GREMLIN Database
YOCM - Uncharacterized protein YocM
UniProt: O34321 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 158 (124)
Sequences: 1020 (866)
Seq/√Len: 77.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
60_M73_I3.8831.00
73_I94_V3.4951.00
79_R82_D3.2841.00
96_G117_F3.1661.00
127_L144_I3.1171.00
79_R137_D3.0811.00
74_Y139_I2.7111.00
111_E119_K2.5891.00
87_S123_L2.4571.00
75_L135_F2.2481.00
58_P117_F2.2081.00
37_N40_S2.1931.00
61_D112_G2.1621.00
64_D146_K2.1281.00
132_N157_D2.1001.00
84_H153_T2.0711.00
39_Q43_P2.0481.00
97_Q116_S2.0261.00
65_T68_E1.9061.00
83_V135_F1.8581.00
69_V146_K1.8541.00
84_H95_K1.7861.00
35_M39_Q1.7661.00
60_M121_I1.6911.00
58_P96_G1.6071.00
78_Y96_G1.5520.99
71_F121_I1.4950.99
107_F110_K1.4710.99
75_L83_V1.4710.99
92_L131_M1.4020.99
95_K118_E1.3740.99
39_Q44_F1.3610.98
68_E143_T1.3530.98
126_H146_K1.3420.98
93_V120_K1.3280.98
75_L117_F1.2830.98
46_Q157_D1.2830.98
36_T39_Q1.2700.98
80_K84_H1.2660.98
69_V126_H1.2500.97
37_N42_F1.2410.97
87_S131_M1.2320.97
91_Y120_K1.1740.96
72_L141_Y1.1680.96
64_D121_I1.1600.96
36_T40_S1.1350.95
65_T70_Q1.0920.94
112_G124_S1.0690.94
111_E115_G1.0640.93
44_F47_Q1.0300.92
71_F142_I1.0260.92
116_S153_T1.0130.92
56_S115_G1.0000.91
83_V112_G0.9960.91
58_P75_L0.9900.91
124_S127_L0.9870.91
60_M94_V0.9720.90
34_F37_N0.9590.89
34_F38_G0.9530.89
83_V114_Y0.9220.87
129_G152_K0.9140.87
41_P49_Q0.9060.86
80_K137_D0.9040.86
70_Q73_I0.9020.86
42_F103_N0.9010.86
62_I131_M0.8930.86
43_P47_Q0.8900.85
90_D125_D0.8890.85
90_D122_P0.8750.85
106_D121_I0.8700.84
74_Y114_Y0.8670.84
119_K133_A0.8590.83
56_S96_G0.8550.83
47_Q88_Y0.8540.83
64_D78_Y0.8530.83
60_M87_S0.8510.83
85_I154_I0.8490.83
78_Y98_R0.8470.83
114_Y135_F0.8450.82
120_K125_D0.8450.82
44_F66_V0.8350.82
92_L154_I0.8310.81
107_F142_I0.8300.81
137_D141_Y0.8260.81
61_D74_Y0.8250.81
75_L96_G0.8110.80
74_Y96_G0.7980.79
109_Q135_F0.7980.79
38_G41_P0.7980.79
117_F131_M0.7920.78
34_F127_L0.7910.78
58_P78_Y0.7910.78
62_I121_I0.7860.78
58_P153_T0.7810.77
96_G115_G0.7800.77
49_Q154_I0.7780.77
142_I148_E0.7630.75
112_G117_F0.7540.75
88_Y128_H0.7530.75
69_V131_M0.7510.74
36_T152_K0.7490.74
129_G132_N0.7400.73
134_I141_Y0.7300.72
74_Y98_R0.7300.72
101_Y104_E0.7280.72
49_Q70_Q0.7180.71
144_I151_A0.7130.70
86_L151_A0.7130.70
100_S154_I0.7040.69
89_G93_V0.7020.69
56_S98_R0.7000.69
61_D78_Y0.6940.68
58_P115_G0.6900.68
91_Y101_Y0.6890.68
98_R114_Y0.6850.67
61_D110_K0.6830.67
108_R144_I0.6790.67
39_Q42_F0.6710.66
94_V104_E0.6710.66
60_M119_K0.6700.66
47_Q132_N0.6650.65
72_L152_K0.6570.64
71_F92_L0.6540.64
56_S135_F0.6500.63
61_D75_L0.6500.63
67_A150_Q0.6500.63
46_Q156_I0.6440.63
99_F142_I0.6410.62
70_Q141_Y0.6400.62
91_Y122_P0.6380.62
112_G139_I0.6290.61
85_I99_F0.6280.61
63_V132_N0.6240.60
118_E151_A0.6230.60
45_A48_D0.6210.60
130_K139_I0.6210.60
50_R82_D0.6100.58
76_P110_K0.6080.58
78_Y82_D0.6070.58
80_K122_P0.6020.57
71_F110_K0.5990.57
108_R113_K0.5990.57
74_Y124_S0.5890.56
99_F114_Y0.5880.56
122_P154_I0.5860.55
61_D70_Q0.5780.54
40_S44_F0.5780.54
42_F66_V0.5750.54
152_K155_V0.5710.54
39_Q47_Q0.5690.53
108_R131_M0.5640.53
73_I85_I0.5620.52
74_Y125_D0.5610.52
81_Q97_Q0.5580.52
103_N124_S0.5510.51
75_L92_L0.5480.51
61_D72_L0.5470.50
41_P46_Q0.5470.50
80_K96_G0.5440.50
35_M43_P0.5380.49
54_D151_A0.5370.49
68_E146_K0.5350.49
71_F108_R0.5330.49
58_P135_F0.5300.48
134_I156_I0.5280.48
67_A155_V0.5260.48
124_S131_M0.5240.48
136_K153_T0.5230.47
56_S113_K0.5200.47
134_I157_D0.5200.47
91_Y154_I0.5200.47
45_A94_V0.5200.47
128_H147_D0.5190.47
57_F121_I0.5190.47
85_I136_K0.5170.47
129_G139_I0.5170.47
109_Q141_Y0.5170.47
112_G115_G0.5160.47
76_P139_I0.5160.47
45_A143_T0.5070.45
110_K137_D0.5070.45
78_Y115_G0.5060.45
89_G149_G0.5050.45
47_Q156_I0.5030.45
103_N107_F0.5030.45
66_V136_K0.5000.44
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3w1zA 7 0.8608 100 0.367 Contact Map
4eldA 4 0.6962 100 0.376 Contact Map
3aabA 2 0.7089 99.9 0.402 Contact Map
1gmeA 6 0.8987 99.9 0.414 Contact Map
3glaA 2 0.6139 99.9 0.427 Contact Map
2bolA 2 0.9367 99.9 0.43 Contact Map
4feiA 2 0.6392 99.9 0.444 Contact Map
4jutA 4 0.557 99.9 0.456 Contact Map
4ye0A 2 0.6076 99.9 0.467 Contact Map
2klrA 2 0.5063 99.9 0.473 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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