TUAC - BACSU - GREMLIN Contacts

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TUAC - Putative teichuronic acid biosynthesis glycosyltransferase TuaC

UniProt:	O32272	Sequences: MKILWITSVYPSSMKPGEGVFHETQVQELQKLGLDITVICPRPFHSAPVRMLKKTYRKKDVRPEYEIRKGIPVYRPFYRAVPGQLKWAQPHRRIASAVLKTMKQRDLYPDLIHAHFAMPSGGAAAVVSESAQIPYVLTLHGSDVNVYPHYSKGAFKAFKRAVGSASVVLAVSHKLQEEAKKLSGFDSSVLPIGIQLSRFQGNEETKEEIRKRLGLPLDQRLAVYVGRLVREKGIFELSEAIESLQDSPKAVFVGDGPAKSTLTQKGHIVTGQVPNHQVRDYLLAADLFVLPSYSEGMPTVVIEALALRVPVICTDVGGVSSLFGKHQHLLIKPKSAQALAEAITRYEHEQIWKPEVADDLYETVQAQFDAGKNAKALHHQYQTVTKTSV	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	389 (339)
Sequences:	54028 (45547)
Seq/√Len:	2473.8

ECOLI - RFAG GLGA WCAL WCAI RFAB WCAC WBBK
BACSU - TUAC YPJH GLGA YTCC EPSD YQGM COTSA EPSF TUAH YKVP CGEB TAGE
HALSA - Q9HQQ0 Q9HSW1 Q9HS45 Q9HRP8 Q9HSV4 Q9HSV2 Q9HQT2 Q9HRP9
SULSO - Q97UM0 Q97XT7 Q97V61 Q97VL4 Q97XT8 Q97ZD3 Q980C8 Q97V80 Q97XU2 Q97XT9 Q97UU3 Q7LXI2 Q97XT5 Q97XF6 Q7LXF8 Q97XT1 Q7LXM9 Q97XT6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
223_V	285_A	4.867	1.00
167_V	188_S	3.341	1.00
288_F	304_A	3.207	1.00
221_L	251_V	3.096	1.00
113_H	381_Y	2.990	1.00
251_V	270_T	2.898	1.00
243_S	340_A	2.863	1.00
363_T	367_Q	2.806	1.00
259_K	263_T	2.774	1.00
224_Y	234_I	2.758	1.00
219_Q	249_K	2.712	1.00
239_E	336_A	2.294	1.00
233_G	236_E	2.276	1.00
176_Q	180_K	2.274	1.00
220_R	347_E	2.223	1.00
37_T	109_P	2.177	1.00
37_T	107_L	2.173	1.00
342_A	345_R	2.136	1.00
315_D	320_S	2.115	1.00
4_L	109_P	2.097	1.00
221_L	249_K	2.075	1.00
253_V	281_Y	2.042	1.00
220_R	286_D	2.037	1.00
34_L	378_H	2.034	1.00
324_G	327_Q	2.033	1.00
222_A	287_L	2.021	1.00
349_E	352_W	2.016	1.00
221_L	284_A	2.009	1.00
323_F	328_H	1.968	1.00
243_S	337_Q	1.909	1.00
241_I	250_A	1.896	1.00
353_K	357_A	1.894	1.00
308_R	361_Y	1.878	1.00
345_R	352_W	1.860	1.00
329_L	342_A	1.851	1.00
167_V	380_Q	1.837	1.00
113_H	138_T	1.825	1.00
372_K	376_A	1.820	1.00
233_G	293_Y	1.806	1.00
273_V	277_Q	1.787	1.00
173_H	176_Q	1.768	1.00
332_K	338_A	1.760	1.00
188_S	383_T	1.757	1.00
288_F	309_V	1.756	1.00
344_T	348_H	1.748	1.00
258_A	261_T	1.747	1.00
176_Q	189_V	1.738	1.00
345_R	349_E	1.735	1.00
32_L	375_K	1.731	1.00
315_D	332_K	1.723	1.00
