GREMLIN Database
YWMB - Uncharacterized protein YwmB
UniProt: O32277 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 246 (238)
Sequences: 212 (193)
Seq/√Len: 12.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
181_L202_A5.5411.00
201_S218_M3.8220.99
204_T207_W3.6020.99
181_L186_A3.3940.98
122_Y186_A2.8960.95
106_F125_Y2.8720.95
122_Y163_G2.7630.94
190_E201_S2.7210.93
194_E225_R2.7040.93
213_T218_M2.4740.90
160_C168_N2.4740.90
238_G245_E2.4650.89
194_E197_F2.4330.89
201_S225_R2.4110.88
82_W95_G2.3010.86
218_M241_I2.2590.85
186_A200_I2.2070.83
197_F225_R2.1510.81
157_I160_C2.1290.81
51_W158_F2.0490.78
160_C241_I2.0220.77
236_T245_E2.0130.77
167_D226_S1.9940.76
186_A202_A1.9280.74
210_Y217_K1.8930.72
11_I16_L1.8680.71
125_Y194_E1.8600.71
75_Q161_L1.8340.70
195_P220_L1.8050.68
177_A202_A1.8020.68
184_F245_E1.7990.68
199_S242_V1.7250.65
130_L235_V1.7170.64
82_W194_E1.7080.64
221_Q243_T1.6730.62
221_Q236_T1.6610.62
123_L220_L1.6610.62
125_Y197_F1.6370.60
51_W207_W1.6020.59
240_P246_Y1.5840.58
168_N242_V1.5800.58
199_S245_E1.5710.57
158_F194_E1.5500.56
204_T208_E1.5450.56
33_P207_W1.5430.56
201_S213_T1.5380.56
125_Y173_L1.5310.55
199_S225_R1.5180.55
219_N240_P1.5100.54
34_L37_M1.4910.53
80_Y95_G1.4790.53
56_K125_Y1.4730.52
51_W184_F1.4560.51
220_L237_V1.4530.51
184_F221_Q1.4490.51
163_G199_S1.4160.49
51_W125_Y1.4160.49
70_V187_R1.4150.49
106_F158_F1.4110.49
221_Q245_E1.4090.49
163_G186_A1.3950.48
238_G241_I1.3840.48
197_F202_A1.3820.48
65_E74_K1.3810.47
218_M238_G1.3790.47
56_K158_F1.3720.47
51_W194_E1.3720.47
223_A246_Y1.3710.47
125_Y158_F1.3630.47
190_E221_Q1.3530.46
223_A242_V1.3470.46
45_D237_V1.3370.45
66_F103_R1.3300.45
236_T243_T1.3170.44
190_E243_T1.2880.43
49_D164_H1.2770.42
56_K153_E1.2740.42
50_K162_N1.2670.42
126_E164_H1.2620.41
43_R180_L1.2610.41
35_A237_V1.2360.40
46_V199_S1.2350.40
196_N227_A1.2270.40
188_S191_H1.2240.40
184_F220_L1.2170.39
221_Q238_G1.2160.39
190_E199_S1.2160.39
106_F194_E1.2160.39
230_G234_T1.2090.39
13_S19_V1.1840.38
11_I223_A1.1830.38
201_S243_T1.1760.37
238_G246_Y1.1690.37
51_W129_S1.1470.36
51_W132_T1.1420.36
201_S245_E1.1300.35
58_N83_V1.1270.35
41_M46_V1.1120.34
207_W236_T1.1080.34
160_C167_D1.0990.34
205_D224_L1.0850.33
53_L200_I1.0820.33
187_R222_I1.0790.33
88_D200_I1.0780.33
153_E237_V1.0740.33
121_S177_A1.0680.32
51_W173_L1.0610.32
54_H184_F1.0440.31
139_T199_S1.0380.31
67_Y84_I1.0330.31
221_Q234_T1.0290.31
199_S246_Y1.0280.30
9_A21_A1.0270.30
41_M68_Q1.0250.30
160_C166_D1.0170.30
6_V65_E1.0170.30
108_L150_I1.0120.30
30_E142_Q1.0090.30
76_E200_I1.0010.29
