GREMLIN Database
TUAH - Putative teichuronic acid biosynthesis glycosyltransferase TuaH
UniProt: O32267 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 397 (336)
Sequences: 52875 (44924)
Seq/√Len: 2450.8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
225_G292_I4.6881.00
250_T275_I3.7771.00
169_S193_H3.2781.00
295_G316_F3.0821.00
111_W391_T3.0031.00
223_V252_L2.7621.00
221_G250_T2.7261.00
252_L277_T2.6391.00
226_F236_F2.5201.00
241_E264_S2.3691.00
43_I107_R2.3461.00
371_R375_A2.3371.00
178_H182_D2.2931.00
245_Q352_I2.2431.00
241_E348_P2.2171.00
235_D238_M2.1471.00
222_I359_L2.1471.00
43_I105_G2.1371.00
254_V288_Y2.1181.00
367_Y371_R2.1001.00
373_N377_T2.0771.00
327_N332_S2.0751.00
243_A251_F2.0071.00
336_K339_V1.9891.00
223_V250_T1.9801.00
40_K388_M1.9711.00
354_A357_K1.9621.00
224_L294_I1.9441.00
264_S268_L1.9381.00
361_Q365_E1.9341.00
252_L275_I1.9001.00
43_I66_F1.8941.00
367_Y370_M1.8741.00
111_W132_D1.8731.00
361_Q364_D1.8611.00
222_I293_D1.8441.00
357_K361_Q1.8351.00
36_Q385_R1.8241.00
382_C386_Q1.8211.00
223_V291_L1.8201.00
245_Q349_I1.8081.00
235_D300_K1.8061.00
175_D178_H1.7951.00
336_K340_Y1.7881.00
198_G380_W1.7831.00
344_E350_D1.7361.00
357_K364_D1.7361.00
341_E354_A1.7291.00
169_S390_Y1.7271.00
178_H194_T1.7231.00
327_N344_E1.7161.00
175_D333_K1.7151.00
239_I251_F1.7131.00
295_G321_K1.7061.00
372_R376_R1.7031.00
172_C192_V1.6911.00
131_Y167_A1.6771.00
280_A284_E1.6701.00
266_Q271_L1.6641.00
356_E360_G1.6551.00
227_I285_V1.6361.00
36_Q388_M1.6231.00
362_N365_E1.5871.00
284_E287_H1.5721.00
32_F35_A1.5691.00
243_A249_W1.5681.00
32_F381_N1.5661.00
347_H350_D1.5421.00
239_I296_I1.5401.00
350_D354_A1.5311.00
374_I377_T1.5291.00
178_H192_V1.5241.00
246_K356_E1.5231.00
281_D284_E1.5201.00
175_D194_T1.5121.00
43_I64_R1.4951.00
233_K301_Q1.4911.00
280_A288_Y1.4711.00
388_M392_G1.4571.00
32_F384_F1.4491.00
224_L355_C1.4301.00
320_G371_R1.4261.00
27_H31_E1.4141.00
341_E357_K1.4071.00
254_V277_T1.4011.00
325_G331_T1.4001.00
238_M348_P1.3951.00
292_I321_K1.3941.00
254_V280_A1.3831.00
230_I253_W1.3801.00
238_M300_K1.3761.00
223_V293_D1.3751.00
372_R375_A1.3721.00
348_P352_I1.3571.00
175_D179_K1.3551.00
242_A351_F1.3551.00
263_V267_E1.3491.00
244_L268_L1.3401.00
171_T387_I1.3371.00
224_L296_I1.3341.00
188_G191_K1.3311.00
218_G221_G1.3271.00
237_K264_S1.3041.00
182_D189_R1.2961.00
225_G254_V1.2961.00
368_K371_R1.2911.00
236_F253_W1.2731.00
34_A37_E1.2721.00
386_Q389_K1.2691.00
252_L288_Y1.2671.00
204_F319_A1.2641.00
172_C178_H1.2561.00
382_C385_R1.2511.00
226_F239_I1.2501.00
343_V354_A1.2491.00
171_T390_Y1.2471.00
112_Y129_V1.2451.00
286_P319_A1.2431.00
277_T280_A1.2401.00
371_R374_I1.2391.00
350_D353_A1.2291.00
222_I294_I1.2251.00
