GREMLIN Database
RAPG - Response regulator aspartate phosphatase G
UniProt: O32294 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 365 (298)
Sequences: 1806 (1661)
Seq/√Len: 96.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
263_K266_Q4.9161.00
224_K227_E4.4401.00
135_G151_T4.3151.00
216_G232_L4.1821.00
143_Q146_V4.0411.00
341_L344_E3.9941.00
184_Q187_E3.9811.00
176_S192_L3.4651.00
103_N106_I3.3631.00
131_H150_H3.3541.00
148_L175_M3.0341.00
95_G111_Y2.8991.00
95_G114_A2.7441.00
189_E215_F2.6771.00
332_A336_Y2.5741.00
333_G349_F2.5351.00
255_I271_Y2.5171.00
212_L231_K2.4201.00
134_V150_H2.3111.00
266_Q269_S2.3071.00
219_H227_E2.2531.00
232_L253_L2.2511.00
111_Y133_K2.2331.00
212_L234_E2.2261.00
258_L263_K2.1951.00
94_E98_E2.1871.00
229_V257_E2.1731.00
179_F187_E2.1711.00
251_A270_Y2.1261.00
227_E230_S2.0901.00
229_V261_I2.0171.00
91_F113_D1.9881.00
148_L178_N1.9881.00
229_V254_L1.9591.00
98_E103_N1.9571.00
180_T192_L1.9451.00
258_L266_Q1.9271.00
138_Y146_V1.9061.00
344_E347_H1.8991.00
98_E106_I1.8921.00
347_H351_E1.8721.00
91_F110_L1.8651.00
95_G110_L1.8511.00
187_E190_A1.8271.00
131_H153_Q1.7681.00
108_I138_Y1.7641.00
336_Y344_E1.7511.00
301_G304_E1.7481.00
193_D215_F1.7051.00
215_F219_H1.7011.00
251_A273_D1.6861.00
337_R350_Y1.6691.00
132_L174_T1.6681.00
229_V233_E1.6671.00
151_T174_T1.6641.00
169_A199_T1.6461.00
172_L191_Y1.6321.00
189_E218_L1.6281.00
226_E261_I1.6271.00
229_V258_L1.6151.00
215_F231_K1.5901.00
88_Y114_A1.5881.00
153_Q156_K1.5871.00
293_L300_G1.5831.00
216_G231_K1.5741.00
175_M179_F1.5621.00
172_L194_E1.5561.00
189_E222_S1.5471.00
155_V172_L1.5271.00
329_S348_F1.5101.00
257_E261_I1.5071.00
99_A111_Y1.4401.00
254_L258_L1.4331.00
255_I274_V1.4291.00
254_L270_Y1.4261.00
173_I214_N1.4231.00
192_L214_N1.4191.00
233_E254_L1.4020.99
169_A195_A1.3960.99
65_E68_G1.3920.99
336_Y341_L1.3800.99
317_L351_E1.3750.99
177_G192_L1.3540.99
112_K134_V1.3430.99
225_S257_E1.3310.99
216_G235_A1.3130.99
152_R175_M1.3120.99
114_A117_Y1.3050.99
186_E222_S1.2980.99
128_A154_A1.2790.99
329_S351_E1.2740.99
127_K131_H1.2680.99
115_E131_H1.2590.99
106_I109_G1.2460.99
179_F184_Q1.2330.99
209_A235_A1.2330.99
296_I304_E1.2290.99
134_V138_Y1.2170.98
328_L332_A1.2050.98
180_T218_L1.2020.98
196_I212_L1.2000.98
189_E193_D1.1990.98
335_R338_E1.1900.98
253_L256_R1.1740.98
60_K65_E1.1730.98
135_G154_A1.1630.98
231_K235_A1.1480.98
233_E266_Q1.1460.98
