GREMLIN Database
YWZA - UPF0410 protein YwzA
UniProt: O32282 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 81 (77)
Sequences: 396 (174)
Seq/√Len: 19.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
71_F75_L3.4371.00
11_I29_I3.2031.00
37_L57_F3.1030.99
47_L64_I3.0460.99
2_S6_S2.4960.97
26_P31_G2.4950.97
40_A62_A2.3240.96
52_P59_I2.0080.91
42_I69_V2.0020.91
6_S37_L1.8230.86
27_G31_G1.8070.86
5_I57_F1.7150.82
16_L19_L1.6980.82
53_H58_A1.6960.82
11_I33_M1.6900.81
72_L76_L1.5400.75
52_P60_I1.5180.74
46_L68_I1.4620.71
24_D31_G1.4350.69
71_F76_L1.4140.68
24_D27_G1.3470.64
3_F6_S1.3340.63
15_W19_L1.2980.61
16_L24_D1.2400.58
40_A70_V1.2150.56
44_H47_L1.1980.55
3_F64_I1.1950.55
69_V73_V1.1840.54
55_A58_A1.1750.54
7_L32_S1.1550.52
67_A71_F1.1420.51
56_G60_I1.1400.51
13_I70_V1.1330.51
13_I62_A1.1230.50
3_F41_W1.0990.49
11_I32_S1.0490.45
43_G48_G1.0000.42
11_I15_W0.9960.42
10_A32_S0.9920.42
23_G26_P0.9910.42
2_S44_H0.9900.42
6_S55_A0.9610.40
6_S57_F0.9550.39
18_S21_V0.9530.39
58_A61_P0.9070.37
64_I70_V0.9050.36
35_A73_V0.8830.35
57_F62_A0.8810.35
5_I23_G0.8730.35
31_G41_W0.8670.34
25_M31_G0.8660.34
37_L63_V0.8600.34
50_W60_I0.8310.32
41_W45_G0.7960.30
17_G74_S0.7900.30
37_L44_H0.7890.30
7_L33_M0.7730.29
49_T66_A0.7690.29
12_I15_W0.7650.29
7_L74_S0.7550.28
15_W77_T0.7530.28
17_G20_F0.7490.28
3_F62_A0.7380.27
17_G22_K0.7170.26
46_L58_A0.7160.26
63_V67_A0.7060.26
26_P41_W0.7030.25
19_L29_I0.7020.25
43_G61_P0.7010.25
12_I77_T0.6900.25
47_L50_W0.6840.24
68_I74_S0.6720.24
13_I55_A0.6700.24
58_A68_I0.6610.23
22_K25_M0.6590.23
73_V77_T0.6580.23
29_I33_M0.6530.23
75_L78_R0.6490.23
5_I9_V0.6440.23
5_I54_L0.6380.22
42_I45_G0.6380.22
47_L53_H0.6200.22
12_I69_V0.6140.21
38_I47_L0.6070.21
48_G61_P0.6010.21
20_F67_A0.5960.21
37_L54_L0.5960.21
21_V27_G0.5940.20
15_W29_I0.5920.20
5_I10_A0.5890.20
19_L24_D0.5890.20
45_G76_L0.5880.20
34_I38_I0.5860.20
33_M76_L0.5850.20
6_S66_A0.5830.20
34_I63_V0.5760.20
30_I49_T0.5730.20
27_G34_I0.5710.19
3_F42_I0.5710.19
20_F68_I0.5650.19
12_I45_G0.5570.19
9_V59_I0.5540.19
15_W26_P0.5430.18
20_F74_S0.5360.18
22_K67_A0.5220.18
30_I77_T0.5220.18
55_A63_V0.5150.17
12_I16_L0.5150.17
9_V13_I0.5140.17
54_L60_I0.5130.17
22_K27_G0.5130.17
49_T53_H0.5070.17
19_L30_I0.5010.17
12_I53_H0.5010.17
8_I33_M0.5010.17
23_G42_I0.5000.17
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4z7fA 2 0.9877 27.7 0.904 Contact Map
4wgvA 2 0.8642 25.6 0.905 Contact Map
3dh4A 3 0.9506 10.5 0.92 Contact Map
2xq2A 2 0.9506 8 0.924 Contact Map
3rlbA 1 0.9259 7.2 0.926 Contact Map
4rfsS 1 0.9259 7.1 0.926 Contact Map
2b2hA 3 0.9136 5.8 0.929 Contact Map
4hzuS 1 0.7531 5.8 0.93 Contact Map
4pd6A 3 0.2593 5.7 0.93 Contact Map
2kluA 1 0.3827 5.4 0.93 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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