GREMLIN Database
TUAB - Teichuronic acid biosynthesis protein TuaB
UniProt: O32273 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 483 (444)
Sequences: 17670 (15132)
Seq/√Len: 718.1

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
279_E282_V4.8111.00
208_K212_S3.3101.00
141_H144_T3.2471.00
99_S102_V3.1551.00
46_G248_N3.0151.00
325_V329_N3.0041.00
70_R73_A2.9581.00
353_R356_L2.8821.00
416_Q420_K2.8371.00
355_D359_Y2.7451.00
306_V329_N2.7351.00
140_L275_K2.7091.00
353_R406_V2.5611.00
246_I323_A2.4531.00
309_S325_V2.3241.00
310_D314_T2.3181.00
231_D247_Y2.2561.00
337_L393_V2.2051.00
330_V382_L2.1951.00
169_A172_A2.1681.00
235_I239_I2.1621.00
309_S329_N2.1041.00
364_V395_N2.1011.00
97_Y117_R2.1001.00
231_D372_L2.0911.00
276_N282_V2.0841.00
219_S358_F2.0801.00
285_E289_N2.0511.00
428_M432_A2.0321.00
38_T41_E2.0271.00
327_I381_L2.0221.00
204_L208_K2.0071.00
113_V117_R2.0001.00
240_G243_A1.9961.00
304_G308_V1.9911.00
417_S420_K1.9851.00
14_W143_N1.9761.00
371_S387_V1.9741.00
360_W398_I1.9441.00
234_L376_V1.9441.00
35_N318_G1.9061.00
280_N284_R1.9031.00
303_I429_G1.8891.00
376_V384_V1.8801.00
330_V389_A1.8791.00
239_I243_A1.8611.00
308_V311_A1.8451.00
311_A314_T1.8051.00
428_M457_G1.7621.00
319_E322_L1.7601.00
239_I381_L1.7581.00
47_M236_G1.7551.00
380_S383_T1.7251.00
379_G386_W1.7231.00
143_N147_K1.7141.00
375_A387_V1.6841.00
282_V285_E1.6751.00
298_S339_V1.6681.00
326_P382_L1.6621.00
383_T387_V1.6621.00
73_A76_R1.6501.00
234_L372_L1.6481.00
313_I328_L1.6451.00
287_F347_V1.6301.00
304_G454_V1.6301.00
101_P113_V1.6241.00
310_D325_V1.6191.00
367_L394_V1.6151.00
254_V331_L1.6121.00
372_L376_V1.5951.00
45_V49_T1.5911.00
330_V386_W1.5781.00
231_D388_Y1.5781.00
34_G249_L1.5771.00
327_I385_A1.5771.00
140_L272_I1.5741.00
223_V362_S1.5651.00
313_I324_A1.5631.00
305_L332_A1.5621.00
374_A377_Q1.5481.00
310_D329_N1.5461.00
283_I347_V1.5411.00
135_M139_Q1.5401.00
375_A379_G1.5371.00
334_V389_A1.5351.00
156_S180_L1.5151.00
302_L336_I1.5141.00
100_S117_R1.5131.00
330_V385_A1.5131.00
299_F425_T1.5101.00
235_I384_V1.5091.00
75_E79_S1.5021.00
304_G428_M1.4741.00
96_L120_A1.4721.00
337_L396_F1.4691.00
432_A457_G1.4591.00
281_S285_E1.4471.00
326_P329_N1.4461.00
397_L401_W1.4461.00
288_L292_K1.4391.00
243_A381_L1.4381.00
412_S416_Q1.4181.00
235_I244_L1.4091.00
387_V391_I1.4061.00
172_A176_S1.4011.00
284_R288_L1.3981.00
273_F283_I1.3961.00
77_Q81_L1.3951.00
308_V312_F1.3941.00
368_Y372_L1.3881.00
216_F358_F1.3871.00
429_G433_F1.3841.00
370_L374_A1.3831.00
48_I119_L1.3771.00
234_L373_F1.3721.00
66_A213_F1.3711.00
434_G437_L1.3691.00
141_H195_K1.3541.00
282_V286_G1.3511.00
76_R203_D1.3441.00
359_Y363_G1.3391.00
21_C150_I1.3381.00
323_A326_P1.3371.00
242_E246_I1.3371.00
155_L183_S1.3361.00
250_A324_A1.3281.00
76_R80_T1.3261.00