189_E219_H1.1440.98
212_L235_A1.1400.98
88_Y92_L1.1230.97
337_R349_F1.1200.97
44_E48_V1.1080.97
208_E212_L1.1040.97
213_H250_S1.0930.97
219_H224_K1.0920.97
216_G228_A1.0820.97
46_Q49_L1.0820.97
128_A158_F1.0790.97
60_K64_H1.0680.96
333_G352_A1.0660.96
269_S273_D1.0330.96
150_H154_A1.0310.96
220_A232_L1.0260.96
200_S208_E1.0230.96
333_G345_A1.0220.95
236_L247_Y1.0220.95
98_E110_L1.0210.95
235_A250_S1.0150.95
94_E110_L1.0140.95
138_Y150_H1.0090.95
234_E237_Q1.0080.95
155_V168_L1.0060.95
258_L270_Y0.9990.95
176_S191_Y0.9990.95
175_M191_Y0.9960.95
173_I211_L0.9940.95
154_A157_T0.9890.95
293_L305_T0.9860.95
114_A130_F0.9810.94
91_F114_A0.9700.94
344_E348_F0.9690.94
178_N182_M0.9580.94
199_T208_E0.9570.94
113_D116_Q0.9540.94
196_I208_E0.9540.94
292_I296_I0.9500.93
264_K268_L0.9500.93
306_F309_C0.9480.93
96_M111_Y0.9390.93
239_D247_Y0.9380.93
189_E192_L0.9270.93
152_R187_E0.9220.92
334_E350_Y0.9210.92
307_H311_Q0.9200.92
61_V65_E0.9180.92
108_I137_L0.9170.92
325_V329_S0.9160.92
348_F352_A0.9150.92
135_G174_T0.9080.92
51_Y55_L0.9080.92
95_G99_A0.9040.92
272_Q292_I0.9040.92
213_H253_L0.9040.92
215_F254_L0.9020.91
137_L141_L0.8970.91
289_K293_L0.8970.91
216_G254_L0.8970.91
172_L251_A0.8960.91
259_F271_Y0.8910.91
236_L250_S0.8900.91
248_Y255_I0.8700.90
333_G337_R0.8680.90
346_A350_Y0.8660.90
148_L179_F0.8640.90
171_A174_T0.8630.90
111_Y271_Y0.8600.89
188_A192_L0.8550.89
132_L171_A0.8540.89
300_G305_T0.8540.89
174_T214_N0.8500.89
115_E127_K0.8490.89
314_D317_L0.8490.89
173_I192_L0.8490.89
236_L251_A0.8470.89
331_L334_E0.8410.88
91_F172_L0.8380.88
147_S178_N0.8380.88
108_I134_V0.8360.88
145_I182_M0.8350.88
149_N153_Q0.8320.88
148_L182_M0.8210.87
274_V277_K0.8160.87
69_Q73_H0.8120.87
335_R339_L0.8120.87
233_E259_F0.8060.86
46_Q55_L0.8010.86
119_D127_K0.8010.86
92_L133_K0.8010.86
131_H154_A0.8000.86
214_N217_L0.7990.86
196_I215_F0.7970.85
130_F133_K0.7960.85
333_G348_F0.7950.85
309_C313_M0.7910.85
239_D250_S0.7870.85
190_A194_E0.7790.84
272_Q304_E0.7750.84
296_I301_G0.7720.84
139_Y151_T0.7690.83
52_F58_R0.7690.83
168_L198_I0.7660.83
77_S81_A0.7640.83
173_I195_A0.7580.83
213_H257_E0.7570.82
177_G214_N0.7560.82
138_Y143_Q0.7550.82
312_H319_E0.7540.82
295_A299_E0.7490.82
142_G183_S0.7480.82
138_Y141_L0.7430.81
289_K324_S0.7430.81
275_K278_L0.7420.81
60_K69_Q0.7380.81
51_Y59_H0.7320.80
151_T155_V0.7310.80
336_Y340_E0.7270.80
111_Y132_L0.7260.80
