DLDH3 - BACSU - GREMLIN Contacts

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DLDH3 - Dihydrolipoyl dehydrogenase

UniProt:	O34324	Sequences: MTLAIIGGGPAGYAAAVSAAQQGRNVLLIDKGKLGGTCLNEGCIPTKSLLESANVLDKIKHADSFGIELPAGAISVDWSKMQSRKQQVVSQLVQGVQYLMKKNQIQVVKGTASFLSERKLLIEGENGKEIREADQVLIASGSEPIELPFAPFDGEWILDSKDALSLSEIPSSLVIVGGGVIGCEYAGLFARLGSQVTIIETADRLIPAEDEDIARLFQEKLEEDGVEVHTSSRLGRVDQTAKTAIWKSGQREFKTKADYVLVAIGRKPRLDGLQLEQAGVDFSPKGIPVNGHMQTNVPHIYACGDAIGGIQLAHAAFHEGIIAASHASGRDVKINEKHVPRCIYTSPEIACIGMTERQARSIYGDVKIGEFSFSANGKALIKQQAEGKVKIMAEPEFGEIVGVSMIGPDVTELIGQAAAIMNGEMTADMAEHFIAAHPTLSETLHEALLSTIGLAVHA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	458 (443)
Sequences:	13438 (8711)
Seq/√Len:	413.9

ECOLI - STHA DLDH GSHR RCLA HCAD NORW
BACSU - DLDH3 DLDH1 DLDH2
HALSA - DLDH Q9HSN0 Q9HP48 Q9HR27
SULSO - Q97VD9 Q97Z19 Q97XZ3 Q97WE3 Q97VQ4 Q97Y24 Q97YT2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
174_V	257_A	4.334	1.00
290_N	294_Q	4.187	1.00
31_K	111_T	4.103	1.00
172_S	195_Q	3.104	1.00
281_D	288_P	3.076	1.00
403_V	417_A	3.068	1.00
116_S	119_K	2.974	1.00
195_Q	227_E	2.926	1.00
365_D	396_E	2.844	1.00
143_E	271_D	2.811	1.00
197_T	229_H	2.799	1.00
365_D	395_P	2.691	1.00
218_Q	222_E	2.688	1.00
274_Q	277_Q	2.671	1.00
416_Q	435_A	2.599	1.00
169_I	194_S	2.584	1.00
27_L	108_V	2.490	1.00
133_A	136_V	2.473	1.00
211_E	357_R	2.468	1.00
145_I	267_K	2.399	1.00
143_E	269_R	2.398	1.00
394_E	397_F	2.381	1.00
15_A	137_L	2.343	1.00
172_S	258_D	2.304	1.00
354_M	362_I	2.300	1.00
367_K	395_P	2.300	1.00
174_V	199_I	2.298	1.00
4_A	131_R	2.241	1.00
398_G	428_D	2.239	1.00
119_K	130_I	2.232	1.00
354_M	359_A	2.228	1.00
121_L	130_I	2.212	1.00
405_M	410_V	2.183	1.00
399_E	424_E	2.163	1.00
323_A	327_A	2.161	1.00
115_L	121_L	2.152	1.00
150_A	236_R	2.089	1.00
113_S	121_L	2.041	1.00
4_A	29_I	2.039	1.00
68_E	77_D	2.030	1.00
183_C	198_I	2.026	1.00
3_L	19_A	2.025	1.00
4_A	120_L	1.987	1.00
291_G	333_K	1.985	1.00
115_L	130_I	1.976	1.00
159_D	162_D	1.975	1.00
249_G	252_E	1.969	1.00
11_A	303_C	1.957	1.00
229_H	253_F	1.944	1.00
203_D	231_S	1.941	1.00
366_V	392_M	1.924	1.00
356_E	360_R	1.914	1.00
247_K	252_E	1.900	1.00
190_A	195_Q	1.873	1.00
420_I	425_M	1.866	1.00
357_R	361_S	1.861	1.00
143_E	267_K	1.838	1.00
114_F	136_V	1.813	1.00
4_A	133_A	1.796	1.00
119_K	132_E	1.761	1.00
68_E	75_S	1.755	1.00
356_E	390_K	1.750	1.00
183_C	345_T	1.731	1.00
