GREMLIN Database
YKCC - Uncharacterized glycosyltransferase YkcC
UniProt: O34319 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 323 (278)
Sequences: 17131 (13738)
Seq/√Len: 823.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
17_E50_R4.8981.00
44_N69_D4.4461.00
165_R169_D4.2591.00
50_R53_E3.2411.00
117_Y193_T3.1451.00
8_S89_G3.0051.00
55_L67_I3.0031.00
8_S39_E2.8881.00
52_I69_D2.8121.00
91_A113_W2.7951.00
39_E66_K2.7111.00
112_K115_E2.6081.00
6_Q90_N2.6041.00
52_I56_R2.5911.00
43_V83_G2.5891.00
13_V51_S2.5791.00
44_N47_S2.4681.00
112_K193_T2.4251.00
21_H57_E2.4111.00
21_H54_I2.3681.00
21_H25_Q2.3491.00
93_V162_L2.2681.00
167_V190_F2.2661.00
52_I67_I2.2491.00
16_E97_A2.2171.00
42_F55_L2.1291.00
113_W162_L2.1271.00
25_Q58_H2.1221.00
91_A162_L2.0821.00
108_E197_Y2.0501.00
118_E164_D2.0461.00
24_Y58_H2.0291.00
54_I57_E1.9811.00
112_K195_V1.9791.00
6_Q37_N1.9561.00
8_S41_L1.9521.00
180_F184_L1.9411.00
70_F82_A1.9331.00
76_H80_I1.9271.00
8_S87_A1.8851.00
6_Q88_Q1.8841.00
53_E57_E1.8731.00
56_R69_D1.8691.00
50_R54_I1.8611.00
7_Y110_I1.8421.00
108_E111_E1.8231.00
170_E190_F1.8101.00
15_N48_K1.8051.00
170_E188_V1.7861.00
34_T107_L1.7801.00
109_M162_L1.7801.00
10_V83_G1.7531.00
39_E89_G1.7431.00
91_A110_I1.7111.00
111_E114_K1.6811.00
25_Q29_E1.6511.00
93_V106_I1.6491.00
118_E190_F1.6141.00
125_T198_V1.5841.00
82_A86_Y1.5751.00
28_K62_D1.5521.00
68_I86_Y1.5371.00
80_I94_V1.5021.00
11_V23_T1.5021.00
17_E54_I1.4861.00
14_Y73_N1.4781.00
57_E61_I1.4611.00
166_K170_E1.4441.00
34_T37_N1.4431.00
84_M168_C1.4431.00
15_N47_S1.4421.00
113_W164_D1.4391.00
22_E25_Q1.4121.00
84_M92_I1.4111.00
119_V192_Q1.3941.00
24_Y62_D1.3911.00
10_V43_V1.3891.00
43_V79_A1.3761.00
6_Q89_G1.3741.00
39_E88_Q1.3631.00
119_V185_V1.3621.00
13_V97_A1.3611.00
146_S149_T1.3601.00
143_R146_S1.3581.00
26_R104_E1.3561.00
123_V196_E1.3401.00
7_Y106_I1.3351.00
44_N52_I1.3281.00
87_A165_R1.3151.00
104_E108_E1.3101.00
26_R101_D1.3021.00
92_I168_C1.2961.00
22_E203_L1.2611.00
24_Y42_F1.2381.00
101_D105_L1.2321.00
213_K216_K1.2321.00
13_V42_F1.1981.00
41_L66_K1.1681.00
82_A85_D1.1651.00
59_S65_V1.1511.00
25_Q61_I1.1481.00
95_I101_D1.1461.00
66_K86_Y1.1371.00
131_T134_K1.1361.00
22_E26_R1.1261.00
54_I58_H1.1231.00
21_H58_H1.1221.00
26_R100_Q1.1131.00
132_F135_K1.1101.00
9_I106_I1.1101.00
92_I165_R1.1091.00
11_V97_A1.1021.00
28_K64_R1.0991.00
213_K217_L1.0901.00
164_D167_V1.0871.00
101_D199_R1.0841.00
167_V185_V1.0831.00
176_E179_P1.0781.00
143_R147_G1.0731.00
85_D172_K1.0691.00
53_E56_R1.0661.00
76_H96_D1.0641.00
45_D73_N1.0551.00
13_V16_E1.0481.00
132_F136_Q1.0321.00
83_G87_A1.0301.00
20_I54_I1.0141.00
137_T140_M1.0131.00
109_M122_A1.0121.00
166_K169_D1.0051.00
217_L221_G0.9991.00
68_I82_A0.9961.00
91_A164_D0.9941.00
124_R159_D0.9911.00
237_G241_S0.9901.00
255_K258_T0.9851.00
156_D161_R0.9751.00
112_K120_V0.9751.00
207_T210_P0.9741.00
9_I93_V0.9661.00
45_D75_G0.9581.00
195_V198_V0.9571.00