97_Y101_K0.7260.80
54_L58_R0.7230.79
154_A171_A0.7230.79
236_L270_Y0.7220.79
295_A300_G0.7210.79
128_A132_L0.7200.79
56_E60_K0.7200.79
126_E135_G0.7190.79
71_F75_E0.7190.79
113_D287_E0.7170.79
115_E130_F0.7160.79
205_H208_E0.7150.79
133_K136_K0.7140.79
159_R168_L0.7120.78
173_I177_G0.7110.78
226_E229_V0.7100.78
311_Q315_D0.7070.78
195_A198_I0.7060.78
199_T207_F0.7050.78
52_F56_E0.7000.77
334_E349_F0.6980.77
166_K204_D0.6970.77
48_V52_F0.6970.77
96_M133_K0.6960.77
95_G137_L0.6940.77
55_L60_K0.6940.77
217_L253_L0.6930.77
105_D141_L0.6920.76
315_D318_S0.6920.76
155_V171_A0.6910.76
99_A137_L0.6910.76
209_A250_S0.6900.76
107_A111_Y0.6890.76
235_A238_N0.6890.76
112_K138_Y0.6870.76
252_Y256_R0.6860.76
59_H62_L0.6830.75
47_E51_Y0.6830.75
279_T284_R0.6820.75
54_L59_H0.6820.75
305_T312_H0.6810.75
60_K68_G0.6810.75
312_H315_D0.6800.75
305_T316_L0.6800.75
236_L254_L0.6760.75
217_L220_A0.6740.75
308_L312_H0.6720.74
91_F117_Y0.6700.74
108_I141_L0.6690.74
158_F171_A0.6670.74
308_L311_Q0.6650.74
60_K66_A0.6650.74
138_Y153_Q0.6640.73
168_L172_L0.6630.73
309_C316_L0.6630.73
220_A253_L0.6620.73
132_L252_Y0.6620.73
270_Y274_V0.6620.73
89_Y93_F0.6610.73
90_F97_Y0.6590.73
316_L328_L0.6590.73
176_S195_A0.6580.73
293_L297_Y0.6580.73
235_A274_V0.6560.73
151_T175_M0.6530.72
71_F74_E0.6530.72
118_L123_D0.6500.72
105_D137_L0.6490.72
296_I299_E0.6460.71
329_S352_A0.6460.71
49_L54_L0.6450.71
228_A257_E0.6420.71
48_V51_Y0.6410.71
50_A56_E0.6400.71
204_D208_E0.6360.70
346_A349_F0.6340.70
136_K140_K0.6330.70
146_V149_N0.6320.70
199_T206_F0.6320.70
228_A250_S0.6320.70
230_S234_E0.6320.70
52_F59_H0.6310.70
340_E349_F0.6300.69
57_L73_H0.6290.69
310_K340_E0.6270.69
92_L96_M0.6270.69
267_A295_A0.6230.69
289_K311_Q0.6220.69
350_Y354_Q0.6220.69
180_T188_A0.6220.69
139_Y178_N0.6210.68
293_L296_I0.6210.68
55_L58_R0.6200.68
265_E268_L0.6180.68
274_V278_L0.6180.68
309_C312_H0.6180.68
216_G219_H0.6120.67
103_N283_N0.6110.67
185_F189_E0.6100.67
51_Y56_E0.6090.67
51_Y58_R0.6080.67
169_A198_I0.6060.67
179_F191_Y0.6050.66
232_L257_E0.6040.66
297_Y331_L0.6030.66
135_G178_N0.6030.66
255_I267_A0.6020.66
305_T335_R0.6010.66
60_K63_L0.6000.66
58_R61_V0.5990.66
149_N152_R0.5970.65
170_S173_I0.5970.65
72_Q75_E0.5970.65
270_Y273_D0.5960.65
88_Y95_G0.5930.65
307_H310_K0.5910.65
297_Y309_C0.5900.64
351_E354_Q0.5890.64
188_A218_L0.5890.64
69_Q72_Q0.5880.64
218_L222_S0.5880.64
93_F97_Y0.5880.64