125_Y225_R0.9960.29
125_Y243_T0.9960.29
25_T29_S0.9910.29
64_K95_G0.9900.29
241_I245_E0.9870.29
13_S210_Y0.9750.28
145_R223_A0.9710.28
238_G243_T0.9690.28
211_I222_I0.9640.28
173_L221_Q0.9630.28
218_M243_T0.9620.28
9_A223_A0.9540.27
197_F201_S0.9520.27
62_T65_E0.9490.27
46_V207_W0.9450.27
199_S238_G0.9430.27
117_H200_I0.9390.27
74_K77_Y0.9270.26
191_H201_S0.9150.26
182_N211_I0.9090.26
82_W202_A0.9030.25
13_S18_F0.8970.25
176_K238_G0.8960.25
80_Y231_G0.8940.25
139_T243_T0.8930.25
51_W56_K0.8880.25
221_Q241_I0.8870.25
112_T210_Y0.8850.25
19_V23_F0.8840.25
106_F197_F0.8830.25
40_G231_G0.8770.24
190_E225_R0.8770.24
45_D223_A0.8760.24
161_L165_L0.8730.24
225_R242_V0.8720.24
73_L77_Y0.8690.24
203_F219_N0.8670.24
56_K236_T0.8660.24
123_L167_D0.8640.24
153_E158_F0.8630.24
165_L235_V0.8630.24
11_I102_N0.8620.24
159_T235_V0.8610.24
145_R181_L0.8550.24
200_I226_S0.8530.23
228_G245_E0.8520.23
15_M24_H0.8510.23
55_A164_H0.8500.23
188_S207_W0.8440.23
79_Q153_E0.8430.23
14_V179_Q0.8420.23
218_M236_T0.8420.23
241_I246_Y0.8400.23
199_S243_T0.8390.23
198_V204_T0.8360.23
46_V165_L0.8350.23
238_G242_V0.8350.23
164_H232_K0.8350.23
11_I144_E0.8340.23
149_G230_G0.8310.23
38_A184_F0.8240.22
189_V213_T0.8200.22
139_T201_S0.8190.22
49_D135_S0.8180.22
88_D222_I0.8160.22
62_T157_I0.8120.22
51_W106_F0.8080.22
15_M25_T0.8080.22
86_R215_K0.8070.22
123_L144_E0.8050.22
160_C169_M0.7970.21
57_Q153_E0.7950.21
192_V242_V0.7950.21
71_Q201_S0.7920.21
85_A149_G0.7910.21
125_Y172_V0.7900.21
110_L198_V0.7870.21
16_L20_I0.7820.21
157_I199_S0.7780.21
202_A219_N0.7710.21
34_L62_T0.7680.20
34_L40_G0.7650.20
89_K94_I0.7640.20
99_D195_P0.7630.20
39_E136_W0.7610.20
127_Q201_S0.7600.20
21_A116_K0.7600.20
129_S221_Q0.7560.20
23_F110_L0.7540.20
196_N220_L0.7520.20
159_T174_Q0.7500.20
54_H207_W0.7390.19
135_S141_E0.7370.19
207_W221_Q0.7350.19
172_V238_G0.7320.19
225_R234_T0.7300.19
28_A152_Q0.7260.19
48_I51_W0.7250.19
134_D137_N0.7230.19
121_S199_S0.7170.19
56_K121_S0.7130.19
46_V125_Y0.7100.19
158_F241_I0.7080.19
43_R182_N0.7070.18
33_P239_T0.7060.18
49_D111_V0.7040.18
124_L224_L0.7040.18
41_M136_W0.7000.18
239_T246_Y0.6990.18
81_D209_E0.6950.18
121_S124_L0.6950.18
16_L214_S0.6870.18
204_T223_A0.6780.18
80_Y92_K0.6770.18
129_S238_G0.6760.18
229_M244_T0.6730.17
126_E224_L0.6680.17
155_V163_G0.6680.17
56_K228_G0.6670.17
177_A181_L0.6640.17
201_S211_I0.6630.17
37_M161_L0.6620.17
159_T168_N0.6620.17
46_V121_S0.6610.17
226_S234_T0.6610.17
68_Q170_N0.6600.17
54_H201_S0.6580.17
125_Y192_V0.6580.17
202_A213_T0.6510.17
168_N202_A0.6480.17
10_I166_D0.6460.17
123_L209_E0.6450.17
