GREMLIN Database
YTRP - Uncharacterized protein YtrP
UniProt: O34325 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 579 (463)
Sequences: 794 (721)
Seq/√Len: 33.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
489_R492_D8.2681.00
454_I537_C5.8131.00
460_N569_K5.3461.00
470_H558_D3.8351.00
519_E522_V3.8121.00
466_D470_H3.7821.00
452_V541_C3.6401.00
488_I494_G3.4781.00
456_V504_I3.4471.00
543_T547_K3.4181.00
446_K489_R3.3101.00
462_K466_D3.1901.00
454_I518_T3.1281.00
459_D536_S3.1001.00
421_H425_T3.0931.00
534_T570_N3.0921.00
466_D558_D2.9921.00
412_N416_R2.9671.00
470_H562_Y2.9491.00
499_G562_Y2.9181.00
500_E534_T2.9071.00
558_D562_Y2.8131.00
418_R422_L2.7471.00
499_G558_D2.7441.00
462_K562_Y2.6101.00
506_L517_I2.6091.00
510_P513_V2.5981.00
564_A573_M2.5811.00
452_V514_G2.5661.00
514_G518_T2.5061.00
522_V572_L2.4981.00
498_G558_D2.4651.00
432_Y436_Y2.4551.00
462_K470_H2.4411.00
539_I572_L2.3560.99
453_F504_I2.3430.99
459_D568_G2.3100.99
500_E561_L2.2790.99
470_H499_G2.2540.99
455_L561_L2.2540.99
458_I561_L2.1980.99
458_I500_E2.1620.99
130_I252_A2.1570.99
489_R520_R2.1520.99
457_D565_K2.1250.99
370_P379_G2.0680.98
466_D562_Y2.0470.98
536_S568_G2.0110.98
501_E558_D1.9990.98
222_G246_A1.9910.98
464_V475_E1.9790.98
415_L419_L1.9650.98
547_K556_E1.9560.98
525_V535_I1.9530.98
409_A413_S1.9390.97
436_Y493_V1.9110.97
549_S552_E1.8950.97
413_S416_R1.8570.97
457_D462_K1.8560.97
489_R517_I1.8550.97
316_L320_P1.8540.97
462_K499_G1.8470.97
437_L503_A1.8220.96
433_S502_L1.8140.96
476_I561_L1.8020.96
460_N500_E1.7620.96
501_E562_Y1.7500.95
462_K558_D1.7220.95
142_D145_D1.7060.95
509_V513_V1.6910.94
461_F477_L1.6840.94
492_D520_R1.6780.94
409_A412_N1.6730.94
320_P323_T1.6700.94
564_A568_G1.6640.94
497_W554_V1.6600.94
462_K465_N1.6510.94
256_A259_Y1.6380.93
457_D499_G1.6020.93
543_T556_E1.5970.92
457_D466_D1.5940.92
195_K198_L1.5880.92
476_I500_E1.5720.92
476_I533_V1.5470.91
408_L413_S1.5430.91
437_L495_A1.5210.91
457_D562_Y1.5070.90
518_T537_C1.5030.90
320_P324_A1.5020.90
498_G501_E1.4950.90
412_N569_K1.4680.89
441_I550_L1.4620.89
497_W500_E1.4480.88
293_A296_M1.4380.88
466_D499_G1.4340.88
560_A564_A1.4290.88
465_N473_G1.4280.87
321_G324_A1.4250.87
151_L163_F1.4110.87
418_R421_H1.4100.87
425_T476_I1.3930.86
258_L262_S1.3920.86
518_T539_I1.3880.86
526_R570_N1.3810.86
488_I520_R1.3780.86
499_G565_K1.3630.85
425_T561_L1.3510.84
522_V537_C1.3430.84
534_T568_G1.3430.84
456_V535_I1.3410.84
269_L272_I1.3290.83
