GREMLIN Database
YYCN - Uncharacterized N-acetyltransferase YycN
UniProt: O32293 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 156 (128)
Sequences: 2445 (1909)
Seq/√Len: 168.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
114_D145_F4.2921.00
73_V100_Y3.2841.00
107_K142_Q3.1661.00
44_K48_T2.7591.00
76_L113_L2.6101.00
110_L143_T2.4311.00
114_D125_L2.2201.00
74_G109_A2.1921.00
100_Y103_K2.1151.00
127_L140_Y2.0681.00
71_D99_P2.0371.00
89_A117_A2.0311.00
127_L136_A1.9701.00
147_E150_V1.9671.00
116_A119_S1.9451.00
112_A115_Q1.8671.00
136_A140_Y1.8651.00
74_G96_L1.7861.00
80_A122_I1.7061.00
24_Y27_E1.6801.00
138_K141_E1.6601.00
31_A97_Y1.6411.00
137_R141_E1.6141.00
66_K69_E1.5781.00
45_Q48_T1.5271.00
107_K143_T1.5061.00
20_T23_H1.4851.00
101_R135_T1.4671.00
64_S72_I1.4561.00
133_N140_Y1.4421.00
74_G105_Y1.4341.00
26_E30_K1.3961.00
61_H116_A1.3661.00
71_D100_Y1.3311.00
129_V140_Y1.3211.00
76_L91_I1.3131.00
111_A143_T1.3091.00
129_V136_A1.3091.00
71_D97_Y1.2671.00
22_K51_L1.2431.00
94_F110_L1.2401.00
112_A116_A1.2331.00
66_K72_I1.2201.00
21_T24_Y1.2191.00
102_G138_K1.2041.00
111_A115_Q1.1841.00
28_K32_G1.1781.00
31_A98_E1.1601.00
65_L74_G1.1521.00
65_L109_A1.1411.00
135_T138_K1.1201.00
115_Q119_S1.1081.00
132_H137_R1.1041.00
30_K41_L1.0921.00
107_K111_A1.0871.00
68_N103_K1.0811.00
96_L109_A1.0791.00
94_F140_Y1.0681.00
129_V133_N1.0661.00
78_I89_A1.0630.99
88_E126_S1.0520.99
21_T25_A1.0470.99
43_S47_F1.0340.99
102_G135_T1.0300.99
96_L106_A1.0190.99
91_I145_F0.9810.99
38_D41_L0.9740.99
88_E124_K0.9540.99
35_L97_Y0.9520.99
117_A125_L0.9440.99
110_L127_L0.9410.99
22_K28_K0.9370.99
75_W95_G0.9370.99
89_A122_I0.9360.99
110_L140_Y0.9220.99
79_H92_Y0.9210.99
108_Q115_Q0.9200.99
141_E146_Q0.9120.98
62_L66_K0.9070.98
106_A109_A0.9050.98
141_E147_E0.9040.98
139_L142_Q0.9000.98
23_H27_E0.8960.98
35_L38_D0.8720.98
137_R147_E0.8690.98
37_E40_Q0.8550.98
136_A139_L0.8470.98
45_Q49_D0.8420.97
94_F136_A0.8420.97
82_P86_Q0.8310.97
139_L143_T0.8310.97
33_T36_P0.8300.97
110_L136_A0.8190.97
77_W92_Y0.8140.97
62_L65_L0.8120.97
25_A28_K0.8100.97
90_F126_S0.8100.97
96_L105_Y0.8090.97
20_T24_Y0.8060.97
23_H44_K0.8000.96
91_I110_L0.7990.96
63_W116_A0.7940.96
133_N136_A0.7910.96
22_K26_E0.7860.96
104_G107_K0.7810.96
87_Q123_R0.7740.96
91_I94_F0.7710.96
28_K31_A0.7680.96
91_I140_Y0.7630.95
134_Q138_K0.7570.95
138_K142_Q0.7490.95
82_P87_Q0.7480.95
25_A61_H0.7450.95
80_A120_M0.7400.95
23_H28_K0.7380.95
109_A113_L0.7330.94
65_L69_E0.7290.94
81_E88_E0.7270.94
43_S46_V0.7180.94
61_H65_L0.7170.94
115_Q118_R0.7080.93
91_I127_L0.7070.93
110_L139_L0.7060.93
97_Y100_Y0.7020.93
24_Y29_V0.7010.93
107_K118_R0.7010.93
91_I136_A0.6980.93
46_V49_D0.6970.93
26_E29_V0.6960.93
94_F143_T0.6950.93
48_T52_P0.6910.92
36_P40_Q0.6780.92
78_I113_L0.6760.92
124_K148_T0.6760.92
73_V82_P0.6480.90
78_I116_A0.6460.90
129_V137_R0.6450.90
110_L129_V0.6440.89
117_A145_F0.6410.89
66_K70_K0.6400.89
82_P85_P0.6390.89
127_L133_N0.6390.89
101_R139_L0.6360.89
30_K42_L0.6340.89
60_H116_A0.6330.89
75_W145_F0.6210.88
33_T39_A0.6190.88
51_L54_G0.6170.87
94_F127_L0.6150.87
108_Q111_A0.6100.87
63_W72_I0.6080.87
93_D130_F0.6070.87
35_L130_F0.6030.86
77_W128_H0.5990.86
23_H26_E0.5960.86
134_Q141_E0.5940.85
126_S131_A0.5910.85
90_F128_H0.5900.85
62_L77_W0.5870.85
78_I117_A0.5850.84
20_T27_E0.5830.84
32_G36_P0.5820.84
95_G130_F0.5800.84
133_N137_R0.5800.84
35_L94_F0.5800.84
58_P68_N0.5720.83
28_K33_T0.5690.83
22_K25_A0.5660.82
52_P57_T0.5650.82
48_T51_L0.5610.82
61_H64_S0.5610.82
77_W135_T0.5600.82
33_T45_Q0.5590.82
107_K139_L0.5560.81
73_V105_Y0.5540.81
57_T60_H0.5530.81
111_A142_Q0.5510.81
110_L145_F0.5510.81
91_I125_L0.5480.80
24_Y28_K0.5470.80
68_N71_D0.5420.80
102_G133_N0.5420.80
114_D143_T0.5390.79
65_L105_Y0.5310.78
26_E44_K0.5280.78
27_E30_K0.5270.78
76_L127_L0.5230.77
125_L145_F0.5220.77
64_S94_F0.5160.76
107_K141_E0.5160.76
135_T143_T0.5160.76
94_F139_L0.5000.74
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ufhA 3 0.9936 99.9 0.327 Contact Map
1on0A 4 0.9936 99.9 0.34 Contact Map
2j8mA 2 0.9487 99.8 0.389 Contact Map
3fixA 2 0.9423 99.8 0.39 Contact Map
3fynA 2 0.8718 99.8 0.4 Contact Map
3d3sA 2 0.8846 99.8 0.411 Contact Map
2oh1A 1 0.9551 99.8 0.413 Contact Map
1vkcA 2 0.9423 99.8 0.415 Contact Map
3jvnA 2 0.75 99.8 0.417 Contact Map
1z4eA 2 0.9359 99.8 0.417 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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