GREMLIN Database
TUAC - Putative teichuronic acid biosynthesis glycosyltransferase TuaC
UniProt: O32272 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 389 (339)
Sequences: 54028 (45547)
Seq/√Len: 2473.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
223_V285_A4.8671.00
167_V188_S3.3411.00
288_F304_A3.2071.00
221_L251_V3.0961.00
113_H381_Y2.9901.00
251_V270_T2.8981.00
243_S340_A2.8631.00
363_T367_Q2.8061.00
259_K263_T2.7741.00
224_Y234_I2.7581.00
219_Q249_K2.7121.00
239_E336_A2.2941.00
233_G236_E2.2761.00
176_Q180_K2.2741.00
220_R347_E2.2231.00
37_T109_P2.1771.00
37_T107_L2.1731.00
342_A345_R2.1361.00
315_D320_S2.1151.00
4_L109_P2.0971.00
221_L249_K2.0751.00
253_V281_Y2.0421.00
220_R286_D2.0371.00
34_L378_H2.0341.00
324_G327_Q2.0331.00
222_A287_L2.0211.00
349_E352_W2.0161.00
221_L284_A2.0091.00
323_F328_H1.9681.00
243_S337_Q1.9091.00
241_I250_A1.8961.00
353_K357_A1.8941.00
308_R361_Y1.8781.00
345_R352_W1.8601.00
329_L342_A1.8511.00
167_V380_Q1.8371.00
113_H138_T1.8251.00
372_K376_A1.8201.00
233_G293_Y1.8061.00
273_V277_Q1.7871.00
173_H176_Q1.7681.00
332_K338_A1.7601.00
188_S383_T1.7571.00
288_F309_V1.7561.00
344_T348_H1.7481.00
258_A261_T1.7471.00
176_Q189_V1.7381.00
345_R349_E1.7351.00
32_L375_K1.7311.00
315_D332_K1.7231.00
378_H382_Q1.6961.00
193_G370_A1.6941.00
225_V278_V1.6931.00
324_G363_T1.6651.00
173_H321_S1.6621.00
137_L165_A1.6551.00
237_L250_A1.6091.00
274_P277_Q1.5951.00
329_L345_R1.5861.00
28_E374_A1.5811.00
237_L289_V1.5761.00
28_E371_G1.5751.00
355_E359_D1.5541.00
37_T74_Y1.5471.00
246_D344_T1.5441.00
170_A187_S1.5431.00
338_A342_A1.5411.00
335_S338_A1.5331.00
28_E31_K1.5301.00
352_W355_E1.5271.00
173_H189_V1.5141.00
253_V270_T1.5071.00
32_L378_H1.5041.00
4_L39_I1.5031.00
23_E27_Q1.4981.00
236_E336_A1.4911.00
244_L344_T1.4871.00
313_C319_V1.4681.00
327_Q359_D1.4651.00
221_L286_D1.4421.00
231_E294_S1.4311.00
170_A176_Q1.4291.00
251_V281_Y1.4201.00
362_E366_A1.4171.00
176_Q187_S1.4161.00
169_L380_Q1.4151.00
285_A309_V1.3951.00
279_R307_L1.3931.00
273_V281_Y1.3891.00
277_Q280_D1.3871.00
251_V285_A1.3851.00
240_A339_L1.3831.00
336_A340_A1.3741.00
228_L252_F1.3711.00
253_V273_V1.3581.00
243_S336_A1.3421.00
223_V253_V1.3411.00
224_Y237_L1.3391.00
331_I342_A1.3371.00
114_A135_Y1.3321.00
236_E293_Y1.3301.00
222_A343_I1.3201.00
270_T273_V1.3141.00
234_I252_F1.3111.00
5_W29_L1.3031.00
180_K184_G1.3001.00
359_D362_E1.2881.00
247_S344_T1.2861.00
222_A289_V1.2771.00
37_T72_P1.2761.00
376_A379_H1.2731.00
167_V383_T1.2701.00
169_L377_L1.2681.00
5_W115_H1.2661.00
340_A344_T1.2551.00
338_A341_E1.2521.00
372_K375_K1.2521.00
290_L301_V1.2411.00
283_L307_L1.2411.00
255_D259_K1.2311.00
220_R287_L1.2191.00
297_M302_I1.2031.00
173_H177_E1.1951.00
