GREMLIN Database
DLDH3 - Dihydrolipoyl dehydrogenase
UniProt: O34324 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 458 (443)
Sequences: 13438 (8711)
Seq/√Len: 413.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
174_V257_A4.3341.00
290_N294_Q4.1871.00
31_K111_T4.1031.00
172_S195_Q3.1041.00
281_D288_P3.0761.00
403_V417_A3.0681.00
116_S119_K2.9741.00
195_Q227_E2.9261.00
365_D396_E2.8441.00
143_E271_D2.8111.00
197_T229_H2.7991.00
365_D395_P2.6911.00
218_Q222_E2.6881.00
274_Q277_Q2.6711.00
416_Q435_A2.5991.00
169_I194_S2.5841.00
27_L108_V2.4901.00
133_A136_V2.4731.00
211_E357_R2.4681.00
145_I267_K2.3991.00
143_E269_R2.3981.00
394_E397_F2.3811.00
15_A137_L2.3431.00
172_S258_D2.3041.00
354_M362_I2.3001.00
367_K395_P2.3001.00
174_V199_I2.2981.00
4_A131_R2.2411.00
398_G428_D2.2391.00
119_K130_I2.2321.00
354_M359_A2.2281.00
121_L130_I2.2121.00
405_M410_V2.1831.00
399_E424_E2.1631.00
323_A327_A2.1611.00
115_L121_L2.1521.00
150_A236_R2.0891.00
113_S121_L2.0411.00
4_A29_I2.0391.00
68_E77_D2.0301.00
183_C198_I2.0261.00
3_L19_A2.0251.00
4_A120_L1.9871.00
291_G333_K1.9851.00
115_L130_I1.9761.00
159_D162_D1.9751.00
249_G252_E1.9691.00
11_A303_C1.9571.00
229_H253_F1.9441.00
203_D231_S1.9411.00
366_V392_M1.9241.00
356_E360_R1.9141.00
247_K252_E1.9001.00
190_A195_Q1.8731.00
420_I425_M1.8661.00
357_R361_S1.8611.00
143_E267_K1.8381.00
114_F136_V1.8131.00
4_A133_A1.7961.00
119_K132_E1.7611.00
68_E75_S1.7551.00
356_E390_K1.7501.00
183_C345_T1.7311.00
77_D80_K1.7281.00
138_I306_A1.7231.00
173_L189_F1.7191.00
348_E411_T1.7131.00
391_I403_V1.7021.00
173_L194_S1.7011.00
135_Q299_H1.6981.00
4_A27_L1.6941.00
6_I112_A1.6901.00
137_L327_A1.6631.00
364_G401_V1.6531.00
294_Q298_P1.6431.00
204_R214_A1.6431.00
359_A366_V1.6191.00
212_D370_E1.6011.00
157_I237_V1.5951.00
108_V131_R1.5891.00
158_L259_Y1.5731.00
110_G122_I1.5481.00
426_T429_M1.5391.00
158_L166_L1.5381.00
201_T233_R1.5291.00
80_K83_S1.5241.00
301_Y326_H1.5231.00
216_L406_I1.5171.00
229_H232_S1.5131.00
2_T134_D1.5081.00
34_L107_V1.4951.00
171_S195_Q1.4931.00
391_I448_L1.4841.00
97_Q109_K1.4821.00
135_Q327_A1.4741.00
190_A226_V1.4621.00
359_A392_M1.4571.00
171_S258_D1.4561.00
55_V58_K1.4311.00
292_H326_H1.4221.00
197_T227_E1.4141.00
358_Q361_S1.4061.00
191_R224_D1.3891.00
140_S306_A1.3841.00
293_M307_I1.3781.00
210_D390_K1.3701.00
213_I406_I1.3681.00
68_E80_K1.3621.00
212_D390_K1.3601.00
3_L24_R1.3421.00
163_A189_F1.3391.00
283_S288_P1.3371.00
114_F120_L1.3331.00
294_Q299_H1.3311.00
365_D394_E1.3211.00
209_E341_R1.3161.00
243_T256_K1.3091.00
27_L131_R1.3081.00
137_L303_C1.3071.00
368_I392_M1.3061.00
61_H64_S1.3061.00
25_N106_Q1.2971.00
18_S325_S1.2931.00
28_L100_M1.2731.00
41_E161_K1.2701.00
114_F138_I1.2671.00
239_Q242_K1.2661.00
82_Q86_Q1.2661.00
156_W239_Q1.2621.00
