GREMLIN Database
TUAE - Teichuronic acid biosynthesis protein TuaE
UniProt: O32270 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 488 (384)
Sequences: 6767 (6187)
Seq/√Len: 315.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
359_F398_L5.4181.00
362_S367_V4.9211.00
401_F405_I4.6131.00
367_V371_N4.5681.00
221_Y229_Q3.9161.00
230_N275_S3.5981.00
324_K328_L3.5911.00
396_E400_N3.5411.00
137_Y408_G3.3501.00
398_L406_M3.3041.00
233_A278_S3.0711.00
241_F285_G3.0051.00
392_N395_V2.9151.00
414_A418_W2.7421.00
397_I409_Y2.7291.00
355_A395_V2.6131.00
355_A390_V2.6021.00
240_F263_S2.5931.00
352_L395_V2.5741.00
299_K302_A2.5341.00
192_L224_S2.5041.00
356_W360_L2.4521.00
360_L363_Y2.3321.00
361_D379_Y2.3191.00
145_A151_G2.3131.00
404_F408_G2.3111.00
367_V399_A2.3061.00
189_T239_S2.2321.00
393_W450_S2.2101.00
358_F367_V2.1361.00
365_F404_F2.1331.00
196_G232_F2.0991.00
406_M410_L2.0981.00
355_A359_F2.0971.00
130_F408_G2.0441.00
179_M183_A2.0401.00
359_F363_Y2.0221.00
130_F411_S2.0071.00
226_F235_F1.9931.00
228_N453_P1.9821.00
137_Y141_S1.9501.00
277_A452_S1.9311.00
237_S445_S1.9291.00
274_G279_L1.9231.00
230_N278_S1.8981.00
137_Y404_F1.8951.00
389_E453_P1.8441.00
404_F407_L1.8411.00
186_L243_Y1.7951.00
230_N391_H1.7791.00
165_I169_V1.7771.00
418_W422_K1.7671.00
390_V396_E1.7651.00
369_A401_F1.7621.00
394_L447_L1.7391.00
355_A399_A1.7351.00
128_L165_I1.7351.00
285_G441_T1.7321.00
173_Q177_R1.7291.00
129_L133_F1.7281.00
247_M263_S1.6821.00
449_S453_P1.6671.00
359_F403_L1.6431.00
357_H360_L1.6421.00
189_T266_A1.6311.00
351_L391_H1.6111.00
240_F270_I1.6081.00
141_S145_A1.5971.00
281_G285_G1.5841.00
236_L273_T1.5821.00
394_L451_I1.5651.00
76_F79_N1.5591.00
358_F361_D1.5581.00
236_L266_A1.5561.00
232_F273_T1.5231.00
359_F399_A1.5191.00
92_F95_R1.4791.00
438_G442_A1.4681.00
358_F399_A1.4611.00
260_L264_L1.4531.00
243_Y262_L1.4421.00
145_A371_N1.4341.00
138_G401_F1.4301.00
241_F442_A1.4231.00
190_V262_L1.4221.00
174_K177_R1.4161.00
245_T438_G1.4161.00
237_S285_G1.4121.00
184_I188_M1.3791.00
175_M179_M1.3761.00
420_L469_V1.3501.00
180_I184_I1.3481.00
228_N391_H1.3471.00
232_F236_L1.3451.00
141_S144_W1.3421.00
328_L337_S1.3161.00
133_F137_Y1.3161.00
370_G400_N1.3121.00
270_I282_I1.3101.00
99_I103_C1.3071.00
137_Y365_F1.2981.00
253_G256_K1.2781.00
449_S454_S1.2761.00
277_A281_G1.2611.00
252_N255_I1.2591.00
449_S452_S1.2581.00
133_F408_G1.2561.00
233_A273_T1.2501.00
242_F438_G1.2461.00
285_G445_S1.2431.00