179_K182_D1.2251.00
252_L292_I1.2221.00
119_L122_S1.2001.00
304_Y314_F1.1981.00
264_S267_E1.1981.00
313_L331_T1.1921.00
285_V289_M1.1811.00
329_P332_S1.1551.00
297_M313_L1.1541.00
299_Y302_S1.1521.00
337_P340_Y1.1421.00
237_K241_E1.1331.00
367_Y374_I1.1231.00
222_I248_D1.1201.00
25_R306_Q1.1171.00
222_I249_W1.1151.00
32_F36_Q1.1051.00
379_D382_C1.0981.00
300_K346_D1.0971.00
173_S177_L1.0971.00
172_C181_V1.0941.00
352_I356_E1.0921.00
290_E319_A1.0911.00
223_V292_I1.0871.00
203_L286_P1.0831.00
246_K360_G1.0821.00
204_F286_P1.0771.00
325_G342_Y1.0751.00
289_M319_A1.0731.00
326_T343_V1.0721.00
134_S306_Q1.0721.00
92_S96_D1.0711.00
245_Q348_P1.0711.00
369_E372_R1.0691.00
282_P285_V1.0651.00
173_S197_N1.0601.00
237_K300_K1.0591.00
298_P351_F1.0551.00
238_M241_E1.0551.00
368_K372_R1.0541.00
383_L386_Q1.0541.00
229_G233_K1.0541.00
380_W383_L1.0541.00
337_P354_A1.0481.00
256_P279_P1.0461.00
238_M326_T1.0401.00
246_K249_W1.0391.00
179_K183_K1.0361.00
265_F270_R1.0341.00
325_G335_Q1.0211.00
221_G248_D1.0201.00
343_V351_F1.0201.00
353_A357_K1.0181.00
385_R389_K1.0171.00
370_M373_N1.0171.00
30_A44_W1.0171.00
277_T288_Y1.0151.00
227_I254_V1.0111.00
340_Y373_N1.0071.00
37_E40_K1.0051.00
225_G288_Y1.0051.00
265_F276_W1.0021.00
241_E268_L1.0011.00
112_Y131_Y1.0011.00
224_L243_A1.0001.00
227_I289_M1.0001.00
238_M346_D0.9981.00
317_L323_V0.9881.00
113_T134_S0.9841.00
320_G368_K0.9841.00
262_D266_Q0.9811.00
286_P290_E0.9761.00
373_N376_R0.9741.00
231_K258_A0.9711.00
344_E347_H0.9661.00
316_F321_K0.9661.00
336_K373_N0.9631.00
362_N366_T0.9621.00
28_R31_E0.9621.00
129_V167_A0.9561.00
198_G383_L0.9541.00
28_R380_W0.9491.00
305_N331_T0.9491.00
341_E358_V0.9491.00
172_C177_L0.9481.00
335_Q340_Y0.9451.00
302_S305_N0.9441.00
226_F253_W0.9371.00
383_L387_I0.9361.00
25_R134_S0.9311.00
330_S333_K0.9221.00
249_W359_L0.9211.00
239_I298_P0.9191.00
180_E183_K0.9161.00
200_E203_L0.9161.00
20_D23_R0.9151.00
238_M351_F0.9121.00
201_Y379_D0.9041.00
297_M307_A0.9031.00
25_R132_D0.8991.00
295_G307_A0.8991.00
296_I355_C0.8911.00
130_I171_T0.8911.00
313_L325_G0.8891.00
41_E64_R0.8861.00
324_V343_V0.8861.00
30_A34_A0.8801.00
242_A352_I0.8801.00
250_T273_N0.8801.00
260_N263_V0.8791.00
349_I353_A0.8741.00
171_T195_V0.8721.00
26_R113_T0.8701.00
313_L323_V0.8691.00
243_A273_N0.8691.00
193_H390_Y0.8691.00
252_L291_L0.8681.00
225_G289_M0.8631.00
226_F295_G0.8631.00
173_S303_P0.8591.00
385_R388_M0.8581.00
294_I358_V0.8541.00
167_A170_I0.8531.00
24_Y28_R0.8521.00
335_Q342_Y0.8501.00
297_M331_T0.8471.00
313_L334_M0.8441.00
193_H386_Q0.8421.00
109_C391_T0.8391.00
196_E333_K0.8381.00
195_V390_Y0.8381.00
289_M321_K0.8371.00
324_V354_A0.8361.00
226_F298_P0.8351.00
128_Q168_D0.8351.00