204_R211_E1.2551.00
217_F406_I1.2541.00
278_A297_V1.2511.00
118_R299_H1.2501.00
178_G205_L1.2431.00
373_F407_G1.2431.00
341_R351_C1.2371.00
218_Q228_V1.2341.00
356_E368_I1.2341.00
211_E215_R1.2321.00
86_Q90_S1.2321.00
238_D245_I1.2281.00
219_E222_E1.2251.00
281_D296_N1.2231.00
247_K250_Q1.2221.00
349_I406_I1.2221.00
209_E351_C1.2211.00
3_L137_L1.2181.00
391_I417_A1.2171.00
199_I255_T1.2121.00
213_I388_K1.2101.00
113_S274_Q1.2101.00
220_K223_E1.2091.00
29_I131_R1.2051.00
283_S308_G1.2021.00
83_S87_Q1.1981.00
146_E159_D1.1971.00
297_V300_I1.1971.00
417_A444_L1.1931.00
394_E399_E1.1921.00
423_G429_M1.1841.00
176_V260_V1.1791.00
32_G41_E1.1751.00
342_C411_T1.1741.00
97_Q101_K1.1621.00
389_V443_T1.1571.00
320_G324_A1.1551.00
322_I334_I1.1511.00
370_E388_K1.1411.00
123_E128_K1.1391.00
358_Q362_I1.1331.00
287_I306_A1.1311.00
113_S123_E1.1301.00
240_T243_T1.1301.00
198_I228_V1.1221.00
342_C436_A1.1201.00
415_G436_A1.1171.00
111_T272_G1.1171.00
223_E386_E1.1161.00
51_E55_V1.1151.00
218_Q230_T1.1121.00
240_T256_K1.1111.00
156_W259_Y1.1091.00
200_E230_T1.1081.00
29_I112_A1.1051.00
356_E366_V1.1041.00
247_K251_R1.1031.00
117_E297_V1.0981.00
359_A364_G1.0961.00
350_A414_I1.0961.00
6_I138_I1.0951.00
245_I254_K1.0921.00
115_L119_K1.0911.00
275_L280_V1.0891.00
17_V103_N1.0891.00
114_F133_A1.0861.00
2_T25_N1.0741.00
204_R218_Q1.0731.00
360_R366_V1.0721.00
270_L282_F1.0721.00
245_I256_K1.0721.00
158_L162_D1.0711.00
303_C323_A1.0701.00
11_A316_A1.0661.00
338_H421_M1.0621.00
59_I62_A1.0561.00
79_S167_S1.0481.00
293_M323_A1.0441.00
364_G392_M1.0441.00
364_G394_E1.0431.00
355_T358_Q1.0421.00
280_V287_I1.0411.00
425_M429_M1.0401.00
173_L259_Y1.0371.00
219_E223_E1.0351.00
29_I110_G1.0351.00
24_R328_S1.0351.00
367_K398_G1.0341.00
310_I339_V1.0301.00
8_G28_L1.0251.00
409_D412_E1.0241.00
221_L226_V1.0241.00
158_L163_A1.0161.00
114_F277_Q1.0131.00
398_G427_A1.0131.00
335_N422_N1.0111.00
172_S197_T1.0101.00
415_G441_S1.0091.00
370_E390_K1.0061.00
248_S251_R1.0051.00
8_G34_L1.0041.00
78_W82_Q1.0021.00
237_V260_V0.9981.00
217_F349_I0.9941.00
22_Q325_S0.9911.00
173_L261_L0.9891.00
22_Q328_S0.9871.00
24_R134_D0.9871.00
289_V307_I0.9821.00
350_A410_V0.9811.00
278_A300_I0.9801.00
213_I404_S0.9801.00
292_H333_K0.9791.00
288_P296_N0.9771.00
172_S194_S0.9761.00
222_E227_E0.9721.00
57_D224_D0.9711.00
113_S277_Q0.9701.00
148_P152_F0.9691.00
246_W249_G0.9691.00
117_E299_H0.9641.00
149_F152_F0.9601.00
240_T245_I0.9591.00
183_C221_L0.9591.00
235_G252_E0.9561.00
216_L219_E0.9531.00
90_S94_Q0.9481.00
204_R357_R0.9481.00
168_E259_Y0.9461.00
352_I421_M0.9431.00
155_E239_Q0.9391.00
100_M105_I0.9371.00
38_C43_C0.9361.00
40_N93_V0.9361.00
151_P154_G0.9351.00
238_D254_K0.9331.00
205_L230_T0.9331.00
205_L218_Q0.9311.00
354_M358_Q0.9291.00