77_D	80_K	1.728	1.00
138_I	306_A	1.723	1.00
173_L	189_F	1.719	1.00
348_E	411_T	1.713	1.00
391_I	403_V	1.702	1.00
173_L	194_S	1.701	1.00
135_Q	299_H	1.698	1.00
4_A	27_L	1.694	1.00
6_I	112_A	1.690	1.00
137_L	327_A	1.663	1.00
364_G	401_V	1.653	1.00
294_Q	298_P	1.643	1.00
204_R	214_A	1.643	1.00
359_A	366_V	1.619	1.00
212_D	370_E	1.601	1.00
157_I	237_V	1.595	1.00
108_V	131_R	1.589	1.00
158_L	259_Y	1.573	1.00
110_G	122_I	1.548	1.00
426_T	429_M	1.539	1.00
158_L	166_L	1.538	1.00
201_T	233_R	1.529	1.00
80_K	83_S	1.524	1.00
301_Y	326_H	1.523	1.00
216_L	406_I	1.517	1.00
229_H	232_S	1.513	1.00
2_T	134_D	1.508	1.00
34_L	107_V	1.495	1.00
171_S	195_Q	1.493	1.00
391_I	448_L	1.484	1.00
97_Q	109_K	1.482	1.00
135_Q	327_A	1.474	1.00
190_A	226_V	1.462	1.00
359_A	392_M	1.457	1.00
171_S	258_D	1.456	1.00
55_V	58_K	1.431	1.00
292_H	326_H	1.422	1.00
197_T	227_E	1.414	1.00
358_Q	361_S	1.406	1.00
191_R	224_D	1.389	1.00
140_S	306_A	1.384	1.00
293_M	307_I	1.378	1.00
210_D	390_K	1.370	1.00
213_I	406_I	1.368	1.00
68_E	80_K	1.362	1.00
212_D	390_K	1.360	1.00
3_L	24_R	1.342	1.00
163_A	189_F	1.339	1.00
283_S	288_P	1.337	1.00
114_F	120_L	1.333	1.00
294_Q	299_H	1.331	1.00
365_D	394_E	1.321	1.00
209_E	341_R	1.316	1.00
243_T	256_K	1.309	1.00
27_L	131_R	1.308	1.00
137_L	303_C	1.307	1.00
368_I	392_M	1.306	1.00
61_H	64_S	1.306	1.00
25_N	106_Q	1.297	1.00
18_S	325_S	1.293	1.00
28_L	100_M	1.273	1.00
41_E	161_K	1.270	1.00
114_F	138_I	1.267	1.00
239_Q	242_K	1.266	1.00
82_Q	86_Q	1.266	1.00
156_W	239_Q	1.262	1.00
204_R	211_E	1.255	1.00
217_F	406_I	1.254	1.00
278_A	297_V	1.251	1.00
118_R	299_H	1.250	1.00
178_G	205_L	1.243	1.00
373_F	407_G	1.243	1.00
341_R	351_C	1.237	1.00
218_Q	228_V	1.234	1.00
356_E	368_I	1.234	1.00
211_E	215_R	1.232	1.00
86_Q	90_S	1.232	1.00
238_D	245_I	1.228	1.00
219_E	222_E	1.225	1.00
281_D	296_N	1.223	1.00
247_K	250_Q	1.222	1.00
349_I	406_I	1.222	1.00
209_E	351_C	1.221	1.00
3_L	137_L	1.218	1.00
391_I	417_A	1.217	1.00
199_I	255_T	1.212	1.00
213_I	388_K	1.210	1.00
113_S	274_Q	1.210	1.00
220_K	223_E	1.209	1.00
29_I	131_R	1.205	1.00
283_S	308_G	1.202	1.00
83_S	87_Q	1.198	1.00
146_E	159_D	1.197	1.00
297_V	300_I	1.197	1.00
417_A	444_L	1.193	1.00
394_E	399_E	1.192	1.00
423_G	429_M	1.184	1.00
176_V	260_V	1.179	1.00
32_G	41_E	1.175	1.00
342_C	411_T	1.174	1.00
97_Q	101_K	1.162	1.00
389_V	443_T	1.157	1.00
320_G	324_A	1.155	1.00
322_I	334_I	1.151	1.00
