TUAH - BACSU - GREMLIN Contacts

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TUAH - Putative teichuronic acid biosynthesis glycosyltransferase TuaH

UniProt:	O32267	Sequences: METKEAIIHVIVATAEWGKDQLRYRRHRLAEFLAAQEETKEVIWVCPAPRAQGKEFQEVHSGIRQFAVKDLLQKKMFRFGRYTDVFYRHKLSPLLDELTPASANGERCCLWYTFPGFPLLSSLYSWDQVIYDCSDLWAAPISGRSNLLSEFRRKVIKSAELRIIQRADSITCSSDYLHKEVDKKLTAGREKVHTVENGVEYELFSANKQAPDRSILQGREGIVLGFIGGIKPKLDFKMIKEAALQKPDWTFLWVGPDATNGDVSFQELLRLPNVIWTGPADPKEVPHYMELIDIGIMPYKQSPYNQAVFPLKLFEFLAAGKPVVGTNLPSTSKMQKPYVYEYVEGDHPIDFIAACEKVLGQNGDETYKEMRRNIARTQDWNCLFRQIMKYTGIQKHA	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	397 (336)
Sequences:	52875 (44924)
Seq/√Len:	2450.8

ECOLI - WCAI GLGA RFAG WCAL WBBK RFAB WCAC
BACSU - TUAH EPSF YPJH YTCC GLGA COTSA EPSD TUAC YQGM YKVP CGEB TAGE
HALSA - Q9HSW1 Q9HQQ0 Q9HS45 Q9HQT2 Q9HSV2 Q9HSV4 Q9HRP8 Q9HRP9
SULSO - Q97V80 Q97UM0 Q980C8 Q97VL4 Q97XT7 Q97ZD3 Q97V61 Q97XT9 Q97UU3 Q97XT8 Q7LXM9 Q97XT6 Q97XT1 Q97XF6 Q97XT5 Q97XU2 Q7LXI2 Q7LXF8