378_H	382_Q	1.696	1.00
193_G	370_A	1.694	1.00
225_V	278_V	1.693	1.00
324_G	363_T	1.665	1.00
173_H	321_S	1.662	1.00
137_L	165_A	1.655	1.00
237_L	250_A	1.609	1.00
274_P	277_Q	1.595	1.00
329_L	345_R	1.586	1.00
28_E	374_A	1.581	1.00
237_L	289_V	1.576	1.00
28_E	371_G	1.575	1.00
355_E	359_D	1.554	1.00
37_T	74_Y	1.547	1.00
246_D	344_T	1.544	1.00
170_A	187_S	1.543	1.00
338_A	342_A	1.541	1.00
335_S	338_A	1.533	1.00
28_E	31_K	1.530	1.00
352_W	355_E	1.527	1.00
173_H	189_V	1.514	1.00
253_V	270_T	1.507	1.00
32_L	378_H	1.504	1.00
4_L	39_I	1.503	1.00
23_E	27_Q	1.498	1.00
236_E	336_A	1.491	1.00
244_L	344_T	1.487	1.00
313_C	319_V	1.468	1.00
327_Q	359_D	1.465	1.00
221_L	286_D	1.442	1.00
231_E	294_S	1.431	1.00
170_A	176_Q	1.429	1.00
251_V	281_Y	1.420	1.00
362_E	366_A	1.417	1.00
176_Q	187_S	1.416	1.00
169_L	380_Q	1.415	1.00
285_A	309_V	1.395	1.00
279_R	307_L	1.393	1.00
273_V	281_Y	1.389	1.00
277_Q	280_D	1.387	1.00
251_V	285_A	1.385	1.00
240_A	339_L	1.383	1.00
336_A	340_A	1.374	1.00
228_L	252_F	1.371	1.00
253_V	273_V	1.358	1.00
243_S	336_A	1.342	1.00
223_V	253_V	1.341	1.00
224_Y	237_L	1.339	1.00
331_I	342_A	1.337	1.00
114_A	135_Y	1.332	1.00
236_E	293_Y	1.330	1.00
222_A	343_I	1.320	1.00
270_T	273_V	1.314	1.00
234_I	252_F	1.311	1.00
5_W	29_L	1.303	1.00
180_K	184_G	1.300	1.00
359_D	362_E	1.288	1.00
247_S	344_T	1.286	1.00
222_A	289_V	1.277	1.00
37_T	72_P	1.276	1.00
376_A	379_H	1.273	1.00
167_V	383_T	1.270	1.00
169_L	377_L	1.268	1.00
5_W	115_H	1.266	1.00
340_A	344_T	1.255	1.00
338_A	341_E	1.252	1.00
372_K	375_K	1.252	1.00
290_L	301_V	1.241	1.00
283_L	307_L	1.241	1.00
255_D	259_K	1.231	1.00
220_R	287_L	1.219	1.00
297_M	302_I	1.203	1.00
173_H	177_E	1.195	1.00
21_F	299_T	1.194	1.00
177_E	180_K	1.173	1.00
199_F	307_L	1.171	1.00
236_E	239_E	1.167	1.00
308_R	358_D	1.161	1.00
5_W	26_V	1.149	1.00
370_A	373_N	1.149	1.00
317_G	320_S	1.148	1.00
354_P	358_D	1.147	1.00
278_V	282_L	1.139	1.00
369_D	372_K	1.134	1.00
235_F	239_E	1.131	1.00
373_N	376_A	1.128	1.00
291_P	339_L	1.126	1.00
171_V	175_L	1.124	1.00
216_P	219_Q	1.121	1.00
242_E	245_Q	1.119	1.00
357_A	360_L	1.112	1.00
293_Y	334_K	1.108	1.00
301_V	319_V	1.107	1.00
245_Q	267_H	1.107	1.00
309_V	357_A	1.106	1.00
