GREMLIN Database
YTOQ - Uncharacterized protein YtoQ
UniProt: O34305 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 148 (145)
Sequences: 268 (126)
Seq/√Len: 10.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
10_E13_S4.9761.00
53_Q62_K3.7250.98
23_T32_F3.2590.96
116_L119_P3.0400.94
4_I33_V2.8830.92
78_A81_V2.5700.87
36_M41_R2.4470.84
44_N59_K2.3780.82
18_E135_N2.3110.80
61_D65_D2.2010.76
29_P145_F2.1420.74
13_S119_P2.1080.73
47_E63_A2.1040.73
21_E24_K1.9520.67
124_S130_T1.9010.65
72_A76_N1.7950.60
69_F144_L1.7810.59
2_E31_T1.7320.57
59_K63_A1.6980.56
56_A59_K1.6180.52
45_I63_A1.5370.48
102_I123_L1.5300.48
110_I141_L1.5240.48
117_H132_E1.4980.46
74_L144_L1.4930.46
35_P78_A1.4750.45
45_I101_A1.4720.45
135_N142_S1.4650.45
66_I140_A1.4640.45
114_E132_E1.4500.44
45_I66_I1.4400.44
22_K135_N1.4180.43
29_P80_F1.3980.42
20_K32_F1.3960.42
35_P81_V1.3840.41
87_E119_P1.3780.41
18_E134_V1.3730.41
50_M66_I1.3620.40
80_F87_E1.3540.40
3_F80_F1.3450.39
101_A108_L1.3210.38
111_I131_V1.3190.38
73_V107_P1.3050.38
49_I101_A1.2860.37
113_P116_L1.2730.36
80_F141_L1.2700.36
22_K138_I1.2680.36
26_L142_S1.2620.36
27_K56_A1.2420.35
94_T99_S1.2320.34
81_V101_A1.2300.34
71_T74_L1.2300.34
47_E130_T1.2280.34
52_V135_N1.2150.34
72_A81_V1.2140.34
36_M76_N1.1910.33
47_E116_L1.1720.32
83_A101_A1.1550.31
30_I138_I1.1470.31
65_D88_K1.1330.30
3_F145_F1.1250.30
4_I106_K1.1140.30
45_I107_P1.1110.29
3_F144_L1.1090.29
72_A99_S1.1080.29
14_N141_L1.1050.29
77_K107_P1.0980.29
20_K138_I1.0900.29
71_T144_L1.0840.28
63_A130_T1.0600.28
129_I140_A1.0540.27
19_I73_V1.0420.27
19_I105_G1.0390.27
14_N18_E1.0280.26
65_D125_N1.0230.26
30_I114_E1.0200.26
33_V74_L1.0090.26
48_E140_A1.0080.26
31_T104_K1.0080.26
5_V18_E1.0030.25
36_M58_L1.0030.25
37_E111_I0.9770.25
99_S130_T0.9770.25
84_L126_K0.9610.24
21_E25_S0.9540.24
13_S36_M0.9360.23
119_P134_V0.9290.23
21_E52_V0.9200.23
20_K37_E0.9150.22
101_A130_T0.9100.22
5_V30_I0.9000.22
117_H139_K0.8930.22
49_I81_V0.8810.21
13_S38_N0.8600.21
38_N41_R0.8580.21
28_L89_Y0.8500.20
21_E77_K0.8490.20
45_I49_I0.8460.20
45_I130_T0.8420.20
110_I130_T0.8420.20
48_E59_K0.8360.20
47_E101_A0.8350.20
61_D125_N0.8250.20
56_A140_A0.8210.20
44_N48_E0.8110.19
41_R74_L0.8060.19
2_E20_K0.8020.19
73_V77_K0.8000.19
24_K142_S0.7970.19
80_F109_I0.7910.19
63_A101_A0.7870.19
17_E21_E0.7830.18
57_V117_H0.7810.18
37_E123_L0.7810.18
4_I135_N0.7780.18
44_N56_A0.7690.18
47_E117_H0.7680.18