240_F282_I1.2411.00
194_I198_Y1.2401.00
284_A448_V1.2371.00
232_F269_L1.2321.00
199_N224_S1.2311.00
69_Y73_A1.2231.00
398_L401_F1.2151.00
389_E454_S1.2131.00
262_L266_A1.2121.00
230_N233_A1.2091.00
281_G448_V1.2081.00
356_W359_F1.2021.00
221_Y275_S1.2001.00
222_P269_L1.1721.00
454_S457_S1.1711.00
239_S266_A1.1671.00
311_A314_A1.1581.00
193_M269_L1.1561.00
389_E396_E1.1461.00
348_R391_H1.1431.00
352_L392_N1.1431.00
392_N451_I1.1431.00
257_A261_V1.1411.00
277_A453_P1.1391.00
395_V398_L1.1351.00
288_V441_T1.1331.00
355_A398_L1.1301.00
390_V399_A1.1301.00
309_G313_F1.1281.00
98_L102_G1.1261.00
192_L225_V1.1251.00
362_S365_F1.1211.00
439_L442_A1.1201.00
351_L390_V1.1191.00
407_L411_S1.1161.00
347_A351_L1.1141.00
139_L155_L1.1081.00
397_I406_M1.1061.00
132_A136_I1.1051.00
75_T79_N1.1031.00
134_W401_F1.0991.00
349_A353_K1.0971.00
125_K128_L1.0951.00
300_R303_I1.0921.00
372_V400_N1.0861.00
459_L463_W1.0791.00
134_W138_G1.0781.00
183_A187_V1.0781.00
467_A471_A1.0771.00
398_L404_F1.0711.00
419_V422_K1.0681.00
257_A260_L1.0681.00
268_Y272_A1.0661.00
240_F266_A1.0611.00
359_F406_M1.0611.00
411_S415_Y1.0611.00
353_K357_H1.0601.00
471_A474_N1.0591.00
176_E180_I1.0491.00
372_V390_V1.0481.00
238_I241_F1.0481.00
246_M259_G1.0431.00
397_I401_F1.0391.00
462_H466_M1.0351.00
243_Y266_A1.0341.00
137_Y144_W1.0261.00
277_A454_S1.0241.00
199_N222_P1.0241.00
130_F412_V1.0231.00
89_F92_F1.0181.00
224_S232_F1.0141.00
372_V376_L1.0141.00
247_M259_G1.0041.00
123_Q126_G1.0031.00
233_A237_S1.0021.00
134_W397_I1.0001.00
182_Y242_F0.9961.00
396_E454_S0.9911.00
368_G400_N0.9911.00
460_F463_W0.9891.00
165_I168_I0.9881.00
351_L355_A0.9881.00
422_K426_R0.9841.00
354_N357_H0.9811.00
394_L406_M0.9751.00
193_M266_A0.9731.00
357_H361_D0.9711.00
231_D389_E0.9711.00
276_R345_N0.9711.00
264_L268_Y0.9671.00
359_F404_F0.9671.00
168_I467_A0.9651.00
308_A315_V0.9641.00
354_N358_F0.9621.00
234_T449_S0.9611.00
420_L439_L0.9601.00
138_G141_S0.9591.00
128_L169_V0.9541.00
415_Y418_W0.9521.00
355_A372_V0.9501.00
358_F376_L0.9471.00
448_V452_S0.9461.00
166_Y170_M0.9451.00
124_V128_L0.9431.00
316_L320_K0.9311.00
313_F317_F0.9301.00
346_V349_A0.9301.00
345_N352_L0.9281.00
344_S349_A0.9281.00
350_N353_K0.9241.00
364_G403_L0.9181.00
241_F445_S0.9181.00
289_Y441_T0.9171.00
230_N453_P0.9141.00
105_H109_M0.9131.00
72_I79_N0.9131.00
196_G199_N0.9081.00
196_G224_S0.9031.00
142_L151_G0.9031.00
141_S369_A0.9011.00
344_S351_L0.9001.00
131_F412_V0.8991.00
371_N400_N0.8991.00