329_L	356_V	1.106	1.00
198_R	279_R	1.103	1.00
346_Y	356_V	1.103	1.00
221_L	285_A	1.099	1.00
236_E	314_T	1.098	1.00
314_T	331_I	1.091	1.00
331_I	339_L	1.089	1.00
282_L	307_L	1.088	1.00
171_V	192_I	1.086	1.00
28_E	32_L	1.084	1.00
352_W	356_V	1.080	1.00
275_N	278_V	1.072	1.00
260_S	263_T	1.068	1.00
290_L	300_V	1.068	1.00
318_G	321_S	1.058	1.00
30_Q	33_G	1.057	1.00
223_V	281_Y	1.057	1.00
292_S	295_E	1.054	1.00
288_F	300_V	1.054	1.00
222_A	241_I	1.051	1.00
236_E	334_K	1.051	1.00
249_K	267_H	1.048	1.00
170_A	179_A	1.042	1.00
24_T	370_A	1.042	1.00
279_R	283_L	1.041	1.00
196_L	369_D	1.040	1.00
305_L	311_V	1.039	1.00
188_S	380_Q	1.036	1.00
24_T	27_Q	1.031	1.00
341_E	345_R	1.025	1.00
313_C	330_L	1.023	1.00
140_H	299_T	1.021	1.00
350_Q	353_K	1.019	1.00
199_F	279_R	1.015	1.00
241_I	267_H	1.014	1.00
251_V	284_A	1.009	1.00
225_V	253_V	1.002	1.00
373_N	377_L	0.998	1.00
298_P	319_V	0.991	1.00
301_V	313_C	0.990	1.00
227_R	231_E	0.990	1.00
225_V	282_L	0.987	1.00
114_A	137_L	0.987	1.00
171_V	296_G	0.985	1.00
270_T	281_Y	0.985	1.00
325_K	342_A	0.982	1.00
192_I	299_T	0.979	1.00
241_I	248_P	0.978	1.00
115_H	140_H	0.973	1.00
170_A	175_L	0.971	1.00
358_D	362_E	0.970	1.00
193_G	373_N	0.969	1.00
26_V	38_V	0.966	1.00
260_S	264_Q	0.960	1.00
99_L	130_S	0.952	1.00
375_K	379_H	0.950	1.00
237_L	291_P	0.947	1.00
243_S	246_D	0.946	1.00
350_Q	354_P	0.944	1.00
261_T	264_Q	0.943	1.00
354_P	357_A	0.937	1.00
16_P	19_G	0.935	1.00
20_V	24_T	0.934	1.00
135_Y	165_A	0.932	1.00
244_L	340_A	0.931	1.00
304_A	309_V	0.929	1.00
236_E	339_L	0.928	1.00
301_V	311_V	0.927	1.00
178_E	181_K	0.923	1.00
295_E	298_P	0.922	1.00
329_L	346_Y	0.921	1.00
305_L	360_L	0.917	1.00
229_V	257_P	0.909	1.00
224_Y	291_P	0.908	1.00
165_A	168_V	0.907	1.00
244_L	343_I	0.899	1.00
313_C	323_F	0.895	1.00
287_L	346_Y	0.895	1.00
356_V	359_D	0.894	1.00
329_L	352_W	0.893	1.00
96_S	100_K	0.891	1.00
244_L	347_E	0.888	1.00
20_V	275_N	0.887	1.00
177_E	181_K	0.886	1.00
178_E	182_L	0.882	1.00
22_H	115_H	0.882	1.00
224_Y	252_F	0.882	1.00
312_I	331_I	0.879	1.00
305_L	363_T	0.878	1.00
310_P	357_A	0.878	1.00
240_A	340_A	0.877	1.00
357_A	361_Y	0.875	1.00
3_I	34_L	0.874	1.00
316_V	319_V	0.869	1.00
26_V	30_Q	0.862	1.00
282_L	309_V	0.861	1.00
