RAPG - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

RAPG - Response regulator aspartate phosphatase G

UniProt:	O32294	Sequences: MNKIAPAEIASMLNDWYLAIKKHEVEESSRLFEEVKPLLDDMEEDQEVLAYFSLLELRHKVLLHEARGQGFQHEEPSHMNATSDMLKYYFFLFEGMYEAYKNNYDIAIGLYKDAEQYLDNIPDPIEKAEFHLKVGKLYYKLGQNIVSLNHTRQAVKTFREETDYKKKLASALITMSGNFTEMSQFEEAEAYLDEAIRITSELEDHFFEAQLLHNFGLLHAQSGKSEEAVSKLEEALQNDEYARSAYYYHSAYLLIRELFKIKKKEQALSYYQDVKEKLTAEPNRICEAKIDILYAIYAEGGHAETFHLCKQHMDDLLSEKEYDSVRELSILAGERYRELELYKEAAHFFYEALQIEELIKRTEVI	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	365 (298)
Sequences:	1806 (1661)
Seq/√Len:	96.2

ECOLI - LPSRP HEMY NLPI YBEQ
BACSU - RAPG RAPK RAPB RAPH RAPJ RAPF RAPA RAPE RAPC RAPI RAPD YVCD YPIA
HALSA - Q9HMM8
SULSO - Q97V36 Q97WM3 Q97VC4 Q97ZS3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
263_K	266_Q	4.916	1.00
224_K	227_E	4.440	1.00
135_G	151_T	4.315	1.00
216_G	232_L	4.182	1.00
143_Q	146_V	4.041	1.00
341_L	344_E	3.994	1.00
184_Q	187_E	3.981	1.00
176_S	192_L	3.465	1.00
103_N	106_I	3.363	1.00
131_H	150_H	3.354	1.00
148_L	175_M	3.034	1.00
95_G	111_Y	2.899	1.00
95_G	114_A	2.744	1.00
189_E	215_F	2.677	1.00
332_A	336_Y	2.574	1.00
333_G	349_F	2.535	1.00
255_I	271_Y	2.517	1.00
212_L	231_K	2.420	1.00
134_V	150_H	2.311	1.00
266_Q	269_S	2.307	1.00
219_H	227_E	2.253	1.00
232_L	253_L	2.251	1.00
111_Y	133_K	2.233	1.00
212_L	234_E	2.226	1.00
258_L	263_K	2.195	1.00
94_E	98_E	2.187	1.00
229_V	257_E	2.173	1.00
179_F	187_E	2.171	1.00
251_A	270_Y	2.126	1.00
227_E	230_S	2.090	1.00
229_V	261_I	2.017	1.00
91_F	113_D	1.988	1.00
148_L	178_N	1.988	1.00
229_V	254_L	1.959	1.00
98_E	103_N	1.957	1.00
180_T	192_L	1.945	1.00
258_L	266_Q	1.927	1.00
138_Y	146_V	1.906	1.00
344_E	347_H	1.899	1.00
98_E	106_I	1.892	1.00
347_H	351_E	1.872	1.00
91_F	110_L	1.865	1.00
95_G	110_L	1.851	1.00
187_E	190_A	1.827	1.00
131_H	153_Q	1.768	1.00
108_I	138_Y	1.764	1.00
336_Y	344_E	1.751	1.00
301_G	304_E	1.748	1.00
193_D	215_F	1.705	1.00
215_F	219_H	1.701	1.00
251_A	273_D	1.686	1.00
337_R	350_Y	1.669	1.00
132_L	174_T	1.668	1.00
229_V	233_E	1.667	1.00
151_T	174_T	1.664	1.00
169_A	199_T	1.646	1.00
172_L	191_Y	1.632	1.00
189_E	218_L	1.628	1.00
226_E	261_I	1.627	1.00
229_V	258_L	1.615	1.00
215_F	231_K	1.590	1.00
88_Y	114_A	1.588	1.00
153_Q	156_K	1.587	1.00
293_L	300_G	1.583	1.00
