YYCN - BACSU - GREMLIN Contacts

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YYCN - Uncharacterized N-acetyltransferase YycN

UniProt:	O32293	Sequences: MTIMLTPMQTEEFRSYLTYTTKHYAEEKVKAGTWLPEDAQLLSKQVFTDLLPRGLETPHHHLWSLKLNEKDIVGWLWIHAEPEHPQQEAFIYDFGLYEPYRGKGYAKQALAALDQAARSMGIRKLSLHVFAHNQTARKLYEQTGFQETDVVMSKKL	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	156 (128)
Sequences:	2445 (1909)
Seq/√Len:	168.7

ECOLI - PHNO YJGM MNAT YPEA YJAB YEDL RIMI YIAC YAFP
BACSU - YYCN YDGE PAIA YHFO YTMI YHDJ YSNE YWNH YQJY YUAI RIMI YESJ YYAR YBFA SPSD BLTD YBBJ YOBR
HALSA - Q9HQD2 Q9HMI8 Q9HSL3 Q9HMF0 Q9HRK6
SULSO - Y209 Q7LXZ8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
114_D	145_F	4.292	1.00
73_V	100_Y	3.284	1.00
107_K	142_Q	3.166	1.00
44_K	48_T	2.759	1.00
76_L	113_L	2.610	1.00
110_L	143_T	2.431	1.00
114_D	125_L	2.220	1.00
74_G	109_A	2.192	1.00
100_Y	103_K	2.115	1.00
127_L	140_Y	2.068	1.00
71_D	99_P	2.037	1.00
89_A	117_A	2.031	1.00
127_L	136_A	1.970	1.00
147_E	150_V	1.967	1.00
116_A	119_S	1.945	1.00
112_A	115_Q	1.867	1.00
136_A	140_Y	1.865	1.00
74_G	96_L	1.786	1.00
80_A	122_I	1.706	1.00
24_Y	27_E	1.680	1.00
138_K	141_E	1.660	1.00
31_A	97_Y	1.641	1.00
137_R	141_E	1.614	1.00
66_K	69_E	1.578	1.00
45_Q	48_T	1.527	1.00
107_K	143_T	1.506	1.00
20_T	23_H	1.485	1.00
101_R	135_T	1.467	1.00
64_S	72_I	1.456	1.00
133_N	140_Y	1.442	1.00
74_G	105_Y	1.434	1.00
26_E	30_K	1.396	1.00
61_H	116_A	1.366	1.00
71_D	100_Y	1.331	1.00
129_V	140_Y	1.321	1.00
76_L	91_I	1.313	1.00
111_A	143_T	1.309	1.00
129_V	136_A	1.309	1.00
71_D	97_Y	1.267	1.00
22_K	51_L	1.243	1.00
94_F	110_L	1.240	1.00
112_A	116_A	1.233	1.00
66_K	72_I	1.220	1.00
21_T	24_Y	1.219	1.00
102_G	138_K	1.204	1.00
111_A	115_Q	1.184	1.00
28_K	32_G	1.178	1.00
31_A	98_E	1.160	1.00
65_L	74_G	1.152	1.00
65_L	109_A	1.141	1.00
135_T	138_K	1.120	1.00
115_Q	119_S	1.108	1.00
132_H	137_R	1.104	1.00
30_K	41_L	1.092	1.00
107_K	111_A	1.087	1.00
68_N	103_K	1.081	1.00
96_L	109_A	1.079	1.00
94_F	140_Y	1.068	1.00
129_V	133_N	1.066	1.00
78_I	89_A	1.063	0.99
88_E	126_S	1.052	0.99
21_T	25_A	1.047	0.99
43_S	47_F	1.034	0.99
102_G	135_T	1.030	0.99
96_L	106_A	1.019	0.99
91_I	145_F	0.981	0.99
38_D	41_L	0.974	0.99
88_E	124_K	0.954	0.99
35_L	97_Y	0.952	0.99
117_A	125_L	0.944	0.99
110_L	127_L	0.941	0.99
22_K	28_K	0.937	0.99
75_W	95_G	0.937	0.99
89_A	122_I	0.936	0.99
110_L	140_Y	0.922	0.99
79_H	92_Y	0.921	0.99
108_Q	115_Q	0.920	0.99
141_E	146_Q	0.912	0.98
62_L	66_K	0.907	0.98
106_A	109_A	0.905	0.98
141_E	147_E	0.904	0.98
139_L	142_Q	0.900	0.98
23_H	27_E	0.896	0.98
35_L	38_D	0.872	0.98
137_R	147_E	0.869	0.98
37_E	40_Q	0.855	0.98
136_A	139_L	0.847	0.98
45_Q	49_D	0.842	0.97
94_F	136_A	0.842	0.97
82_P	86_Q	0.831	0.97
139_L	143_T	0.831	0.97
33_T	36_P	0.830	0.97
