GREMLIN Database
YLOU - Uncharacterized protein YloU
UniProt: O34318 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 120 (109)
Sequences: 1942 (1110)
Seq/√Len: 106.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_D109_N4.9401.00
67_Q104_A3.0891.00
74_I89_V2.9421.00
70_I97_V2.3291.00
22_V100_T2.2591.00
76_V82_I2.2361.00
67_Q106_D2.2091.00
29_D92_K2.2071.00
73_Y111_Y2.1491.00
73_Y113_Q1.9951.00
24_G55_F1.9481.00
33_I89_V1.9331.00
69_H107_S1.9301.00
64_E67_Q1.9091.00
105_V108_V1.8481.00
44_D48_E1.8281.00
64_E69_H1.7601.00
27_A36_M1.6921.00
34_V116_R1.6361.00
44_D50_L1.6341.00
72_M93_V1.5351.00
66_E106_D1.5091.00
80_T85_V1.4841.00
64_E106_D1.4621.00
94_K98_N1.4591.00
88_N91_T1.4481.00
23_A70_I1.4401.00
76_V85_V1.3841.00
62_R69_H1.3821.00
82_I112_V1.3701.00
59_V72_M1.3601.00
84_E88_N1.3320.99
43_K47_T1.3230.99
31_Y77_S1.3110.99
47_T50_L1.3010.99
75_I114_G1.2940.99
37_A75_I1.2440.99
69_H106_D1.2210.99
30_C90_Q1.2080.99
26_A96_T1.1990.99
23_A97_V1.1680.99
98_N104_A1.1530.98
20_A61_V1.1360.98
81_K84_E1.1330.98
31_Y80_T1.1190.98
10_G115_V1.1180.98
43_K49_I1.0990.98
27_A89_V1.0970.98
96_T100_T1.0910.98
33_I74_I1.0880.98
45_G50_L1.0560.97
84_E87_H1.0560.97
33_I60_Q1.0530.97
44_D47_T1.0380.97
43_K48_E1.0340.97
90_Q94_K1.0080.96
35_G75_I1.0060.96
34_V117_V0.9980.96
61_V70_I0.9820.96
18_V99_Q0.9740.96
12_I98_N0.9670.95
64_E112_V0.9590.95
74_I112_V0.9520.95
76_V80_T0.9500.95
23_A105_V0.9420.95
36_M58_G0.9270.94
19_I103_L0.9200.94
98_N105_V0.9020.93
35_G49_I0.8990.93
28_V115_V0.8980.93
89_V110_I0.8960.93
23_A61_V0.8840.93
27_A72_M0.8710.92
24_G36_M0.8670.92
29_D96_T0.8620.92
16_N63_Q0.8580.92
64_E107_S0.8470.91
20_A56_S0.8430.91
45_G48_E0.8270.90
15_S60_Q0.8180.89
79_G82_I0.8180.89
18_V22_V0.8160.89
28_V33_I0.8160.89
81_K86_A0.8000.88
19_I64_E0.8000.88
75_I116_R0.7900.88
7_T88_N0.7850.87
47_T57_R0.7650.86
42_I90_Q0.7570.86
14_I82_I0.7570.86
19_I68_I0.7570.86
61_V68_I0.7500.85
86_A112_V0.7400.84
10_G110_I0.7380.84
31_Y88_N0.7300.83
38_S43_K0.7280.83
23_A27_A0.7280.83
9_Y12_I0.7230.83
33_I86_A0.7220.83
77_S80_T0.7170.82
102_G115_V0.6970.80
22_V103_L0.6880.80
34_V85_V0.6790.79
71_D111_Y0.6780.79
18_V100_T0.6770.79
19_I61_V0.6740.78
18_V38_S0.6630.77
17_E60_Q0.6490.76
22_V31_Y0.6490.76
72_M76_V0.6440.75
70_I105_V0.6440.75
42_I46_L0.6410.75
92_K96_T0.6400.75
86_A111_Y0.6350.74
22_V101_I0.6350.74
17_E54_N0.6340.74
13_D19_I0.6340.74
15_S18_V0.6330.74
24_G28_V0.6320.74
60_Q71_D0.6290.73
87_H90_Q0.6260.73
30_C92_K0.6240.73
21_M51_R0.6230.73
43_K50_L0.6230.73
93_V97_V0.6220.72
46_L50_L0.6140.71
27_A91_T0.6100.71
88_N95_Y0.5990.70
13_D96_T0.5960.69
97_V101_I0.5940.69
33_I107_S0.5920.69
31_Y83_S0.5920.69
12_I90_Q0.5890.68
69_H109_N0.5870.68
46_L55_F0.5840.68
36_M113_Q0.5780.67
31_Y95_Y0.5720.66
47_T102_G0.5680.66
60_Q101_I0.5670.65
7_T98_N0.5650.65
28_V35_G0.5600.64
25_G55_F0.5590.64
50_L57_R0.5590.64
24_G97_V0.5550.64
13_D16_N0.5520.63
102_G108_V0.5510.63
76_V86_A0.5470.63
74_I105_V0.5420.62
23_A26_A0.5400.62
36_M51_R0.5350.61
81_K85_V0.5310.60
87_H111_Y0.5310.60
95_Y99_Q0.5300.60
97_V105_V0.5280.60
33_I72_M0.5270.60
79_G103_L0.5250.60
61_V64_E0.5250.60
32_G80_T0.5220.59
14_I110_I0.5120.58
29_D99_Q0.5090.57
7_T69_H0.5030.56
9_Y62_R0.5020.56
20_A58_G0.5000.56
67_Q103_L0.5000.56
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4alzA 1 0.8583 26.6 0.915 Contact Map
4d2uA 3 0.5917 14.2 0.925 Contact Map
3ne5A 3 0.8083 13.6 0.925 Contact Map
2f2hA 4 0.5167 11.1 0.928 Contact Map
1wh9A 1 0.7 10.5 0.929 Contact Map
4k0jA 3 0.825 8.9 0.931 Contact Map
2dyjA 1 0.325 8.4 0.932 Contact Map
4w23D 1 0.775 5.3 0.938 Contact Map
1qvrA 3 0.6 5.1 0.938 Contact Map
2qt7A 3 0.7583 5 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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