GREMLIN Database
YXNA - Uncharacterized oxidoreductase YxnA
UniProt: O32291 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 356 (274)
Sequences: 6111 (4878)
Seq/√Len: 294.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
34_I111_T3.7021.00
165_N192_T3.5151.00
91_K94_D3.3361.00
61_A98_I2.9521.00
65_E69_K2.8741.00
49_R74_E2.8631.00
139_N184_A2.8491.00
194_S198_E2.8341.00
57_K81_D2.7561.00
72_T76_K2.6381.00
114_N165_N2.3731.00
47_T249_I2.3631.00
45_L71_L2.3601.00
45_L74_E2.3341.00
133_K137_D2.3131.00
85_V98_I2.2811.00
144_V187_A2.2611.00
61_A87_A2.2321.00
40_S62_A2.1831.00
140_F188_L2.1041.00
92_E148_R2.0981.00
72_T84_W1.9931.00
36_I48_A1.9811.00
101_T105_T1.9341.00
85_V101_T1.9291.00
120_T131_D1.9271.00
96_N149_A1.9161.00
73_D76_K1.8551.00
114_N147_T1.8521.00
192_T208_V1.8491.00
140_F187_A1.8341.00
41_S219_P1.8271.00
47_T166_V1.8031.00
47_T113_V1.7971.00
32_Q110_D1.7741.00
111_T162_A1.7501.00
113_V166_V1.7071.00
89_V142_G1.6951.00
34_I56_A1.6861.00
102_A109_F1.6851.00
42_G218_T1.6711.00
69_K73_D1.6631.00
35_V109_F1.6531.00
34_I51_A1.6511.00
53_E78_K1.6461.00
189_H210_L1.6371.00
103_I153_H1.6321.00
50_M54_K1.6301.00
147_T163_L1.6211.00
50_M250_L1.6171.00
87_A98_I1.6141.00
40_S71_L1.6071.00
43_I216_I1.5991.00
100_E104_S1.5931.00
49_R78_K1.5781.00
50_M247_E1.5571.00
97_R101_T1.5441.00
46_V243_E1.5281.00
39_A60_A1.4891.00
119_S220_Y1.4731.00
99_A149_A1.4601.00
94_D97_R1.4491.00
143_P188_L1.4441.00
186_F190_G1.4411.00
147_T195_I1.4361.00
46_V49_R1.4071.00
50_M53_E1.4041.00
209_T252_A1.4021.00
52_A75_L1.3981.00
103_I157_R1.3961.00
194_S197_M1.3951.00
241_P244_A1.3911.00
46_V50_M1.3911.00
102_A106_F1.3891.00
64_N67_A1.3881.00
69_K72_T1.3871.00
167_G189_H1.3771.00
95_V149_A1.3761.00
59_V102_A1.3751.00
59_V106_F1.3631.00
68_L84_W1.3551.00
196_R200_E1.3511.00
65_E84_W1.3441.00
57_K83_I1.3391.00
194_S286_K1.3391.00
140_F292_Q1.3351.00
48_A60_A1.3271.00
251_F255_H1.3241.00
192_T210_L1.3181.00
96_N100_E1.3091.00
263_G268_A1.2811.00
52_A80_H1.2711.00
65_E86_K1.2711.00
123_H126_D1.2701.00
109_F150_A1.2611.00
62_A68_L1.2461.00
154_Y157_R1.2411.00
112_W163_L1.2411.00
72_T82_A1.2381.00
33_V57_K1.2381.00
35_V61_A1.2371.00
83_I105_T1.2371.00
35_V98_I1.2191.00
33_V108_R1.2191.00
87_A94_D1.2121.00
85_V105_T1.2091.00
128_T131_D1.2081.00
128_T137_D1.2071.00
54_K254_E1.2051.00
165_N208_V1.1991.00
138_T142_G1.1961.00
95_V145_Y1.1941.00
120_T134_R1.1901.00
92_E145_Y1.1841.00
73_D77_E1.1841.00
144_V147_T1.1821.00
90_G137_D1.1801.00
196_R262_I1.1801.00
70_E73_D1.1771.00
93_E97_R1.1721.00
113_V249_I1.1621.00
33_V59_V1.1611.00
147_T194_S1.1611.00
89_V95_V1.1531.00
49_R53_E1.1491.00
136_F140_F1.1451.00
145_Y149_A1.1421.00
263_G266_A1.1231.00
59_V85_V1.1081.00
99_A150_A1.1051.00
147_T191_W1.0981.00
112_W150_A1.0731.00
49_R75_L1.0731.00
95_V98_I1.0671.00
168_S181_Y1.0661.00
265_Q268_A1.0661.00
166_V211_I1.0511.00
92_E149_A1.0451.00
76_K81_D1.0331.00
79_G82_A1.0321.00
