YXNA - BACSU - GREMLIN Contacts

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YXNA - Uncharacterized oxidoreductase YxnA

UniProt:	O32291	Sequences: MTIDHSVTNTEQLEQQNPAIKTKLKLKKLKDQVIVITGASSGIGLVTARMAAEKGAKVVAAARNEEALKELTDELKEKGHDAIWVKADVGKEEDVNRIAETAISTFGRFDTWVNNAAVSTFGHAMDVTVEDMKRMFDTNFWGPVYGTRAAVKHYTGRGVPGALINVGSLFGDRGTVIQSTYASAKFALHGWTESIRMELEKEQAPVSVTLIHPGRIDTPYNEHAHSYLDKQPAHYRSMIYPPEAVAEAILFAAEHPKRDMYIGSQAKAIAMLGALFPRLTDRLMEKIMYHSQHAERPSNPREESALYDAGCGMHDRGTNKGWMRSRSYYTKATKRPIVSAAVVAGLVAWAAAKRCR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	356 (274)
Sequences:	6111 (4878)
Seq/√Len:	294.7

ECOLI - YGHA IDNO YGCW YBBO SRLD YCIK YOHF HDHA KDUD FABG YGFF UCPA HCAB YDFG ENTA FOLM BDCA FABI
BACSU - YXNA YHXD GS39 YHDF UXUB YHXC YXJF YWFH DHBA YXBG FABL FADH DHG2 YOXD YQJQ FABG YUSZ YJDA DLTE DHG YVAG YKVO YVRD BACC YTKK KDUD YMFI FABI YUXG BZRD
HALSA - Q9HRZ2 Q9HSR4 Q9HNC5 Q9HQ41 Q9HRV8 Q9HMA5 Q9HPP2 Q9HS80 Q9HP93
SULSO - Q97UK6 Q97ZE4 Q97WF0 Q97UA4 Q97VV6 Q97WD7 Q97Y09 Q97VG2 Q97WL1 Q97ZA0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
34_I	111_T	3.702	1.00
165_N	192_T	3.515	1.00
91_K	94_D	3.336	1.00
61_A	98_I	2.952	1.00
65_E	69_K	2.874	1.00
49_R	74_E	2.863	1.00
139_N	184_A	2.849	1.00
194_S	198_E	2.834	1.00
57_K	81_D	2.756	1.00
72_T	76_K	2.638	1.00
114_N	165_N	2.373	1.00
47_T	249_I	2.363	1.00
45_L	71_L	2.360	1.00
45_L	74_E	2.334	1.00
133_K	137_D	2.313	1.00
85_V	98_I	2.281	1.00
144_V	187_A	2.261	1.00
61_A	87_A	2.232	1.00
40_S	62_A	2.183	1.00
140_F	188_L	2.104	1.00
92_E	148_R	2.098	1.00
72_T	84_W	1.993	1.00
36_I	48_A	1.981	1.00
101_T	105_T	1.934	1.00
85_V	101_T	1.929	1.00
120_T	131_D	1.927	1.00
96_N	149_A	1.916	1.00
73_D	76_K	1.855	1.00
114_N	147_T	1.852	1.00
192_T	208_V	1.849	1.00
140_F	187_A	1.834	1.00
41_S	219_P	1.827	1.00
47_T	166_V	1.803	1.00
47_T	113_V	1.797	1.00
32_Q	110_D	1.774	1.00
111_T	162_A	1.750	1.00
113_V	166_V	1.707	1.00
89_V	142_G	1.695	1.00
34_I	56_A	1.686	1.00
102_A	109_F	1.685	1.00
42_G	218_T	1.671	1.00
69_K	73_D	1.663	1.00
35_V	109_F	1.653	1.00
34_I	51_A	1.651	1.00
53_E	78_K	1.646	1.00
189_H	210_L	1.637	1.00
103_I	153_H	1.632	1.00
50_M	54_K	1.630	1.00
147_T	163_L	1.621	1.00
50_M	250_L	1.617	1.00
87_A	98_I	1.614	1.00
40_S	71_L	1.607	1.00
43_I	216_I	1.599	1.00
100_E	104_S	1.593	1.00
49_R	78_K	1.578	1.00
50_M	247_E	1.557	1.00
97_R	101_T	1.544	1.00
46_V	243_E	1.528	1.00
39_A	60_A	1.489	1.00
119_S	220_Y	1.473	1.00
99_A	149_A	1.460	1.00
94_D	97_R	1.449	1.00
143_P	188_L	1.444	1.00
186_F	190_G	1.441	1.00
147_T	195_I	1.436	1.00
46_V	49_R	1.407	1.00
50_M	53_E	1.404	1.00
209_T	252_A	1.402	1.00
52_A	75_L	1.398	1.00
103_I	157_R	1.396	1.00
194_S	197_M	1.395	1.00
241_P	244_A	1.391	1.00
46_V	50_M	1.391	1.00