63_D80_K0.9261.00
229_H255_T0.9221.00
172_S256_K0.9211.00
52_S81_M0.9201.00
18_S22_Q0.9181.00
420_I430_A0.9181.00
87_Q91_Q0.9171.00
220_K386_E0.9171.00
114_F278_A0.9161.00
136_V300_I0.9141.00
205_L228_V0.9121.00
294_Q326_H0.9071.00
178_G200_E0.9021.00
282_F288_P0.9021.00
154_G162_D0.9011.00
289_V302_A0.8981.00
98_Y102_K0.8971.00
302_A306_A0.8961.00
24_R135_Q0.8961.00
232_S253_F0.8961.00
100_M107_V0.8951.00
121_L128_K0.8951.00
176_V262_V0.8941.00
356_E392_M0.8881.00
215_R218_Q0.8881.00
199_I229_H0.8871.00
82_Q85_K0.8871.00
323_A326_H0.8841.00
53_A191_R0.8831.00
3_L324_A0.8831.00
176_V264_I0.8821.00
114_F274_Q0.8801.00
220_K406_I0.8791.00
113_S272_G0.8791.00
220_K224_D0.8791.00
14_A317_F0.8761.00
272_G275_L0.8731.00
83_S167_S0.8701.00
275_L278_A0.8691.00
172_S257_A0.8661.00
175_I261_L0.8661.00
425_M430_A0.8651.00
294_Q301_Y0.8651.00
174_V255_T0.8631.00
117_E279_G0.8631.00
52_S84_R0.8611.00
389_V405_M0.8601.00
215_R219_E0.8591.00
322_I326_H0.8581.00
280_V297_V0.8581.00
137_L323_A0.8581.00
49_L82_Q0.8571.00
56_L60_K0.8561.00
280_V296_N0.8551.00
213_I349_I0.8541.00
416_Q419_A0.8531.00
216_L220_K0.8531.00
176_V234_L0.8521.00
60_K73_A0.8511.00
204_R215_R0.8471.00
145_I264_I0.8451.00
352_I418_A0.8441.00
6_I273_L0.8431.00
232_S251_R0.8421.00
279_G297_V0.8411.00
233_R250_Q0.8401.00
57_D191_R0.8391.00
400_I417_A0.8381.00
50_L188_L0.8351.00
6_I120_L0.8351.00
54_N58_K0.8341.00
118_R132_E0.8321.00
199_I232_S0.8311.00
394_E401_V0.8301.00
57_D60_K0.8281.00
135_Q301_Y0.8261.00
91_Q380_L0.8231.00
202_A207_P0.8231.00
157_I262_V0.8231.00
18_S324_A0.8221.00
182_G200_E0.8211.00
367_K393_A0.8211.00
355_T404_S0.8151.00
162_D165_S0.8151.00
24_R327_A0.8141.00
4_A136_V0.8141.00
174_V247_K0.8091.00
227_E253_F0.8081.00
206_I217_F0.8061.00
72_G75_S0.7971.00
18_S21_Q0.7971.00
46_T185_Y0.7951.00
197_T257_A0.7941.00
315_A339_V0.7941.00
146_E152_F0.7931.00
274_Q278_A0.7921.00
190_A224_D0.7911.00
63_D68_E0.7871.00
250_Q253_F0.7871.00
2_T27_L0.7841.00
217_F345_T0.7841.00
422_N432_H0.7831.00
293_M326_H0.7831.00
94_Q97_Q0.7831.00
96_V100_M0.7801.00
85_K89_V0.7751.00
89_V92_L0.7731.00
324_A328_S0.7731.00
125_E128_K0.7711.00
154_G239_Q0.7711.00
136_V299_H0.7671.00
235_G247_K0.7651.00
110_G126_N0.7631.00
122_I131_R0.7621.00
337_K362_I0.7621.00
30_D33_K0.7581.00
140_S273_L0.7571.00
278_A282_F0.7541.00
221_L228_V0.7521.00
19_A24_R0.7521.00
188_L192_L0.7491.00
400_I421_M0.7491.00
373_F443_T0.7491.00
175_I182_G0.7471.00
15_A320_G0.7471.00
79_S83_S0.7471.00
417_A421_M0.7441.00
403_V421_M0.7431.00
369_G447_A0.7411.00
278_A296_N0.7401.00
203_D211_E0.7381.00
52_S65_F0.7371.00
15_A324_A0.7361.00
391_I447_A0.7361.00
191_R346_S0.7361.00
59_I67_I0.7341.00
61_H383_Q0.7321.00
85_K165_S0.7311.00
292_H331_D0.7281.00
419_A430_A0.7271.00
182_G201_T0.7251.00
