GREMLIN Database
PTXA - Putative phosphotransferase enzyme IIA component YyzE
UniProt: O32292 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 76 (73)
Sequences: 3117 (2338)
Seq/√Len: 273.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
38_K53_E2.6431.00
38_K50_V2.5241.00
34_P58_F2.3361.00
40_K43_D2.3221.00
36_S53_E2.2621.00
6_K37_L2.2281.00
23_I52_V2.2111.00
58_F62_I2.1681.00
29_T64_E2.1411.00
14_A44_T2.0281.00
33_T62_I1.9071.00
46_K49_E1.7301.00
9_I52_V1.6811.00
56_K66_A1.6351.00
23_I54_F1.5811.00
56_K60_E1.5471.00
66_A69_Q1.5031.00
43_D49_E1.4901.00
33_T58_F1.4401.00
12_R18_E1.3851.00
26_D29_T1.3651.00
57_A61_D1.3611.00
50_V53_E1.3361.00
10_G73_T1.3171.00
57_A60_E1.3081.00
58_F61_D1.3051.00
30_F58_F1.2151.00
18_E74_V1.2111.00
30_F34_P1.2091.00
25_L69_Q1.2001.00
37_L52_V1.1481.00
54_F59_I1.1191.00
13_S17_V1.1071.00
23_I68_H1.0991.00
9_I51_L1.0681.00
2_V41_E1.0641.00
39_V43_D1.0501.00
47_K50_V1.0451.00
30_F59_I1.0451.00
21_A70_K1.0311.00
9_I21_A1.0261.00
34_P62_I1.0251.00
17_V72_F1.0251.00
55_D58_F1.0101.00
34_P64_E1.0011.00
39_V49_E0.9961.00
30_F64_E0.9871.00
60_E66_A0.9811.00
4_P31_D0.9551.00
19_L72_F0.9361.00
30_F33_T0.8991.00
6_K36_S0.8941.00
11_L21_A0.8280.99
11_L51_L0.8110.99
26_D64_E0.8080.99
59_I64_E0.8070.99
37_L41_E0.8060.99
4_P41_E0.8000.99
2_V37_L0.7780.99
59_I66_A0.7500.99
9_I39_V0.7440.99
30_F66_A0.7370.99
21_A51_L0.7310.99
2_V6_K0.7160.99
25_L71_I0.7150.98
25_L65_S0.6970.98
9_I54_F0.6790.98
34_P65_S0.6650.98
8_A26_D0.6630.98
21_A68_H0.6580.97
9_I37_L0.6570.97
59_I63_E0.6540.97
65_S68_H0.6490.97
29_T35_F0.6470.97
19_L74_V0.6300.97
25_L67_L0.6290.97
70_K74_V0.6260.97
39_V51_L0.6240.96
58_F63_E0.6120.96
4_P10_G0.5980.96
6_K38_K0.5980.96
20_L73_T0.5960.95
2_V52_V0.5880.95
4_P35_F0.5800.95
13_S19_L0.5750.94
14_A47_K0.5650.94
54_F68_H0.5570.94
25_L66_A0.5530.93
6_K41_E0.5520.93
2_V10_G0.5440.93
12_R16_G0.5420.93
5_T37_L0.5420.93
48_G69_Q0.5400.92
18_E73_T0.5400.92
10_G18_E0.5390.92
21_A69_Q0.5390.92
3_T37_L0.5340.92
38_K52_V0.5330.92
30_F55_D0.5270.92
2_V39_V0.5260.91
14_A46_K0.5230.91
3_T6_K0.5220.91
26_D67_L0.5220.91
40_K60_E0.5140.91
59_I62_I0.5110.90
10_G20_L0.5070.90
10_G60_E0.5070.90
19_L45_V0.5010.89
2_V9_I0.5010.89
30_F62_I0.5000.89
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3ourB 1 1 100 0.065 Contact Map
2gprA 1 1 100 0.067 Contact Map
1f3zA 2 1 100 0.07 Contact Map
1ax3A 1 1 100 0.083 Contact Map
1dczA 1 0.8026 88.7 0.845 Contact Map
4iqzA 4 0.8553 82.1 0.859 Contact Map
4tkoB 1 0.8947 79.6 0.862 Contact Map
2d5dA 1 0.7105 76.8 0.865 Contact Map
2xhaA 1 0.8026 73.7 0.869 Contact Map
1iyuA 1 0.75 70.5 0.872 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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