GREMLIN Database
TUAG - Putative teichuronic acid biosynthesis glycosyltransferase TuaG
UniProt: O32268 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 252 (213)
Sequences: 45177 (38073)
Seq/√Len: 2608.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
163_R167_G3.1651.00
17_A95_S2.9741.00
18_R48_G2.7211.00
106_K198_E2.4171.00
42_D67_Y2.4031.00
181_A185_S2.3931.00
9_S87_G2.3741.00
80_K84_R2.2101.00
50_R67_Y2.1841.00
14_S49_T2.1501.00
68_L80_K2.1271.00
89_Y111_M2.1021.00
50_R54_Q2.0971.00
37_E64_H2.0871.00
32_S105_E2.0821.00
100_K202_E2.0181.00
22_E26_H1.9961.00
116_C194_Y1.9511.00
41_V81_A1.9221.00
11_I81_A1.8871.00
12_T38_M1.8151.00
7_L88_R1.8151.00
16_N46_T1.8031.00
165_Q191_F1.8001.00
9_S37_E1.7951.00
48_G51_D1.7921.00
23_D204_R1.7851.00
78_R94_D1.7611.00
72_S76_V1.7581.00
22_E56_Y1.7291.00
66_V84_R1.7271.00
99_W103_K1.7181.00
23_D98_K1.7091.00
110_F196_M1.7061.00
107_Q160_M1.7021.00
91_A160_M1.6791.00
54_Q67_Y1.6781.00
74_A78_R1.6731.00
42_D45_S1.6531.00
18_R52_I1.6361.00
8_V108_L1.6081.00
117_A162_D1.5971.00
64_H84_R1.5921.00
110_F194_Y1.5731.00
26_H56_Y1.5721.00
102_D106_K1.5591.00
33_H108_L1.5531.00
40_I53_L1.5211.00
22_E52_I1.5141.00
103_K107_Q1.4991.00
89_Y160_M1.4921.00
50_R65_V1.4851.00
12_T24_T1.4761.00
124_S202_E1.4761.00
7_L35_H1.4701.00
22_E55_Q1.4691.00
80_K83_E1.4661.00
111_M160_M1.4491.00
98_K202_E1.4351.00
15_Y71_N1.4301.00
168_Q189_K1.4111.00
37_E87_G1.4111.00
26_H30_D1.4101.00
117_A191_F1.4071.00
75_A178_Q1.3921.00
14_S40_I1.3781.00
118_F193_A1.3771.00
93_L99_W1.3711.00
66_V80_K1.3711.00
110_F114_R1.3421.00
105_E109_E1.3411.00
91_A103_K1.3401.00
106_K109_E1.3311.00
91_A104_L1.3301.00
164_E168_Q1.3151.00
9_S85_A1.3061.00
33_H36_W1.2941.00
14_S17_A1.2881.00
8_V104_L1.2701.00
168_Q191_F1.2701.00
78_R92_F1.2631.00
90_V163_R1.2581.00
69_E72_S1.2241.00
82_L166_T1.2191.00
27_S99_W1.2171.00
16_N45_S1.2131.00
68_L72_S1.2101.00
17_A20_Y1.1721.00
43_D71_N1.1621.00
54_Q57_E1.1561.00
165_Q186_L1.1381.00
159_V183_W1.1361.00
14_S95_S1.1311.00
111_M119_S1.1251.00
25_V38_M1.1191.00
88_R162_D1.1161.00
109_E113_E1.1141.00
9_S39_I1.1091.00
69_E80_K1.1071.00
107_Q121_T1.1041.00
85_A163_R1.1041.00
68_L77_A1.1021.00
110_F113_E1.1011.00
52_I56_Y1.1011.00
42_D50_R1.0911.00
74_A178_Q1.0901.00
164_E167_G1.0731.00
41_V77_A1.0731.00
122_G195_G1.0681.00
98_K204_R1.0591.00
82_L92_F1.0571.00
91_A99_W1.0561.00
37_E86_Q1.0531.00
102_D105_E1.0451.00
7_L87_G1.0361.00
162_D165_Q1.0341.00
51_D54_Q1.0251.00
29_L60_D1.0221.00
55_Q59_I1.0201.00
7_L86_Q1.0151.00
108_L112_M1.0141.00
115_S192_T1.0121.00
30_D101_K0.9941.00
24_T93_L0.9931.00
82_L90_V0.9921.00
53_L65_V0.9891.00
13_P77_A0.9861.00
8_V160_M0.9761.00
52_I55_Q0.9751.00
117_A192_T0.9701.00
27_S98_K0.9691.00
106_K196_M0.9671.00
114_R194_Y0.9661.00
32_S102_D0.9391.00
83_E170_Q0.9381.00
118_F186_L0.9341.00
26_H29_L0.9261.00
51_D55_Q0.9221.00
48_G52_I0.9211.00
38_M63_I0.9151.00
29_L62_R0.9101.00
25_V56_Y0.9091.00
64_H86_Q0.9051.00
78_R178_Q0.9011.00
123_Y157_L0.9011.00
110_F119_S0.8941.00
89_Y108_L0.8921.00
74_A94_D0.8921.00
29_L56_Y0.8901.00
107_Q119_S0.8861.00
74_A210_I0.8861.00
124_S199_C0.8851.00
126_M130_G0.8721.00
216_K220_K0.8681.00
206_V209_S0.8611.00
107_Q111_M0.8571.00
28_V93_L0.8571.00
103_K121_T0.8491.00
76_V80_K0.8461.00
166_T182_T0.8451.00
74_A156_C0.8451.00
57_E63_I0.8341.00
69_E76_V0.8261.00
43_D77_A0.8261.00
106_K110_F0.8261.00
10_V28_V0.8221.00
10_V91_A0.8071.00
