GREMLIN Database
YODS - Probable coenzyme A transferase subunit alpha
UniProt: O34317 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 229 (218)
Sequences: 3513 (1823)
Seq/√Len: 123.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
164_E197_P3.4651.00
122_D142_K3.3241.00
159_A168_L3.3051.00
138_T143_R3.1651.00
18_R21_S3.0951.00
19_D47_T2.7091.00
161_I194_R2.6531.00
170_Y208_T2.6411.00
168_L190_A2.6391.00
48_D73_K2.6171.00
85_V88_K2.4481.00
201_I206_I2.3931.00
140_A148_E2.3861.00
73_K96_E2.2761.00
88_K92_E2.2751.00
11_D43_D2.2711.00
24_M152_A2.2191.00
9_S12_T2.1241.00
17_V41_I2.0991.00
155_A185_A2.0301.00
70_Q89_Q1.9971.00
40_A43_D1.9921.00
74_T96_E1.9531.00
136_I143_R1.9361.00
50_T76_I1.9221.00
162_A192_A1.9141.00
39_E65_P1.8921.00
112_G151_T1.8921.00
24_M109_I1.8551.00
16_D215_G1.8411.00
160_Y171_D1.8111.00
37_L156_F1.8061.00
89_Q94_T1.7911.00
151_T186_R1.7891.00
165_F198_M1.7861.00
70_Q94_T1.7411.00
162_A190_A1.7371.00
187_R215_G1.7271.00
118_G146_I1.6461.00
164_E198_M1.6321.00
202_S205_M1.6311.00
125_I143_R1.6241.00
60_D68_V1.6081.00
52_I150_L1.6041.00
8_I215_G1.5921.00
42_L71_R1.5831.00
20_G48_D1.5471.00
21_S154_F1.5421.00
24_M181_M1.5371.00
12_T15_A1.5321.00
41_I156_F1.5101.00
161_I169_T1.5071.00
163_D167_N1.4591.00
66_L71_R1.4551.00
50_T74_T1.4421.00
111_A119_I1.4111.00
98_Q108_R1.4071.00
162_A195_I1.3951.00
8_I12_T1.3871.00
182_A188_T1.3641.00
25_F156_F1.3531.00
120_L137_V1.3461.00
219_S222_V1.3401.00
154_F187_R1.3111.00
22_V52_I1.3001.00
19_D46_V1.2881.00
135_D140_A1.2781.00
17_V21_S1.2771.00
14_I40_A1.2721.00
11_D40_A1.2721.00
52_I152_A1.2641.00
69_N94_T1.2481.00
74_T98_Q1.2420.99
197_P200_E1.2190.99
33_S38_I1.2170.99
161_I196_V1.2110.99
117_G139_V1.2050.99
42_L68_V1.2010.99
10_I40_A1.1700.99
109_I181_M1.1610.99
17_V154_F1.1600.99
100_S108_R1.1580.99
50_T73_K1.1570.99
40_A44_S1.1570.99
172_K204_E1.1480.99
107_E110_R1.1420.99
104_T121_T1.1420.99
117_G149_A1.1290.99
116_L119_I1.1240.99
14_I17_V1.1170.99
25_F38_I1.1140.99
36_S191_E1.1100.99
51_V72_V1.0910.99
138_T141_G1.0910.99
108_R149_A1.0910.99
67_I89_Q1.0870.99
128_Q132_E1.0780.99
42_L69_N1.0740.98
18_R154_F1.0690.98
189_F217_V1.0690.98
157_I181_M1.0670.98
157_I190_A1.0650.98
42_L65_P1.0600.98
159_A192_A1.0580.98
36_S219_S1.0420.98
14_I44_S1.0390.98
45_G71_R1.0340.98
13_A217_V1.0240.98
195_I218_R1.0230.98
172_K193_E1.0210.98
16_D187_R1.0130.98
194_R218_R1.0020.98
39_E43_D1.0010.98
190_A208_T1.0000.98
56_A86_A0.9970.98
183_M212_F0.9970.98
56_A75_L0.9920.97
111_A116_L0.9890.97
162_A168_L0.9880.97
13_A189_F0.9850.97
46_V71_R0.9740.97
109_I184_A0.9670.97
160_Y193_E0.9580.97
8_I14_I0.9540.97
168_L192_A0.9470.97
164_E200_E0.9430.97
192_A195_I0.9380.96
5_Q8_I0.9380.96
156_F189_F0.9360.96
162_A216_V0.9330.96
17_V189_F0.9220.96
157_I182_A0.9160.96
108_R148_E0.9160.96
77_A80_I0.9120.96
158_N222_V0.9120.96
24_M150_L0.9100.96
21_S153_D0.9070.96
120_L146_I0.9000.96
68_V85_V0.8890.95
85_V89_Q0.8870.95
169_T205_M0.8870.95
161_I171_D0.8870.95
181_M185_A0.8840.95
187_R190_A0.8810.95
158_N219_S0.8800.95
175_R204_E0.8780.95
26_G178_N0.8690.95
175_R207_V0.8650.94
36_S223_K0.8640.94
136_I145_L0.8630.94
189_F215_G0.8580.94
125_I145_L0.8510.94
120_L139_V0.8500.94
118_G148_E0.8450.94
131_C136_I0.8440.94
19_D48_D0.8420.94
7_A215_G0.8360.93
168_L208_T0.8330.93
110_R114_A0.8250.93
79_H82_S0.8240.93
90_M97_V0.8230.93
15_A44_S0.8220.93
67_I72_V0.8200.93
24_M52_I0.8170.93
23_L156_F0.8130.92
170_Y179_P0.8060.92
188_T214_E0.7890.91
139_V146_I0.7880.91
22_V152_A0.7840.91
112_G150_L0.7840.91