379_D383_L0.8301.00
162_R166_R0.8251.00
234_L302_S0.8251.00
197_N306_Q0.8251.00
242_A348_P0.8231.00
234_L299_Y0.8161.00
95_L99_T0.8151.00
218_G250_T0.8131.00
328_L331_T0.8121.00
294_I355_C0.8091.00
263_V266_Q0.8061.00
361_Q366_T0.8031.00
20_D229_G0.8001.00
28_R200_E0.7991.00
207_N290_E0.7981.00
24_Y282_P0.7971.00
260_N264_S0.7961.00
182_D192_V0.7951.00
176_Y179_K0.7911.00
34_A62_G0.7881.00
322_P358_V0.7851.00
324_V358_V0.7831.00
353_A356_E0.7821.00
240_K265_F0.7771.00
367_Y375_A0.7761.00
219_R222_I0.7731.00
200_E204_F0.7731.00
173_S306_Q0.7721.00
224_L249_W0.7691.00
135_D233_K0.7671.00
29_L387_I0.7661.00
25_R197_N0.7651.00
196_E378_Q0.7651.00
134_S173_S0.7641.00
180_E184_K0.7641.00
317_L374_I0.7591.00
232_P237_K0.7571.00
287_H291_L0.7561.00
288_Y291_L0.7531.00
158_S161_L0.7511.00
93_P97_E0.7501.00
34_A42_V0.7491.00
36_Q381_N0.7451.00
113_T132_D0.7441.00
381_N385_R0.7421.00
228_G236_F0.7421.00
95_L98_L0.7421.00
28_R32_F0.7421.00
287_H290_E0.7411.00
109_C130_I0.7391.00
341_E364_D0.7381.00
196_E386_Q0.7371.00
380_W384_F0.7361.00
244_L270_R0.7341.00
187_A191_K0.7311.00
335_Q339_V0.7311.00
158_S162_R0.7311.00
124_Y127_D0.7311.00
389_K392_G0.7301.00
130_I169_S0.7271.00
43_I47_P0.7271.00
25_R387_I0.7271.00
111_W387_I0.7221.00
369_E373_N0.7211.00
195_V387_I0.7171.00
31_E61_S0.7161.00
35_A381_N0.7161.00
237_K260_N0.7141.00
227_I295_G0.7121.00
241_E245_Q0.7121.00
327_N342_Y0.7091.00
282_P286_P0.7061.00
387_I391_T0.7051.00
367_Y373_N0.7041.00
241_E244_L0.7041.00
36_Q384_F0.7001.00
265_F268_L0.6991.00
34_A40_K0.6981.00
130_I391_T0.6981.00
193_H196_E0.6971.00
358_V365_E0.6941.00
154_K157_K0.6901.00
326_T345_G0.6901.00
224_L359_L0.6891.00
104_N107_R0.6891.00
326_T351_F0.6821.00
161_L165_Q0.6821.00
317_L340_Y0.6801.00
24_Y27_H0.6791.00
226_F251_F0.6791.00
296_I351_F0.6791.00
235_D298_P0.6781.00
357_K360_G0.6761.00
280_A285_V0.6751.00
242_A355_C0.6751.00
176_Y180_E0.6731.00
228_G234_L0.6651.00
107_R110_L0.6651.00
314_F378_Q0.6621.00
240_K274_V0.6571.00
349_I352_I0.6571.00
305_N313_L0.6571.00
304_Y378_Q0.6561.00
232_P300_K0.6551.00
247_P356_E0.6551.00
195_V386_Q0.6541.00
338_Y357_K0.6521.00
22_L114_F0.6471.00
30_A42_V0.6461.00
30_A63_I0.6451.00
332_S342_Y0.6451.00
288_Y292_I0.6441.00
172_C194_T0.6431.00
255_G278_G0.6431.00
201_Y318_A0.6421.00
321_K367_Y0.6401.00
374_I378_Q0.6381.00
299_Y305_N0.6381.00
187_A190_E0.6381.00
246_K359_L0.6351.00
94_L97_E0.6321.00
235_D346_D0.6301.00
125_S128_Q0.6301.00
343_V350_D0.6291.00
37_E42_V0.6291.00
230_I257_D0.6261.00
31_E35_A0.6241.00
132_D387_I0.6241.00
248_D273_N0.6241.00
59_V62_G0.6231.00
203_L282_P0.6221.00
202_E205_S0.6201.00
205_S290_E0.6181.00
265_F271_L0.6181.00
40_K392_G0.6161.00
370_M374_I0.6161.00
