GREMLIN Database
TUAD - UDP-glucose 6-dehydrogenase TuaD
UniProt: O32271 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 461 (408)
Sequences: 8422 (5062)
Seq/√Len: 250.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
129_K199_E4.7001.00
34_E38_R4.5581.00
349_Y390_V4.0671.00
3_K26_K3.3171.00
301_L382_L3.3051.00
312_T345_H3.2431.00
323_N388_P3.1971.00
312_T347_K3.1311.00
70_D73_S2.9751.00
39_S44_V2.9601.00
302_L342_L2.9361.00
148_V182_I2.7571.00
196_T235_K2.5751.00
301_L380_A2.5551.00
101_K130_L2.5411.00
105_K134_I2.5221.00
132_Q147_V2.5201.00
314_S378_T2.5151.00
22_E58_K2.5021.00
295_V338_M2.4131.00
315_V336_I2.3981.00
5_A78_S2.3781.00
174_T178_A2.3531.00
227_E300_K2.3181.00
281_K288_E2.2781.00
41_K67_F2.2591.00
38_R42_N2.2531.00
197_N200_S2.2351.00
319_A353_A2.1741.00
379_D403_K2.1531.00
335_I384_L2.1291.00
112_N115_K2.1011.00
161_H165_N2.0891.00
26_K66_T2.0681.00
232_D235_K2.0541.00
25_N188_P2.0021.00
80_I185_L1.9971.00
140_K143_Y1.9961.00
105_K138_A1.9841.00
34_E69_N1.9411.00
313_I344_A1.9391.00
9_T29_C1.9151.00
347_K378_T1.9101.00
105_K137_K1.8981.00
71_I106_T1.8931.00
26_K64_R1.8761.00
196_T204_I1.8521.00
370_D373_A1.8501.00
229_V276_A1.8491.00
399_K405_P1.8471.00
210_A218_F1.8461.00
375_M398_V1.8431.00
208_A240_V1.8421.00
35_S38_R1.8361.00
117_I135_V1.8231.00
146_D175_S1.8131.00
45_I56_V1.7641.00
372_Y397_K1.7621.00
180_A184_E1.7591.00
179_A195_K1.7531.00
81_I115_K1.7421.00
90_S94_E1.7411.00
383_I413_L1.7361.00
347_K368_Y1.7081.00
274_K284_E1.6881.00
203_M226_C1.6681.00
102_A105_K1.6651.00
214_T286_V1.6561.00
108_G138_A1.6461.00
314_S374_A1.6451.00
279_P284_E1.6381.00
33_D36_K1.6191.00
104_A131_V1.6071.00
38_R41_K1.5991.00
179_A183_E1.5931.00
101_K105_K1.5771.00
109_E138_A1.5761.00
114_Y146_D1.5721.00
4_I185_L1.5571.00
3_K77_A1.5511.00
116_V181_I1.5331.00
394_E397_K1.5101.00
5_A81_I1.5091.00
132_Q136_Q1.5091.00
211_F215_K1.5081.00
338_M341_Q1.5061.00
183_E195_K1.5031.00
296_H300_K1.4921.00
284_E288_E1.4791.00
180_A194_I1.4761.00
18_T56_V1.4661.00
388_P391_K1.4611.00
270_L284_E1.4611.00
19_C22_E1.4591.00
31_D37_I1.4561.00
301_L408_I1.4511.00
18_T65_L1.4461.00
228_R278_Y1.4331.00
40_L67_F1.4301.00
39_S46_P1.4291.00
18_T55_L1.4071.00
20_F185_L1.4021.00
53_A57_E1.4001.00
101_K134_I1.3981.00
318_L348_A1.3951.00
322_P386_D1.3891.00
37_I69_N1.3871.00
224_N296_H1.3851.00
30_C71_I1.3721.00
227_E296_H1.3711.00
51_G54_D1.3701.00
54_D58_K1.3491.00
338_M342_L1.3481.00
339_L344_A1.3451.00
130_L133_S1.3441.00
80_I116_V1.3441.00
224_N293_Q1.3281.00
211_F249_K1.3231.00
35_S39_S1.3221.00