273_D277_K0.5870.64
339_L348_F0.5870.64
46_Q50_A0.5860.64
217_L232_L0.5850.64
176_S188_A0.5850.64
227_E266_Q0.5850.64
275_K279_T0.5840.64
332_A348_F0.5830.64
349_F353_L0.5830.64
333_G346_A0.5820.63
56_E65_E0.5810.63
68_G72_Q0.5800.63
193_D227_E0.5800.63
278_L282_P0.5780.63
325_V332_A0.5750.62
57_L64_H0.5740.62
222_S235_A0.5740.62
185_F225_S0.5730.62
347_H350_Y0.5710.62
224_K230_S0.5710.62
111_Y137_L0.5710.62
82_T86_L0.5680.62
176_S214_N0.5670.61
116_Q119_D0.5670.61
53_S60_K0.5670.61
167_K170_S0.5660.61
297_Y302_H0.5660.61
228_A232_L0.5640.61
213_H216_G0.5640.61
59_H63_L0.5620.61
46_Q53_S0.5600.60
306_F332_A0.5590.60
110_L114_A0.5590.60
293_L301_G0.5580.60
45_D53_S0.5580.60
239_D343_K0.5540.60
47_E50_A0.5540.60
220_A257_E0.5540.60
86_L89_Y0.5520.59
155_V159_R0.5520.59
44_E49_L0.5510.59
118_L130_F0.5510.59
135_G140_K0.5490.59
51_Y54_L0.5490.59
189_E268_L0.5480.59
159_R194_E0.5460.59
45_D52_F0.5410.58
210_Q214_N0.5400.58
54_L62_L0.5390.58
272_Q276_E0.5370.57
50_A53_S0.5370.57
99_A133_K0.5360.57
54_L57_L0.5360.57
57_L60_K0.5350.57
291_D294_Y0.5340.57
112_K146_V0.5330.57
311_Q314_D0.5330.57
44_E56_E0.5310.56
312_H316_L0.5310.56
54_L61_V0.5290.56
309_C328_L0.5270.56
51_Y57_L0.5250.56
51_Y65_E0.5240.55
152_R156_K0.5230.55
289_K292_I0.5220.55
325_V335_R0.5190.55
87_K91_F0.5190.55
193_D197_R0.5180.55
62_L68_G0.5180.55
46_Q51_Y0.5170.54
119_D153_Q0.5170.54
339_L342_Y0.5170.54
141_L178_N0.5160.54
310_K314_D0.5160.54
306_F335_R0.5150.54
110_L231_K0.5140.54
48_V55_L0.5140.54
192_L215_F0.5130.54
87_K263_K0.5120.54
93_F96_M0.5120.54
56_E182_M0.5120.54
48_V56_E0.5120.54
226_E230_S0.5120.54
158_F176_S0.5120.54
135_G150_H0.5110.54
63_L69_Q0.5110.54
90_F94_E0.5090.53
226_E263_K0.5090.53
88_Y118_L0.5080.53
290_I316_L0.5080.53
52_F55_L0.5060.53
56_E66_A0.5050.53
179_F190_A0.5040.53
136_K151_T0.5030.53
225_S261_I0.5020.52
260_K263_K0.5000.52
348_F351_E0.5000.52
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ulqA 1 0.9781 100 0.221 Contact Map
4i1aA 2 0.9589 100 0.222 Contact Map
3q15A 2 0.9781 100 0.225 Contact Map
4gyoA 2 0.9726 100 0.228 Contact Map
4gpkA 3 0.9479 100 0.274 Contact Map
3sf4A 1 0.874 100 0.367 Contact Map
1w3bA 2 0.863 100 0.376 Contact Map
3ro2A 1 0.8466 100 0.378 Contact Map
4a1sA 1 0.8466 100 0.387 Contact Map
4l9pA 1 0.7534 100 0.387 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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