216_G	231_K	1.574	1.00
175_M	179_F	1.562	1.00
172_L	194_E	1.556	1.00
189_E	222_S	1.547	1.00
155_V	172_L	1.527	1.00
329_S	348_F	1.510	1.00
257_E	261_I	1.507	1.00
99_A	111_Y	1.440	1.00
254_L	258_L	1.433	1.00
255_I	274_V	1.429	1.00
254_L	270_Y	1.426	1.00
173_I	214_N	1.423	1.00
192_L	214_N	1.419	1.00
233_E	254_L	1.402	0.99
169_A	195_A	1.396	0.99
65_E	68_G	1.392	0.99
336_Y	341_L	1.380	0.99
317_L	351_E	1.375	0.99
177_G	192_L	1.354	0.99
112_K	134_V	1.343	0.99
225_S	257_E	1.331	0.99
216_G	235_A	1.313	0.99
152_R	175_M	1.312	0.99
114_A	117_Y	1.305	0.99
186_E	222_S	1.298	0.99
128_A	154_A	1.279	0.99
329_S	351_E	1.274	0.99
127_K	131_H	1.268	0.99
115_E	131_H	1.259	0.99
106_I	109_G	1.246	0.99
179_F	184_Q	1.233	0.99
209_A	235_A	1.233	0.99
296_I	304_E	1.229	0.99
134_V	138_Y	1.217	0.98
328_L	332_A	1.205	0.98
180_T	218_L	1.202	0.98
196_I	212_L	1.200	0.98
189_E	193_D	1.199	0.98
335_R	338_E	1.190	0.98
253_L	256_R	1.174	0.98
60_K	65_E	1.173	0.98
135_G	154_A	1.163	0.98
231_K	235_A	1.148	0.98
233_E	266_Q	1.146	0.98
189_E	219_H	1.144	0.98
212_L	235_A	1.140	0.98
88_Y	92_L	1.123	0.97
337_R	349_F	1.120	0.97
44_E	48_V	1.108	0.97
208_E	212_L	1.104	0.97
213_H	250_S	1.093	0.97
219_H	224_K	1.092	0.97
216_G	228_A	1.082	0.97
46_Q	49_L	1.082	0.97
128_A	158_F	1.079	0.97
60_K	64_H	1.068	0.96
333_G	352_A	1.066	0.96
269_S	273_D	1.033	0.96
150_H	154_A	1.031	0.96
220_A	232_L	1.026	0.96
200_S	208_E	1.023	0.96
333_G	345_A	1.022	0.95
236_L	247_Y	1.022	0.95
98_E	110_L	1.021	0.95
235_A	250_S	1.015	0.95
94_E	110_L	1.014	0.95
138_Y	150_H	1.009	0.95
234_E	237_Q	1.008	0.95
155_V	168_L	1.006	0.95
258_L	270_Y	0.999	0.95
176_S	191_Y	0.999	0.95
175_M	191_Y	0.996	0.95
173_I	211_L	0.994	0.95
154_A	157_T	0.989	0.95
293_L	305_T	0.986	0.95
114_A	130_F	0.981	0.94
91_F	114_A	0.970	0.94
344_E	348_F	0.969	0.94
178_N	182_M	0.958	0.94
199_T	208_E	0.957	0.94
113_D	116_Q	0.954	0.94
196_I	208_E	0.954	0.94
292_I	296_I	0.950	0.93
264_K	268_L	0.950	0.93
306_F	309_C	0.948	0.93
96_M	111_Y	0.939	0.93
239_D	247_Y	0.938	0.93
189_E	192_L	0.927	0.93
152_R	187_E	0.922	0.92
334_E	350_Y	0.921	0.92
307_H	311_Q	0.920	0.92
61_V	65_E	0.918	0.92
108_I	137_L	0.917	0.92
325_V	329_S	0.916	0.92
348_F	352_A	0.915	0.92
135_G	174_T	0.908	0.92
51_Y	55_L	0.908	0.92
95_G	99_A	0.904	0.92
272_Q	292_I	0.904	0.92
213_H	253_L	0.904	0.92
