GREMLIN Database
YWZB - Uncharacterized membrane protein YwzB
UniProt: O32278 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 76 (74)
Sequences: 213 (159)
Seq/√Len: 18.4

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
22_T54_I3.4171.00
22_T51_T3.3021.00
18_F62_F3.0140.99
11_G68_Y2.5120.97
16_L44_R2.2560.94
24_W42_Q2.1610.92
11_G63_L2.1250.92
30_N33_P2.1020.91
14_V59_A2.0440.90
35_I43_A1.9970.89
6_Q66_L1.8190.84
34_L39_K1.6980.79
9_A72_L1.6450.77
16_L76_F1.6020.75
31_I43_A1.5330.71
35_I46_L1.5080.70
12_I64_D1.4450.67
25_A46_L1.3830.63
22_T53_A1.3580.62
31_I36_K1.2870.58
53_A57_A1.2580.56
57_A60_N1.2400.55
22_T55_G1.2190.53
60_N71_Q1.2150.53
56_T71_Q1.1720.50
35_I65_Y1.1400.48
49_L58_V1.1290.48
57_A75_L1.1210.47
32_D38_G1.1000.46
21_V36_K1.0880.45
28_A35_I1.0830.45
12_I21_V1.0450.43
39_K49_L1.0410.42
14_V18_F1.0310.42
39_K68_Y1.0120.41
8_A28_A1.0110.40
10_I55_G1.0090.40
51_T76_F1.0030.40
13_V32_D1.0010.40
32_D74_Y0.9800.39
24_W65_Y0.9770.38
15_H59_A0.9580.37
29_V34_L0.9440.37
30_N36_K0.9420.36
12_I16_L0.9280.36
16_L20_A0.8960.34
42_Q45_L0.8960.34
14_V19_I0.8940.34
41_V60_N0.8900.33
28_A36_K0.8700.32
19_I55_G0.8680.32
6_Q63_L0.8620.32
4_L63_L0.8530.31
19_I64_D0.8480.31
43_A66_L0.8360.31
4_L74_Y0.8230.30
14_V62_F0.8050.29
60_N64_D0.7890.28
14_V41_V0.7860.28
24_W35_I0.7760.27
6_Q34_L0.7750.27
29_V75_L0.7740.27
8_A57_A0.7730.27
8_A19_I0.7530.26
28_A57_A0.7510.26
44_R65_Y0.7490.26
38_G47_M0.7490.26
54_I58_V0.7390.26
10_I13_V0.7370.26
56_T60_N0.7140.25
5_G74_Y0.7130.24
17_I54_I0.6980.24
29_V37_K0.6870.23
5_G8_A0.6640.22
49_L56_T0.6570.22
21_V41_V0.6560.22
10_I48_I0.6550.22
18_F22_T0.6520.22
25_A68_Y0.6500.22
25_A69_S0.6470.22
23_W45_L0.6440.21
4_L59_A0.6420.21
31_I47_M0.6350.21
15_H40_V0.6220.21
16_L65_Y0.6210.20
58_V69_S0.6110.20
17_I66_L0.5900.19
18_F59_A0.5860.19
38_G73_P0.5840.19
19_I70_Q0.5780.19
3_V13_V0.5770.19
11_G71_Q0.5620.18
30_N37_K0.5590.18
5_G12_I0.5480.18
41_V56_T0.5480.18
52_I69_S0.5450.18
32_D48_I0.5440.18
28_A62_F0.5370.17
27_Q50_L0.5350.17
35_I50_L0.5340.17
10_I36_K0.5320.17
23_W65_Y0.5260.17
18_F55_G0.5260.17
31_I34_L0.5250.17
37_K74_Y0.5200.17
29_V47_M0.5150.17
22_T70_Q0.5070.16
20_A26_L0.5040.16
8_A47_M0.5030.16
9_A73_P0.5010.16
32_D73_P0.5000.16
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4bfrA 1 0.6316 3.5 0.934 Contact Map
3ne5A 3 0.7895 3.3 0.934 Contact Map
2wxfA 1 0.6316 3.2 0.935 Contact Map
2nwlA 3 0.4605 3.1 0.935 Contact Map
4mt1A 3 0.7895 3 0.936 Contact Map
2kseA 1 0.5 3 0.936 Contact Map
2y3aA 1 0.6316 2.6 0.938 Contact Map
4k0jA 3 0.7895 2.1 0.941 Contact Map
3w9iA 3 0.8289 2 0.941 Contact Map
4dx5A 3 0.8289 1.9 0.942 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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