21_F299_T1.1941.00
177_E180_K1.1731.00
199_F307_L1.1711.00
236_E239_E1.1671.00
308_R358_D1.1611.00
5_W26_V1.1491.00
370_A373_N1.1491.00
317_G320_S1.1481.00
354_P358_D1.1471.00
278_V282_L1.1391.00
369_D372_K1.1341.00
235_F239_E1.1311.00
373_N376_A1.1281.00
291_P339_L1.1261.00
171_V175_L1.1241.00
216_P219_Q1.1211.00
242_E245_Q1.1191.00
357_A360_L1.1121.00
293_Y334_K1.1081.00
301_V319_V1.1071.00
245_Q267_H1.1071.00
309_V357_A1.1061.00
329_L356_V1.1061.00
198_R279_R1.1031.00
346_Y356_V1.1031.00
221_L285_A1.0991.00
236_E314_T1.0981.00
314_T331_I1.0911.00
331_I339_L1.0891.00
282_L307_L1.0881.00
171_V192_I1.0861.00
28_E32_L1.0841.00
352_W356_V1.0801.00
275_N278_V1.0721.00
260_S263_T1.0681.00
290_L300_V1.0681.00
318_G321_S1.0581.00
30_Q33_G1.0571.00
223_V281_Y1.0571.00
292_S295_E1.0541.00
288_F300_V1.0541.00
222_A241_I1.0511.00
236_E334_K1.0511.00
249_K267_H1.0481.00
170_A179_A1.0421.00
24_T370_A1.0421.00
279_R283_L1.0411.00
196_L369_D1.0401.00
305_L311_V1.0391.00
188_S380_Q1.0361.00
24_T27_Q1.0311.00
341_E345_R1.0251.00
313_C330_L1.0231.00
140_H299_T1.0211.00
350_Q353_K1.0191.00
199_F279_R1.0151.00
241_I267_H1.0141.00
251_V284_A1.0091.00
225_V253_V1.0021.00
373_N377_L0.9981.00
298_P319_V0.9911.00
301_V313_C0.9901.00
227_R231_E0.9901.00
225_V282_L0.9871.00
114_A137_L0.9871.00
171_V296_G0.9851.00
270_T281_Y0.9851.00
325_K342_A0.9821.00
192_I299_T0.9791.00
241_I248_P0.9781.00
115_H140_H0.9731.00
170_A175_L0.9711.00
358_D362_E0.9701.00
193_G373_N0.9691.00
26_V38_V0.9661.00
260_S264_Q0.9601.00
99_L130_S0.9521.00
375_K379_H0.9501.00
237_L291_P0.9471.00
243_S246_D0.9461.00
350_Q354_P0.9441.00
261_T264_Q0.9431.00
354_P357_A0.9371.00
16_P19_G0.9351.00
20_V24_T0.9341.00
135_Y165_A0.9321.00
244_L340_A0.9311.00
304_A309_V0.9291.00
236_E339_L0.9281.00
301_V311_V0.9271.00
178_E181_K0.9231.00
295_E298_P0.9221.00
329_L346_Y0.9211.00
305_L360_L0.9171.00
229_V257_P0.9091.00
224_Y291_P0.9081.00
165_A168_V0.9071.00
244_L343_I0.8991.00
313_C323_F0.8951.00
287_L346_Y0.8951.00
356_V359_D0.8941.00
329_L352_W0.8931.00
96_S100_K0.8911.00
244_L347_E0.8881.00
20_V275_N0.8871.00
177_E181_K0.8861.00
178_E182_L0.8821.00
22_H115_H0.8821.00
224_Y252_F0.8821.00
312_I331_I0.8791.00
305_L363_T0.8781.00
310_P357_A0.8781.00
240_A340_A0.8771.00
357_A361_Y0.8751.00
3_I34_L0.8741.00
316_V319_V0.8691.00
26_V30_Q0.8621.00
282_L309_V0.8611.00
21_F138_T0.8611.00
239_E243_S0.8531.00
174_K177_E0.8531.00
188_S376_A0.8491.00
195_Q198_R0.8481.00
341_E344_T0.8451.00
223_V282_L0.8431.00
290_L319_V0.8381.00
301_V322_L0.8381.00
24_T195_Q0.8381.00
312_I342_A0.8371.00
232_K300_V0.8331.00
375_K378_H0.8311.00
190_L380_Q0.8301.00
239_E242_E0.8301.00
21_F140_H0.8251.00
232_K295_E0.8251.00
37_T41_P0.8221.00