276_N286_G1.3161.00
401_W405_Y1.3141.00
159_Y176_S1.3131.00
30_F252_Q1.3131.00
78_L135_M1.3071.00
318_G321_W1.3061.00
249_L317_F1.2911.00
223_V365_L1.2891.00
31_A35_N1.2881.00
234_L238_F1.2871.00
230_I369_G1.2871.00
270_F274_A1.2841.00
115_L174_V1.2801.00
20_M24_I1.2671.00
203_D206_G1.2661.00
360_W402_L1.2631.00
27_I31_A1.2621.00
39_L246_I1.2611.00
269_A290_M1.2501.00
305_L328_L1.2481.00
313_I325_V1.2471.00
250_A327_I1.2411.00
280_N351_K1.2351.00
229_N232_M1.2321.00
162_I166_M1.2301.00
22_I153_N1.2291.00
382_L385_A1.2281.00
29_Q157_F1.2211.00
424_I428_M1.2151.00
273_F350_A1.2101.00
295_A299_F1.1921.00
360_W399_G1.1911.00
281_S284_R1.1911.00
42_F46_G1.1901.00
374_A378_T1.1871.00
34_G317_F1.1831.00
124_L127_P1.1811.00
148_I187_L1.1791.00
347_V403_L1.1761.00
333_I389_A1.1761.00
46_G245_G1.1751.00
213_F354_A1.1751.00
368_Y388_Y1.1711.00
235_I247_Y1.1701.00
18_S146_S1.1681.00
161_A165_F1.1681.00
415_F419_M1.1661.00
186_I190_A1.1651.00
148_I188_Y1.1631.00
158_G162_I1.1591.00
132_Y189_W1.1581.00
375_A378_T1.1521.00
287_F344_N1.1491.00
425_T429_G1.1471.00
371_S375_A1.1451.00
344_N400_R1.1451.00
24_I28_V1.1421.00
41_E44_L1.1421.00
434_G438_S1.1381.00
334_V385_A1.1361.00
327_I382_L1.1281.00
60_D64_G1.1231.00
379_G383_T1.1201.00
142_F268_V1.1191.00
84_L207_M1.1161.00
101_P105_G1.1111.00
223_V358_F1.1091.00
215_A219_S1.1091.00
220_S357_A1.1081.00
372_L388_Y1.1051.00
101_P117_R1.1051.00
302_L306_V1.1041.00
87_M91_L1.1011.00
125_I185_G1.1011.00
39_L320_K1.1001.00
45_V173_Y1.0981.00
47_M244_L1.0941.00
53_V57_I1.0921.00
93_F96_L1.0901.00
144_T191_V1.0861.00
97_Y101_P1.0841.00
68_I134_Y1.0821.00
216_F355_D1.0821.00
121_I178_V1.0761.00
367_L371_S1.0741.00
309_S328_L1.0691.00
12_A268_V1.0691.00
79_S83_W1.0681.00
39_L245_G1.0621.00
44_L241_A1.0621.00
246_I324_A1.0591.00
368_Y391_I1.0581.00
433_F436_S1.0511.00
372_L375_A1.0511.00
272_I275_K1.0471.00
70_R74_T1.0471.00
15_T268_V1.0451.00
226_L365_L1.0431.00
83_W87_M1.0421.00
311_A436_S1.0411.00
362_S366_L1.0391.00
436_S453_S1.0381.00
102_V105_G1.0351.00
171_L174_V1.0341.00
125_I182_S1.0341.00
71_D74_T1.0311.00
11_G140_L1.0181.00
430_I434_G1.0151.00
175_I179_L1.0141.00
231_D368_Y1.0141.00
334_V337_L1.0111.00
81_L210_F1.0101.00
30_F317_F1.0091.00
227_G368_Y1.0071.00
93_F97_Y1.0061.00
25_I157_F1.0021.00
189_W193_R1.0011.00
209_D352_G1.0011.00
80_T207_M1.0001.00
19_T23_T0.9971.00
100_S113_V0.9951.00
303_I425_T0.9941.00
7_Q10_S0.9921.00
359_Y362_S0.9891.00
446_A449_R0.9841.00
235_I381_L0.9831.00
344_N399_G0.9831.00
32_L36_M0.9811.00
340_L396_F0.9781.00
121_I124_L0.9761.00
449_R453_S0.9721.00
159_Y163_A0.9711.00
98_V101_P0.9711.00
356_L402_L0.9681.00
90_V94_V0.9671.00
176_S180_L0.9611.00
67_L81_L0.9601.00
308_V453_S0.9581.00
69_Q352_G0.9571.00
211_F214_G0.9551.00
283_I351_K0.9541.00
349_L357_A0.9511.00