201_S242_V0.6400.16
223_A240_P0.6380.16
31_L202_A0.6380.16
58_N77_Y0.6350.16
51_W197_F0.6350.16
48_I117_H0.6280.16
199_S202_A0.6260.16
148_L200_I0.6230.16
92_K204_T0.6220.16
207_W238_G0.6170.16
158_F229_M0.6160.16
137_N231_G0.6130.16
184_F238_G0.6120.16
15_M43_R0.6090.16
93_A237_V0.6060.16
74_K82_W0.6060.16
59_L88_D0.6040.16
203_F217_K0.6000.15
41_M45_D0.5990.15
157_I223_A0.5990.15
33_P204_T0.5960.15
69_K154_K0.5960.15
125_Y201_S0.5950.15
129_S173_L0.5950.15
8_H48_I0.5920.15
89_K211_I0.5910.15
53_L85_A0.5890.15
173_L243_T0.5890.15
145_R183_E0.5870.15
56_K132_T0.5860.15
124_L181_L0.5850.15
106_F129_S0.5850.15
52_T162_N0.5830.15
22_V165_L0.5830.15
12_I208_E0.5810.15
53_L203_F0.5800.15
227_A230_G0.5800.15
10_I134_D0.5790.15
41_M208_E0.5780.15
11_I87_E0.5770.15
218_M221_Q0.5770.15
125_Y236_T0.5750.15
89_K213_T0.5750.15
42_E61_L0.5740.15
34_L51_W0.5720.15
168_N200_I0.5720.15
225_R245_E0.5700.15
59_L214_S0.5660.15
34_L125_Y0.5660.15
111_V203_F0.5640.14
18_F196_N0.5620.14
37_M77_Y0.5600.14
50_K110_L0.5580.14
25_T28_A0.5540.14
167_D234_T0.5540.14
84_I142_Q0.5530.14
11_I19_V0.5530.14
37_M204_T0.5530.14
135_S145_R0.5520.14
92_K239_T0.5470.14
190_E211_I0.5460.14
6_V93_A0.5450.14
56_K245_E0.5440.14
40_G163_G0.5440.14
186_A190_E0.5430.14
191_H202_A0.5410.14
105_S203_F0.5400.14
201_S244_T0.5400.14
106_F239_T0.5390.14
69_K136_W0.5390.14
54_H122_Y0.5360.14
228_G236_T0.5350.14
173_L184_F0.5330.14
8_H14_V0.5320.14
10_I13_S0.5310.14
116_K184_F0.5310.14
39_E121_S0.5300.14
54_H242_V0.5300.14
11_I237_V0.5290.14
55_A147_T0.5250.13
51_W229_M0.5250.13
146_E227_A0.5240.13
192_V238_G0.5230.13
66_F70_V0.5190.13
119_P203_F0.5180.13
52_T127_Q0.5170.13
137_N147_T0.5160.13
171_I231_G0.5150.13
137_N140_Y0.5150.13
198_V225_R0.5140.13
72_R150_I0.5140.13
156_V238_G0.5140.13
177_A235_V0.5130.13
65_E239_T0.5120.13
66_F202_A0.5090.13
76_E87_E0.5090.13
11_I145_R0.5080.13
219_N246_Y0.5080.13
26_I120_T0.5070.13
48_I238_G0.5070.13
96_T125_Y0.5030.13
18_F34_L0.5030.13
129_S245_E0.5020.13
170_N202_A0.5010.13
64_K138_D0.5010.13
169_M221_Q0.5000.13
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2fpnA 2 0.8333 100 0.207 Contact Map
4gycB 2 0.0976 34.6 0.942 Contact Map
1l7bA 1 0.2967 22 0.948 Contact Map
2f95B 2 0.0813 16.9 0.95 Contact Map
2nteA 1 0.2764 12.8 0.953 Contact Map
4cq4A 4 0.3333 12.4 0.953 Contact Map
2etxA 2 0.252 10.3 0.955 Contact Map
2qguA 1 0.6057 9.9 0.955 Contact Map
4fybB 1 0.561 9.1 0.956 Contact Map
4nv5A 1 0.5 9 0.956 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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