370_E	388_K	1.141	1.00
123_E	128_K	1.139	1.00
358_Q	362_I	1.133	1.00
287_I	306_A	1.131	1.00
113_S	123_E	1.130	1.00
240_T	243_T	1.130	1.00
198_I	228_V	1.122	1.00
342_C	436_A	1.120	1.00
415_G	436_A	1.117	1.00
111_T	272_G	1.117	1.00
223_E	386_E	1.116	1.00
51_E	55_V	1.115	1.00
218_Q	230_T	1.112	1.00
240_T	256_K	1.111	1.00
156_W	259_Y	1.109	1.00
200_E	230_T	1.108	1.00
29_I	112_A	1.105	1.00
356_E	366_V	1.104	1.00
247_K	251_R	1.103	1.00
117_E	297_V	1.098	1.00
359_A	364_G	1.096	1.00
350_A	414_I	1.096	1.00
6_I	138_I	1.095	1.00
245_I	254_K	1.092	1.00
115_L	119_K	1.091	1.00
275_L	280_V	1.089	1.00
17_V	103_N	1.089	1.00
114_F	133_A	1.086	1.00
2_T	25_N	1.074	1.00
204_R	218_Q	1.073	1.00
360_R	366_V	1.072	1.00
270_L	282_F	1.072	1.00
245_I	256_K	1.072	1.00
158_L	162_D	1.071	1.00
303_C	323_A	1.070	1.00
11_A	316_A	1.066	1.00
338_H	421_M	1.062	1.00
59_I	62_A	1.056	1.00
79_S	167_S	1.048	1.00
293_M	323_A	1.044	1.00
364_G	392_M	1.044	1.00
364_G	394_E	1.043	1.00
355_T	358_Q	1.042	1.00
280_V	287_I	1.041	1.00
425_M	429_M	1.040	1.00
173_L	259_Y	1.037	1.00
219_E	223_E	1.035	1.00
29_I	110_G	1.035	1.00
24_R	328_S	1.035	1.00
367_K	398_G	1.034	1.00
310_I	339_V	1.030	1.00
8_G	28_L	1.025	1.00
409_D	412_E	1.024	1.00
221_L	226_V	1.024	1.00
158_L	163_A	1.016	1.00
114_F	277_Q	1.013	1.00
398_G	427_A	1.013	1.00
335_N	422_N	1.011	1.00
172_S	197_T	1.010	1.00
415_G	441_S	1.009	1.00
370_E	390_K	1.006	1.00
248_S	251_R	1.005	1.00
8_G	34_L	1.004	1.00
78_W	82_Q	1.002	1.00
237_V	260_V	0.998	1.00
217_F	349_I	0.994	1.00
22_Q	325_S	0.991	1.00
173_L	261_L	0.989	1.00
22_Q	328_S	0.987	1.00
24_R	134_D	0.987	1.00
289_V	307_I	0.982	1.00
350_A	410_V	0.981	1.00
278_A	300_I	0.980	1.00
213_I	404_S	0.980	1.00
292_H	333_K	0.979	1.00
288_P	296_N	0.977	1.00
172_S	194_S	0.976	1.00
222_E	227_E	0.972	1.00
57_D	224_D	0.971	1.00
113_S	277_Q	0.970	1.00
148_P	152_F	0.969	1.00
246_W	249_G	0.969	1.00
117_E	299_H	0.964	1.00
149_F	152_F	0.960	1.00
240_T	245_I	0.959	1.00
183_C	221_L	0.959	1.00
235_G	252_E	0.956	1.00
216_L	219_E	0.953	1.00
90_S	94_Q	0.948	1.00
204_R	357_R	0.948	1.00
168_E	259_Y	0.946	1.00
352_I	421_M	0.943	1.00
155_E	239_Q	0.939	1.00
100_M	105_I	0.937	1.00
38_C	43_C	0.936	1.00
40_N	93_V	0.936	1.00
151_P	154_G	0.935	1.00
238_D	254_K	0.933	1.00
205_L	230_T	0.933	1.00
205_L	218_Q	0.931	1.00
354_M	358_Q	0.929	1.00
63_D	80_K	0.926	1.00
229_H	255_T	0.922	1.00