316_L319_S0.8961.00
277_A280_L0.8951.00
74_C79_N0.8941.00
412_V416_L0.8891.00
394_L398_L0.8871.00
270_I278_S0.8871.00
440_I444_V0.8871.00
228_N231_D0.8861.00
72_I75_T0.8861.00
185_W239_S0.8841.00
317_F320_K0.8841.00
286_I290_I0.8831.00
177_R180_I0.8821.00
196_G225_V0.8821.00
237_S241_F0.8791.00
180_I183_A0.8771.00
198_Y202_T0.8721.00
355_A391_H0.8711.00
311_A315_V0.8661.00
342_L346_V0.8661.00
218_K221_Y0.8651.00
147_S150_V0.8651.00
358_F372_V0.8641.00
97_L101_A0.8641.00
307_A311_A0.8631.00
130_F133_F0.8601.00
144_W365_F0.8591.00
182_Y246_M0.8561.00
122_L125_K0.8561.00
199_N223_T0.8541.00
183_A259_G0.8541.00
352_L390_V0.8511.00
186_L246_M0.8501.00
250_I259_G0.8501.00
128_L132_A0.8491.00
242_F246_M0.8491.00
398_L405_I0.8471.00
266_A269_L0.8451.00
245_T249_N0.8431.00
126_G130_F0.8431.00
277_A449_S0.8401.00
275_S278_S0.8391.00
228_N396_E0.8381.00
247_M260_L0.8381.00
463_W467_A0.8381.00
410_L414_A0.8341.00
193_M262_L0.8331.00
136_I139_L0.8331.00
390_V454_S0.8271.00
190_V194_I0.8261.00
394_L409_Y0.8221.00
267_L282_I0.8211.00
437_E441_T0.8161.00
317_F321_I0.8161.00
187_V191_F0.8151.00
352_L391_H0.8141.00
322_Y328_L0.8141.00
196_G269_L0.8131.00
394_L410_L0.8111.00
193_M222_P0.8091.00
243_Y263_S0.8071.00
154_Y157_L0.8011.00
221_Y273_T0.8001.00
168_I171_Y0.7971.00
122_L126_G0.7951.00
237_S278_S0.7951.00
466_M470_I0.7911.00
289_Y293_V0.7811.00
309_G316_L0.7811.00
130_F415_Y0.7801.00
453_P456_V0.7791.00
423_F436_T0.7781.00
190_V265_C0.7771.00
358_F362_S0.7761.00
288_V292_I0.7761.00
343_P347_A0.7731.00
435_I438_G0.7710.99
283_F287_A0.7690.99
103_C107_F0.7650.99
244_I263_S0.7640.99
258_I262_L0.7640.99
344_S347_A0.7600.99
94_Y97_L0.7600.99
315_V319_S0.7590.99
183_A246_M0.7570.99
237_S282_I0.7560.99
400_N457_S0.7520.99
193_M265_C0.7510.99
280_L283_F0.7500.99
197_F265_C0.7470.99
389_E400_N0.7450.99
105_H108_G0.7410.99
445_S449_S0.7410.99
196_G222_P0.7410.99
199_N391_H0.7410.99
231_D453_P0.7410.99
186_L189_T0.7400.99
395_V399_A0.7380.99
162_I166_Y0.7380.99
256_K259_G0.7370.99
182_Y186_L0.7370.99
345_N349_A0.7360.99
288_V444_V0.7340.99
230_N449_S0.7330.99
449_S455_S0.7330.99
248_K289_Y0.7320.99
421_Y425_E0.7320.99
393_W397_I0.7320.99
390_V393_W0.7290.99
197_F269_L0.7290.99
323_S327_E0.7240.99
193_M197_F0.7240.99
127_I130_F0.7230.99
391_H396_E0.7220.99
143_L146_K0.7220.99
70_I74_C0.7190.99
108_G111_R0.7170.99
349_A352_L0.7150.99
394_L413_Y0.7140.99
240_F243_Y0.7120.99
454_S458_N0.7120.99
359_F405_I0.7120.99