102_A	106_F	1.389	1.00
64_N	67_A	1.388	1.00
69_K	72_T	1.387	1.00
167_G	189_H	1.377	1.00
95_V	149_A	1.376	1.00
59_V	102_A	1.375	1.00
59_V	106_F	1.363	1.00
68_L	84_W	1.355	1.00
196_R	200_E	1.351	1.00
65_E	84_W	1.344	1.00
57_K	83_I	1.339	1.00
194_S	286_K	1.339	1.00
140_F	292_Q	1.335	1.00
48_A	60_A	1.327	1.00
251_F	255_H	1.324	1.00
192_T	210_L	1.318	1.00
96_N	100_E	1.309	1.00
263_G	268_A	1.281	1.00
52_A	80_H	1.271	1.00
65_E	86_K	1.271	1.00
123_H	126_D	1.270	1.00
109_F	150_A	1.261	1.00
62_A	68_L	1.246	1.00
154_Y	157_R	1.241	1.00
112_W	163_L	1.241	1.00
72_T	82_A	1.238	1.00
33_V	57_K	1.238	1.00
35_V	61_A	1.237	1.00
83_I	105_T	1.237	1.00
35_V	98_I	1.219	1.00
33_V	108_R	1.219	1.00
87_A	94_D	1.212	1.00
85_V	105_T	1.209	1.00
128_T	131_D	1.208	1.00
128_T	137_D	1.207	1.00
54_K	254_E	1.205	1.00
165_N	208_V	1.199	1.00
138_T	142_G	1.196	1.00
95_V	145_Y	1.194	1.00
120_T	134_R	1.190	1.00
92_E	145_Y	1.184	1.00
73_D	77_E	1.184	1.00
144_V	147_T	1.182	1.00
90_G	137_D	1.180	1.00
196_R	262_I	1.180	1.00
70_E	73_D	1.177	1.00
93_E	97_R	1.172	1.00
113_V	249_I	1.162	1.00
33_V	59_V	1.161	1.00
147_T	194_S	1.161	1.00
89_V	95_V	1.153	1.00
49_R	53_E	1.149	1.00
136_F	140_F	1.145	1.00
145_Y	149_A	1.142	1.00
263_G	266_A	1.123	1.00
59_V	85_V	1.108	1.00
99_A	150_A	1.105	1.00
147_T	191_W	1.098	1.00
112_W	150_A	1.073	1.00
49_R	75_L	1.073	1.00
95_V	98_I	1.067	1.00
168_S	181_Y	1.066	1.00
265_Q	268_A	1.066	1.00
166_V	211_I	1.051	1.00
92_E	149_A	1.045	1.00
76_K	81_D	1.033	1.00
79_G	82_A	1.032	1.00
137_D	141_W	1.030	1.00
110_D	161_G	1.029	1.00
136_F	187_A	1.025	1.00
51_A	113_V	1.024	1.00
151_V	199_L	1.021	1.00
92_E	96_N	1.021	1.00
166_V	249_I	1.018	1.00
216_I	245_V	1.017	1.00
144_V	191_W	1.017	1.00
283_L	287_I	1.016	1.00
46_V	242_P	1.010	1.00
143_P	191_W	1.009	1.00
127_V	180_T	0.981	1.00
199_L	206_V	0.977	1.00
108_R	157_R	0.968	1.00
117_A	220_Y	0.967	1.00
158_G	161_G	0.964	1.00
74_E	77_E	0.961	1.00
74_E	78_K	0.960	1.00
140_F	191_W	0.956	1.00
217_D	241_P	0.955	1.00
263_G	267_K	0.951	1.00
121_F	178_Q	0.928	1.00
29_L	56_A	0.923	1.00
246_A	250_L	0.923	1.00
190_G	285_E	0.920	1.00
218_T	221_N	0.919	1.00
67_A	70_E	0.915	1.00
92_E	95_V	0.914	1.00
170_F	182_A	0.911	1.00
155_T	206_V	0.906	1.00
70_E	74_E	0.900	1.00
155_T	198_E	0.898	1.00
219_P	222_E	0.879	1.00
132_M	180_T	0.877	1.00
103_I	108_R	0.873	1.00
29_L	161_G	0.871	1.00
83_I	106_F	0.870	1.00
29_L	32_Q	0.870	1.00
213_P	216_I	0.868	1.00
136_F	141_W	0.867	1.00
157_R	161_G	0.865	1.00
122_G	131_D	0.864	1.00
211_I	249_I	0.860	1.00
120_T	178_Q	0.854	1.00
137_D	142_G	0.853	1.00
66_E	69_K	0.851	1.00
97_R	100_E	0.850	1.00
281_D	284_M	0.847	1.00
240_Y	244_A	0.843	1.00
60_A	72_T	0.842	1.00
71_L	74_E	0.840	1.00
289_Y	292_Q	0.836	1.00
43_I	249_I	0.834	1.00
