GREMLIN Database
TCYL - L-cystine transport system permease protein TcyL
UniProt: O34315 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 239 (203)
Sequences: 29707 (18136)
Seq/√Len: 1272.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
131_A141_A3.7121.00
22_P26_Y3.5021.00
34_F105_A3.3461.00
137_S140_Q2.9931.00
100_A172_A2.9851.00
193_H196_E2.9741.00
159_G216_F2.9441.00
30_L101_V2.9271.00
139_S143_R2.6031.00
132_Y141_A2.3381.00
45_P57_A2.2431.00
214_W218_V2.2111.00
140_Q144_R2.1951.00
128_T141_A2.1491.00
67_T72_Q2.1281.00
42_L113_A2.1251.00
127_Q149_Q2.0841.00
128_T132_Y1.9441.00
52_I56_L1.9071.00
184_G201_L1.8721.00
26_Y97_F1.8661.00
23_V26_Y1.8541.00
52_I55_Q1.8531.00
43_A116_I1.8481.00
182_G186_T1.8411.00
42_L109_A1.8201.00
136_L140_Q1.8051.00
51_P55_Q1.7671.00
32_L162_V1.7381.00
40_L116_I1.7171.00
18_T22_P1.7161.00
183_R186_T1.6831.00
119_G153_Q1.6681.00
117_R121_G1.6621.00
218_V221_K1.6581.00
185_Q188_I1.6551.00
51_P54_N1.6161.00
210_V214_W1.6001.00
184_G188_I1.5921.00
37_V41_F1.5801.00
19_A22_P1.5761.00
76_V103_T1.5731.00
38_L109_A1.5731.00
180_M183_R1.5721.00
182_G185_Q1.5701.00
128_T146_V1.5391.00
137_S141_A1.5151.00
132_Y138_G1.5081.00
138_G142_F1.5071.00
28_L162_V1.5031.00
140_Q143_R1.4991.00
112_A161_M1.4951.00
138_G141_A1.4381.00
131_A136_L1.4251.00
214_W217_R1.4241.00
215_F218_V1.4121.00
101_V105_A1.4071.00
95_D98_Y1.3991.00
46_R58_K1.3971.00
184_G187_L1.3771.00
34_F101_V1.3741.00
16_T19_A1.3691.00
47_I121_G1.3211.00
206_Y210_V1.3151.00
26_Y30_L1.3081.00
58_K117_R1.2981.00
188_I194_S1.2971.00
50_I55_Q1.2951.00
39_G112_A1.2751.00
136_L144_R1.2751.00
114_E117_R1.2621.00
131_A145_I1.2621.00
179_D183_R1.2601.00
23_V177_V1.2541.00
125_K129_E1.2471.00
21_L208_V1.2411.00
112_A158_M1.2361.00
61_I113_A1.2291.00
30_L105_A1.2111.00
122_S153_Q1.2071.00
35_G108_N1.1691.00
36_F158_M1.1361.00
185_Q189_T1.1291.00
98_Y101_V1.1271.00
218_V222_R1.1201.00
72_Q107_S1.1081.00
116_I154_A1.1081.00
97_F101_V1.1071.00
41_F45_P1.0751.00
19_A23_V1.0741.00
56_L59_V1.0671.00
119_G154_A1.0551.00
186_T190_S1.0551.00
120_V146_V1.0491.00
50_I53_V1.0461.00
56_L60_Y1.0421.00
178_M182_G1.0361.00
28_L166_L1.0341.00
179_D182_G1.0341.00
54_N58_K1.0211.00
28_L169_T1.0081.00
191_S194_S1.0031.00
112_A116_I0.9961.00
47_I128_T0.9901.00
199_I202_S0.9891.00
55_Q59_V0.9871.00
115_I157_N0.9871.00
27_I172_A0.9871.00
15_P19_A0.9761.00
16_T183_R0.9701.00
184_G197_V0.9681.00
211_L215_F0.9621.00
217_R220_E0.9571.00
31_S165_S0.9511.00
94_M98_Y0.9471.00
30_L34_F0.9431.00
125_K128_T0.9421.00
198_Y201_L0.9401.00
50_I54_N0.9321.00
67_T107_S0.9311.00
31_S105_A0.9301.00
181_S184_G0.9301.00
79_G83_L0.9231.00
196_E199_I0.9201.00
115_I161_M0.9171.00
120_V150_A0.9161.00
42_L57_A0.9031.00
39_G116_I0.9021.00
200_A204_V0.9011.00
213_E217_R0.8981.00
179_D184_G0.8931.00
217_R221_K0.8911.00
45_P48_Y0.8891.00
126_G129_E0.8891.00
24_T166_L0.8861.00
153_Q157_N0.8861.00
198_Y202_S0.8841.00
44_L142_F0.8821.00
64_F106_L0.8811.00
174_S178_M0.8781.00
73_L172_A0.8721.00
33_L37_V0.8671.00
31_S104_Y0.8641.00
181_S185_Q0.8611.00
108_N161_M0.8521.00
209_A213_E0.8391.00
76_V80_I0.8291.00
188_I198_Y0.8251.00
49_N52_I0.8251.00
142_F147_L0.8171.00
123_V150_A0.8141.00
43_A120_V0.8091.00
97_F177_V0.8051.00
47_I120_V0.7981.00
130_A133_S0.7951.00
73_L103_T0.7921.00
164_S168_D0.7911.00
39_G113_A0.7871.00