367_V400_N0.7120.99
421_Y424_Y0.7110.99
450_S453_P0.7090.99
206_L210_T0.7080.99
335_L338_F0.7070.99
228_N392_N0.7030.99
229_Q233_A0.7020.99
204_H208_S0.7010.99
307_A314_A0.7000.99
352_L389_E0.6990.99
95_R98_L0.6980.99
362_S399_A0.6980.99
352_L454_S0.6890.99
101_A105_H0.6880.99
229_Q273_T0.6870.99
160_M163_F0.6860.99
160_M164_F0.6820.99
190_V266_A0.6800.99
421_Y440_I0.6740.99
156_A160_M0.6730.99
275_S348_R0.6710.99
222_P272_A0.6700.99
415_Y419_V0.6690.99
276_R344_S0.6670.99
91_L94_Y0.6660.99
298_L302_A0.6660.99
394_L450_S0.6640.98
108_G112_N0.6620.98
241_F438_G0.6610.98
186_L266_A0.6600.98
156_A159_A0.6590.98
106_I110_V0.6590.98
247_M257_A0.6580.98
228_N454_S0.6580.98
65_M69_Y0.6570.98
234_T455_S0.6530.98
97_L100_A0.6530.98
270_I273_T0.6520.98
193_M236_L0.6500.98
197_F201_I0.6500.98
355_A358_F0.6500.98
220_H391_H0.6490.98
229_Q275_S0.6480.98
294_L299_K0.6470.98
241_F245_T0.6470.98
228_N449_S0.6430.98
359_F395_V0.6420.98
368_G372_V0.6410.98
73_A79_N0.6390.98
73_A76_F0.6370.98
303_I306_S0.6370.98
347_A352_L0.6370.98
409_Y450_S0.6370.98
223_T226_F0.6350.98
306_S310_I0.6340.98
449_S458_N0.6340.98
361_D367_V0.6330.98
145_A148_V0.6330.98
358_F379_Y0.6330.98
298_L301_M0.6320.98
109_M113_R0.6320.98
127_I415_Y0.6270.98
372_V399_A0.6240.98
281_G445_S0.6240.98
157_L160_M0.6230.98
354_N376_L0.6230.98
393_W409_Y0.6230.98
74_C77_L0.6220.98
156_A163_F0.6220.98
141_S401_F0.6210.98
153_K157_L0.6200.98
95_R99_I0.6190.98
75_T78_N0.6140.97
417_I444_V0.6110.97
167_L171_Y0.6110.97
281_G449_S0.6110.97
342_L345_N0.6110.97
351_L399_A0.6100.97
142_L145_A0.6100.97
176_E183_A0.6090.97
452_S456_V0.6080.97
363_Y398_L0.6050.97
290_I294_L0.6030.97
356_W398_L0.6020.97
276_R452_S0.6010.97
96_L104_L0.5990.97
138_G158_L0.5980.97
372_V375_Y0.5970.97
245_T248_K0.5960.97
222_P229_Q0.5940.97
367_V375_Y0.5930.97
360_L403_L0.5920.97
391_H453_P0.5920.97
148_V151_G0.5920.97
231_D351_L0.5920.97
356_W395_V0.5910.97
107_F110_V0.5900.97
91_L95_R0.5900.97
276_R328_L0.5890.97
346_V457_S0.5890.97
179_M246_M0.5880.97
233_A270_I0.5870.97
287_A291_F0.5860.97
314_A318_A0.5850.97
370_G373_S0.5850.97
420_L440_I0.5820.97
188_M192_L0.5820.97
419_V423_F0.5790.96
245_T434_L0.5790.96
237_S449_S0.5780.96
88_F92_F0.5780.96
312_L315_V0.5780.96
323_S326_W0.5770.96
312_L316_L0.5760.96
123_Q128_L0.5750.96
146_K151_G0.5750.96
324_K327_E0.5750.96
67_V79_N0.5740.96
243_Y259_G0.5740.96
165_I467_A0.5730.96
319_S324_K0.5700.96
127_I412_V0.5690.96
322_Y326_W0.5690.96
168_I172_V0.5680.96