172_S	256_K	0.921	1.00
52_S	81_M	0.920	1.00
18_S	22_Q	0.918	1.00
420_I	430_A	0.918	1.00
87_Q	91_Q	0.917	1.00
220_K	386_E	0.917	1.00
114_F	278_A	0.916	1.00
136_V	300_I	0.914	1.00
205_L	228_V	0.912	1.00
294_Q	326_H	0.907	1.00
178_G	200_E	0.902	1.00
282_F	288_P	0.902	1.00
154_G	162_D	0.901	1.00
289_V	302_A	0.898	1.00
98_Y	102_K	0.897	1.00
302_A	306_A	0.896	1.00
24_R	135_Q	0.896	1.00
232_S	253_F	0.896	1.00
100_M	107_V	0.895	1.00
121_L	128_K	0.895	1.00
176_V	262_V	0.894	1.00
356_E	392_M	0.888	1.00
215_R	218_Q	0.888	1.00
199_I	229_H	0.887	1.00
82_Q	85_K	0.887	1.00
323_A	326_H	0.884	1.00
53_A	191_R	0.883	1.00
3_L	324_A	0.883	1.00
176_V	264_I	0.882	1.00
114_F	274_Q	0.880	1.00
220_K	406_I	0.879	1.00
113_S	272_G	0.879	1.00
220_K	224_D	0.879	1.00
14_A	317_F	0.876	1.00
272_G	275_L	0.873	1.00
83_S	167_S	0.870	1.00
275_L	278_A	0.869	1.00
172_S	257_A	0.866	1.00
175_I	261_L	0.866	1.00
425_M	430_A	0.865	1.00
294_Q	301_Y	0.865	1.00
174_V	255_T	0.863	1.00
117_E	279_G	0.863	1.00
52_S	84_R	0.861	1.00
389_V	405_M	0.860	1.00
215_R	219_E	0.859	1.00
322_I	326_H	0.858	1.00
280_V	297_V	0.858	1.00
137_L	323_A	0.858	1.00
49_L	82_Q	0.857	1.00
56_L	60_K	0.856	1.00
280_V	296_N	0.855	1.00
213_I	349_I	0.854	1.00
416_Q	419_A	0.853	1.00
216_L	220_K	0.853	1.00
176_V	234_L	0.852	1.00
60_K	73_A	0.851	1.00
204_R	215_R	0.847	1.00
145_I	264_I	0.845	1.00
352_I	418_A	0.844	1.00
6_I	273_L	0.843	1.00
232_S	251_R	0.842	1.00
279_G	297_V	0.841	1.00
233_R	250_Q	0.840	1.00
57_D	191_R	0.839	1.00
400_I	417_A	0.838	1.00
50_L	188_L	0.835	1.00
6_I	120_L	0.835	1.00
54_N	58_K	0.834	1.00
118_R	132_E	0.832	1.00
199_I	232_S	0.831	1.00
394_E	401_V	0.830	1.00
57_D	60_K	0.828	1.00
135_Q	301_Y	0.826	1.00
91_Q	380_L	0.823	1.00
202_A	207_P	0.823	1.00
157_I	262_V	0.823	1.00
18_S	324_A	0.822	1.00
182_G	200_E	0.821	1.00
367_K	393_A	0.821	1.00
355_T	404_S	0.815	1.00
162_D	165_S	0.815	1.00
24_R	327_A	0.814	1.00
4_A	136_V	0.814	1.00
174_V	247_K	0.809	1.00
227_E	253_F	0.808	1.00
206_I	217_F	0.806	1.00
72_G	75_S	0.797	1.00
18_S	21_Q	0.797	1.00
46_T	185_Y	0.795	1.00
197_T	257_A	0.794	1.00
315_A	339_V	0.794	1.00
146_E	152_F	0.793	1.00
274_Q	278_A	0.792	1.00
190_A	224_D	0.791	1.00
63_D	68_E	0.787	1.00
250_Q	253_F	0.787	1.00
2_T	27_L	0.784	1.00
217_F	345_T	0.784	1.00
422_N	432_H	0.783	1.00
293_M	326_H	0.783	1.00
94_Q	97_Q	0.783	1.00
96_V	100_M	0.780	1.00
85_K	89_V	0.775	1.00
89_V	92_L	0.773	1.00
