GREMLIN Database
PLYC - Pectate lyase C
UniProt: O34310 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 221 (202)
Sequences: 509 (281)
Seq/√Len: 19.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
72_V76_A6.7931.00
44_Y51_F4.1021.00
78_L91_V3.7871.00
134_I150_A3.6691.00
79_K100_Q3.5281.00
171_I183_I3.3491.00
137_I157_I3.1781.00
129_K152_N2.9950.99
104_W112_L2.9120.99
171_I174_C2.7300.98
121_T144_T2.6940.98
50_R105_E2.6870.98
106_D129_K2.4480.97
135_F145_V2.3580.96
214_Y217_N2.3110.96
157_I169_V2.1450.93
144_T170_I2.1160.93
30_K49_Q2.0720.92
146_K172_D2.0240.91
77_T100_Q2.0100.91
213_I217_N2.0000.91
26_F82_V1.9920.90
93_T97_V1.9750.90
112_L135_F1.9570.90
32_V36_I1.9220.89
74_D96_N1.9040.88
37_I73_E1.8780.87
213_I218_N1.8130.86
168_D192_T1.7990.85
195_M198_T1.7540.84
43_T79_K1.7400.83
183_I193_V1.7040.82
172_D196_T1.6130.78
172_D197_N1.6080.78
23_S128_Q1.6050.78
26_F50_R1.6030.78
160_L163_S1.5600.76
213_I216_N1.5240.74
205_Q208_I1.4900.72
46_G70_F1.4720.71
123_D146_K1.4620.71
207_W210_V1.4550.70
123_D147_N1.4130.68
71_R94_Y1.3940.67
153_G179_M1.3450.64
100_Q123_D1.3340.63
114_V135_F1.3310.63
137_I169_V1.3240.63
107_V130_A1.3130.62
51_F70_F1.3090.62
56_E88_A1.2970.61
156_F174_C1.2950.61
30_K51_F1.2820.60
104_W148_F1.2770.60
214_Y218_N1.2700.59
35_T71_R1.2690.59
62_Q108_G1.2630.59
78_L99_I1.2550.58
68_P92_H1.2540.58
147_N173_K1.2470.58
52_V86_P1.2420.58
23_S116_K1.2380.57
167_V186_T1.2340.57
57_L60_G1.2260.57
207_W212_H1.2120.56
103_K126_S1.1960.55
89_D108_G1.1810.54
133_K136_Q1.1790.54
135_F143_F1.1650.53
162_G218_N1.1580.52
38_V46_G1.1500.52
28_A49_Q1.1190.50
55_K88_A1.1100.49
178_N202_N1.0940.48
73_E94_Y1.0890.48
64_E108_G1.0880.48
137_I193_V1.0810.47
44_Y70_F1.0720.47
64_E89_D1.0680.46
163_S167_V1.0430.45
19_Q23_S1.0280.44
27_A30_K1.0250.44
153_G176_I1.0210.43
92_H113_T1.0190.43
132_D138_N1.0190.43
150_A153_G1.0170.43
62_Q89_D1.0150.43
46_G78_L1.0080.43
156_F182_A0.9990.42
120_V143_F0.9940.42
150_A176_I0.9880.41
68_P89_D0.9870.41
98_N121_T0.9750.41
89_D92_H0.9730.40
146_K173_K0.9720.40
112_L122_I0.9680.40
149_T177_T0.9670.40
27_A82_V0.9670.40
110_D113_T0.9580.40
57_L89_D0.9420.39
64_E68_P0.9410.38
109_E138_N0.9310.38
142_T170_I0.9280.38
118_G198_T0.9270.38
143_F157_I0.9200.37
119_K144_T0.9170.37
57_L108_G0.9170.37
61_S66_Q0.9150.37
151_D177_T0.9140.37
96_N120_V0.9110.37
116_K120_V0.9000.36
130_A134_I0.8990.36
110_D132_D0.8980.36
63_S67_D0.8970.36
167_V191_S0.8970.36
58_G61_S0.8950.36
159_Q189_K0.8930.36
163_S191_S0.8870.35
145_V169_V0.8790.35
38_V72_V0.8790.35
109_E132_D0.8640.34
132_D136_Q0.8610.34
99_I112_L0.8610.34
62_Q66_Q0.8610.34
123_D144_T0.8600.34
53_A57_L0.8570.33
65_N92_H0.8570.33
43_T77_T0.8530.33
114_V120_V0.8520.33
58_G66_Q0.8390.32
189_K210_V0.8390.32
16_G19_Q0.8360.32
142_T168_D0.8340.32
58_G88_A0.8340.32
100_Q124_G0.8330.32
37_I71_R0.8330.32
133_K161_G0.8270.32
188_S191_S0.8210.31
80_N101_N0.8160.31
38_V44_Y0.8160.31
32_V81_V0.8090.31
104_W135_F0.8080.31
23_S26_F0.8030.30
26_F48_G0.8020.30
157_I193_V0.8010.30
109_E158_R0.8000.30
60_G89_D0.8000.30
37_I94_Y0.7980.30
186_T189_K0.7980.30
15_M18_S0.7950.30
163_S186_T0.7910.30
37_I41_N0.7890.30
186_T191_S0.7840.29
147_N197_N0.7820.29
109_E136_Q0.7810.29
160_L186_T0.7800.29
53_A89_D0.7790.29
187_D209_G0.7740.29
70_F78_L0.7690.29
118_G195_M0.7630.28