306_V309_S0.9501.00
100_S104_A0.9481.00
378_T382_L0.9471.00
250_A331_L0.9451.00
31_A317_F0.9431.00
12_A265_V0.9431.00
187_L191_V0.9391.00
433_F437_L0.9381.00
177_Q181_Q0.9361.00
366_L370_L0.9341.00
329_N333_I0.9341.00
404_A407_I0.9321.00
38_T320_K0.9311.00
272_I276_N0.9301.00
111_E114_F0.9301.00
238_F376_V0.9291.00
66_A210_F0.9271.00
322_L325_V0.9241.00
331_L385_A0.9241.00
245_G249_L0.9201.00
114_F117_R0.9181.00
36_M164_V0.9171.00
36_M165_F0.9161.00
389_A392_S0.9151.00
454_V458_A0.9141.00
386_W389_A0.9071.00
206_G209_D0.9071.00
40_T241_A0.9061.00
401_W404_A0.9051.00
451_A455_A0.9021.00
276_N279_E0.9011.00
38_T321_W0.8991.00
324_A327_I0.8981.00
48_I115_L0.8971.00
33_L173_Y0.8941.00
98_V102_V0.8901.00
348_L402_L0.8901.00
159_Y179_L0.8881.00
315_A450_L0.8871.00
312_F316_V0.8871.00
236_G244_L0.8861.00
211_F215_A0.8841.00
104_A112_L0.8791.00
66_A214_G0.8791.00
87_M90_V0.8791.00
254_V335_G0.8781.00
117_R121_I0.8761.00
175_I178_V0.8761.00
398_I401_W0.8741.00
180_L184_K0.8741.00
25_I29_Q0.8721.00
205_R208_K0.8711.00
398_I402_L0.8691.00
120_A124_L0.8681.00
31_A34_G0.8681.00
95_L99_S0.8671.00
454_V457_G0.8671.00
68_I138_K0.8661.00
16_S264_I0.8651.00
250_A328_L0.8641.00
163_A168_D0.8611.00
306_V310_D0.8601.00
247_Y331_L0.8581.00
358_F362_S0.8541.00
306_V333_I0.8511.00
114_F171_L0.8511.00
369_G373_F0.8441.00
129_G185_G0.8401.00
307_S429_G0.8371.00
240_G244_L0.8371.00
82_Y132_Y0.8361.00
160_L176_S0.8361.00
122_M181_Q0.8341.00
394_V398_I0.8341.00
268_V271_P0.8331.00
178_V181_Q0.8301.00
15_T146_S0.8301.00
74_T77_Q0.8291.00
386_W390_I0.8281.00
296_L300_P0.8261.00
72_D76_R0.8231.00
10_S143_N0.8221.00
373_F377_Q0.8221.00
300_P303_I0.8211.00
82_Y85_N0.8211.00
104_A113_V0.8201.00
357_A361_D0.8161.00
69_Q354_A0.8161.00
62_G214_G0.8151.00
31_A316_V0.8141.00
136_L192_Y0.8111.00
356_L359_Y0.8091.00
89_G127_P0.8091.00
91_L95_L0.8081.00
156_S160_L0.8051.00
300_P425_T0.8051.00
322_L326_P0.8041.00
39_L242_E0.8021.00
289_N292_K0.8011.00
248_N252_Q0.8011.00
12_A16_S0.7971.00
45_V170_I0.7961.00
251_Y255_T0.7951.00
63_F81_L0.7941.00
427_A430_I0.7931.00
212_S215_A0.7921.00
402_L406_V0.7901.00
294_L339_V0.7901.00
217_Q354_A0.7851.00
212_S355_D0.7841.00
118_I178_V0.7831.00
73_A206_G0.7821.00
74_T139_Q0.7801.00
419_M423_L0.7801.00
216_F354_A0.7791.00
156_S176_S0.7771.00
333_I336_I0.7771.00
453_S457_G0.7751.00
372_L384_V0.7731.00
93_F124_L0.7731.00
311_A453_S0.7721.00
125_I178_V0.7721.00
252_Q256_I0.7721.00
9_M13_K0.7701.00
315_A447_E0.7691.00
334_V388_Y0.7671.00
371_S390_I0.7671.00
89_G93_F0.7661.00
86_I90_V0.7641.00
152_S156_S0.7621.00
270_F350_A0.7621.00
162_I165_F0.7611.00
425_T428_M0.7611.00
50_T232_M0.7601.00
8_I12_A0.7561.00
37_M41_E0.7551.00
421_P425_T0.7541.00
249_L321_W0.7541.00
402_L405_Y0.7541.00
49_T53_V0.7531.00
39_L321_W0.7531.00