3_K28_V1.3201.00
74_A77_A1.3191.00
173_S179_A1.3181.00
111_L115_K1.3171.00
225_I280_F1.3131.00
214_T218_F1.3091.00
333_L337_P1.3011.00
70_D74_A1.3001.00
19_C164_M1.2851.00
255_I410_G1.2741.00
37_I67_F1.2701.00
66_T74_A1.2691.00
298_V335_I1.2661.00
76_R112_N1.2571.00
352_I389_E1.2361.00
184_E187_Q1.2351.00
235_K238_D1.2261.00
300_K408_I1.2251.00
114_Y177_K1.2211.00
282_L285_A1.2111.00
130_L134_I1.2101.00
146_D178_A1.1911.00
173_S178_A1.1911.00
304_V408_I1.1861.00
22_E164_M1.1851.00
108_G139_S1.1851.00
55_L160_I1.1821.00
39_S42_N1.1721.00
41_K66_T1.1701.00
214_T282_L1.1691.00
219_I237_A1.1651.00
407_I414_F1.1651.00
158_S161_H1.1631.00
105_K109_E1.1631.00
98_T102_A1.1621.00
204_I239_G1.1561.00
312_T377_D1.1541.00
146_D177_K1.1521.00
314_S381_C1.1491.00
28_V78_S1.1491.00
80_I181_I1.1481.00
224_N228_R1.1441.00
57_E61_L1.1421.00
282_L289_T1.1361.00
298_V338_M1.1261.00
226_C233_V1.1231.00
7_I103_A1.1191.00
334_D337_P1.1101.00
197_N235_K1.1091.00
104_A134_I1.1021.00
207_A222_I1.0981.00
318_L358_S1.0971.00
316_L393_M1.0971.00
313_I380_A1.0971.00
257_F287_I1.0961.00
375_M381_C1.0961.00
150_N186_H1.0921.00
28_V66_T1.0871.00
181_I184_E1.0851.00
383_I407_I1.0811.00
40_L65_L1.0791.00
314_S347_K1.0781.00
28_V77_A1.0671.00
73_S76_R1.0661.00
104_A108_G1.0641.00
295_V299_D1.0621.00
234_S252_K1.0581.00
108_G135_V1.0581.00
281_K292_K1.0581.00
71_I110_H1.0551.00
162_D165_N1.0481.00
222_I233_V1.0411.00
388_P392_E1.0411.00
187_Q192_P1.0401.00
183_E187_Q1.0371.00
234_S238_D1.0361.00
36_K46_P1.0361.00
7_I81_I1.0361.00
9_T17_G1.0351.00
119_N131_V1.0331.00
77_A112_N1.0321.00
55_L58_K1.0301.00
28_V68_T1.0301.00
336_I340_Q1.0271.00
119_N128_G1.0161.00
88_P96_D1.0141.00
244_S249_K1.0101.00
200_S231_A1.0041.00
356_E359_A1.0031.00
116_V148_V0.9991.00
144_S177_K0.9971.00
22_E54_D0.9951.00
37_I41_K0.9941.00
146_D174_T0.9931.00
383_I414_F0.9881.00
345_H366_E0.9791.00
114_Y144_S0.9791.00
231_A236_V0.9781.00
177_K181_I0.9751.00
308_V344_A0.9751.00
272_I275_S0.9751.00
4_I20_F0.9741.00
175_S178_A0.9731.00
301_L410_G0.9701.00
337_P340_Q0.9681.00
238_D248_R0.9631.00
224_N292_K0.9631.00
178_A182_I0.9591.00
102_A106_T0.9581.00
271_Q275_S0.9561.00
79_D115_K0.9541.00
17_G29_C0.9541.00
334_D338_M0.9431.00
52_L56_V0.9421.00
313_I382_L0.9351.00
132_Q174_T0.9331.00
171_I182_I0.9321.00
9_T65_L0.9311.00
311_R379_D0.9301.00
200_S236_V0.9301.00
183_E194_I0.9281.00
292_K295_V0.9281.00
106_T109_E0.9251.00
337_P341_Q0.9251.00
359_A366_E0.9241.00
304_V406_V0.9221.00
225_I278_Y0.9211.00
83_I107_I0.9211.00
111_L145_F0.9191.00
294_R334_D0.9161.00