295_G323_V0.6141.00
46_C65_Q0.6141.00
220_E248_D0.6141.00
246_K273_N0.6111.00
340_Y374_I0.6111.00
132_D171_T0.6091.00
176_Y332_S0.6091.00
238_M242_A0.6061.00
67_A70_D0.6041.00
337_P341_E0.6041.00
174_S177_L0.6021.00
123_L166_R0.6011.00
289_M307_A0.6011.00
94_L98_L0.6011.00
230_I236_F0.6001.00
251_F274_V0.5991.00
222_I362_N0.5971.00
88_R92_S0.5951.00
368_K375_A0.5951.00
134_S197_N0.5931.00
324_V355_C0.5931.00
89_H92_S0.5931.00
229_G234_L0.5921.00
118_P121_S0.5901.00
225_G295_G0.5881.00
25_R113_T0.5871.00
254_V285_V0.5871.00
175_D196_E0.5861.00
225_G321_K0.5841.00
373_N378_Q0.5831.00
316_F323_V0.5831.00
367_Y372_R0.5811.00
270_R273_N0.5811.00
297_M305_N0.5791.00
294_I324_V0.5781.00
363_G366_T0.5751.00
91_L97_E0.5751.00
239_I243_A0.5741.00
384_F388_M0.5721.00
178_H189_R0.5711.00
328_L345_G0.5701.00
32_F380_W0.5701.00
242_A296_I0.5681.00
328_L332_S0.5681.00
377_T382_C0.5671.00
90_K94_L0.5661.00
150_E154_K0.5661.00
339_V369_E0.5651.00
154_K158_S0.5621.00
377_T386_Q0.5611.00
294_I359_L0.5591.00
289_M295_G0.5581.00
298_P326_T0.5561.00
129_V168_D0.5551.00
177_L180_E0.5551.00
222_I225_G0.5531.00
177_L303_P0.5511.00
36_Q40_K0.5511.00
247_P360_G0.5501.00
322_P365_E0.5491.00
265_F274_V0.5411.00
136_L139_A0.5391.00
200_E380_W0.5381.00
201_Y375_A0.5371.00
221_G291_L0.5371.00
137_W140_P0.5361.00
222_I250_T0.5351.00
247_P273_N0.5351.00
317_L367_Y0.5341.00
106_E127_D0.5341.00
40_K108_C0.5331.00
58_E67_A0.5331.00
322_P367_Y0.5321.00
87_Y90_K0.5311.00
225_G252_L0.5311.00
26_R44_W0.5311.00
91_L94_L0.5301.00
29_L32_F0.5301.00
176_Y333_K0.5301.00
64_R105_G0.5301.00
89_H93_P0.5281.00
110_L127_D0.5281.00
188_G192_V0.5271.00
352_I355_C0.5271.00
261_G265_F0.5261.00
61_S64_R0.5251.00
162_R165_Q0.5231.00
107_R127_D0.5211.00
317_L370_M0.5211.00
58_E62_G0.5191.00
196_E383_L0.5171.00
235_D326_T0.5171.00
314_F334_M0.5161.00
327_N345_G0.5151.00
305_N314_F0.5141.00
135_D138_A0.5141.00
28_R306_Q0.5141.00
196_E304_Y0.5131.00
28_R198_G0.5131.00
64_R67_A0.5111.00
117_F120_L0.5071.00
19_K279_P0.5071.00
31_E60_H0.5061.00
340_Y370_M0.5051.00
33_L40_K0.5041.00
240_K270_R0.5041.00
320_G372_R0.5041.00
222_I365_E0.5021.00
232_P259_T0.5011.00
199_V318_A0.5001.00
285_V288_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2r60A 1 0.9521 100 0.235 Contact Map
3c48A 2 0.932 100 0.26 Contact Map
3froA 3 0.9647 100 0.263 Contact Map
1rzuA 1 0.9547 100 0.278 Contact Map
4n9wA 1 0.8539 100 0.285 Contact Map
2jjmA 4 0.8665 100 0.289 Contact Map
2qzsA 1 0.9471 100 0.291 Contact Map
3okpA 1 0.8942 100 0.302 Contact Map
2x0dA 2 0.8463 100 0.308 Contact Map
3s28A 4 0.9773 100 0.309 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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