222_L226_L0.7501.00
30_F34_G0.7501.00
371_S374_A0.7491.00
334_V392_S0.7471.00
14_W18_S0.7461.00
292_K296_L0.7451.00
382_L386_W0.7451.00
333_I337_L0.7441.00
245_G248_N0.7411.00
303_I307_S0.7411.00
301_L304_G0.7391.00
231_D251_Y0.7371.00
32_L161_A0.7351.00
435_V456_A0.7341.00
9_M12_A0.7341.00
225_R229_N0.7331.00
271_P275_K0.7331.00
94_V98_V0.7311.00
229_N255_T0.7301.00
360_W364_V0.7271.00
313_I317_F0.7271.00
13_K17_I0.7241.00
249_L252_Q0.7221.00
197_H200_F0.7221.00
213_F217_Q0.7221.00
152_S184_K0.7201.00
346_S349_L0.7201.00
53_V56_Q0.7191.00
133_Q137_Q0.7191.00
202_F207_M0.7191.00
197_H201_V0.7181.00
306_V332_A0.7171.00
212_S216_F0.7171.00
117_R120_A0.7161.00
16_S20_M0.7151.00
97_Y100_S0.7141.00
100_S103_I0.7121.00
252_Q255_T0.7111.00
232_M244_L0.7101.00
363_G398_I0.7081.00
102_V106_F0.7081.00
239_I380_S0.7081.00
11_G268_V0.7071.00
348_L357_A0.7061.00
304_G457_G0.7031.00
290_M343_P0.7031.00
43_G245_G0.7031.00
17_I21_C0.7011.00
393_V397_L0.7001.00
432_A436_S0.7001.00
348_L403_L0.6991.00
294_L343_P0.6951.00
47_M50_T0.6931.00
314_T322_L0.6931.00
233_I237_R0.6931.00
67_L77_Q0.6901.00
76_R79_S0.6901.00
159_Y162_I0.6881.00
223_V361_D0.6871.00
344_N403_L0.6861.00
417_S421_P0.6841.00
426_A430_I0.6841.00
18_S150_I0.6831.00
79_S82_Y0.6821.00
84_L88_T0.6811.00
270_F346_S0.6801.00
190_A194_K0.6791.00
309_S332_A0.6791.00
253_I317_F0.6791.00
304_G458_A0.6781.00
422_F425_T0.6771.00
71_D75_E0.6751.00
238_F373_F0.6751.00
100_S120_A0.6751.00
262_N266_T0.6751.00
33_L160_L0.6741.00
137_Q145_L0.6721.00
37_M170_I0.6711.00
286_G290_M0.6671.00
400_R404_A0.6671.00
367_L370_L0.6661.00
144_T147_K0.6641.00
346_S350_A0.6631.00
276_N283_I0.6621.00
62_G69_Q0.6621.00
74_T78_L0.6621.00
114_F118_I0.6621.00
423_L426_A0.6601.00
344_N396_F0.6571.00
83_W86_I0.6541.00
265_V269_A0.6541.00
60_D85_N0.6531.00
157_F161_A0.6531.00
85_N89_G0.6521.00
133_Q149_E0.6511.00
243_A246_I0.6501.00
42_F249_L0.6491.00
254_V257_P0.6481.00
377_Q384_V0.6481.00
42_F245_G0.6451.00
389_A393_V0.6431.00
56_Q60_D0.6431.00
432_A453_S0.6421.00
328_L332_A0.6421.00
101_P104_A0.6411.00
21_C25_I0.6411.00
423_L427_A0.6381.00
320_K323_A0.6331.00
229_N233_I0.6321.00
232_M248_N0.6311.00
230_I234_L0.6311.00
428_M431_I0.6281.00
220_S361_D0.6271.00
72_D75_E0.6251.00
227_G365_L0.6181.00
80_T84_L0.6171.00
447_E451_A0.6171.00
118_I174_V0.6161.00
167_M172_A0.6141.00
40_T44_L0.6141.00
128_I185_G0.6141.00
188_Y191_V0.6131.00
21_C154_V0.6121.00
341_M396_F0.6111.00
154_V158_G0.6111.00
151_F155_L0.6101.00
126_A181_Q0.6101.00
300_P428_M0.6101.00
314_T325_V0.6091.00
52_T123_F0.6091.00
436_S449_R0.6081.00
163_A166_M0.6071.00
73_A77_Q0.6061.00
30_F42_F0.6051.00
363_G366_L0.6031.00
134_Y138_K0.6021.00
41_E170_I0.6021.00
392_S395_N0.6011.00
184_K188_Y0.6011.00
247_Y251_Y0.6011.00
450_L454_V0.6001.00