215_F	254_L	0.902	0.91
137_L	141_L	0.897	0.91
289_K	293_L	0.897	0.91
216_G	254_L	0.897	0.91
172_L	251_A	0.896	0.91
259_F	271_Y	0.891	0.91
236_L	250_S	0.890	0.91
248_Y	255_I	0.870	0.90
333_G	337_R	0.868	0.90
346_A	350_Y	0.866	0.90
148_L	179_F	0.864	0.90
171_A	174_T	0.863	0.90
111_Y	271_Y	0.860	0.89
188_A	192_L	0.855	0.89
132_L	171_A	0.854	0.89
300_G	305_T	0.854	0.89
174_T	214_N	0.850	0.89
115_E	127_K	0.849	0.89
314_D	317_L	0.849	0.89
173_I	192_L	0.849	0.89
236_L	251_A	0.847	0.89
331_L	334_E	0.841	0.88
91_F	172_L	0.838	0.88
147_S	178_N	0.838	0.88
108_I	134_V	0.836	0.88
145_I	182_M	0.835	0.88
149_N	153_Q	0.832	0.88
148_L	182_M	0.821	0.87
274_V	277_K	0.816	0.87
69_Q	73_H	0.812	0.87
335_R	339_L	0.812	0.87
233_E	259_F	0.806	0.86
46_Q	55_L	0.801	0.86
119_D	127_K	0.801	0.86
92_L	133_K	0.801	0.86
131_H	154_A	0.800	0.86
214_N	217_L	0.799	0.86
196_I	215_F	0.797	0.85
130_F	133_K	0.796	0.85
333_G	348_F	0.795	0.85
309_C	313_M	0.791	0.85
239_D	250_S	0.787	0.85
190_A	194_E	0.779	0.84
272_Q	304_E	0.775	0.84
296_I	301_G	0.772	0.84
139_Y	151_T	0.769	0.83
52_F	58_R	0.769	0.83
168_L	198_I	0.766	0.83
77_S	81_A	0.764	0.83
173_I	195_A	0.758	0.83
213_H	257_E	0.757	0.82
177_G	214_N	0.756	0.82
138_Y	143_Q	0.755	0.82
312_H	319_E	0.754	0.82
295_A	299_E	0.749	0.82
142_G	183_S	0.748	0.82
138_Y	141_L	0.743	0.81
289_K	324_S	0.743	0.81
275_K	278_L	0.742	0.81
60_K	69_Q	0.738	0.81
51_Y	59_H	0.732	0.80
151_T	155_V	0.731	0.80
336_Y	340_E	0.727	0.80
111_Y	132_L	0.726	0.80
97_Y	101_K	0.726	0.80
54_L	58_R	0.723	0.79
154_A	171_A	0.723	0.79
236_L	270_Y	0.722	0.79
295_A	300_G	0.721	0.79
128_A	132_L	0.720	0.79
56_E	60_K	0.720	0.79
126_E	135_G	0.719	0.79
71_F	75_E	0.719	0.79
113_D	287_E	0.717	0.79
115_E	130_F	0.716	0.79
205_H	208_E	0.715	0.79
133_K	136_K	0.714	0.79
159_R	168_L	0.712	0.78
173_I	177_G	0.711	0.78
226_E	229_V	0.710	0.78
311_Q	315_D	0.707	0.78
195_A	198_I	0.706	0.78
199_T	207_F	0.705	0.78
52_F	56_E	0.700	0.77
334_E	349_F	0.698	0.77
166_K	204_D	0.697	0.77
48_V	52_F	0.697	0.77
96_M	133_K	0.696	0.77
95_G	137_L	0.694	0.77
55_L	60_K	0.694	0.77
217_L	253_L	0.693	0.77
105_D	141_L	0.692	0.76
315_D	318_S	0.692	0.76
155_V	171_A	0.691	0.76
99_A	137_L	0.691	0.76
209_A	250_S	0.690	0.76
107_A	111_Y	0.689	0.76
235_A	238_N	0.689	0.76
112_K	138_Y	0.687	0.76
252_Y	256_R	0.686	0.76
59_H	62_L	0.683	0.75