129_K133_S0.9161.00
302_L344_A0.9151.00
271_Q274_K0.9151.00
116_V178_A0.9141.00
17_G65_L0.9111.00
255_I384_L0.9111.00
327_V358_S0.9101.00
318_L330_A0.9091.00
368_Y374_A0.9081.00
316_L381_C0.9061.00
396_V400_T0.9041.00
134_I138_A0.9041.00
397_K400_T0.9041.00
353_A367_Y0.9021.00
380_A406_V0.9011.00
5_A30_C0.9001.00
107_I117_I0.9001.00
95_A124_P0.8991.00
302_L308_V0.8971.00
312_T378_T0.8941.00
132_Q198_L0.8911.00
299_D303_T0.8901.00
129_K198_L0.8891.00
128_G198_L0.8861.00
377_D403_K0.8841.00
226_C236_V0.8821.00
135_V147_V0.8811.00
68_T74_A0.8791.00
19_C163_T0.8781.00
332_A384_L0.8731.00
73_S77_A0.8731.00
113_G144_S0.8721.00
213_A287_I0.8670.99
30_C74_A0.8660.99
134_I137_K0.8630.99
180_A195_K0.8610.99
141_G173_S0.8570.99
316_L390_V0.8510.99
183_E192_P0.8460.99
83_I100_V0.8450.99
5_A28_V0.8440.99
4_I25_N0.8430.99
301_L313_I0.8420.99
118_V182_I0.8410.99
79_D113_G0.8390.99
305_M311_R0.8380.99
310_G345_H0.8370.99
16_S163_T0.8360.99
24_G188_P0.8360.99
80_I118_V0.8360.99
32_I106_T0.8320.99
79_D181_I0.8320.99
280_F283_I0.8300.99
395_L414_F0.8280.99
318_L327_V0.8270.99
347_K366_E0.8250.99
114_Y145_F0.8200.99
66_T73_S0.8180.99
215_K251_L0.8110.99
180_A183_E0.8070.99
80_I182_I0.8040.99
30_C68_T0.8040.99
300_K303_T0.8030.99
314_S375_M0.8000.99
270_L283_I0.7970.99
104_A119_N0.7960.99
71_I109_E0.7960.99
179_A194_I0.7920.99
5_A75_I0.7890.99
297_I410_G0.7880.99
327_V353_A0.7870.99
298_V342_L0.7840.99
267_T287_I0.7830.99
95_A268_A0.7810.99
133_S137_K0.7810.99
322_P388_P0.7790.99
292_K299_D0.7750.99
368_Y373_A0.7750.99
257_F266_T0.7740.99
340_Q365_V0.7740.99
373_A376_E0.7740.99
316_L375_M0.7710.99
270_L287_I0.7690.99
340_Q364_Q0.7670.99
291_E334_D0.7660.99
347_K377_D0.7610.99
56_V65_L0.7610.99
127_T131_V0.7600.99
301_L339_L0.7590.99
225_I269_L0.7580.99
386_D411_R0.7570.99
327_V357_A0.7530.99
371_V375_M0.7500.99
318_L336_I0.7470.98
23_I189_F0.7420.98
330_A333_L0.7420.98
371_V389_E0.7400.98
228_R279_P0.7400.98
297_I408_I0.7390.98
154_L163_T0.7370.98
327_V333_L0.7360.98
194_I242_L0.7330.98
141_G145_F0.7300.98
28_V74_A0.7290.98
129_K132_Q0.7290.98
340_Q346_V0.7290.98
6_V17_G0.7280.98
107_I110_H0.7270.98
120_K186_H0.7270.98
306_G311_R0.7260.98
233_V237_A0.7260.98
241_G250_F0.7230.98
135_V138_A0.7190.98
113_G143_Y0.7150.98
336_I348_A0.7140.98
81_I107_I0.7040.98
41_K60_V0.7030.98
16_S20_F0.7030.98
211_F251_L0.7020.98
118_V185_L0.7020.98
273_A280_F0.7020.98
148_V173_S0.7010.98
155_R158_S0.6990.98
295_V334_D0.6970.98
75_I81_I0.6960.98
83_I117_I0.6950.98
136_Q145_F0.6930.98
354_I367_Y0.6930.98
48_Y352_I0.6900.97
167_E244_S0.6900.97