340_E343_Y1.3270.83
162_E227_E1.3220.83
474_D499_G1.3210.83
547_K553_L1.3120.83
534_T561_L1.3070.82
141_L258_L1.3030.82
470_H474_D1.3000.82
500_E570_N1.2810.81
337_E340_E1.2760.81
466_D489_R1.2730.81
439_E493_V1.2710.80
449_Q508_N1.2700.80
437_L441_I1.2680.80
440_K493_V1.2660.80
473_G498_G1.2660.80
468_Y500_E1.2550.80
320_P408_L1.2530.80
500_E569_K1.2510.79
459_D499_G1.2500.79
465_N474_D1.2450.79
436_Y440_K1.2370.79
431_L476_I1.2370.79
459_D558_D1.2350.79
416_R419_L1.2200.78
458_I535_I1.2190.78
536_S558_D1.2170.77
440_K443_Y1.2170.77
367_M379_G1.2050.77
500_E525_V1.1930.76
522_V570_N1.1790.75
408_L416_R1.1780.75
542_W547_K1.1750.75
424_K436_Y1.1730.75
185_E188_K1.1680.74
154_L163_F1.1680.74
462_K474_D1.1660.74
425_T436_Y1.1600.74
461_F560_A1.1540.74
381_A406_A1.1530.74
266_I269_L1.1510.73
432_Y493_V1.1480.73
244_L248_A1.1470.73
455_L500_E1.1450.73
113_Q117_Q1.1430.73
425_T432_Y1.1420.73
176_G182_L1.1350.72
252_A255_N1.1340.72
465_N499_G1.1300.72
500_E522_V1.1200.71
468_Y522_V1.1160.71
473_G499_G1.1160.71
112_N115_M1.1140.71
323_T327_K1.1120.71
168_S171_Q1.1120.71
379_G407_T1.1080.70
465_N470_H1.1080.70
127_Q130_I1.1080.70
214_I221_Y1.1070.70
489_R506_L1.1070.70
176_G180_K1.1070.70
487_N521_L1.1060.70
151_L227_E1.0950.70
446_K491_H1.0940.69
255_N258_L1.0920.69
434_R558_D1.0880.69
133_M150_L1.0870.69
251_K255_N1.0840.69
558_D565_K1.0820.69
434_R501_E1.0800.68
464_V508_N1.0780.68
459_D570_N1.0710.68
441_I506_L1.0700.68
452_V509_V1.0690.68
498_G562_Y1.0640.67
320_P410_V1.0610.67
293_A305_V1.0600.67
409_A416_R1.0550.67
343_Y480_V1.0500.66
457_D558_D1.0480.66
478_I482_S1.0480.66
426_D496_R1.0410.66
458_I477_L1.0390.65
224_L234_L1.0380.65
143_Q253_F1.0370.65
403_I407_T1.0360.65
434_R474_D1.0350.65
438_D495_A1.0350.65
371_M379_G1.0330.65
500_E558_D1.0290.65
208_S228_G1.0270.65
436_Y439_E1.0240.64
431_L497_W1.0230.64
444_S493_V1.0220.64
166_F227_E1.0170.64
489_R558_D1.0160.64
500_E518_T1.0150.64
501_E536_S1.0090.63
208_S234_L1.0070.63
405_H408_L1.0070.63
474_D558_D1.0040.63
458_I480_V1.0020.63
318_L322_S0.9880.61
271_L275_T0.9880.61
245_L420_E0.9860.61
459_D534_T0.9830.61
415_L422_L0.9830.61
563_S573_M0.9780.61
130_I184_M0.9770.61
519_E523_Y0.9740.60
462_K501_E0.9710.60
564_A571_R0.9690.60
522_V534_T0.9680.60
542_W553_L0.9660.60
535_I561_L0.9650.60
476_I483_V0.9640.60
435_A464_V0.9630.59
195_K203_L0.9620.59
458_I534_T0.9610.59
545_E574_I0.9610.59
379_G410_V0.9570.59
517_I520_R0.9550.59