286_D353_K0.8191.00
180_K183_S0.8161.00
169_L190_L0.8151.00
332_K335_S0.8151.00
281_Y284_A0.8141.00
226_G234_I0.8121.00
323_F330_L0.8081.00
240_A336_A0.8071.00
289_V343_I0.8041.00
217_L220_R0.8041.00
310_P346_Y0.8041.00
136_V169_L0.8001.00
247_S348_H0.7991.00
32_L371_G0.7971.00
235_F261_T0.7971.00
244_L248_P0.7961.00
95_A99_L0.7951.00
287_L343_I0.7951.00
101_T107_L0.7901.00
21_F192_I0.7861.00
134_P166_S0.7851.00
363_T368_F0.7851.00
370_A374_A0.7841.00
275_N279_R0.7831.00
156_K160_R0.7831.00
235_F293_Y0.7801.00
140_H171_V0.7801.00
337_Q341_E0.7791.00
160_R164_S0.7781.00
280_D283_L0.7771.00
230_R235_F0.7771.00
369_D373_N0.7761.00
298_P301_V0.7761.00
67_I70_G0.7721.00
280_D284_A0.7711.00
136_V167_V0.7701.00
232_K292_S0.7691.00
128_S135_Y0.7671.00
379_H383_T0.7661.00
156_K159_K0.7651.00
171_V299_T0.7641.00
174_K178_E0.7641.00
224_Y250_A0.7641.00
24_T28_E0.7631.00
345_R348_H0.7631.00
191_P376_A0.7601.00
326_H345_R0.7571.00
315_D330_L0.7571.00
16_P227_R0.7561.00
92_R96_S0.7521.00
5_W36_I0.7491.00
7_T22_H0.7441.00
377_L381_Y0.7441.00
202_N283_L0.7421.00
371_G375_K0.7391.00
273_V278_V0.7391.00
355_E358_D0.7381.00
141_G231_E0.7361.00
225_V288_F0.7351.00
180_K187_S0.7341.00
126_V130_S0.7241.00
224_Y288_F0.7241.00
113_H377_L0.7241.00
302_I368_F0.7221.00
195_Q199_F0.7211.00
314_T333_P0.7191.00
255_D272_Q0.7181.00
241_I244_L0.7181.00
115_H138_T0.7181.00
312_I346_Y0.7161.00
7_T18_E0.7141.00
188_S191_P0.7131.00
20_V23_E0.7131.00
222_A347_E0.7081.00
190_L377_L0.7071.00
290_L298_P0.7061.00
191_P321_S0.7051.00
356_V360_L0.7041.00
337_Q340_A0.7041.00
379_H382_Q0.7001.00
191_P368_F0.6961.00
111_L136_V0.6961.00
297_M368_F0.6961.00
320_S330_L0.6921.00
32_L374_A0.6911.00
314_T339_L0.6891.00
30_Q36_I0.6881.00
351_I355_E0.6851.00
220_R350_Q0.6791.00
346_Y353_K0.6781.00
196_L306_A0.6771.00
289_V339_L0.6771.00
248_P347_E0.6761.00
242_E265_K0.6751.00
325_K329_L0.6751.00
281_Y285_A0.6741.00
25_Q377_L0.6731.00
327_Q363_T0.6721.00
226_G232_K0.6691.00
380_Q383_T0.6691.00
111_L381_Y0.6681.00
131_A134_P0.6671.00
361_Y364_V0.6651.00
240_A244_L0.6641.00
288_F311_V0.6621.00
26_V36_I0.6621.00
136_V381_Y0.6601.00
220_R248_P0.6581.00
21_F377_L0.6561.00
238_S268_I0.6561.00
233_G334_K0.6551.00
129_E164_S0.6551.00
159_K163_G0.6421.00
5_W113_H0.6411.00
21_F25_Q0.6391.00
33_G378_H0.6381.00
96_S99_L0.6351.00
114_A124_A0.6341.00
190_L376_A0.6331.00
305_L357_A0.6331.00
138_T377_L0.6331.00
127_V131_A0.6321.00
349_E353_K0.6321.00
228_L234_I0.6281.00
374_A378_H0.6251.00
180_K186_D0.6241.00
367_Q372_K0.6231.00
359_D363_T0.6221.00
121_G124_A0.6221.00
220_R223_V0.6181.00
282_L300_V0.6181.00
9_V19_G0.6171.00
30_Q34_L0.6161.00
198_R275_N0.6151.00
287_L312_I0.6151.00
216_P249_K0.6141.00
35_D72_P0.6141.00