21_F	138_T	0.861	1.00
239_E	243_S	0.853	1.00
174_K	177_E	0.853	1.00
188_S	376_A	0.849	1.00
195_Q	198_R	0.848	1.00
341_E	344_T	0.845	1.00
223_V	282_L	0.843	1.00
290_L	319_V	0.838	1.00
301_V	322_L	0.838	1.00
24_T	195_Q	0.838	1.00
312_I	342_A	0.837	1.00
232_K	300_V	0.833	1.00
375_K	378_H	0.831	1.00
190_L	380_Q	0.830	1.00
239_E	242_E	0.830	1.00
21_F	140_H	0.825	1.00
232_K	295_E	0.825	1.00
37_T	41_P	0.822	1.00
286_D	353_K	0.819	1.00
180_K	183_S	0.816	1.00
169_L	190_L	0.815	1.00
332_K	335_S	0.815	1.00
281_Y	284_A	0.814	1.00
226_G	234_I	0.812	1.00
323_F	330_L	0.808	1.00
240_A	336_A	0.807	1.00
289_V	343_I	0.804	1.00
217_L	220_R	0.804	1.00
310_P	346_Y	0.804	1.00
136_V	169_L	0.800	1.00
247_S	348_H	0.799	1.00
32_L	371_G	0.797	1.00
235_F	261_T	0.797	1.00
244_L	248_P	0.796	1.00
95_A	99_L	0.795	1.00
287_L	343_I	0.795	1.00
101_T	107_L	0.790	1.00
21_F	192_I	0.786	1.00
134_P	166_S	0.785	1.00
363_T	368_F	0.785	1.00
370_A	374_A	0.784	1.00
275_N	279_R	0.783	1.00
156_K	160_R	0.783	1.00
235_F	293_Y	0.780	1.00
140_H	171_V	0.780	1.00
337_Q	341_E	0.779	1.00
160_R	164_S	0.778	1.00
280_D	283_L	0.777	1.00
230_R	235_F	0.777	1.00
369_D	373_N	0.776	1.00
298_P	301_V	0.776	1.00
67_I	70_G	0.772	1.00
280_D	284_A	0.771	1.00
136_V	167_V	0.770	1.00
232_K	292_S	0.769	1.00
128_S	135_Y	0.767	1.00
379_H	383_T	0.766	1.00
156_K	159_K	0.765	1.00
171_V	299_T	0.764	1.00
174_K	178_E	0.764	1.00
224_Y	250_A	0.764	1.00
24_T	28_E	0.763	1.00
345_R	348_H	0.763	1.00
191_P	376_A	0.760	1.00
326_H	345_R	0.757	1.00
315_D	330_L	0.757	1.00
16_P	227_R	0.756	1.00
92_R	96_S	0.752	1.00
5_W	36_I	0.749	1.00
7_T	22_H	0.744	1.00
377_L	381_Y	0.744	1.00
202_N	283_L	0.742	1.00
371_G	375_K	0.739	1.00
273_V	278_V	0.739	1.00
355_E	358_D	0.738	1.00
141_G	231_E	0.736	1.00
225_V	288_F	0.735	1.00
180_K	187_S	0.734	1.00
126_V	130_S	0.724	1.00
224_Y	288_F	0.724	1.00
113_H	377_L	0.724	1.00
302_I	368_F	0.722	1.00
195_Q	199_F	0.721	1.00
314_T	333_P	0.719	1.00
255_D	272_Q	0.718	1.00
241_I	244_L	0.718	1.00
115_H	138_T	0.718	1.00
312_I	346_Y	0.716	1.00
7_T	18_E	0.714	1.00
188_S	191_P	0.713	1.00
20_V	23_E	0.713	1.00
222_A	347_E	0.708	1.00
190_L	377_L	0.707	1.00
290_L	298_P	0.706	1.00
191_P	321_S	0.705	1.00
356_V	360_L	0.704	1.00