538_G557_A0.9500.58
447_I521_L0.9500.58
431_L560_A0.9490.58
452_V507_P0.9470.58
162_E205_K0.9460.58
500_E507_P0.9440.58
337_E341_K0.9400.58
462_K473_G0.9380.57
379_G403_I0.9360.57
434_R462_K0.9340.57
293_A300_F0.9290.57
309_H379_G0.9280.57
351_I355_Q0.9270.57
444_S500_E0.9250.56
518_T572_L0.9250.56
436_Y509_V0.9250.56
483_V572_L0.9240.56
470_H501_E0.9200.56
130_I134_T0.9180.56
479_Q483_V0.9150.56
506_L537_C0.9090.55
259_Y262_S0.9090.55
457_D470_H0.9070.55
464_V531_P0.9060.55
427_Q505_Y0.9050.55
418_R534_T0.9010.54
283_L286_T0.9000.54
322_S325_F0.9000.54
130_I255_N0.8960.54
527_K571_R0.8950.54
458_I464_V0.8940.54
459_D565_K0.8940.54
462_K565_K0.8900.53
483_V531_P0.8850.53
219_G525_V0.8780.52
197_Y200_G0.8780.52
321_G325_F0.8770.52
377_L380_F0.8740.52
147_L157_T0.8740.52
496_R501_E0.8720.52
265_S269_L0.8710.52
422_L555_H0.8690.52
506_L514_G0.8690.52
151_L158_F0.8670.52
316_L323_T0.8670.52
435_A570_N0.8640.51
389_Y505_Y0.8630.51
455_L503_A0.8620.51
146_V159_S0.8610.51
500_E568_G0.8600.51
466_D565_K0.8540.50
431_L458_I0.8530.50
404_H409_A0.8520.50
367_M370_P0.8510.50
470_H569_K0.8500.50
195_K200_G0.8490.50
329_A333_D0.8490.50
466_D474_D0.8480.50
184_M210_A0.8480.50
523_Y526_R0.8470.50
296_M305_V0.8470.50
446_K492_D0.8470.50
567_S571_R0.8460.50
424_K432_Y0.8460.50
368_A383_L0.8430.50
263_K266_I0.8420.49
216_G254_E0.8400.49
342_L345_G0.8400.49
431_L483_V0.8400.49
218_Q561_L0.8390.49
536_S560_A0.8370.49
275_T279_L0.8360.49
183_Y187_E0.8350.49
262_S265_S0.8340.49
263_K274_E0.8330.49
460_N561_L0.8320.49
238_C245_L0.8310.49
182_L185_E0.8290.48
272_I284_T0.8280.48
294_V437_L0.8270.48
140_L238_C0.8260.48
293_A297_A0.8260.48
426_D538_G0.8260.48
465_N565_K0.8250.48
288_T293_A0.8240.48
434_R461_F0.8220.48
428_L462_K0.8220.48
317_T320_P0.8210.48
432_Y483_V0.8160.47
451_G507_P0.8150.47
184_M187_E0.8140.47
197_Y201_D0.8140.47
457_D465_N0.8140.47
451_G531_P0.8140.47
500_E574_I0.8130.47
162_E166_F0.8100.47
417_D505_Y0.8090.47
129_K143_Q0.8090.47
196_V200_G0.8080.47
465_N562_Y0.8070.46
134_T151_L0.8050.46
543_T553_L0.8040.46
194_L200_G0.8030.46
370_P409_A0.8030.46
533_V561_L0.8020.46
210_A238_C0.8010.46
143_Q164_S0.8000.46
368_A382_V0.7980.46
441_I505_Y0.7980.46
305_V407_T0.7980.46
275_T278_R0.7980.46
476_I535_I0.7970.46
428_L434_R0.7970.46
419_L568_G0.7950.45
273_N277_R0.7950.45
439_E443_Y0.7950.45
461_F501_E0.7930.45
165_L507_P0.7920.45
151_L166_F0.7920.45
425_T520_R0.7920.45
305_V409_A0.7900.45
147_L246_A0.7890.45