110_L	136_A	0.819	0.97
77_W	92_Y	0.814	0.97
62_L	65_L	0.812	0.97
25_A	28_K	0.810	0.97
90_F	126_S	0.810	0.97
96_L	105_Y	0.809	0.97
20_T	24_Y	0.806	0.97
23_H	44_K	0.800	0.96
91_I	110_L	0.799	0.96
63_W	116_A	0.794	0.96
133_N	136_A	0.791	0.96
22_K	26_E	0.786	0.96
104_G	107_K	0.781	0.96
87_Q	123_R	0.774	0.96
91_I	94_F	0.771	0.96
28_K	31_A	0.768	0.96
91_I	140_Y	0.763	0.95
134_Q	138_K	0.757	0.95
138_K	142_Q	0.749	0.95
82_P	87_Q	0.748	0.95
25_A	61_H	0.745	0.95
80_A	120_M	0.740	0.95
23_H	28_K	0.738	0.95
109_A	113_L	0.733	0.94
65_L	69_E	0.729	0.94
81_E	88_E	0.727	0.94
43_S	46_V	0.718	0.94
61_H	65_L	0.717	0.94
115_Q	118_R	0.708	0.93
91_I	127_L	0.707	0.93
110_L	139_L	0.706	0.93
97_Y	100_Y	0.702	0.93
24_Y	29_V	0.701	0.93
107_K	118_R	0.701	0.93
91_I	136_A	0.698	0.93
46_V	49_D	0.697	0.93
26_E	29_V	0.696	0.93
94_F	143_T	0.695	0.93
48_T	52_P	0.691	0.92
36_P	40_Q	0.678	0.92
78_I	113_L	0.676	0.92
124_K	148_T	0.676	0.92
73_V	82_P	0.648	0.90
78_I	116_A	0.646	0.90
129_V	137_R	0.645	0.90
110_L	129_V	0.644	0.89
117_A	145_F	0.641	0.89
66_K	70_K	0.640	0.89
82_P	85_P	0.639	0.89
127_L	133_N	0.639	0.89
101_R	139_L	0.636	0.89
30_K	42_L	0.634	0.89
60_H	116_A	0.633	0.89
75_W	145_F	0.621	0.88
33_T	39_A	0.619	0.88
51_L	54_G	0.617	0.87
94_F	127_L	0.615	0.87
108_Q	111_A	0.610	0.87
63_W	72_I	0.608	0.87
93_D	130_F	0.607	0.87
35_L	130_F	0.603	0.86
77_W	128_H	0.599	0.86
23_H	26_E	0.596	0.86
134_Q	141_E	0.594	0.85
126_S	131_A	0.591	0.85
90_F	128_H	0.590	0.85
62_L	77_W	0.587	0.85
78_I	117_A	0.585	0.84
20_T	27_E	0.583	0.84
32_G	36_P	0.582	0.84
95_G	130_F	0.580	0.84
133_N	137_R	0.580	0.84
35_L	94_F	0.580	0.84
58_P	68_N	0.572	0.83
28_K	33_T	0.569	0.83
22_K	25_A	0.566	0.82
52_P	57_T	0.565	0.82
48_T	51_L	0.561	0.82
61_H	64_S	0.561	0.82
77_W	135_T	0.560	0.82
33_T	45_Q	0.559	0.82
107_K	139_L	0.556	0.81
73_V	105_Y	0.554	0.81
57_T	60_H	0.553	0.81
111_A	142_Q	0.551	0.81
110_L	145_F	0.551	0.81
91_I	125_L	0.548	0.80
24_Y	28_K	0.547	0.80
68_N	71_D	0.542	0.80
102_G	133_N	0.542	0.80
114_D	143_T	0.539	0.79
65_L	105_Y	0.531	0.78
26_E	44_K	0.528	0.78
27_E	30_K	0.527	0.78
76_L	127_L	0.523	0.77
125_L	145_F	0.522	0.77
64_S	94_F	0.516	0.76
107_K	141_E	0.516	0.76
135_T	143_T	0.516	0.76
94_F	139_L	0.500	0.74

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ufhA	3	0.9936	99.9	0.327	Contact Map
1on0A	4	0.9936	99.9	0.34	Contact Map
2j8mA	2	0.9487	99.8	0.389	Contact Map
3fixA	2	0.9423	99.8	0.39	Contact Map
3fynA	2	0.8718	99.8	0.4	Contact Map
3d3sA	2	0.8846	99.8	0.411	Contact Map
2oh1A	1	0.9551	99.8	0.413	Contact Map
1vkcA	2	0.9423	99.8	0.415	Contact Map
3jvnA	2	0.75	99.8	0.417	Contact Map
1z4eA	2	0.9359	99.8	0.417	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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