137_D141_W1.0301.00
110_D161_G1.0291.00
136_F187_A1.0251.00
51_A113_V1.0241.00
151_V199_L1.0211.00
92_E96_N1.0211.00
166_V249_I1.0181.00
216_I245_V1.0171.00
144_V191_W1.0171.00
283_L287_I1.0161.00
46_V242_P1.0101.00
143_P191_W1.0091.00
127_V180_T0.9811.00
199_L206_V0.9771.00
108_R157_R0.9681.00
117_A220_Y0.9671.00
158_G161_G0.9641.00
74_E77_E0.9611.00
74_E78_K0.9601.00
140_F191_W0.9561.00
217_D241_P0.9551.00
263_G267_K0.9511.00
121_F178_Q0.9281.00
29_L56_A0.9231.00
246_A250_L0.9231.00
190_G285_E0.9201.00
218_T221_N0.9191.00
67_A70_E0.9151.00
92_E95_V0.9141.00
170_F182_A0.9111.00
155_T206_V0.9061.00
70_E74_E0.9001.00
155_T198_E0.8981.00
219_P222_E0.8791.00
132_M180_T0.8771.00
103_I108_R0.8731.00
29_L161_G0.8711.00
83_I106_F0.8701.00
29_L32_Q0.8701.00
213_P216_I0.8681.00
136_F141_W0.8671.00
157_R161_G0.8651.00
122_G131_D0.8641.00
211_I249_I0.8601.00
120_T178_Q0.8541.00
137_D142_G0.8531.00
66_E69_K0.8511.00
97_R100_E0.8501.00
281_D284_M0.8471.00
240_Y244_A0.8431.00
60_A72_T0.8421.00
71_L74_E0.8401.00
289_Y292_Q0.8361.00
43_I249_I0.8341.00
89_V146_G0.8321.00
91_K129_V0.8311.00
145_Y148_R0.8291.00
271_M275_L0.8211.00
154_Y161_G0.8191.00
211_I263_G0.8181.00
226_S229_D0.8161.00
69_K76_K0.8161.00
276_F279_L0.8131.00
45_L49_R0.8121.00
52_A58_V0.8111.00
219_P223_H0.8111.00
171_G189_H0.8101.00
98_I102_A0.8091.00
144_V148_R0.8091.00
149_A153_H0.8081.00
279_L282_R0.8071.00
91_K130_E0.8061.00
242_P246_A0.8011.00
111_T253_A0.7970.99
134_R138_T0.7960.99
285_E288_M0.7920.99
37_T116_A0.7910.99
66_E70_E0.7870.99
291_S294_A0.7850.99
86_K97_R0.7840.99
195_I200_E0.7830.99
166_V213_P0.7820.99
220_Y224_A0.7750.99
171_G212_H0.7710.99
282_R285_E0.7680.99
141_W145_Y0.7660.99
284_M287_I0.7650.99
36_I58_V0.7620.99
163_L208_V0.7600.99
31_D57_K0.7540.99
139_N185_K0.7520.99
184_A187_A0.7490.99
250_L254_E0.7480.99
260_M263_G0.7430.99
290_H294_A0.7430.99
112_W147_T0.7420.99
124_A179_S0.7400.99
47_T246_A0.7340.99
218_T242_P0.7330.99
102_A107_G0.7330.99
195_I208_V0.7310.99
103_I107_G0.7290.99
57_K106_F0.7210.99
220_Y223_H0.7210.99
121_F135_M0.7170.99
36_I51_A0.7130.99
265_Q269_I0.7120.99
225_H228_L0.7110.99
54_K250_L0.7070.99
119_S135_M0.7070.99
114_N143_P0.7040.99
119_S122_G0.7040.99
62_A84_W0.7040.99
37_T117_A0.7030.99
269_I272_L0.7020.99
33_V102_A0.7010.99
46_V246_A0.7000.99
282_R287_I0.6990.99
221_N224_A0.6980.99
39_A48_A0.6970.99
278_R281_D0.6960.99
289_Y293_H0.6960.99
40_S44_G0.6960.99
240_Y245_V0.6960.99
48_A58_V0.6960.99
267_K270_A0.6940.99
171_G276_F0.6930.99
58_V80_H0.6930.99
36_I47_T0.6920.99
133_K141_W0.6900.99
281_D287_I0.6850.98
35_V146_G0.6820.98
40_S63_R0.6820.98
59_V98_I0.6810.98
151_V195_I0.6790.98
251_F254_E0.6760.98
68_L72_T0.6740.98
75_L80_H0.6700.98
264_S268_A0.6680.98
109_F157_R0.6670.98
285_E289_Y0.6660.98
101_T104_S0.6630.98
191_W195_I0.6620.98
271_M274_A0.6610.98
153_H156_G0.6570.98
115_N166_V0.6570.98
277_P280_T0.6560.98
215_R239_I0.6560.98