32_L165_F0.5981.00
93_F120_A0.5971.00
264_I267_R0.5971.00
421_P424_I0.5951.00
362_S365_L0.5951.00
311_A449_R0.5941.00
263_P267_R0.5941.00
168_D172_A0.5931.00
302_L332_A0.5931.00
210_F214_G0.5921.00
207_M211_F0.5921.00
356_L360_W0.5911.00
26_Q30_F0.5901.00
435_V453_S0.5891.00
217_Q349_L0.5891.00
294_L298_S0.5891.00
52_T56_Q0.5881.00
314_T318_G0.5871.00
100_S116_V0.5861.00
64_G134_Y0.5861.00
81_L85_N0.5841.00
99_S103_I0.5821.00
286_G289_N0.5811.00
45_V174_V0.5791.00
220_S224_N0.5761.00
160_L164_V0.5761.00
92_L96_L0.5751.00
96_L100_S0.5751.00
148_I184_K0.5701.00
295_A336_I0.5701.00
372_L387_V0.5691.00
118_I171_L0.5681.00
404_A408_K0.5681.00
308_V457_G0.5681.00
388_Y392_S0.5671.00
83_W200_F0.5661.00
205_R209_D0.5651.00
77_Q206_G0.5641.00
185_G189_W0.5641.00
171_L175_I0.5631.00
232_M251_Y0.5631.00
10_S13_K0.5631.00
153_N156_S0.5631.00
269_A273_F0.5621.00
136_L144_T0.5621.00
252_Q317_F0.5571.00
307_S425_T0.5561.00
40_T242_E0.5541.00
376_V383_T0.5521.00
23_T26_Q0.5501.00
408_K411_L0.5491.00
272_I286_G0.5471.00
249_L324_A0.5461.00
261_I264_I0.5461.00
364_V391_I0.5461.00
354_A357_A0.5461.00
33_L37_M0.5451.00
54_F225_R0.5441.00
148_I152_S0.5441.00
139_Q195_K0.5431.00
7_Q140_L0.5421.00
178_V182_S0.5411.00
15_T19_T0.5391.00
357_A399_G0.5391.00
435_V438_S0.5381.00
347_V351_K0.5381.00
429_G432_A0.5361.00
337_L389_A0.5341.00
118_I175_I0.5331.00
33_L42_F0.5321.00
455_A459_L0.5321.00
367_L391_I0.5311.00
47_M232_M0.5311.00
155_L158_G0.5311.00
22_I26_Q0.5301.00
431_I456_A0.5301.00
147_K151_F0.5281.00
299_F336_I0.5281.00
358_F361_D0.5281.00
120_A123_F0.5261.00
338_R392_S0.5261.00
392_S396_F0.5241.00
118_I122_M0.5221.00
221_R225_R0.5211.00
104_A116_V0.5211.00
104_A108_Q0.5191.00
10_S14_W0.5191.00
13_K20_M0.5191.00
148_I191_V0.5191.00
76_R206_G0.5191.00
345_G349_L0.5191.00
239_I376_V0.5191.00
51_V55_A0.5191.00
137_Q142_F0.5171.00
29_Q160_L0.5161.00
430_I433_F0.5131.00
231_D234_L0.5121.00
163_A176_S0.5121.00
431_I434_G0.5111.00
57_I60_D0.5111.00
21_C24_I0.5111.00
190_A193_R0.5111.00
116_V120_A0.5091.00
455_A458_A0.5081.00
230_I368_Y0.5070.99
43_G242_E0.5060.99
227_G230_I0.5060.99
395_N399_G0.5040.99
338_R342_N0.5040.99
420_K423_L0.5010.99
314_T319_E0.5010.99
68_I137_Q0.5010.99
345_G357_A0.5000.99
224_N228_A0.5000.99
34_G321_W0.5000.99
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4lz6A 1 0.8509 100 0.386 Contact Map
4humA 1 0.8634 100 0.394 Contact Map
3w4tA 1 0.8344 100 0.395 Contact Map
3mktA 1 0.8592 100 0.407 Contact Map
2cfqA 1 0.8199 90.5 0.916 Contact Map
3wdoA 1 0.793 81 0.927 Contact Map
3o7qA 1 0.7805 48.1 0.942 Contact Map
4pypA 1 0.824 37.9 0.945 Contact Map
4xnjA 1 0.882 35.6 0.946 Contact Map
1pw4A 1 0.4265 20.6 0.952 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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