428_L473_G0.7870.45
415_L561_L0.7860.45
335_Y342_L0.7860.45
464_V476_I0.7840.45
504_I507_P0.7820.44
458_I562_Y0.7820.44
452_V468_Y0.7810.44
417_D504_I0.7810.44
473_G477_L0.7800.44
487_N520_R0.7800.44
468_Y525_V0.7790.44
495_A556_E0.7780.44
470_H473_G0.7760.44
434_R498_G0.7750.44
459_D462_K0.7750.44
500_E531_P0.7740.44
471_Q554_V0.7740.44
140_L150_L0.7730.44
210_A234_L0.7710.44
444_S453_F0.7710.44
542_W545_E0.7650.43
452_V476_I0.7640.43
444_S509_V0.7640.43
211_Y245_L0.7620.43
288_T413_S0.7590.43
269_L277_R0.7580.42
447_I489_R0.7560.42
457_D474_D0.7530.42
160_L211_Y0.7530.42
248_A251_K0.7530.42
420_E424_K0.7520.42
336_N342_L0.7510.42
470_H565_K0.7420.41
499_G536_S0.7410.41
114_S117_Q0.7400.41
225_K228_G0.7400.41
397_K408_L0.7390.41
225_K250_G0.7330.40
160_L164_S0.7320.40
497_W507_P0.7310.40
235_T238_C0.7290.40
459_D569_K0.7280.40
435_A514_G0.7250.40
243_S445_M0.7240.40
151_L225_K0.7230.40
437_L488_I0.7200.39
432_Y455_L0.7200.39
224_L240_D0.7190.39
460_N572_L0.7180.39
461_F564_A0.7170.39
280_N283_L0.7170.39
281_Q287_D0.7160.39
423_V437_L0.7150.39
220_T227_E0.7140.39
344_E347_K0.7130.39
210_A248_A0.7120.39
428_L465_N0.7110.39
453_F471_Q0.7100.39
473_G562_Y0.7060.38
473_G496_R0.7050.38
288_T292_L0.7040.38
444_S451_G0.7030.38
438_D539_I0.7030.38
234_L253_F0.7020.38
355_Q504_I0.7020.38
488_I492_D0.7010.38
514_G550_L0.6970.38
371_M539_I0.6970.38
214_I569_K0.6960.37
273_N279_L0.6960.37
412_N415_L0.6920.37
441_I453_F0.6890.37
151_L165_L0.6890.37
515_K574_I0.6880.37
143_Q238_C0.6870.37
432_Y500_E0.6860.37
329_A334_F0.6860.37
184_M193_A0.6840.37
453_F554_V0.6820.36
434_R438_D0.6820.36
289_M293_A0.6810.36
411_T414_M0.6810.36
297_A305_V0.6810.36
540_S559_E0.6810.36
462_K498_G0.6800.36
461_F568_G0.6800.36
538_G562_Y0.6780.36
407_T410_V0.6770.36
504_I515_K0.6770.36
313_F511_V0.6770.36
134_T252_A0.6770.36
276_S280_N0.6760.36
239_L253_F0.6750.36
194_L201_D0.6730.36
432_Y476_I0.6700.35
466_D569_K0.6700.35
330_K333_D0.6690.35
483_V500_E0.6680.35
431_L543_T0.6680.35
243_S247_N0.6660.35
428_L498_G0.6650.35
370_P408_L0.6630.35
446_K513_V0.6620.35
147_L222_G0.6590.35
461_F474_D0.6580.35
279_L282_R0.6570.34
286_T289_M0.6570.34
128_K450_K0.6570.34
187_E190_D0.6570.34
392_T553_L0.6540.34
464_V555_H0.6540.34
496_R538_G0.6530.34
141_L256_A0.6520.34
572_L575_H0.6510.34
416_R420_E0.6490.34
397_K404_H0.6480.34
522_V568_G0.6480.34
462_K538_G0.6470.34
255_N259_Y0.6470.34
210_A224_L0.6450.34
550_L554_V0.6440.33
266_I270_E0.6430.33