19_D45_G0.7810.91
109_I152_A0.7740.90
117_G144_Y0.7740.90
107_E116_L0.7740.90
107_E119_I0.7690.90
124_G145_L0.7650.90
17_V156_F0.7640.90
155_A181_M0.7630.90
60_D64_G0.7580.90
36_S39_E0.7490.89
78_S105_L0.7470.89
196_V200_E0.7470.89
36_S220_E0.7400.88
134_K147_E0.7400.88
16_D21_S0.7360.88
8_I16_D0.7320.88
102_Q106_A0.7300.88
172_K202_S0.7260.87
139_V148_E0.7230.87
152_A185_A0.7220.87
118_G149_A0.7190.87
113_G183_M0.7150.87
191_E219_S0.7050.86
169_T201_I0.7040.86
13_A16_D0.7040.86
80_I86_A0.7030.86
179_P183_M0.7010.86
118_G137_V0.7000.85
66_L72_V0.6990.85
56_A82_S0.6990.85
47_T71_R0.6960.85
157_I208_T0.6910.85
158_N191_E0.6880.84
53_C63_I0.6840.84
196_V199_G0.6800.84
182_A208_T0.6770.84
41_I71_R0.6760.83
59_P64_G0.6730.83
11_D15_A0.6720.83
204_E207_V0.6700.83
169_T206_I0.6690.83
6_K216_V0.6690.83
153_D186_R0.6670.83
58_F61_I0.6670.83
13_A44_S0.6660.83
179_P208_T0.6650.82
5_Q164_E0.6600.82
59_P84_P0.6590.82
35_P61_I0.6580.82
31_V174_A0.6570.82
78_S102_Q0.6520.81
140_A151_T0.6510.81
194_R200_E0.6450.80
25_F53_C0.6430.80
100_S133_K0.6410.80
135_D138_T0.6400.80
22_V50_T0.6400.80
13_A17_V0.6370.80
220_E223_K0.6370.80
108_R150_L0.6360.80
74_T133_K0.6360.80
14_I37_L0.6350.79
58_F64_G0.6280.79
37_L217_V0.6280.79
13_A215_G0.6250.78
160_Y194_R0.6230.78
41_I46_V0.6220.78
17_V46_V0.6210.78
114_A183_M0.6210.78
61_I65_P0.6200.78
29_G82_S0.6190.78
9_S13_A0.6190.78
37_L41_I0.6160.77
7_A12_T0.6140.77
122_D144_Y0.6130.77
32_G170_Y0.6090.77
180_L183_M0.6070.76
170_Y207_V0.6060.76
30_G58_F0.6050.76
16_D189_F0.6020.76
51_V56_A0.6010.76
52_I109_I0.6000.76
54_N177_M0.6000.76
134_K145_L0.5970.75
146_I149_A0.5970.75
160_Y169_T0.5960.75
14_I215_G0.5960.75
54_N102_Q0.5950.75
34_P37_L0.5930.75
26_G176_N0.5930.75
172_K192_A0.5900.74
10_I219_S0.5900.74
36_S222_V0.5890.74
42_L45_G0.5810.73
137_V146_I0.5790.73
89_Q92_E0.5750.72
158_N192_A0.5720.72
165_F210_G0.5720.72
108_R147_E0.5700.72
24_M185_A0.5690.72
25_F57_G0.5690.72
25_F51_V0.5680.72
64_G82_S0.5670.71
125_I136_I0.5670.71
169_T207_V0.5660.71
88_K91_T0.5640.71
60_D85_V0.5610.71
169_T202_S0.5600.70
112_G152_A0.5590.70
6_K195_I0.5590.70
64_G83_N0.5570.70
109_I180_L0.5570.70
25_F34_P0.5550.70
69_N92_E0.5530.69
41_I66_L0.5520.69
18_R46_V0.5520.69
155_A180_L0.5520.69
29_G55_D0.5520.69
87_G91_T0.5510.69
116_L120_L0.5510.69
46_V49_L0.5500.69
54_N78_S0.5470.69
75_L86_A0.5460.69
187_R214_E0.5450.68
135_D146_I0.5440.68
112_G149_A0.5440.68
158_N193_E0.5440.68
24_M184_A0.5330.67
44_S71_R0.5330.67
128_Q131_C0.5310.66
161_I205_M0.5260.66
6_K9_S0.5250.66
26_G34_P0.5250.66
106_A177_M0.5240.65
87_G90_M0.5240.65
33_S82_S0.5210.65
35_P219_S0.5200.65
28_F54_N0.5170.64
175_R179_P0.5170.64
80_I90_M0.5160.64
55_D81_G0.5120.64
40_A46_V0.5110.63
76_I98_Q0.5090.63
107_E114_A0.5080.63
72_V86_A0.5060.63
67_I85_V0.5050.63
105_L109_I0.5050.63
103_G127_N0.5040.62
29_G83_N0.5030.62
33_S193_E0.5020.62
75_L95_L0.5020.62
116_L144_Y0.5010.62
154_F189_F0.5010.62
55_D63_I0.5010.62
35_P42_L0.5000.62
76_I150_L0.5000.62
157_I188_T0.5000.62
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1poiA 3 0.9651 100 0.251 Contact Map
4kgbA 2 0.9825 100 0.277 Contact Map
3k6mA 2 0.9869 100 0.279 Contact Map
3cdkA 2 0.9782 100 0.28 Contact Map
3rrlA 2 0.9869 100 0.288 Contact Map
1k6dA 2 0.9563 100 0.295 Contact Map
2ahuA 3 1 100 0.31 Contact Map
2hj0A 2 0.821 100 0.546 Contact Map
1xr4A 2 0.8122 100 0.548 Contact Map
3qliA 2 0.8384 100 0.55 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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