337_Q	340_A	0.704	1.00
379_H	382_Q	0.700	1.00
191_P	368_F	0.696	1.00
111_L	136_V	0.696	1.00
297_M	368_F	0.696	1.00
320_S	330_L	0.692	1.00
32_L	374_A	0.691	1.00
314_T	339_L	0.689	1.00
30_Q	36_I	0.688	1.00
351_I	355_E	0.685	1.00
220_R	350_Q	0.679	1.00
346_Y	353_K	0.678	1.00
196_L	306_A	0.677	1.00
289_V	339_L	0.677	1.00
248_P	347_E	0.676	1.00
242_E	265_K	0.675	1.00
325_K	329_L	0.675	1.00
281_Y	285_A	0.674	1.00
25_Q	377_L	0.673	1.00
327_Q	363_T	0.672	1.00
226_G	232_K	0.669	1.00
380_Q	383_T	0.669	1.00
111_L	381_Y	0.668	1.00
131_A	134_P	0.667	1.00
361_Y	364_V	0.665	1.00
240_A	244_L	0.664	1.00
288_F	311_V	0.662	1.00
26_V	36_I	0.662	1.00
136_V	381_Y	0.660	1.00
220_R	248_P	0.658	1.00
21_F	377_L	0.656	1.00
238_S	268_I	0.656	1.00
233_G	334_K	0.655	1.00
129_E	164_S	0.655	1.00
159_K	163_G	0.642	1.00
5_W	113_H	0.641	1.00
21_F	25_Q	0.639	1.00
33_G	378_H	0.638	1.00
96_S	99_L	0.635	1.00
114_A	124_A	0.634	1.00
190_L	376_A	0.633	1.00
305_L	357_A	0.633	1.00
138_T	377_L	0.633	1.00
127_V	131_A	0.632	1.00
349_E	353_K	0.632	1.00
228_L	234_I	0.628	1.00
374_A	378_H	0.625	1.00
180_K	186_D	0.624	1.00
367_Q	372_K	0.623	1.00
359_D	363_T	0.622	1.00
121_G	124_A	0.622	1.00
220_R	223_V	0.618	1.00
282_L	300_V	0.618	1.00
9_V	19_G	0.617	1.00
30_Q	34_L	0.616	1.00
198_R	275_N	0.615	1.00
287_L	312_I	0.615	1.00
216_P	249_K	0.614	1.00
35_D	72_P	0.614	1.00
240_A	343_I	0.614	1.00
175_L	178_E	0.613	1.00
245_Q	248_P	0.611	1.00
223_V	288_F	0.609	1.00
27_Q	69_K	0.608	1.00
170_A	189_V	0.608	1.00
360_L	363_T	0.607	1.00
27_Q	31_K	0.607	1.00
18_E	116_F	0.606	1.00
172_S	175_L	0.603	1.00
109_P	133_I	0.603	1.00
300_V	304_A	0.603	1.00
221_L	281_Y	0.603	1.00
331_I	338_A	0.601	1.00
235_F	258_A	0.601	1.00
24_T	299_T	0.600	1.00
315_D	333_P	0.599	1.00
34_L	382_Q	0.599	1.00
149_H	153_G	0.595	1.00
128_S	131_A	0.594	1.00
31_K	371_G	0.594	1.00
230_R	258_A	0.594	1.00
312_I	343_I	0.593	1.00
184_G	187_S	0.592	1.00
351_I	354_P	0.591	1.00
286_D	350_Q	0.590	1.00
291_P	314_T	0.589	1.00
174_K	320_S	0.588	1.00
302_I	322_L	0.587	1.00
142_S	145_N	0.585	1.00
28_E	370_A	0.585	1.00
233_G	291_P	0.584	1.00
228_L	259_K	0.583	1.00
304_A	311_V	0.581	1.00
236_E	240_A	0.581	1.00
112_I	133_I	0.580	1.00
93_R	96_S	0.579	1.00
4_L	37_T	0.578	1.00