89_V	146_G	0.832	1.00
91_K	129_V	0.831	1.00
145_Y	148_R	0.829	1.00
271_M	275_L	0.821	1.00
154_Y	161_G	0.819	1.00
211_I	263_G	0.818	1.00
226_S	229_D	0.816	1.00
69_K	76_K	0.816	1.00
276_F	279_L	0.813	1.00
45_L	49_R	0.812	1.00
52_A	58_V	0.811	1.00
219_P	223_H	0.811	1.00
171_G	189_H	0.810	1.00
98_I	102_A	0.809	1.00
144_V	148_R	0.809	1.00
149_A	153_H	0.808	1.00
279_L	282_R	0.807	1.00
91_K	130_E	0.806	1.00
242_P	246_A	0.801	1.00
111_T	253_A	0.797	0.99
134_R	138_T	0.796	0.99
285_E	288_M	0.792	0.99
37_T	116_A	0.791	0.99
66_E	70_E	0.787	0.99
291_S	294_A	0.785	0.99
86_K	97_R	0.784	0.99
195_I	200_E	0.783	0.99
166_V	213_P	0.782	0.99
220_Y	224_A	0.775	0.99
171_G	212_H	0.771	0.99
282_R	285_E	0.768	0.99
141_W	145_Y	0.766	0.99
284_M	287_I	0.765	0.99
36_I	58_V	0.762	0.99
163_L	208_V	0.760	0.99
31_D	57_K	0.754	0.99
139_N	185_K	0.752	0.99
184_A	187_A	0.749	0.99
250_L	254_E	0.748	0.99
260_M	263_G	0.743	0.99
290_H	294_A	0.743	0.99
112_W	147_T	0.742	0.99
124_A	179_S	0.740	0.99
47_T	246_A	0.734	0.99
218_T	242_P	0.733	0.99
102_A	107_G	0.733	0.99
195_I	208_V	0.731	0.99
103_I	107_G	0.729	0.99
57_K	106_F	0.721	0.99
220_Y	223_H	0.721	0.99
121_F	135_M	0.717	0.99
36_I	51_A	0.713	0.99
265_Q	269_I	0.712	0.99
225_H	228_L	0.711	0.99
54_K	250_L	0.707	0.99
119_S	135_M	0.707	0.99
114_N	143_P	0.704	0.99
119_S	122_G	0.704	0.99
62_A	84_W	0.704	0.99
37_T	117_A	0.703	0.99
269_I	272_L	0.702	0.99
33_V	102_A	0.701	0.99
46_V	246_A	0.700	0.99
282_R	287_I	0.699	0.99
221_N	224_A	0.698	0.99
39_A	48_A	0.697	0.99
278_R	281_D	0.696	0.99
289_Y	293_H	0.696	0.99
40_S	44_G	0.696	0.99
240_Y	245_V	0.696	0.99
48_A	58_V	0.696	0.99
267_K	270_A	0.694	0.99
171_G	276_F	0.693	0.99
58_V	80_H	0.693	0.99
36_I	47_T	0.692	0.99
133_K	141_W	0.690	0.99
281_D	287_I	0.685	0.98
35_V	146_G	0.682	0.98
40_S	63_R	0.682	0.98
59_V	98_I	0.681	0.98
151_V	195_I	0.679	0.98
251_F	254_E	0.676	0.98
68_L	72_T	0.674	0.98
75_L	80_H	0.670	0.98
264_S	268_A	0.668	0.98
109_F	157_R	0.667	0.98
285_E	289_Y	0.666	0.98
101_T	104_S	0.663	0.98
191_W	195_I	0.662	0.98
271_M	274_A	0.661	0.98
153_H	156_G	0.657	0.98
115_N	166_V	0.657	0.98
277_P	280_T	0.656	0.98
215_R	239_I	0.656	0.98
268_A	271_M	0.656	0.98
44_G	115_N	0.651	0.98
281_D	288_M	0.649	0.98
165_N	188_L	0.646	0.98
276_F	284_M	0.644	0.98
35_V	102_A	0.643	0.98
85_V	102_A	0.642	0.98
169_L	172_D	0.641	0.98
91_K	95_V	0.640	0.98
286_K	290_H	0.639	0.98
162_A	253_A	0.637	0.98
98_I	101_T	0.635	0.97
33_V	106_F	0.634	0.97
281_D	289_Y	0.633	0.97
102_A	150_A	0.632	0.97
270_A	273_G	0.626	0.97
135_M	180_T	0.626	0.97
39_A	82_A	0.625	0.97
23_K	26_L	0.622	0.97
283_L	286_K	0.621	0.97
217_D	239_I	0.619	0.97
188_L	191_W	0.619	0.97
288_M	291_S	0.618	0.97
193_E	210_L	0.617	0.97
93_E	96_N	0.617	0.97
147_T	165_N	0.614	0.97