160_L191_S0.7630.28
19_Q27_A0.7620.28
184_F210_V0.7600.28
46_G101_N0.7540.28
32_V38_V0.7500.28
114_V122_I0.7480.28
79_K123_D0.7480.28
36_I44_Y0.7400.27
21_Q149_T0.7370.27
160_L188_S0.7330.27
206_K210_V0.7280.27
51_F91_V0.7270.26
47_K78_L0.7260.26
160_L167_V0.7220.26
62_Q67_D0.7170.26
23_S82_V0.7160.26
182_A195_M0.7130.26
53_A108_G0.7120.26
101_N124_G0.7080.26
171_I195_M0.7070.25
31_V55_K0.7070.25
137_I183_I0.7070.25
59_D67_D0.7050.25
30_K173_K0.7010.25
50_R112_L0.7000.25
145_V171_I0.7000.25
57_L62_Q0.7000.25
127_A148_F0.6990.25
125_G148_F0.6970.25
215_E218_N0.6960.25
59_D66_Q0.6960.25
153_G156_F0.6950.25
31_V52_V0.6940.25
181_E210_V0.6900.25
184_F207_W0.6890.25
150_A154_G0.6870.25
140_A165_F0.6840.24
133_K138_N0.6830.24
144_T196_T0.6810.24
132_D155_K0.6790.24
110_D136_Q0.6690.24
173_K201_S0.6680.24
126_S141_S0.6660.24
53_A69_V0.6660.24
166_H189_K0.6660.24
142_T194_R0.6650.23
60_G108_G0.6640.23
53_A64_E0.6620.23
35_T135_F0.6600.23
87_A108_G0.6580.23
112_L148_F0.6570.23
53_A87_A0.6520.23
164_T217_N0.6510.23
187_D211_Q0.6410.22
171_I176_I0.6390.22
67_D218_N0.6360.22
28_A48_G0.6350.22
153_G180_K0.6340.22
53_A62_Q0.6310.22
162_G188_S0.6250.22
15_M192_T0.6240.22
28_A147_N0.6240.22
84_G130_A0.6220.22
140_A168_D0.6180.21
107_V110_D0.6160.21
163_S188_S0.6160.21
97_V191_S0.6120.21
82_V103_K0.6070.21
169_V193_V0.6070.21
164_T204_G0.6060.21
62_Q68_P0.6050.21
175_T199_R0.6050.21
48_G101_N0.6020.21
36_I180_K0.6020.21
60_G64_E0.6020.21
176_I179_M0.6020.21
57_L87_A0.6010.21
70_F81_V0.6000.21
200_Y203_V0.5990.21
149_T175_T0.5950.20
93_T191_S0.5880.20
35_T108_G0.5880.20
26_F105_E0.5880.20
57_L64_E0.5870.20
38_V81_V0.5860.20
82_V141_S0.5860.20
146_K170_I0.5850.20
132_D154_G0.5830.20
202_N217_N0.5830.20
93_T163_S0.5810.20
62_Q87_A0.5800.20
132_D158_R0.5770.20
106_D138_N0.5750.20
92_H110_D0.5710.19
189_K214_Y0.5700.19
58_G63_S0.5700.19
46_G51_F0.5690.19
182_A186_T0.5670.19
130_A150_A0.5650.19
138_N154_G0.5640.19
46_G49_Q0.5630.19
35_T62_Q0.5610.19
35_T89_D0.5590.19
110_D158_R0.5560.19
41_N74_D0.5530.19
185_R210_V0.5520.19
137_I206_K0.5510.19
85_A106_D0.5490.19
32_V76_A0.5480.18
32_V37_I0.5470.18
115_K155_K0.5470.18
83_L141_S0.5450.18
57_L88_A0.5450.18
145_V155_K0.5430.18
25_V82_V0.5430.18
43_T166_H0.5420.18
118_G199_R0.5410.18
138_N155_K0.5400.18
91_V102_V0.5390.18
18_S22_P0.5350.18
52_V81_V0.5340.18
159_Q163_S0.5340.18
66_Q108_G0.5330.18
165_F168_D0.5300.18
25_V33_H0.5290.18
167_V184_F0.5230.18
93_T167_V0.5220.18
26_F115_K0.5210.17
163_S190_T0.5210.17
170_I192_T0.5200.17
93_T141_S0.5190.17
34_E173_K0.5190.17
106_D109_E0.5180.17
130_A153_G0.5140.17
52_V108_G0.5130.17
150_A182_A0.5120.17
107_V158_R0.5120.17
191_S207_W0.5080.17
83_L126_S0.5070.17
22_P34_E0.5060.17
114_V117_E0.5040.17
36_I189_K0.5030.17
65_N94_Y0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ee6A 1 0.8643 100 0.181 Contact Map
3t9gA 3 0.8869 100 0.203 Contact Map
3b4nA 1 0.9005 100 0.248 Contact Map
4u49A 1 0.9367 100 0.251 Contact Map
1czfA 2 0.8009 94.5 0.933 Contact Map
2uvfA 2 0.9955 91.8 0.939 Contact Map
1rmgA 1 0.9412 89.5 0.942 Contact Map
1ogoX 1 0.9231 88.7 0.943 Contact Map
1ia5A 1 0.9457 84.7 0.947 Contact Map
1bheA 1 0.9186 81.7 0.948 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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