234_S412_N0.6850.97
215_K219_I0.6850.97
30_C106_T0.6850.97
355_P358_S0.6840.97
337_P359_A0.6830.97
100_V127_T0.6820.97
305_M380_A0.6790.97
30_C69_N0.6780.97
44_V52_L0.6760.97
225_I273_A0.6760.97
16_S168_R0.6750.97
32_I99_Y0.6750.97
127_T130_L0.6730.97
36_K39_S0.6730.97
358_S367_Y0.6700.97
355_P369_T0.6700.97
9_T31_D0.6700.97
386_D391_K0.6700.97
192_P242_L0.6680.97
19_C160_I0.6680.97
36_K40_L0.6660.97
26_K77_A0.6660.97
381_C390_V0.6660.97
222_I269_L0.6650.97
172_G179_A0.6650.97
218_F222_I0.6630.97
270_L274_K0.6620.97
316_L383_I0.6610.97
183_E193_V0.6610.97
354_I358_S0.6610.97
6_V16_S0.6610.97
174_T198_L0.6600.97
136_Q141_G0.6590.97
83_I131_V0.6590.97
291_E294_R0.6580.97
210_A283_I0.6580.97
119_N135_V0.6550.97
267_T291_E0.6550.97
7_I71_I0.6540.97
200_S235_K0.6540.97
381_C398_V0.6540.97
82_Y185_L0.6510.96
255_I297_I0.6500.96
370_D397_K0.6500.96
54_D57_E0.6490.96
270_L280_F0.6480.96
316_L371_V0.6450.96
44_V57_E0.6440.96
73_S110_H0.6430.96
63_Q66_T0.6420.96
11_Y328_R0.6420.96
128_G149_S0.6410.96
371_V393_M0.6400.96
76_R110_H0.6400.96
170_V183_E0.6400.96
22_E55_L0.6360.96
100_V104_A0.6360.96
348_A365_V0.6350.96
221_D289_T0.6350.96
305_M313_I0.6330.96
266_T287_I0.6310.96
169_A204_I0.6310.96
83_I119_N0.6310.96
274_K281_K0.6300.96
274_K279_P0.6300.96
272_I276_A0.6300.96
305_M406_V0.6270.96
173_S195_K0.6260.96
237_A253_A0.6250.96
154_L159_A0.6250.96
108_G117_I0.6250.96
106_T110_H0.6250.96
44_V53_A0.6240.95
393_M398_V0.6240.95
5_A74_A0.6230.95
23_I164_M0.6220.95
336_I365_V0.6210.95
315_V382_L0.6200.95
294_R335_I0.6190.95
237_A241_G0.6180.95
146_D181_I0.6180.95
395_L407_I0.6170.95
237_A252_K0.6160.95
89_M267_T0.6160.95
348_A367_Y0.6150.95
122_T265_D0.6150.95
111_L135_V0.6140.95
120_K150_N0.6140.95
285_A288_E0.6140.95
238_D241_G0.6120.95
396_V399_K0.6120.95
351_P390_V0.6110.95
177_K180_A0.6110.95
349_Y371_V0.6100.95
30_C103_A0.6090.95
298_V308_V0.6070.95
9_T40_L0.6060.95
170_V204_I0.6060.95
7_I75_I0.6030.95
53_A56_V0.6010.94
219_I222_I0.6010.94
353_A357_A0.6000.94
278_Y289_T0.6000.94
21_A64_R0.5990.94
100_V119_N0.5980.94
224_N278_Y0.5980.94
182_I186_H0.5980.94
170_V192_P0.5970.94
122_T261_C0.5970.94
152_E261_C0.5950.94
24_G64_R0.5950.94
175_S180_A0.5940.94
75_I115_K0.5940.94
81_I110_H0.5930.94
97_L101_K0.5930.94
293_Q296_H0.5910.94
196_T200_S0.5910.94
300_K304_V0.5900.94
170_V179_A0.5890.94
156_E320_F0.5880.94
213_A257_F0.5880.94
281_K285_A0.5870.94
148_V171_I0.5870.94
298_V302_L0.5860.94
280_F284_E0.5820.93
266_T283_I0.5810.93
255_I322_P0.5810.93
25_N80_I0.5800.93
57_E60_V0.5770.93
31_D69_N0.5760.93