47_E	51_Y	0.683	0.75
279_T	284_R	0.682	0.75
54_L	59_H	0.682	0.75
305_T	312_H	0.681	0.75
60_K	68_G	0.681	0.75
312_H	315_D	0.680	0.75
305_T	316_L	0.680	0.75
236_L	254_L	0.676	0.75
217_L	220_A	0.674	0.75
308_L	312_H	0.672	0.74
91_F	117_Y	0.670	0.74
108_I	141_L	0.669	0.74
158_F	171_A	0.667	0.74
308_L	311_Q	0.665	0.74
60_K	66_A	0.665	0.74
138_Y	153_Q	0.664	0.73
168_L	172_L	0.663	0.73
309_C	316_L	0.663	0.73
220_A	253_L	0.662	0.73
132_L	252_Y	0.662	0.73
270_Y	274_V	0.662	0.73
89_Y	93_F	0.661	0.73
90_F	97_Y	0.659	0.73
316_L	328_L	0.659	0.73
176_S	195_A	0.658	0.73
293_L	297_Y	0.658	0.73
235_A	274_V	0.656	0.73
151_T	175_M	0.653	0.72
71_F	74_E	0.653	0.72
118_L	123_D	0.650	0.72
105_D	137_L	0.649	0.72
296_I	299_E	0.646	0.71
329_S	352_A	0.646	0.71
49_L	54_L	0.645	0.71
228_A	257_E	0.642	0.71
48_V	51_Y	0.641	0.71
50_A	56_E	0.640	0.71
204_D	208_E	0.636	0.70
346_A	349_F	0.634	0.70
136_K	140_K	0.633	0.70
146_V	149_N	0.632	0.70
199_T	206_F	0.632	0.70
228_A	250_S	0.632	0.70
230_S	234_E	0.632	0.70
52_F	59_H	0.631	0.70
340_E	349_F	0.630	0.69
57_L	73_H	0.629	0.69
310_K	340_E	0.627	0.69
92_L	96_M	0.627	0.69
267_A	295_A	0.623	0.69
289_K	311_Q	0.622	0.69
350_Y	354_Q	0.622	0.69
180_T	188_A	0.622	0.69
139_Y	178_N	0.621	0.68
293_L	296_I	0.621	0.68
55_L	58_R	0.620	0.68
265_E	268_L	0.618	0.68
274_V	278_L	0.618	0.68
309_C	312_H	0.618	0.68
216_G	219_H	0.612	0.67
103_N	283_N	0.611	0.67
185_F	189_E	0.610	0.67
51_Y	56_E	0.609	0.67
51_Y	58_R	0.608	0.67
169_A	198_I	0.606	0.67
179_F	191_Y	0.605	0.66
232_L	257_E	0.604	0.66
297_Y	331_L	0.603	0.66
135_G	178_N	0.603	0.66
255_I	267_A	0.602	0.66
305_T	335_R	0.601	0.66
60_K	63_L	0.600	0.66
58_R	61_V	0.599	0.66
149_N	152_R	0.597	0.65
170_S	173_I	0.597	0.65
72_Q	75_E	0.597	0.65
270_Y	273_D	0.596	0.65
88_Y	95_G	0.593	0.65
307_H	310_K	0.591	0.65
297_Y	309_C	0.590	0.64
351_E	354_Q	0.589	0.64
188_A	218_L	0.589	0.64
69_Q	72_Q	0.588	0.64
218_L	222_S	0.588	0.64
93_F	97_Y	0.588	0.64
273_D	277_K	0.587	0.64
339_L	348_F	0.587	0.64
46_Q	50_A	0.586	0.64
217_L	232_L	0.585	0.64
176_S	188_A	0.585	0.64
227_E	266_Q	0.585	0.64
275_K	279_T	0.584	0.64
332_A	348_F	0.583	0.64
349_F	353_L	0.583	0.64
333_G	346_A	0.582	0.63
56_E	65_E	0.581	0.63
68_G	72_Q	0.580	0.63
193_D	227_E	0.580	0.63
278_L	282_P	0.578	0.63
325_V	332_A	0.575	0.62
57_L	64_H	0.574	0.62