219_M223_T0.9551.00
23_T27_L0.9551.00
275_F279_V0.9521.00
11_V27_L0.9391.00
24_Y28_K0.9371.00
38_Y64_R0.9321.00
105_L160_F0.9321.00
105_L108_E0.9291.00
81_T85_D0.9281.00
220_D223_T0.9241.00
93_V105_L0.9231.00
170_E173_R0.9141.00
16_E19_V0.9131.00
29_E103_P0.9081.00
145_L149_T0.9071.00
202_R205_G0.9051.00
22_E100_Q0.9031.00
107_L111_E0.9001.00
11_V40_L0.8991.00
115_E193_T0.8921.00
84_M94_V0.8911.00
137_T141_F0.8881.00
19_V203_L0.8821.00
9_I27_L0.8741.00
42_F65_V0.8721.00
74_F78_I0.8711.00
143_R148_M0.8691.00
214_M217_L0.8691.00
56_R59_S0.8681.00
134_K137_T0.8671.00
30_V107_L0.8641.00
40_L65_V0.8621.00
234_S237_G0.8591.00
24_Y65_V0.8421.00
26_R29_E0.8401.00
58_H62_D0.8361.00
87_A92_I0.8361.00
90_N166_K0.8331.00
136_Q140_M0.8311.00
122_A160_F0.8251.00
21_H61_I0.8221.00
133_F137_T0.8221.00
113_W120_V0.8201.00
244_G248_M0.8201.00
274_L278_I0.8171.00
26_R30_V0.8161.00
76_H158_G0.8131.00
218_S221_G0.8121.00
254_L258_T0.8081.00
41_L87_A0.8061.00
38_Y106_I0.8031.00
6_Q39_E0.7881.00
241_S245_F0.7841.00
118_E166_K0.7831.00
215_L219_M0.7811.00
19_V23_T0.7771.00
250_I254_L0.7751.00
163_M185_V0.7741.00
27_L40_L0.7731.00
117_Y191_K0.7701.00
13_V20_I0.7681.00
26_R200_D0.7681.00
253_Y257_F0.7661.00
66_K88_Q0.7661.00
11_V42_F0.7611.00
8_S165_R0.7601.00
283_L286_I0.7601.00
15_N49_D0.7591.00
123_V194_A0.7581.00
20_I51_S0.7581.00
71_S82_A0.7561.00
23_T26_R0.7521.00
109_M198_V0.7481.00
23_T97_A0.7391.00
99_L202_R0.7391.00
163_M168_C0.7361.00
47_S51_S0.7301.00
12_P79_A0.7281.00
11_V95_I0.7241.00
80_I96_D0.7241.00
20_I55_L0.7231.00
56_R67_I0.7201.00
14_Y48_K0.7131.00
90_N164_D0.7111.00
20_I42_F0.7091.00
180_F183_G0.7081.00
145_L148_M0.7081.00
260_S263_T0.7081.00
143_R149_T0.7071.00
224_T227_H0.7071.00
55_L59_S0.7051.00
175_K180_F0.7011.00
226_S229_P0.6981.00
134_K138_A0.6981.00
17_E49_D0.6971.00
238_I241_S0.6931.00
71_S74_F0.6931.00
108_E112_K0.6921.00
39_E87_A0.6861.00
211_L215_L0.6861.00
70_F74_F0.6841.00
227_H231_K0.6841.00
133_F136_Q0.6811.00
144_L149_T0.6801.00
167_V170_E0.6801.00
121_Y124_R0.6761.00
5_I110_I0.6751.00
125_T196_E0.6751.00
35_K110_I0.6751.00
110_I162_L0.6741.00
112_K117_Y0.6741.00
217_L220_D0.6731.00
235_Y239_L0.6731.00
77_Q177_K0.6681.00
136_Q139_A0.6671.00
118_E191_K0.6621.00
84_M87_A0.6621.00
34_T38_Y0.6571.00
89_G165_R0.6571.00
17_E53_E0.6521.00
30_V34_T0.6491.00
30_V106_I0.6471.00
171_M185_V0.6461.00
146_S150_D0.6441.00
115_E191_K0.6431.00
14_Y46_G0.6411.00
211_L214_M0.6391.00
164_D190_F0.6391.00
58_H61_I0.6381.00
185_V190_F0.6371.00
109_M160_F0.6361.00
241_S244_G0.6351.00
193_T196_E0.6351.00
228_K235_Y0.6311.00
77_Q81_T0.6311.00
15_N51_S0.6291.00
242_G245_F0.6291.00
237_G244_G0.6281.00
242_G246_L0.6251.00
52_I55_L0.6241.00
277_G281_L0.6231.00
144_L148_M0.6231.00
41_L83_G0.6221.00
228_K231_K0.6201.00
93_V109_M0.6191.00
90_N165_R0.6181.00
59_S67_I0.6171.00
280_L284_G0.6171.00
10_V87_A0.6151.00
244_G274_L0.6141.00
35_K38_Y0.6131.00