324_A	328_S	0.773	1.00
125_E	128_K	0.771	1.00
154_G	239_Q	0.771	1.00
136_V	299_H	0.767	1.00
235_G	247_K	0.765	1.00
110_G	126_N	0.763	1.00
122_I	131_R	0.762	1.00
337_K	362_I	0.762	1.00
30_D	33_K	0.758	1.00
140_S	273_L	0.757	1.00
278_A	282_F	0.754	1.00
221_L	228_V	0.752	1.00
19_A	24_R	0.752	1.00
188_L	192_L	0.749	1.00
400_I	421_M	0.749	1.00
373_F	443_T	0.749	1.00
175_I	182_G	0.747	1.00
15_A	320_G	0.747	1.00
79_S	83_S	0.747	1.00
417_A	421_M	0.744	1.00
403_V	421_M	0.743	1.00
369_G	447_A	0.741	1.00
278_A	296_N	0.740	1.00
203_D	211_E	0.738	1.00
52_S	65_F	0.737	1.00
15_A	324_A	0.736	1.00
391_I	447_A	0.736	1.00
191_R	346_S	0.736	1.00
59_I	67_I	0.734	1.00
61_H	383_Q	0.732	1.00
85_K	165_S	0.731	1.00
292_H	331_D	0.728	1.00
419_A	430_A	0.727	1.00
182_G	201_T	0.725	1.00
338_H	422_N	0.721	1.00
5_I	12_G	0.721	1.00
359_A	401_V	0.720	1.00
319_E	336_E	0.720	1.00
287_I	302_A	0.718	1.00
145_I	148_P	0.716	1.00
19_A	324_A	0.716	1.00
117_E	278_A	0.715	1.00
210_D	404_S	0.712	1.00
166_L	259_Y	0.710	1.00
180_V	343_I	0.709	1.00
51_E	54_N	0.709	1.00
419_A	425_M	0.709	1.00
86_Q	165_S	0.708	1.00
81_M	192_L	0.706	1.00
200_E	207_P	0.705	1.00
149_F	234_L	0.705	1.00
98_Y	101_K	0.704	1.00
33_K	41_E	0.704	1.00
393_A	427_A	0.703	1.00
150_A	154_G	0.702	1.00
120_L	299_H	0.701	1.00
118_R	297_V	0.701	1.00
295_T	302_A	0.700	1.00
392_M	395_P	0.700	1.00
270_L	306_A	0.699	1.00
233_R	247_K	0.697	1.00
216_L	388_K	0.697	1.00
405_M	413_L	0.697	1.00
186_A	198_I	0.695	1.00
199_I	246_W	0.695	1.00
209_E	343_I	0.694	1.00
325_S	329_G	0.692	1.00
236_R	248_S	0.692	1.00
366_V	401_V	0.692	1.00
29_I	122_I	0.691	1.00
348_E	409_D	0.690	1.00
271_D	276_E	0.688	1.00
372_S	375_A	0.687	1.00
397_F	424_E	0.686	1.00
427_A	431_E	0.681	1.00
201_T	207_P	0.679	1.00
152_F	157_I	0.679	1.00
363_Y	366_V	0.679	1.00
147_L	262_V	0.677	1.00
146_E	151_P	0.677	1.00
95_G	99_L	0.676	1.00
238_D	248_S	0.675	1.00
429_M	432_H	0.673	1.00
325_S	330_R	0.672	0.99
30_D	107_V	0.671	0.99
15_A	323_A	0.671	0.99
249_G	253_F	0.670	0.99
338_H	418_A	0.668	0.99
275_L	282_F	0.664	0.99
59_I	74_I	0.664	0.99
248_S	252_E	0.663	0.99
289_V	293_M	0.663	0.99
62_A	65_F	0.663	0.99
437_H	442_E	0.661	0.99
244_A	260_V	0.661	0.99
152_F	159_D	0.661	0.99
57_D	61_H	0.661	0.99
76_V	81_M	0.660	0.99
246_W	251_R	0.658	0.99
293_M	322_I	0.657	0.99
419_A	423_G	0.656	0.99
399_E	426_T	0.655	0.99
369_G	393_A	0.655	0.99
187_G	191_R	0.654	0.99
