080.51
51_L57_E0.5080.51
219_I222_A0.5060.51
55_L59_R0.5060.51
180_V209_H0.5050.51
224_Y261_A0.5030.50
62_I70_V0.5020.50
60_H71_K0.5020.50
104_F107_M0.5010.50
36_I48_D0.5000.50
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4gyoA 2 0.9651 100 0.22 Contact Map
3q15A 2 0.9705 100 0.238 Contact Map
3ulqA 1 0.9866 100 0.245 Contact Map
4i1aA 2 0.9598 100 0.249 Contact Map
4gpkA 3 0.9196 100 0.303 Contact Map
3q7aA 1 0.7399 100 0.382 Contact Map
1w3bA 2 0.8204 100 0.385 Contact Map
4l9pA 1 0.7507 100 0.389 Contact Map
3dssA 1 0.7131 100 0.401 Contact Map
4n5cA 1 0.9357 100 0.409 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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