173_H	191_P	0.577	1.00
282_L	304_A	0.575	1.00
230_R	293_Y	0.575	1.00
97_A	100_K	0.574	1.00
93_R	97_A	0.572	1.00
138_T	169_L	0.571	1.00
200_Q	203_E	0.569	1.00
105_R	131_A	0.567	1.00
195_Q	370_A	0.567	1.00
282_L	288_F	0.562	1.00
27_Q	30_Q	0.562	1.00
223_V	251_V	0.560	1.00
316_V	320_S	0.558	1.00
140_H	192_I	0.557	1.00
237_L	241_I	0.557	1.00
197_S	200_Q	0.556	1.00
21_F	115_H	0.553	1.00
233_G	314_T	0.553	1.00
353_K	356_V	0.552	1.00
30_Q	70_G	0.552	1.00
215_L	251_V	0.549	1.00
200_Q	283_L	0.549	1.00
5_W	381_Y	0.548	1.00
114_A	121_G	0.548	1.00
227_R	232_K	0.545	1.00
305_L	364_V	0.544	1.00
220_R	353_K	0.544	1.00
316_V	333_P	0.541	1.00
310_P	353_K	0.540	1.00
167_V	171_V	0.540	1.00
246_D	340_A	0.540	1.00
263_T	269_V	0.539	1.00
278_V	281_Y	0.537	1.00
69_K	72_P	0.537	1.00
223_V	309_V	0.535	1.00
135_Y	166_S	0.535	1.00
253_V	278_V	0.533	1.00
143_D	146_V	0.531	1.00
25_Q	28_E	0.530	1.00
99_L	105_R	0.529	1.00
196_L	364_V	0.529	1.00
273_V	280_D	0.529	1.00
222_A	248_P	0.529	1.00
128_S	166_S	0.526	1.00
72_P	75_R	0.525	1.00
175_L	296_G	0.525	1.00
176_Q	184_G	0.524	1.00
33_G	36_I	0.524	1.00
194_I	306_A	0.524	1.00
66_E	75_R	0.523	1.00
4_L	112_I	0.523	1.00
90_P	93_R	0.523	1.00
15_K	272_Q	0.522	1.00
26_V	71_I	0.520	1.00
191_P	297_M	0.520	1.00
240_A	289_V	0.520	1.00
167_V	170_A	0.520	1.00
376_A	380_Q	0.519	1.00
10_Y	23_E	0.518	1.00
215_L	221_L	0.514	1.00
306_A	364_V	0.514	1.00
220_R	249_K	0.511	1.00
287_L	347_E	0.511	1.00
250_A	268_I	0.511	1.00
298_P	302_I	0.509	1.00
287_L	353_K	0.509	1.00
256_G	259_K	0.509	1.00
358_D	361_Y	0.504	1.00
292_S	298_P	0.503	1.00
90_P	94_I	0.503	1.00
160_R	163_G	0.502	1.00
95_A	98_V	0.500	1.00
308_R	357_A	0.500	1.00
22_H	38_V	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3froA	3	0.9871	100	0.181	Contact Map
1rzuA	1	0.9846	100	0.186	Contact Map
4n9wA	1	0.8817	100	0.192	Contact Map
2r60A	1	0.9692	100	0.195	Contact Map
3c48A	2	0.9409	100	0.196	Contact Map
2qzsA	1	0.9717	100	0.197	Contact Map
3okpA	1	0.9177	100	0.207	Contact Map
2jjmA	4	0.8843	100	0.22	Contact Map
2x6qA	1	0.8997	100	0.237	Contact Map
3s28A	4	0.9794	100	0.239	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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