48_E139_K0.7670.18
31_T52_V0.7590.18
40_D102_I0.7550.18
44_N101_A0.7440.17
4_I90_K0.7430.17
88_K142_S0.7400.17
24_K135_N0.7390.17
72_A116_L0.7390.17
57_V61_D0.7360.17
21_E75_M0.7340.17
34_G123_L0.7310.17
99_S103_A0.7310.17
20_K78_A0.7300.17
24_K77_K0.7260.17
81_V108_L0.7250.17
10_E105_G0.7240.17
36_M57_V0.7190.17
38_N76_N0.7150.17
24_K40_D0.7140.17
94_T124_S0.7120.17
80_F145_F0.7120.17
72_A82_I0.7080.16
30_I80_F0.7000.16
3_F74_L0.6970.16
41_R140_A0.6960.16
61_D129_I0.6960.16
54_P108_L0.6950.16
26_L139_K0.6920.16
59_K116_L0.6860.16
34_G37_E0.6850.16
57_V129_I0.6800.16
4_I75_M0.6760.16
31_T76_N0.6740.16
107_P117_H0.6720.16
30_I129_I0.6710.16
72_A128_N0.6690.15
21_E142_S0.6680.15
29_P109_I0.6680.15
3_F132_E0.6670.15
25_S139_K0.6640.15
57_V65_D0.6620.15
69_F140_A0.6610.15
64_S71_T0.6540.15
47_E59_K0.6530.15
50_M131_V0.6500.15
80_F130_T0.6480.15
25_S80_F0.6430.15
49_I108_L0.6390.15
44_N108_L0.6330.15
5_V29_P0.6290.15
10_E80_F0.6290.15
44_N49_I0.6280.14
111_I123_L0.6260.14
26_L36_M0.6240.14
128_N140_A0.6230.14
36_M117_H0.6200.14
22_K84_L0.6170.14
52_V55_N0.6090.14
49_I63_A0.6060.14
99_S126_K0.6050.14
10_E26_L0.6020.14
137_A142_S0.6010.14
68_N71_T0.5910.14
1_M47_E0.5870.14
23_T53_Q0.5840.13
55_N114_E0.5830.13
3_F134_V0.5780.13
108_L130_T0.5780.13
45_I81_V0.5770.13
32_F114_E0.5700.13
1_M63_A0.5580.13
18_E21_E0.5570.13
88_K115_S0.5570.13
94_T123_L0.5470.13
21_E31_T0.5450.13
59_K90_K0.5440.13
115_S134_V0.5420.13
33_V78_A0.5390.13
74_L119_P0.5370.12
19_I138_I0.5360.12
88_K103_A0.5350.12
31_T119_P0.5310.12
8_A112_R0.5190.12
13_S115_S0.5180.12
10_E138_I0.5170.12
22_K25_S0.5160.12
37_E73_V0.5140.12
59_K117_H0.5080.12
44_N63_A0.5080.12
69_F115_S0.5070.12
141_L144_L0.5040.12
75_M99_S0.5040.12
87_E116_L0.5030.12
8_A84_L0.5020.12
5_V17_E0.5010.12
45_I59_K0.5010.12
11_I43_D0.5000.12
11_I39_H0.5000.12
39_H93_N0.5000.12
11_I93_N0.5000.12
39_H43_D0.5000.12
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4jenA 2 0.7568 99.8 0.747 Contact Map
1s2dA 5 0.9527 99.7 0.766 Contact Map
4p5eA 2 0.8649 99.7 0.781 Contact Map
4jelA 2 0.8581 99.5 0.8 Contact Map
4ohrA 2 0.8581 99.5 0.803 Contact Map
1eiwA 1 0.7095 99.4 0.812 Contact Map
4jemA 2 0.8581 99.4 0.815 Contact Map
1f8yA 5 0.9122 99.4 0.819 Contact Map
3ehdA 4 0.8784 99.2 0.831 Contact Map
2f62A 2 0.8311 98.1 0.886 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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