164_I	253_A	0.614	0.97
190_G	284_M	0.612	0.97
171_G	186_F	0.609	0.97
48_A	75_L	0.609	0.97
218_T	223_H	0.609	0.97
161_G	206_V	0.608	0.97
114_N	192_T	0.605	0.97
76_K	79_G	0.605	0.97
87_A	95_V	0.602	0.97
279_L	284_M	0.596	0.96
143_P	165_N	0.595	0.96
147_T	198_E	0.592	0.96
95_V	142_G	0.591	0.96
143_P	146_G	0.589	0.96
153_H	157_R	0.588	0.96
102_A	153_H	0.587	0.96
169_L	173_R	0.586	0.96
154_Y	163_L	0.585	0.96
262_I	265_Q	0.585	0.96
81_D	105_T	0.583	0.96
112_W	146_G	0.581	0.96
90_G	134_R	0.577	0.96
287_I	290_H	0.575	0.95
186_F	189_H	0.573	0.95
82_A	85_V	0.573	0.95
43_I	166_V	0.572	0.95
152_K	156_G	0.569	0.95
136_F	184_A	0.569	0.95
213_P	245_V	0.568	0.95
164_I	209_T	0.568	0.95
278_R	284_M	0.568	0.95
33_V	107_G	0.566	0.95
51_A	253_A	0.566	0.95
277_P	282_R	0.564	0.95
224_A	228_L	0.562	0.95
160_P	163_L	0.562	0.95
165_N	191_W	0.562	0.95
118_V	134_R	0.561	0.95
60_A	68_L	0.561	0.95
244_A	247_E	0.559	0.95
262_I	268_A	0.559	0.95
29_L	254_E	0.558	0.95
292_Q	295_E	0.556	0.95
29_L	110_D	0.556	0.95
216_I	240_Y	0.556	0.95
226_S	230_K	0.555	0.95
37_T	115_N	0.555	0.95
263_G	269_I	0.552	0.94
122_G	126_D	0.551	0.94
241_P	245_V	0.550	0.94
167_G	210_L	0.545	0.94
132_M	137_D	0.543	0.94
147_T	150_A	0.543	0.94
41_S	67_A	0.542	0.94
147_T	200_E	0.540	0.94
270_A	274_A	0.538	0.94
150_A	157_R	0.538	0.94
51_A	58_V	0.537	0.94
51_A	111_T	0.536	0.94
96_N	145_Y	0.533	0.93
59_V	83_I	0.530	0.93
266_A	269_I	0.530	0.93
261_Y	266_A	0.529	0.93
39_A	84_W	0.529	0.93
40_S	60_A	0.529	0.93
148_R	191_W	0.527	0.93
296_R	299_N	0.527	0.93
43_I	213_P	0.526	0.93
181_Y	185_K	0.525	0.93
42_G	220_Y	0.523	0.93
123_H	127_V	0.521	0.93
297_P	300_P	0.520	0.92
32_Q	56_A	0.520	0.92
76_K	82_A	0.520	0.92
61_A	89_V	0.518	0.92
240_Y	248_A	0.518	0.92
280_T	284_M	0.518	0.92
276_F	280_T	0.517	0.92
118_V	138_T	0.517	0.92
89_V	145_Y	0.516	0.92
279_L	283_L	0.514	0.92
126_D	134_R	0.513	0.92
60_A	82_A	0.513	0.92
224_A	227_Y	0.512	0.92
176_V	186_F	0.512	0.92
83_I	101_T	0.512	0.92
28_K	161_G	0.512	0.92
96_N	152_K	0.508	0.92
98_I	146_G	0.508	0.92
154_Y	158_G	0.507	0.92
38_G	63_R	0.506	0.91
49_R	71_L	0.505	0.91
51_A	56_A	0.504	0.91
228_L	232_P	0.501	0.91
39_A	71_L	0.500	0.91
260_M	264_S	0.500	0.91
167_G	171_G	0.500	0.91

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1vl8A	4	0.691	100	0.351	Contact Map
4is2A	3	0.5983	100	0.36	Contact Map
4gh5A	4	0.677	100	0.36	Contact Map
3sjuA	4	0.6742	100	0.362	Contact Map
4weoA	4	0.6545	100	0.362	Contact Map
2rhcB	4	0.7107	100	0.364	Contact Map
4trrA	4	0.691	100	0.365	Contact Map
2c07A	4	0.6854	100	0.366	Contact Map
3ftpA	4	0.691	100	0.367	Contact Map
3gvcA	4	0.6966	100	0.368	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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