240_A343_I0.6141.00
175_L178_E0.6131.00
245_Q248_P0.6111.00
223_V288_F0.6091.00
27_Q69_K0.6081.00
170_A189_V0.6081.00
360_L363_T0.6071.00
27_Q31_K0.6071.00
18_E116_F0.6061.00
172_S175_L0.6031.00
109_P133_I0.6031.00
300_V304_A0.6031.00
221_L281_Y0.6031.00
331_I338_A0.6011.00
235_F258_A0.6011.00
24_T299_T0.6001.00
315_D333_P0.5991.00
34_L382_Q0.5991.00
149_H153_G0.5951.00
128_S131_A0.5941.00
31_K371_G0.5941.00
230_R258_A0.5941.00
312_I343_I0.5931.00
184_G187_S0.5921.00
351_I354_P0.5911.00
286_D350_Q0.5901.00
291_P314_T0.5891.00
174_K320_S0.5881.00
302_I322_L0.5871.00
142_S145_N0.5851.00
28_E370_A0.5851.00
233_G291_P0.5841.00
228_L259_K0.5831.00
304_A311_V0.5811.00
236_E240_A0.5811.00
112_I133_I0.5801.00
93_R96_S0.5791.00
4_L37_T0.5781.00
173_H191_P0.5771.00
282_L304_A0.5751.00
230_R293_Y0.5751.00
97_A100_K0.5741.00
93_R97_A0.5721.00
138_T169_L0.5711.00
200_Q203_E0.5691.00
105_R131_A0.5671.00
195_Q370_A0.5671.00
282_L288_F0.5621.00
27_Q30_Q0.5621.00
223_V251_V0.5601.00
316_V320_S0.5581.00
140_H192_I0.5571.00
237_L241_I0.5571.00
197_S200_Q0.5561.00
21_F115_H0.5531.00
233_G314_T0.5531.00
353_K356_V0.5521.00
30_Q70_G0.5521.00
215_L251_V0.5491.00
200_Q283_L0.5491.00
5_W381_Y0.5481.00
114_A121_G0.5481.00
227_R232_K0.5451.00
305_L364_V0.5441.00
220_R353_K0.5441.00
316_V333_P0.5411.00
310_P353_K0.5401.00
167_V171_V0.5401.00
246_D340_A0.5401.00
263_T269_V0.5391.00
278_V281_Y0.5371.00
69_K72_P0.5371.00
223_V309_V0.5351.00
135_Y166_S0.5351.00
253_V278_V0.5331.00
143_D146_V0.5311.00
25_Q28_E0.5301.00
99_L105_R0.5291.00
196_L364_V0.5291.00
273_V280_D0.5291.00
222_A248_P0.5291.00
128_S166_S0.5261.00
72_P75_R0.5251.00
175_L296_G0.5251.00
176_Q184_G0.5241.00
33_G36_I0.5241.00
194_I306_A0.5241.00
66_E75_R0.5231.00
4_L112_I0.5231.00
90_P93_R0.5231.00
15_K272_Q0.5221.00
26_V71_I0.5201.00
191_P297_M0.5201.00
240_A289_V0.5201.00
167_V170_A0.5201.00
376_A380_Q0.5191.00
10_Y23_E0.5181.00
215_L221_L0.5141.00
306_A364_V0.5141.00
220_R249_K0.5111.00
287_L347_E0.5111.00
250_A268_I0.5111.00
298_P302_I0.5091.00
287_L353_K0.5091.00
256_G259_K0.5091.00
358_D361_Y0.5041.00
292_S298_P0.5031.00
90_P94_I0.5031.00
160_R163_G0.5021.00
95_A98_V0.5001.00
308_R357_A0.5001.00
22_H38_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3froA 3 0.9871 100 0.181 Contact Map
1rzuA 1 0.9846 100 0.186 Contact Map
4n9wA 1 0.8817 100 0.192 Contact Map
2r60A 1 0.9692 100 0.195 Contact Map
3c48A 2 0.9409 100 0.196 Contact Map
2qzsA 1 0.9717 100 0.197 Contact Map
3okpA 1 0.9177 100 0.207 Contact Map
2jjmA 4 0.8843 100 0.22 Contact Map
2x6qA 1 0.8997 100 0.237 Contact Map
3s28A 4 0.9794 100 0.239 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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