GREMLIN Database
YVLA - Uncharacterized protein YvlA
UniProt: O34322 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 108 (99)
Sequences: 182 (149)
Seq/√Len: 15.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
23_V27_A4.4851.00
12_C43_S3.3970.99
12_C27_A2.5700.95
37_K96_W2.4480.93
19_A44_L2.4190.93
30_V52_V2.3030.91
96_W99_I2.0520.84
9_A104_V2.0110.83
91_I103_K1.9670.82
4_N62_L1.7450.73
52_V81_G1.7120.72
14_F101_G1.6950.71
46_S93_I1.6490.69
14_F46_S1.6130.67
14_F39_H1.5300.63
74_L102_I1.3970.55
36_T50_P1.3940.55
99_I103_K1.3640.54
77_F102_I1.3310.52
10_S17_F1.3190.51
100_Q103_K1.3100.51
22_I99_I1.3090.51
29_F96_W1.2750.49
37_K46_S1.2510.47
16_V81_G1.2460.47
10_S105_L1.2390.47
56_F99_I1.2160.45
16_V48_I1.2130.45
9_A39_H1.2100.45
26_V30_V1.2030.45
17_F98_V1.2000.44
80_I98_V1.1960.44
21_I52_V1.1880.44
86_Y95_I1.1750.43
21_I51_F1.1670.43
58_F74_L1.1650.43
61_L102_I1.1630.42
25_I79_I1.1620.42
85_I104_V1.1510.42
16_V94_I1.1470.42
46_S96_W1.1460.41
84_V88_L1.1370.41
40_A80_I1.1320.41
8_I98_V1.1230.40
22_I58_F1.1000.39
22_I73_L1.0890.38
11_L18_I1.0650.37
44_L88_L1.0640.37
62_L69_D1.0590.37
26_V60_A1.0580.37
22_I49_V1.0550.37
58_F63_G1.0240.35
65_A76_V1.0000.34
25_I91_I0.9900.33
54_W90_V0.9890.33
11_L105_L0.9840.33
29_F37_K0.9780.33
80_I87_F0.9740.33
9_A14_F0.9710.32
8_I39_H0.9710.32
89_V94_I0.9630.32
44_L99_I0.9580.32
9_A82_G0.9520.31
59_I82_G0.9510.31
22_I62_L0.9480.31
17_F25_I0.9480.31
77_F81_G0.9440.31
19_A41_I0.9250.30
48_I68_I0.9220.30
7_I61_L0.9210.30
14_F105_L0.9200.30
28_Y96_W0.9160.30
8_I62_L0.9070.29
42_R104_V0.9010.29
39_H97_N0.8880.28
38_R95_I0.8880.28
6_A105_L0.8840.28
9_A42_R0.8780.28
62_L84_V0.8650.27
37_K99_I0.8590.27
63_G67_A0.8540.27
6_A16_V0.8440.26
73_L84_V0.8430.26
50_P96_W0.8360.26
22_I101_G0.8330.26
58_F67_A0.8250.26
26_V102_I0.8230.26
14_F21_I0.8000.25
42_R83_A0.8000.25
14_F52_V0.7890.24
46_S98_V0.7710.23
49_V86_Y0.7690.23
74_L80_I0.7670.23
35_E66_V0.7600.23
83_A102_I0.7500.23
48_I82_G0.7420.22
12_C21_I0.7410.22
46_S99_I0.7240.22
55_L102_I0.7180.21
6_A94_I0.7130.21
24_P97_N0.6980.21
31_V86_Y0.6950.20
58_F65_A0.6940.20
63_G91_I0.6910.20
30_V90_V0.6830.20
7_I81_G0.6780.20
47_H101_G0.6680.19
20_P60_A0.6640.19
54_W61_L0.6610.19
21_I45_I0.6530.19
26_V29_F0.6470.19
7_I105_L0.6440.19
26_V99_I0.6420.19
65_A89_V0.6390.18
7_I75_P0.6310.18
7_I69_D0.6300.18
63_G80_I0.6200.18
48_I53_G0.6100.18
22_I38_R0.6030.17
12_C40_A0.5980.17
94_I99_I0.5960.17
11_L41_I0.5900.17
37_K41_I0.5850.17
44_L64_G0.5820.17
31_V84_V0.5810.17
16_V95_I0.5780.17
9_A94_I0.5780.17
45_I67_A0.5750.16
4_N34_K0.5730.16
22_I105_L0.5660.16
46_S82_G0.5620.16
51_F57_L0.5600.16
8_I30_V0.5600.16
21_I78_V0.5570.16
28_Y43_S0.5480.16
35_E50_P0.5460.16
18_I88_L0.5410.15
31_V42_R0.5400.15
22_I41_I0.5380.15
17_F95_I0.5340.15
10_S39_H0.5260.15
65_A102_I0.5230.15
20_P43_S0.5200.15
35_E38_R0.5200.15
14_F93_I0.5190.15
62_L72_S0.5090.14
44_L97_N0.5030.14
18_I24_P0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ev6A 3 0.6296 4.2 0.945 Contact Map
4p6vB 1 0.3611 3.4 0.947 Contact Map
1v54A 1 0.9444 2.7 0.95 Contact Map
3kpeB 1 0.1019 2.7 0.95 Contact Map
4lvpA 4 0.4722 2.5 0.951 Contact Map
4ak1A 5 0.2593 2.3 0.952 Contact Map
3ayfA 2 0.963 2.2 0.952 Contact Map
4ak2A 1 0.3241 2.2 0.952 Contact Map
2yevA 1 0.963 2.2 0.952 Contact Map
3s8fA 1 0.963 2.2 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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