398_L408_L0.6420.33
147_L165_L0.6410.33
451_G505_Y0.6410.33
561_L568_G0.6400.33
536_S570_N0.6400.33
539_I574_I0.6400.33
503_A561_L0.6400.33
548_K556_E0.6390.33
213_P242_M0.6390.33
327_K334_F0.6390.33
559_E572_L0.6380.33
465_N558_D0.6380.33
140_L147_L0.6370.33
380_F385_K0.6360.33
451_G497_W0.6350.33
412_N436_Y0.6350.33
246_A437_L0.6340.33
427_Q435_A0.6330.33
136_L155_T0.6330.33
414_M418_R0.6310.32
208_S211_Y0.6300.32
272_I275_T0.6290.32
187_E192_F0.6280.32
473_G565_K0.6280.32
423_V466_D0.6260.32
214_I480_V0.6260.32
463_N467_T0.6250.32
279_L443_Y0.6250.32
432_Y495_A0.6250.32
133_M136_L0.6240.32
423_V476_I0.6230.32
180_K184_M0.6220.32
500_E562_Y0.6220.32
331_P334_F0.6210.32
278_R282_R0.6210.32
531_P540_S0.6190.32
452_V492_D0.6170.31
540_S566_R0.6170.31
542_W556_E0.6170.31
248_A437_L0.6160.31
411_T494_G0.6150.31
426_D469_G0.6140.31
434_R470_H0.6140.31
292_L406_A0.6130.31
438_D554_V0.6110.31
501_E504_I0.6090.31
412_N503_A0.6090.31
426_D477_L0.6090.31
132_K156_S0.6090.31
183_Y504_I0.6060.31
214_I437_L0.6040.31
463_N561_L0.6030.30
444_S507_P0.6030.30
366_L370_P0.6030.30
472_T531_P0.6030.30
114_S118_E0.6030.30
467_T498_G0.6020.30
134_T244_L0.6020.30
126_Y134_T0.6020.30
210_A220_T0.6010.30
176_G179_A0.6000.30
459_D562_Y0.5990.30
504_I544_T0.5990.30
442_Q506_L0.5990.30
276_S288_T0.5980.30
245_L249_A0.5980.30
303_E453_F0.5980.30
176_G183_Y0.5970.30
146_V561_L0.5970.30
458_I549_S0.5960.30
136_L140_L0.5950.30
221_Y245_L0.5950.30
450_K509_V0.5930.30
249_A262_S0.5920.30
261_Q268_N0.5900.30
424_K531_P0.5900.30
292_L410_V0.5890.29
211_Y227_E0.5890.29
164_S227_E0.5890.29
150_L284_T0.5890.29
134_T248_A0.5890.29
455_L497_W0.5870.29
214_I289_M0.5870.29
521_L537_C0.5850.29
368_A384_L0.5830.29
425_T460_N0.5820.29
187_E194_L0.5820.29
310_I333_D0.5820.29
425_T500_E0.5810.29
470_H538_G0.5810.29
310_I535_I0.5790.29
146_V251_K0.5770.29
411_T419_L0.5770.29
279_L390_A0.5770.29
534_T569_K0.5740.28
458_I463_N0.5720.28
147_L258_L0.5710.28
206_N554_V0.5700.28
214_I223_V0.5700.28
447_I493_V0.5700.28
127_Q251_K0.5690.28
454_I522_V0.5690.28
155_T197_Y0.5680.28
151_L162_E0.5670.28
461_F470_H0.5670.28
210_A242_M0.5670.28
272_I437_L0.5670.28
457_D473_G0.5670.28
214_I418_R0.5670.28
214_I250_G0.5660.28
353_N364_G0.5650.28
365_S391_F0.5640.28
123_K126_Y0.5630.28
159_S226_A0.5600.27
466_D501_E0.5600.27
403_I408_L0.5580.27
319_L334_F0.5580.27
474_D565_K0.5580.27
120_L124_T0.5580.27
432_Y440_K0.5570.27
209_V223_V0.5560.27