222_S	235_A	0.574	0.62
185_F	225_S	0.573	0.62
347_H	350_Y	0.571	0.62
224_K	230_S	0.571	0.62
111_Y	137_L	0.571	0.62
82_T	86_L	0.568	0.62
176_S	214_N	0.567	0.61
116_Q	119_D	0.567	0.61
53_S	60_K	0.567	0.61
167_K	170_S	0.566	0.61
297_Y	302_H	0.566	0.61
228_A	232_L	0.564	0.61
213_H	216_G	0.564	0.61
59_H	63_L	0.562	0.61
46_Q	53_S	0.560	0.60
306_F	332_A	0.559	0.60
110_L	114_A	0.559	0.60
293_L	301_G	0.558	0.60
45_D	53_S	0.558	0.60
239_D	343_K	0.554	0.60
47_E	50_A	0.554	0.60
220_A	257_E	0.554	0.60
86_L	89_Y	0.552	0.59
155_V	159_R	0.552	0.59
44_E	49_L	0.551	0.59
118_L	130_F	0.551	0.59
135_G	140_K	0.549	0.59
51_Y	54_L	0.549	0.59
189_E	268_L	0.548	0.59
159_R	194_E	0.546	0.59
45_D	52_F	0.541	0.58
210_Q	214_N	0.540	0.58
54_L	62_L	0.539	0.58
272_Q	276_E	0.537	0.57
50_A	53_S	0.537	0.57
99_A	133_K	0.536	0.57
54_L	57_L	0.536	0.57
57_L	60_K	0.535	0.57
291_D	294_Y	0.534	0.57
112_K	146_V	0.533	0.57
311_Q	314_D	0.533	0.57
44_E	56_E	0.531	0.56
312_H	316_L	0.531	0.56
54_L	61_V	0.529	0.56
309_C	328_L	0.527	0.56
51_Y	57_L	0.525	0.56
51_Y	65_E	0.524	0.55
152_R	156_K	0.523	0.55
289_K	292_I	0.522	0.55
325_V	335_R	0.519	0.55
87_K	91_F	0.519	0.55
193_D	197_R	0.518	0.55
62_L	68_G	0.518	0.55
46_Q	51_Y	0.517	0.54
119_D	153_Q	0.517	0.54
339_L	342_Y	0.517	0.54
141_L	178_N	0.516	0.54
310_K	314_D	0.516	0.54
306_F	335_R	0.515	0.54
110_L	231_K	0.514	0.54
48_V	55_L	0.514	0.54
192_L	215_F	0.513	0.54
87_K	263_K	0.512	0.54
93_F	96_M	0.512	0.54
56_E	182_M	0.512	0.54
48_V	56_E	0.512	0.54
226_E	230_S	0.512	0.54
158_F	176_S	0.512	0.54
135_G	150_H	0.511	0.54
63_L	69_Q	0.511	0.54
90_F	94_E	0.509	0.53
226_E	263_K	0.509	0.53
88_Y	118_L	0.508	0.53
290_I	316_L	0.508	0.53
52_F	55_L	0.506	0.53
56_E	66_A	0.505	0.53
179_F	190_A	0.504	0.53
136_K	151_T	0.503	0.53
225_S	261_I	0.502	0.52
260_K	263_K	0.500	0.52
348_F	351_E	0.500	0.52

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3ulqA	1	0.9781	100	0.221	Contact Map
4i1aA	2	0.9589	100	0.222	Contact Map
3q15A	2	0.9781	100	0.225	Contact Map
4gyoA	2	0.9726	100	0.228	Contact Map
4gpkA	3	0.9479	100	0.274	Contact Map
3sf4A	1	0.874	100	0.367	Contact Map
1w3bA	2	0.863	100	0.376	Contact Map
3ro2A	1	0.8466	100	0.378	Contact Map
4a1sA	1	0.8466	100	0.387	Contact Map
4l9pA	1	0.7534	100	0.387	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0092 seconds.