142_F146_V0.7841.00
72_Q103_T0.7831.00
18_T21_L0.7761.00
180_M184_G0.7661.00
199_I203_I0.7611.00
53_V56_L0.7571.00
35_G112_A0.7551.00
32_L158_M0.7501.00
108_N165_S0.7491.00
62_S210_V0.7481.00
27_I31_S0.7461.00
75_I79_G0.7441.00
202_S205_Y0.7441.00
96_P176_G0.7421.00
27_I97_F0.7411.00
29_T33_L0.7411.00
79_G82_A0.7391.00
64_F110_A0.7331.00
72_Q76_V0.7331.00
70_M174_S0.7211.00
73_L175_I0.7201.00
123_V149_Q0.7161.00
32_L165_S0.7131.00
166_L208_V0.7051.00
55_Q58_K0.7041.00
215_F219_A0.7011.00
38_L105_A0.7011.00
28_L32_L0.7001.00
188_I191_S0.6971.00
197_V201_L0.6951.00
98_Y102_A0.6851.00
116_I120_V0.6841.00
190_S193_H0.6801.00
46_R114_E0.6761.00
45_P53_V0.6741.00
76_V81_P0.6741.00
146_V149_Q0.6701.00
57_A113_A0.6671.00
207_A211_L0.6631.00
104_Y165_S0.6601.00
43_A47_I0.6571.00
69_I168_D0.6571.00
169_T172_A0.6561.00
81_P84_T0.6561.00
187_L191_S0.6551.00
22_P25_L0.6531.00
60_Y64_F0.6521.00
186_T191_S0.6521.00
128_T138_G0.6521.00
44_L147_L0.6491.00
49_N54_N0.6471.00
170_S173_F0.6471.00
59_V62_S0.6451.00
21_L204_V0.6421.00
46_R113_A0.6361.00
123_V153_Q0.6331.00
30_L97_F0.6331.00
216_F220_E0.6311.00
96_P99_A0.6291.00
197_V200_A0.6281.00
186_T189_T0.6261.00
28_L31_S0.6211.00
201_L205_Y0.6201.00
42_L45_P0.6181.00
181_S187_L0.6181.00
123_V146_V0.6121.00
104_Y172_A0.6081.00
172_A177_V0.6081.00
30_L33_L0.6071.00
76_V99_A0.6031.00
48_Y138_G0.6021.00
78_Y81_P0.5991.00
75_I199_I0.5901.00
34_F37_V0.5901.00
157_N160_N0.5901.00
20_Y183_R0.5891.00
58_K62_S0.5881.00
26_Y29_T0.5861.00
73_L171_L0.5841.00
212_F216_F0.5831.00
23_V97_F0.5831.00
60_Y109_A0.5821.00
187_L190_S0.5801.00
26_Y98_Y0.5781.00
62_S114_E0.5771.00
195_L199_I0.5751.00
181_S186_T0.5731.00
95_D99_A0.5721.00
48_Y51_P0.5721.00
25_L29_T0.5711.00
210_V213_E0.5691.00
185_Q190_S0.5691.00
64_F72_Q0.5691.00
69_I107_S0.5661.00
182_G188_I0.5621.00
77_F99_A0.5611.00
77_F81_P0.5601.00
50_I56_L0.5601.00
192_N195_L0.5591.00
187_L197_V0.5571.00
32_L37_V0.5561.00
32_L112_A0.5541.00
31_S101_V0.5451.00
46_R54_N0.5441.00
49_N53_V0.5441.00
100_A177_V0.5411.00
94_M99_A0.5391.00
208_V212_F0.5391.00
179_D186_T0.5381.00
81_P94_M0.5381.00
184_G190_S0.5381.00
206_Y213_E0.5381.00
107_S168_D0.5371.00
93_K96_P0.5371.00
46_R49_N0.5351.00
48_Y57_A0.5341.00
136_L141_A0.5321.00
96_P177_V0.5321.00
63_F67_T0.5311.00
37_V40_L0.5311.00
185_Q192_N0.5271.00
48_Y128_T0.5261.00
183_R187_L0.5261.00
211_L214_W0.5261.00
109_A113_A0.5251.00
36_F116_I0.5241.00
80_I84_T0.5241.00
27_I100_A0.5161.00
198_Y204_V0.5141.00
203_I207_A0.5121.00
189_T192_N0.5121.00
100_A104_Y0.5121.00
151_L155_F0.5121.00
185_Q191_S0.5101.00
125_K132_Y0.5091.00
170_S205_Y0.5071.00
179_D187_L0.5061.00
43_A113_A0.5061.00
53_V57_A0.5051.00
80_I94_M0.5051.00
178_M183_R0.5041.00
108_N168_D0.5041.00
105_A109_A0.5021.00
119_G123_V0.5011.00
76_V79_G0.5011.00
179_D185_Q0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4ymuD 2 0.8996 100 0.408 Contact Map
2onkC 2 0.9163 100 0.416 Contact Map
3d31C 2 0.8996 100 0.429 Contact Map
3rlfF 1 0.8954 100 0.437 Contact Map
4tquM 1 0.9289 100 0.451 Contact Map
3rlfG 1 0.9498 99.9 0.469 Contact Map
3tuiA 2 0.8745 99.9 0.47 Contact Map
4tquN 1 0.8787 99.9 0.505 Contact Map
4mt1A 3 0.7657 22.7 0.938 Contact Map
4dx5A 3 0.7908 20.1 0.939 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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