268_A271_M0.6560.98
44_G115_N0.6510.98
281_D288_M0.6490.98
165_N188_L0.6460.98
276_F284_M0.6440.98
35_V102_A0.6430.98
85_V102_A0.6420.98
169_L172_D0.6410.98
91_K95_V0.6400.98
286_K290_H0.6390.98
162_A253_A0.6370.98
98_I101_T0.6350.97
33_V106_F0.6340.97
281_D289_Y0.6330.97
102_A150_A0.6320.97
270_A273_G0.6260.97
135_M180_T0.6260.97
39_A82_A0.6250.97
23_K26_L0.6220.97
283_L286_K0.6210.97
217_D239_I0.6190.97
188_L191_W0.6190.97
288_M291_S0.6180.97
193_E210_L0.6170.97
93_E96_N0.6170.97
147_T165_N0.6140.97
164_I253_A0.6140.97
190_G284_M0.6120.97
171_G186_F0.6090.97
48_A75_L0.6090.97
218_T223_H0.6090.97
161_G206_V0.6080.97
114_N192_T0.6050.97
76_K79_G0.6050.97
87_A95_V0.6020.97
279_L284_M0.5960.96
143_P165_N0.5950.96
147_T198_E0.5920.96
95_V142_G0.5910.96
143_P146_G0.5890.96
153_H157_R0.5880.96
102_A153_H0.5870.96
169_L173_R0.5860.96
154_Y163_L0.5850.96
262_I265_Q0.5850.96
81_D105_T0.5830.96
112_W146_G0.5810.96
90_G134_R0.5770.96
287_I290_H0.5750.95
186_F189_H0.5730.95
82_A85_V0.5730.95
43_I166_V0.5720.95
152_K156_G0.5690.95
136_F184_A0.5690.95
213_P245_V0.5680.95
164_I209_T0.5680.95
278_R284_M0.5680.95
33_V107_G0.5660.95
51_A253_A0.5660.95
277_P282_R0.5640.95
224_A228_L0.5620.95
160_P163_L0.5620.95
165_N191_W0.5620.95
118_V134_R0.5610.95
60_A68_L0.5610.95
244_A247_E0.5590.95
262_I268_A0.5590.95
29_L254_E0.5580.95
292_Q295_E0.5560.95
29_L110_D0.5560.95
216_I240_Y0.5560.95
226_S230_K0.5550.95
37_T115_N0.5550.95
263_G269_I0.5520.94
122_G126_D0.5510.94
241_P245_V0.5500.94
167_G210_L0.5450.94
132_M137_D0.5430.94
147_T150_A0.5430.94
41_S67_A0.5420.94
147_T200_E0.5400.94
270_A274_A0.5380.94
150_A157_R0.5380.94
51_A58_V0.5370.94
51_A111_T0.5360.94
96_N145_Y0.5330.93
59_V83_I0.5300.93
266_A269_I0.5300.93
261_Y266_A0.5290.93
39_A84_W0.5290.93
40_S60_A0.5290.93
148_R191_W0.5270.93
296_R299_N0.5270.93
43_I213_P0.5260.93
181_Y185_K0.5250.93
42_G220_Y0.5230.93
123_H127_V0.5210.93
297_P300_P0.5200.92
32_Q56_A0.5200.92
76_K82_A0.5200.92
61_A89_V0.5180.92
240_Y248_A0.5180.92
280_T284_M0.5180.92
276_F280_T0.5170.92
118_V138_T0.5170.92
89_V145_Y0.5160.92
279_L283_L0.5140.92
126_D134_R0.5130.92
60_A82_A0.5130.92
224_A227_Y0.5120.92
176_V186_F0.5120.92
83_I101_T0.5120.92
28_K161_G0.5120.92
96_N152_K0.5080.92
98_I146_G0.5080.92
154_Y158_G0.5070.92
38_G63_R0.5060.91
49_R71_L0.5050.91
51_A56_A0.5040.91
228_L232_P0.5010.91
39_A71_L0.5000.91
260_M264_S0.5000.91
167_G171_G0.5000.91
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1vl8A 4 0.691 100 0.351 Contact Map
4is2A 3 0.5983 100 0.36 Contact Map
4gh5A 4 0.677 100 0.36 Contact Map
3sjuA 4 0.6742 100 0.362 Contact Map
4weoA 4 0.6545 100 0.362 Contact Map
2rhcB 4 0.7107 100 0.364 Contact Map
4trrA 4 0.691 100 0.365 Contact Map
2c07A 4 0.6854 100 0.366 Contact Map
3ftpA 4 0.691 100 0.367 Contact Map
3gvcA 4 0.6966 100 0.368 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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