338_H422_N0.7211.00
5_I12_G0.7211.00
359_A401_V0.7201.00
319_E336_E0.7201.00
287_I302_A0.7181.00
145_I148_P0.7161.00
19_A324_A0.7161.00
117_E278_A0.7151.00
210_D404_S0.7121.00
166_L259_Y0.7101.00
180_V343_I0.7091.00
51_E54_N0.7091.00
419_A425_M0.7091.00
86_Q165_S0.7081.00
81_M192_L0.7061.00
200_E207_P0.7051.00
149_F234_L0.7051.00
98_Y101_K0.7041.00
33_K41_E0.7041.00
393_A427_A0.7031.00
150_A154_G0.7021.00
120_L299_H0.7011.00
118_R297_V0.7011.00
295_T302_A0.7001.00
392_M395_P0.7001.00
270_L306_A0.6991.00
233_R247_K0.6971.00
216_L388_K0.6971.00
405_M413_L0.6971.00
186_A198_I0.6951.00
199_I246_W0.6951.00
209_E343_I0.6941.00
325_S329_G0.6921.00
236_R248_S0.6921.00
366_V401_V0.6921.00
29_I122_I0.6911.00
348_E409_D0.6901.00
271_D276_E0.6881.00
372_S375_A0.6871.00
397_F424_E0.6861.00
427_A431_E0.6811.00
201_T207_P0.6791.00
152_F157_I0.6791.00
363_Y366_V0.6791.00
147_L262_V0.6771.00
146_E151_P0.6771.00
95_G99_L0.6761.00
238_D248_S0.6751.00
429_M432_H0.6731.00
325_S330_R0.6720.99
30_D107_V0.6710.99
15_A323_A0.6710.99
249_G253_F0.6700.99
338_H418_A0.6680.99
275_L282_F0.6640.99
59_I74_I0.6640.99
248_S252_E0.6630.99
289_V293_M0.6630.99
62_A65_F0.6630.99
437_H442_E0.6610.99
244_A260_V0.6610.99
152_F159_D0.6610.99
57_D61_H0.6610.99
76_V81_M0.6600.99
246_W251_R0.6580.99
293_M322_I0.6570.99
419_A423_G0.6560.99
399_E426_T0.6550.99
369_G393_A0.6550.99
187_G191_R0.6540.99
186_A226_V0.6540.99
146_E262_V0.6520.99
318_H334_I0.6520.99
142_S266_R0.6510.99
152_F262_V0.6500.99
403_V444_L0.6490.99
148_P153_D0.6490.99
384_Q408_P0.6490.99
430_A448_L0.6490.99
82_Q167_S0.6470.99
187_G221_L0.6460.99
235_G250_Q0.6430.99
96_V99_L0.6420.99
19_A26_V0.6410.99
248_S253_F0.6390.99
172_S190_A0.6370.99
412_E441_S0.6350.99
318_H321_I0.6330.99
419_A433_F0.6300.99
94_Q98_Y0.6290.99
197_T255_T0.6280.99
378_K381_I0.6270.99
393_A398_G0.6270.99
161_K266_R0.6270.99
213_I216_L0.6260.99
83_S86_Q0.6250.99
294_Q297_V0.6240.99
166_L189_F0.6220.99
180_V341_R0.6190.99
354_M402_G0.6180.99
150_A153_D0.6180.99
160_S266_R0.6150.99
284_P288_P0.6150.99
209_E349_I0.6150.99
2_T24_R0.6140.99
174_V260_V0.6130.99
287_I295_T0.6120.99
187_G224_D0.6120.99
111_T123_E0.6110.99
27_L106_Q0.6110.99
235_G248_S0.6100.99
280_V300_I0.6090.99
379_A440_L0.6070.99
301_Y327_A0.6030.99
357_R360_R0.6030.99
354_M364_G0.6000.99
170_P194_S0.5990.99
407_G410_V0.5980.99
416_Q441_S0.5970.99
51_E58_K0.5970.99
58_K61_H0.5970.99
54_N346_S0.5970.99
87_Q90_S0.5960.99
232_S250_Q0.5960.99
183_C205_L0.5930.99
185_Y188_L0.5920.99
144_P160_S0.5910.99
33_K93_V0.5910.99
92_L380_L0.5910.99
282_F287_I0.5900.99
256_K259_Y0.5900.99
28_L105_I0.5880.99
67_I76_V0.5850.99
123_E127_G0.5850.99
117_E300_I0.5840.99
20_A105_I0.5840.99
137_L324_A0.5840.99
108_V122_I0.5830.99
351_C404_S0.5830.99
80_K84_R0.5820.99