90_S101_K0.5760.93
133_S136_Q0.5760.93
294_R331_P0.5750.93
136_Q144_S0.5750.93
140_K144_S0.5750.93
99_Y103_A0.5750.93
299_D342_L0.5740.93
168_R186_H0.5740.93
255_I335_I0.5730.93
327_V332_A0.5720.93
207_A210_A0.5720.93
301_L308_V0.5710.93
209_N265_D0.5710.93
224_N227_E0.5710.93
336_I384_L0.5690.93
340_Q345_H0.5670.93
132_Q173_S0.5660.93
248_R252_K0.5660.93
87_T121_S0.5660.93
366_E377_D0.5660.93
348_A354_I0.5650.92
51_G160_I0.5640.92
52_L55_L0.5640.92
118_V148_V0.5640.92
241_G246_I0.5630.92
375_M378_T0.5630.92
173_S198_L0.5600.92
318_L332_A0.5590.92
168_R208_A0.5580.92
45_I53_A0.5570.92
222_I226_C0.5560.92
71_I75_I0.5560.92
305_M308_V0.5560.92
395_L398_V0.5540.92
37_I40_L0.5540.92
260_S264_K0.5530.92
97_L130_L0.5530.92
305_M404_Q0.5520.92
380_A408_I0.5520.92
56_V60_V0.5500.91
369_T373_A0.5500.91
120_K168_R0.5480.91
282_L286_V0.5460.91
372_Y375_M0.5460.91
281_K284_E0.5460.91
234_S253_A0.5450.91
51_G55_L0.5440.91
223_A293_Q0.5430.91
85_V99_Y0.5420.91
265_D328_R0.5410.91
228_R276_A0.5400.91
120_K264_K0.5370.90
82_Y186_H0.5370.90
243_D246_I0.5370.90
108_G145_F0.5350.90
163_T189_F0.5320.90
336_I346_V0.5320.90
225_I229_V0.5320.90
391_K413_L0.5320.90
98_T101_K0.5310.90
156_E264_K0.5310.90
171_I193_V0.5310.90
217_S282_L0.5300.90
339_L346_V0.5290.90
209_N261_C0.5270.90
94_E275_S0.5270.90
38_R69_N0.5260.90
304_V380_A0.5250.89
362_G367_Y0.5250.89
90_S93_G0.5250.89
227_E293_Q0.5250.89
361_L365_V0.5240.89
203_M222_I0.5230.89
267_T329_S0.5220.89
120_K156_E0.5220.89
58_K61_L0.5210.89
373_A377_D0.5210.89
302_L306_G0.5200.89
97_L127_T0.5200.89
283_I286_V0.5200.89
88_P329_S0.5190.89
40_L46_P0.5180.89
171_I179_A0.5170.89
211_F219_I0.5150.89
287_I291_E0.5140.88
132_Q135_V0.5130.88
257_F286_V0.5110.88
315_V384_L0.5110.88
153_F208_A0.5110.88
200_S204_I0.5100.88
318_L367_Y0.5100.88
88_P326_D0.5080.88
285_A289_T0.5070.88
264_K320_F0.5070.88
27_V65_L0.5060.88
361_L364_Q0.5050.88
394_E398_V0.5040.87
12_V328_R0.5040.87
209_N321_K0.5030.87
167_E245_R0.5030.87
203_M231_A0.5030.87
381_C407_I0.5010.87
48_Y325_N0.5000.87
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2y0cA 4 0.9523 100 0.286 Contact Map
2q3eA 5 0.9371 100 0.295 Contact Map
3gg2A 3 0.9197 100 0.297 Contact Map
2o3jA 4 0.9328 100 0.297 Contact Map
3g79A 2 0.9349 100 0.314 Contact Map
4a7pA 2 0.9262 100 0.317 Contact Map
3ojoA 2 0.8937 100 0.323 Contact Map
3vtfA 2 0.9089 100 0.336 Contact Map
4xr9A 2 0.9284 100 0.341 Contact Map
1mv8A 2 0.9046 100 0.36 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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