375_Y379_Y0.5680.96
66_A69_Y0.5670.96
224_S235_F0.5670.96
234_T453_P0.5660.96
67_V78_N0.5660.96
69_Y72_I0.5660.96
236_L270_I0.5650.96
105_H170_M0.5630.96
176_E179_M0.5620.96
222_P225_V0.5620.96
231_D394_L0.5610.96
369_A400_N0.5590.96
285_G292_I0.5590.96
252_N256_K0.5590.96
189_T269_L0.5570.96
140_V144_W0.5570.96
236_L269_L0.5570.96
393_W455_S0.5570.96
228_N275_S0.5560.96
319_S322_Y0.5550.95
165_I171_Y0.5550.95
413_Y447_L0.5540.95
100_A104_L0.5530.95
393_W457_S0.5530.95
90_S94_Y0.5520.95
308_A311_A0.5520.95
459_L465_F0.5500.95
243_Y246_M0.5500.95
363_Y367_V0.5470.95
375_Y378_H0.5460.95
88_F91_L0.5450.95
240_F244_I0.5450.95
389_E392_N0.5440.95
422_K425_E0.5440.95
263_S267_L0.5440.95
135_F159_A0.5440.95
192_L232_F0.5420.95
398_L403_L0.5420.95
230_N277_A0.5410.95
68_I76_F0.5390.95
351_L395_V0.5390.95
144_W369_A0.5390.95
277_A355_A0.5380.95
138_G144_W0.5380.95
228_N393_W0.5370.95
138_G142_L0.5370.95
207_A210_T0.5350.95
396_E456_V0.5340.94
230_N348_R0.5340.94
124_V132_A0.5340.94
250_I256_K0.5330.94
313_F316_L0.5330.94
396_E457_S0.5330.94
228_N389_E0.5320.94
230_N457_S0.5320.94
233_A454_S0.5310.94
304_W307_A0.5280.94
228_N351_L0.5280.94
275_S393_W0.5270.94
393_W454_S0.5270.94
98_L101_A0.5270.94
351_L392_N0.5260.94
377_E380_A0.5260.94
228_N274_G0.5250.94
364_G404_F0.5240.94
424_Y433_K0.5240.94
456_V459_L0.5240.94
280_L345_N0.5240.94
66_A70_I0.5230.94
261_V265_C0.5230.94
102_G106_I0.5220.94
68_I75_T0.5210.94
281_G441_T0.5190.94
363_Y399_A0.5190.94
267_L271_F0.5180.94
403_L407_L0.5170.93
411_S414_A0.5150.93
65_M73_A0.5150.93
244_I289_Y0.5150.93
110_V113_R0.5150.93
161_G169_V0.5150.93
391_H394_L0.5130.93
373_S391_H0.5120.93
359_F362_S0.5110.93
96_L100_A0.5110.93
227_F232_F0.5100.93
215_P218_K0.5100.93
195_I224_S0.5090.93
133_F325_F0.5080.93
74_C78_N0.5070.93
459_L462_H0.5060.93
226_F230_N0.5030.93
319_S323_S0.5020.92
413_Y417_I0.5010.92
96_L103_C0.5010.92
389_E455_S0.5000.92
343_P346_V0.5000.92
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2rddB 1 0.0717 10.4 0.957 Contact Map
4pgrA 1 0.3934 4.4 0.964 Contact Map
3wxwA 1 0.2398 3.8 0.965 Contact Map
4qncA 2 0.1598 3.5 0.966 Contact Map
2ks1B 1 0.0902 3.4 0.966 Contact Map
3hd7A 1 0.0717 2.9 0.967 Contact Map
2l2tA 2 0.0902 2.9 0.967 Contact Map
4x5mA 2 0.1803 2.8 0.967 Contact Map
1m56D 1 0.0697 2.5 0.968 Contact Map
2m20A 2 0.084 2.2 0.969 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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