186_A	226_V	0.654	0.99
146_E	262_V	0.652	0.99
318_H	334_I	0.652	0.99
142_S	266_R	0.651	0.99
152_F	262_V	0.650	0.99
403_V	444_L	0.649	0.99
148_P	153_D	0.649	0.99
384_Q	408_P	0.649	0.99
430_A	448_L	0.649	0.99
82_Q	167_S	0.647	0.99
187_G	221_L	0.646	0.99
235_G	250_Q	0.643	0.99
96_V	99_L	0.642	0.99
19_A	26_V	0.641	0.99
248_S	253_F	0.639	0.99
172_S	190_A	0.637	0.99
412_E	441_S	0.635	0.99
318_H	321_I	0.633	0.99
419_A	433_F	0.630	0.99
94_Q	98_Y	0.629	0.99
197_T	255_T	0.628	0.99
378_K	381_I	0.627	0.99
393_A	398_G	0.627	0.99
161_K	266_R	0.627	0.99
213_I	216_L	0.626	0.99
83_S	86_Q	0.625	0.99
294_Q	297_V	0.624	0.99
166_L	189_F	0.622	0.99
180_V	341_R	0.619	0.99
354_M	402_G	0.618	0.99
150_A	153_D	0.618	0.99
160_S	266_R	0.615	0.99
284_P	288_P	0.615	0.99
209_E	349_I	0.615	0.99
2_T	24_R	0.614	0.99
174_V	260_V	0.613	0.99
287_I	295_T	0.612	0.99
187_G	224_D	0.612	0.99
111_T	123_E	0.611	0.99
27_L	106_Q	0.611	0.99
235_G	248_S	0.610	0.99
280_V	300_I	0.609	0.99
379_A	440_L	0.607	0.99
301_Y	327_A	0.603	0.99
357_R	360_R	0.603	0.99
354_M	364_G	0.600	0.99
170_P	194_S	0.599	0.99
407_G	410_V	0.598	0.99
416_Q	441_S	0.597	0.99
51_E	58_K	0.597	0.99
58_K	61_H	0.597	0.99
54_N	346_S	0.597	0.99
87_Q	90_S	0.596	0.99
232_S	250_Q	0.596	0.99
183_C	205_L	0.593	0.99
185_Y	188_L	0.592	0.99
144_P	160_S	0.591	0.99
33_K	93_V	0.591	0.99
92_L	380_L	0.591	0.99
282_F	287_I	0.590	0.99
256_K	259_Y	0.590	0.99
28_L	105_I	0.588	0.99
67_I	76_V	0.585	0.99
123_E	127_G	0.585	0.99
117_E	300_I	0.584	0.99
20_A	105_I	0.584	0.99
137_L	324_A	0.584	0.99
108_V	122_I	0.583	0.99
351_C	404_S	0.583	0.99
80_K	84_R	0.582	0.99
160_S	181_I	0.581	0.99
17_V	21_Q	0.581	0.99
114_F	299_H	0.581	0.99
183_C	228_V	0.579	0.99
325_S	332_V	0.578	0.98
366_V	395_P	0.578	0.98
308_G	311_Q	0.578	0.98
55_V	62_A	0.578	0.98
303_C	320_G	0.578	0.98
157_I	260_V	0.576	0.98
389_V	447_A	0.576	0.98
246_W	254_K	0.575	0.98
413_L	440_L	0.575	0.98
418_A	422_N	0.575	0.98
84_R	88_V	0.571	0.98
189_F	194_S	0.570	0.98
199_I	257_A	0.569	0.98
421_M	425_M	0.568	0.98
318_H	445_H	0.567	0.98
149_F	153_D	0.564	0.98
315_A	336_E	0.564	0.98
115_L	277_Q	0.563	0.98
428_D	432_H	0.562	0.98
246_W	252_E	0.562	0.98
403_V	414_I	0.562	0.98
33_K	40_N	0.560	0.98
360_R	365_D	0.558	0.98
318_H	322_I	0.558	0.98
50_L	54_N	0.556	0.98
380_L	385_A	0.554	0.98
237_V	262_V	0.554	0.98
46_T	50_L	0.554	0.98
422_N	433_F	0.553	0.98