160_S181_I0.5810.99
17_V21_Q0.5810.99
114_F299_H0.5810.99
183_C228_V0.5790.99
325_S332_V0.5780.98
366_V395_P0.5780.98
308_G311_Q0.5780.98
55_V62_A0.5780.98
303_C320_G0.5780.98
157_I260_V0.5760.98
389_V447_A0.5760.98
246_W254_K0.5750.98
413_L440_L0.5750.98
418_A422_N0.5750.98
84_R88_V0.5710.98
189_F194_S0.5700.98
199_I257_A0.5690.98
421_M425_M0.5680.98
318_H445_H0.5670.98
149_F153_D0.5640.98
315_A336_E0.5640.98
115_L277_Q0.5630.98
428_D432_H0.5620.98
246_W252_E0.5620.98
403_V414_I0.5620.98
33_K40_N0.5600.98
360_R365_D0.5580.98
318_H322_I0.5580.98
50_L54_N0.5560.98
380_L385_A0.5540.98
237_V262_V0.5540.98
46_T50_L0.5540.98
422_N433_F0.5530.98
56_L67_I0.5530.98
373_F440_L0.5530.98
5_I16_A0.5510.98
248_S254_K0.5500.98
206_I343_I0.5500.98
307_I319_E0.5500.98
20_A25_N0.5490.98
391_I400_I0.5490.98
37_T160_S0.5490.98
65_F84_R0.5480.98
109_K125_E0.5460.98
79_S82_Q0.5460.98
53_A56_L0.5450.98
201_T264_I0.5450.98
51_E382_K0.5450.98
172_S259_Y0.5440.98
372_S386_E0.5430.98
110_G120_L0.5430.98
249_G255_T0.5420.98
317_F445_H0.5420.98
346_S384_Q0.5410.98
78_W169_I0.5400.98
385_A408_P0.5400.98
369_G391_I0.5400.98
117_E298_P0.5400.98
21_Q103_N0.5390.98
405_M414_I0.5390.98
232_S246_W0.5390.98
445_H449_L0.5390.98
315_A319_E0.5380.98
32_G161_K0.5380.98
84_R383_Q0.5370.98
110_G123_E0.5360.98
342_C350_A0.5360.98
93_V97_Q0.5360.98
34_L97_Q0.5360.98
34_L100_M0.5350.98
239_Q243_T0.5350.98
363_Y401_V0.5340.97
351_C358_Q0.5330.97
418_A433_F0.5310.97
187_G346_S0.5300.97
224_D346_S0.5290.97
86_Q89_V0.5290.97
268_P282_F0.5280.97
354_M363_Y0.5280.97
172_S243_T0.5280.97
90_S93_V0.5280.97
194_S258_D0.5280.97
326_H333_K0.5270.97
229_H246_W0.5260.97
79_S168_E0.5260.97
44_I377_G0.5250.97
404_S417_A0.5230.97
338_H352_I0.5220.97
95_G98_Y0.5220.97
118_R134_D0.5210.97
246_W255_T0.5210.97
120_L136_V0.5210.97
97_Q107_V0.5190.97
68_E74_I0.5190.97
182_G263_A0.5180.97
175_I185_Y0.5160.97
350_A405_M0.5160.97
138_I287_I0.5140.97
37_T42_G0.5120.97
376_N443_T0.5110.97
56_L76_V0.5100.97
393_A400_I0.5090.97
146_E157_I0.5090.97
147_L152_F0.5080.97
99_L102_K0.5080.97
205_L214_A0.5070.97
200_E234_L0.5070.97
22_Q330_R0.5070.97
78_W167_S0.5050.96
123_E126_N0.5040.96
54_N348_E0.5030.96
182_G207_P0.5020.96
31_K269_R0.5000.96
142_S311_Q0.5000.96
61_H65_F0.5000.96
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ojtA 2 0.9913 100 0.184 Contact Map
3ladA 2 0.9934 100 0.188 Contact Map
1zmdA 4 0.9934 100 0.202 Contact Map
1xdiA 3 0.9738 100 0.204 Contact Map
3urhA 2 0.9869 100 0.205 Contact Map
2a8xA 2 0.9891 100 0.207 Contact Map
1ebdA 2 0.9803 100 0.209 Contact Map
3ic9A 2 0.9825 100 0.211 Contact Map
1lvlA 2 0.9782 100 0.212 Contact Map
2qaeA 2 0.9934 100 0.212 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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