212_K215_L0.6121.00
268_L271_I0.6121.00
5_I90_N0.6091.00
213_K220_D0.6071.00
99_L200_D0.6061.00
218_S222_I0.6061.00
105_L109_M0.6061.00
273_L277_G0.6061.00
108_E195_V0.6051.00
266_S269_I0.6011.00
94_V161_R0.6001.00
247_Y251_V0.5991.00
12_P97_A0.5991.00
18_L54_I0.5981.00
214_M221_G0.5961.00
20_I25_Q0.5951.00
273_L280_L0.5951.00
226_S231_K0.5951.00
37_N64_R0.5941.00
109_M113_W0.5911.00
237_G240_M0.5891.00
107_L110_I0.5881.00
249_F253_Y0.5871.00
59_S62_D0.5871.00
176_E180_F0.5871.00
266_S270_V0.5861.00
175_K184_L0.5851.00
258_T261_T0.5801.00
212_K216_K0.5791.00
41_L86_Y0.5791.00
224_T228_K0.5781.00
259_D263_T0.5771.00
205_G208_K0.5771.00
15_N44_N0.5761.00
14_Y45_D0.5751.00
104_E107_L0.5731.00
20_I58_H0.5731.00
16_E76_H0.5721.00
274_L281_L0.5721.00
167_V188_V0.5701.00
12_P80_I0.5671.00
147_G150_D0.5661.00
167_V171_M0.5661.00
259_D262_I0.5651.00
24_Y40_L0.5651.00
121_Y194_A0.5621.00
216_K219_M0.5601.00
28_K58_H0.5601.00
225_F231_K0.5601.00
233_A237_G0.5591.00
8_S88_Q0.5581.00
16_E51_S0.5581.00
17_E21_H0.5561.00
135_K139_A0.5551.00
145_L150_D0.5551.00
267_S270_V0.5551.00
51_S97_A0.5541.00
75_G98_D0.5521.00
12_P45_D0.5521.00
158_G161_R0.5511.00
27_L101_D0.5501.00
186_S192_Q0.5481.00
142_Y146_S0.5481.00
20_I97_A0.5431.00
59_S63_P0.5431.00
28_K65_V0.5431.00
118_E167_V0.5421.00
277_G280_L0.5401.00
120_V195_V0.5401.00
106_I162_L0.5391.00
225_F228_K0.5391.00
62_D65_V0.5381.00
101_D160_F0.5371.00
263_T266_S0.5371.00
216_K220_D0.5371.00
139_A143_R0.5351.00
121_Y156_D0.5341.00
70_F78_I0.5331.00
176_E220_D0.5321.00
66_K69_D0.5321.00
46_G73_N0.5311.00
171_M188_V0.5301.00
5_I37_N0.5301.00
278_I282_I0.5291.00
6_Q36_E0.5281.00
274_L277_G0.5281.00
233_A282_I0.5261.00
244_G247_Y0.5261.00
181_V185_V0.5251.00
102_P105_L0.5251.00
19_V97_A0.5231.00
70_F79_A0.5221.00
14_Y44_N0.5191.00
176_E182_R0.5191.00
245_F249_F0.5191.00
138_A141_F0.5191.00
102_P199_R0.5191.00
132_F137_T0.5171.00
214_M218_S0.5171.00
272_Q276_S0.5171.00
275_F278_I0.5161.00
273_L281_L0.5161.00
99_L159_D0.5161.00
113_W117_Y0.5151.00
273_L276_S0.5151.00
51_S55_L0.5141.00
264_G267_S0.5121.00
76_H79_A0.5111.00
147_G151_I0.5101.00
16_E20_I0.5091.00
46_G70_F0.5081.00
271_I275_F0.5071.00
238_I245_F0.5051.00
279_V283_L0.5051.00
236_A240_M0.5041.00
270_V274_L0.5031.00
36_E114_K0.5021.00
84_M173_R0.5021.00
26_R99_L0.5011.00
163_M181_V0.5011.00
109_M120_V0.5011.00
70_F73_N0.5011.00
140_M143_R0.5001.00
131_T138_A0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4p02A 1 0.969 100 0.443 Contact Map
3bcvA 2 0.5294 100 0.455 Contact Map
2z86A 2 0.7554 100 0.459 Contact Map
2d7iA 1 0.9783 100 0.475 Contact Map
1qg8A 1 0.6656 100 0.485 Contact Map
3l7iA 4 0.0836 100 0.489 Contact Map
1xhbA 1 0.935 100 0.49 Contact Map
4fixA 3 0.9721 100 0.506 Contact Map
5ajoA 1 0.9443 100 0.507 Contact Map
2bo4A 4 0.8514 100 0.508 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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