56_L	67_I	0.553	0.98
373_F	440_L	0.553	0.98
5_I	16_A	0.551	0.98
248_S	254_K	0.550	0.98
206_I	343_I	0.550	0.98
307_I	319_E	0.550	0.98
20_A	25_N	0.549	0.98
391_I	400_I	0.549	0.98
37_T	160_S	0.549	0.98
65_F	84_R	0.548	0.98
109_K	125_E	0.546	0.98
79_S	82_Q	0.546	0.98
53_A	56_L	0.545	0.98
201_T	264_I	0.545	0.98
51_E	382_K	0.545	0.98
172_S	259_Y	0.544	0.98
372_S	386_E	0.543	0.98
110_G	120_L	0.543	0.98
249_G	255_T	0.542	0.98
317_F	445_H	0.542	0.98
346_S	384_Q	0.541	0.98
78_W	169_I	0.540	0.98
385_A	408_P	0.540	0.98
369_G	391_I	0.540	0.98
117_E	298_P	0.540	0.98
21_Q	103_N	0.539	0.98
405_M	414_I	0.539	0.98
232_S	246_W	0.539	0.98
445_H	449_L	0.539	0.98
315_A	319_E	0.538	0.98
32_G	161_K	0.538	0.98
84_R	383_Q	0.537	0.98
110_G	123_E	0.536	0.98
342_C	350_A	0.536	0.98
93_V	97_Q	0.536	0.98
34_L	97_Q	0.536	0.98
34_L	100_M	0.535	0.98
239_Q	243_T	0.535	0.98
363_Y	401_V	0.534	0.97
351_C	358_Q	0.533	0.97
418_A	433_F	0.531	0.97
187_G	346_S	0.530	0.97
224_D	346_S	0.529	0.97
86_Q	89_V	0.529	0.97
268_P	282_F	0.528	0.97
354_M	363_Y	0.528	0.97
172_S	243_T	0.528	0.97
90_S	93_V	0.528	0.97
194_S	258_D	0.528	0.97
326_H	333_K	0.527	0.97
229_H	246_W	0.526	0.97
79_S	168_E	0.526	0.97
44_I	377_G	0.525	0.97
404_S	417_A	0.523	0.97
338_H	352_I	0.522	0.97
95_G	98_Y	0.522	0.97
118_R	134_D	0.521	0.97
246_W	255_T	0.521	0.97
120_L	136_V	0.521	0.97
97_Q	107_V	0.519	0.97
68_E	74_I	0.519	0.97
182_G	263_A	0.518	0.97
175_I	185_Y	0.516	0.97
350_A	405_M	0.516	0.97
138_I	287_I	0.514	0.97
37_T	42_G	0.512	0.97
376_N	443_T	0.511	0.97
56_L	76_V	0.510	0.97
393_A	400_I	0.509	0.97
146_E	157_I	0.509	0.97
147_L	152_F	0.508	0.97
99_L	102_K	0.508	0.97
205_L	214_A	0.507	0.97
200_E	234_L	0.507	0.97
22_Q	330_R	0.507	0.97
78_W	167_S	0.505	0.96
123_E	126_N	0.504	0.96
54_N	348_E	0.503	0.96
182_G	207_P	0.502	0.96
31_K	269_R	0.500	0.96
142_S	311_Q	0.500	0.96
61_H	65_F	0.500	0.96

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ojtA	2	0.9913	100	0.184	Contact Map
3ladA	2	0.9934	100	0.188	Contact Map
1zmdA	4	0.9934	100	0.202	Contact Map
1xdiA	3	0.9738	100	0.204	Contact Map
3urhA	2	0.9869	100	0.205	Contact Map
2a8xA	2	0.9891	100	0.207	Contact Map
1ebdA	2	0.9803	100	0.209	Contact Map
3ic9A	2	0.9825	100	0.211	Contact Map
1lvlA	2	0.9782	100	0.212	Contact Map
2qaeA	2	0.9934	100	0.212	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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