419_L566_R0.5540.27
538_G558_D0.5520.27
135_E153_S0.5520.27
293_A304_E0.5510.27
370_P383_L0.5510.27
262_S266_I0.5500.27
132_K270_E0.5490.27
498_G507_P0.5490.27
340_E344_E0.5490.27
223_V248_A0.5480.27
455_L458_I0.5480.27
306_G326_F0.5480.27
220_T255_N0.5480.27
507_P534_T0.5480.27
474_D496_R0.5480.27
113_Q116_K0.5450.26
420_E534_T0.5450.26
300_F305_V0.5450.26
459_D466_D0.5440.26
435_A444_S0.5440.26
478_I508_N0.5430.26
418_R547_K0.5430.26
155_T234_L0.5420.26
207_E356_S0.5410.26
461_F536_S0.5410.26
447_I520_R0.5390.26
528_N531_P0.5390.26
405_H409_A0.5390.26
339_K343_Y0.5380.26
151_L155_T0.5370.26
436_Y444_S0.5370.26
507_P569_K0.5370.26
468_Y476_I0.5370.26
155_T159_S0.5360.26
260_E346_E0.5360.26
313_F510_P0.5350.26
240_D249_A0.5350.26
469_G538_G0.5350.26
238_C246_A0.5340.26
279_L285_L0.5330.26
460_N531_P0.5330.26
476_I531_P0.5330.26
126_Y162_E0.5320.26
454_I504_I0.5310.26
445_M451_G0.5300.26
134_T137_F0.5280.25
560_A568_G0.5280.25
379_G383_L0.5280.25
507_P518_T0.5270.25
154_L406_A0.5270.25
383_L409_A0.5260.25
423_V571_R0.5260.25
130_I213_P0.5260.25
455_L489_R0.5260.25
242_M362_G0.5250.25
317_T573_M0.5250.25
468_Y529_T0.5240.25
275_T284_T0.5230.25
469_G496_R0.5220.25
316_L324_A0.5220.25
370_P410_V0.5220.25
537_C568_G0.5210.25
224_L533_V0.5210.25
168_S221_Y0.5200.25
497_W520_R0.5200.25
488_I493_V0.5190.25
459_D561_L0.5190.25
238_C467_T0.5180.25
422_L435_A0.5170.25
368_A379_G0.5160.25
312_H329_A0.5160.25
345_G349_V0.5140.25
423_V474_D0.5130.24
429_T474_D0.5130.24
193_A196_V0.5130.24
416_R455_L0.5120.24
457_D501_E0.5110.24
209_V227_E0.5100.24
500_E575_H0.5100.24
214_I222_G0.5090.24
446_K508_N0.5090.24
138_H258_L0.5070.24
496_R499_G0.5070.24
208_S227_E0.5060.24
261_Q265_S0.5050.24
468_Y493_V0.5030.24
273_N276_S0.5030.24
466_D473_G0.5030.24
137_F463_N0.5030.24
431_L494_G0.5030.24
288_T408_L0.5020.24
175_L521_L0.5020.24
322_S326_F0.5010.24
434_R466_D0.5010.24
223_V227_E0.5000.24
319_L330_K0.5000.24
404_H408_L0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1w25A 2 0.7047 100 0.61 Contact Map
3ezuA 2 0.5233 100 0.636 Contact Map
4h54A 2 0.456 100 0.647 Contact Map
4j40A 2 0 100 0.647 Contact Map
3pjxA 1 0.2919 100 0.658 Contact Map
4rnhA 2 0.2608 100 0.662 Contact Map
3breA 4 0.475 100 0.667 Contact Map
3ignA 1 0.2694 100 0.671 Contact Map
3mtkA 2 0.2642 100 0.672 Contact Map
3i5cA 2 0.3161 100 0.672 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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