98_K126_M0.8051.00
103_K200_L0.8041.00
29_L63_I0.8001.00
217_A220_K0.7981.00
28_V38_M0.7961.00
126_M202_E0.7891.00
7_L112_M0.7811.00
75_A79_N0.7721.00
127_A131_T0.7671.00
26_H59_I0.7671.00
43_D73_G0.7491.00
43_D72_S0.7451.00
144_T147_D0.7451.00
82_L85_A0.7451.00
14_S21_I0.7441.00
100_K124_S0.7421.00
41_V80_K0.7411.00
23_D26_H0.7351.00
166_T171_M0.7331.00
28_V99_W0.7291.00
117_A165_Q0.7291.00
25_V40_I0.7271.00
36_W104_L0.7271.00
114_R192_T0.7261.00
32_S101_K0.7251.00
24_T27_S0.7221.00
76_V172_P0.7221.00
20_Y204_R0.7211.00
100_K103_K0.7061.00
122_G197_N0.7051.00
174_I177_R0.6981.00
165_Q169_I0.6981.00
169_I186_L0.6961.00
57_E65_V0.6941.00
54_Q65_V0.6921.00
72_S77_A0.6881.00
88_R164_E0.6851.00
169_I189_K0.6811.00
13_P95_S0.6791.00
33_H104_L0.6781.00
209_S212_S0.6771.00
10_V104_L0.6761.00
14_S53_L0.6751.00
25_V29_L0.6731.00
77_A80_K0.6701.00
39_I81_A0.6691.00
74_A77_A0.6671.00
121_T200_L0.6671.00
121_T158_T0.6671.00
33_H105_E0.6641.00
127_A130_G0.6631.00
32_S36_W0.6571.00
100_K200_L0.6551.00
167_G171_M0.6551.00
39_I84_R0.6511.00
110_F116_C0.6511.00
111_M116_C0.6501.00
12_T28_V0.6491.00
142_S145_Y0.6491.00
17_A206_V0.6471.00
171_M182_T0.6421.00
182_T186_L0.6421.00
43_D68_L0.6411.00
133_L137_I0.6381.00
21_I52_I0.6381.00
186_L191_F0.6371.00
108_L160_M0.6361.00
157_L201_A0.6341.00
79_N83_E0.6331.00
165_Q168_Q0.6321.00
109_E112_M0.6321.00
60_D63_I0.6311.00
68_L76_V0.6281.00
18_R22_E0.6261.00
8_V91_A0.6221.00
22_E59_I0.6221.00
156_C159_V0.6201.00
64_H67_Y0.6151.00
161_I183_W0.6151.00
111_M162_D0.6131.00
216_K219_K0.6121.00
167_G170_Q0.6091.00
44_C71_N0.6061.00
13_P43_D0.6051.00
85_A90_V0.6041.00
134_D137_I0.6031.00
196_M199_C0.5961.00
79_N171_M0.5961.00
89_Y162_D0.5961.00
103_K158_T0.5931.00
120_F195_G0.5921.00
7_L36_W0.5911.00
120_F154_I0.5901.00
39_I64_H0.5881.00
20_Y206_V0.5861.00
150_K192_T0.5831.00
9_S86_Q0.5831.00
50_R53_L0.5831.00
116_C162_D0.5831.00
7_L33_H0.5821.00
161_I182_T0.5781.00
53_L57_E0.5781.00
117_A120_F0.5771.00
21_I95_S0.5771.00
57_E60_D0.5751.00
15_Y43_D0.5721.00
72_S80_K0.5701.00
13_P78_R0.5701.00
83_E171_M0.5681.00
10_V36_W0.5651.00
24_T28_V0.5641.00
56_Y60_D0.5631.00
97_D203_Y0.5611.00
18_R51_D0.5601.00
56_Y59_I0.5581.00
21_I53_L0.5551.00
77_A94_D0.5541.00
76_V173_N0.5541.00
39_I85_A0.5521.00
7_L37_E0.5521.00
161_I166_T0.5521.00
91_A158_T0.5471.00
11_I41_V0.5431.00
99_W104_L0.5421.00
92_F161_I0.5371.00
154_I183_W0.5361.00
18_R21_I0.5361.00
15_Y44_C0.5351.00
128_Q131_T0.5341.00
145_Y148_A0.5341.00
88_R112_M0.5321.00
141_E144_T0.5321.00
68_L71_N0.5291.00
172_P175_R0.5221.00
94_D178_Q0.5201.00
31_Q105_E0.5201.00
180_L184_L0.5191.00
165_Q190_G0.5191.00
115_S162_D0.5171.00
18_R47_D0.5161.00
44_C68_L0.5151.00
29_L59_I0.5141.00
117_A164_E0.5141.00
7_L108_L0.5121.00
177_R180_L0.5091.00
141_E145_Y0.5081.00
199_C202_E0.5041.00
126_M204_R0.5041.00
24_T96_D0.5041.00
161_I186_L0.5031.00
83_E167_G0.5021.00
154_I159_V0.5001.00
35_H62_R0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3bcvA 2 0.6905 100 0.227 Contact Map
3l7iA 4 0 100 0.253 Contact Map
1qg8A 1 0.8651 100 0.254 Contact Map
2d7iA 1 1 100 0.277 Contact Map
2z86A 2 0.9683 100 0.281 Contact Map
1xhbA 1 0.9643 100 0.283 Contact Map
5ajoA 1 0.9841 100 0.294 Contact Map
4fixA 3 0.996 100 0.335 Contact Map
3ckjA 2 0.9603 100 0.364 Contact Map
4p02A 1 0.9881 100 0.37 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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