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
225_G	292_I	4.688	1.00
250_T	275_I	3.777	1.00
169_S	193_H	3.278	1.00
295_G	316_F	3.082	1.00
111_W	391_T	3.003	1.00
223_V	252_L	2.762	1.00
221_G	250_T	2.726	1.00
252_L	277_T	2.639	1.00
226_F	236_F	2.520	1.00
241_E	264_S	2.369	1.00
43_I	107_R	2.346	1.00
371_R	375_A	2.337	1.00
178_H	182_D	2.293	1.00
245_Q	352_I	2.243	1.00
241_E	348_P	2.217	1.00
235_D	238_M	2.147	1.00
222_I	359_L	2.147	1.00
43_I	105_G	2.137	1.00
254_V	288_Y	2.118	1.00
367_Y	371_R	2.100	1.00
373_N	377_T	2.077	1.00
327_N	332_S	2.075	1.00
243_A	251_F	2.007	1.00
336_K	339_V	1.989	1.00
223_V	250_T	1.980	1.00
40_K	388_M	1.971	1.00
354_A	357_K	1.962	1.00
224_L	294_I	1.944	1.00
264_S	268_L	1.938	1.00
361_Q	365_E	1.934	1.00
252_L	275_I	1.900	1.00
43_I	66_F	1.894	1.00
367_Y	370_M	1.874	1.00
111_W	132_D	1.873	1.00
361_Q	364_D	1.861	1.00
222_I	293_D	1.844	1.00
357_K	361_Q	1.835	1.00
36_Q	385_R	1.824	1.00
382_C	386_Q	1.821	1.00
223_V	291_L	1.820	1.00
245_Q	349_I	1.808	1.00
235_D	300_K	1.806	1.00
175_D	178_H	1.795	1.00
336_K	340_Y	1.788	1.00
198_G	380_W	1.783	1.00
344_E	350_D	1.736	1.00
357_K	364_D	1.736	1.00
341_E	354_A	1.729	1.00
169_S	390_Y	1.727	1.00
178_H	194_T	1.723	1.00
327_N	344_E	1.716	1.00
175_D	333_K	1.715	1.00
239_I	251_F	1.713	1.00
295_G	321_K	1.706	1.00
372_R	376_R	1.703	1.00
172_C	192_V	1.691	1.00
131_Y	167_A	1.677	1.00
280_A	284_E	1.670	1.00
266_Q	271_L	1.664	1.00
356_E	360_G	1.655	1.00
227_I	285_V	1.636	1.00
36_Q	388_M	1.623	1.00
362_N	365_E	1.587	1.00
284_E	287_H	1.572	1.00
32_F	35_A	1.569	1.00
243_A	249_W	1.568	1.00
32_F	381_N	1.566	1.00
347_H	350_D	1.542	1.00
239_I	296_I	1.540	1.00
350_D	354_A	1.531	1.00
374_I	377_T	1.529	1.00
178_H	192_V	1.524	1.00
246_K	356_E	1.523	1.00
281_D	284_E	1.520	1.00
175_D	194_T	1.512	1.00
43_I	64_R	1.495	1.00
233_K	301_Q	1.491	1.00
280_A	288_Y	1.471	1.00
388_M	392_G	1.457	1.00
32_F	384_F	1.449	1.00
224_L	355_C	1.430	1.00
320_G	371_R	1.426	1.00
27_H	31_E	1.414	1.00
341_E	357_K	1.407	1.00
254_V	277_T	1.401	1.00
325_G	331_T	1.400	1.00
238_M	348_P	1.395	1.00
292_I	321_K	1.394	1.00
254_V	280_A	1.383	1.00
230_I	253_W	1.380	1.00
238_M	300_K	1.376	1.00
223_V	293_D	1.375	1.00
372_R	375_A	1.372	1.00
348_P	352_I	1.357	1.00
175_D	179_K	1.355	1.00
242_A	351_F	1.355	1.00
263_V	267_E	1.349	1.00
244_L	268_L	1.340	1.00
171_T	387_I	1.337	1.00
224_L	296_I	1.334	1.00
188_G	191_K	1.331	1.00
218_G	221_G	1.327	1.00
237_K	264_S	1.304	1.00
182_D	189_R	1.296	1.00
225_G	254_V	1.296	1.00
368_K	371_R	1.291	1.00
236_F	253_W	1.273	1.00
34_A	37_E	1.272	1.00
386_Q	389_K	1.269	1.00
252_L	288_Y	1.267	1.00
204_F	319_A	1.264	1.00
172_C	178_H	1.256	1.00
382_C	385_R	1.251	1.00
226_F	239_I	1.250	1.00
343_V	354_A	1.249	1.00
171_T	390_Y	1.247	1.00
112_Y	129_V	1.245	1.00
286_P	319_A	1.243	1.00
277_T	280_A	1.240	1.00
371_R	374_I	1.239	1.00
350_D	353_A	1.229	1.00
222_I	294_I	1.225	1.00
179_K	182_D	1.225	1.00
252_L	292_I	1.222	1.00
119_L	122_S	1.200	1.00
304_Y	314_F	1.198	1.00
264_S	267_E	1.198	1.00
313_L	331_T	1.192	1.00
285_V	289_M	1.181	1.00
329_P	332_S	1.155	1.00
297_M	313_L	1.154	1.00
299_Y	302_S	1.152	1.00
337_P	340_Y	1.142	1.00
237_K	241_E	1.133	1.00
367_Y	374_I	1.123	1.00
222_I	248_D	1.120	1.00
25_R	306_Q	1.117	1.00
222_I	249_W	1.115	1.00
32_F	36_Q	1.105	1.00
379_D	382_C	1.098	1.00
300_K	346_D	1.097	1.00
173_S	177_L	1.097	1.00
172_C	181_V	1.094	1.00
352_I	356_E	1.092	1.00
290_E	319_A	1.091	1.00
223_V	292_I	1.087	1.00
203_L	286_P	1.083	1.00
246_K	360_G	1.082	1.00
204_F	286_P	1.077	1.00
325_G	342_Y	1.075	1.00
289_M	319_A	1.073	1.00
326_T	343_V	1.072	1.00
134_S	306_Q	1.072	1.00
92_S	96_D	1.071	1.00
245_Q	348_P	1.071	1.00
369_E	372_R	1.069	1.00
282_P	285_V	1.065	1.00
173_S	197_N	1.060	1.00
237_K	300_K	1.059	1.00
298_P	351_F	1.055	1.00
238_M	241_E	1.055	1.00
368_K	372_R	1.054	1.00
383_L	386_Q	1.054	1.00
229_G	233_K	1.054	1.00
380_W	383_L	1.054	1.00
337_P	354_A	1.048	1.00
256_P	279_P	1.046	1.00
238_M	326_T	1.040	1.00
246_K	249_W	1.039	1.00
179_K	183_K	1.036	1.00
265_F	270_R	1.034	1.00
325_G	335_Q	1.021	1.00
221_G	248_D	1.020	1.00
343_V	351_F	1.020	1.00
353_A	357_K	1.018	1.00
385_R	389_K	1.017	1.00
370_M	373_N	1.017	1.00
30_A	44_W	1.017	1.00
277_T	288_Y	1.015	1.00
227_I	254_V	1.011	1.00
340_Y	373_N	1.007	1.00
37_E	40_K	1.005	1.00
225_G	288_Y	1.005	1.00
265_F	276_W	1.002	1.00
241_E	268_L	1.001	1.00
112_Y	131_Y	1.001	1.00
224_L	243_A	1.000	1.00
227_I	289_M	1.000	1.00
238_M	346_D	0.998	1.00
317_L	323_V	0.988	1.00
113_T	134_S	0.984	1.00
320_G	368_K	0.984	1.00
262_D	266_Q	0.981	1.00
286_P	290_E	0.976	1.00
373_N	376_R	0.974	1.00
231_K	258_A	0.971	1.00
344_E	347_H	0.966	1.00
316_F	321_K	0.966	1.00
336_K	373_N	0.963	1.00
362_N	366_T	0.962	1.00
28_R	31_E	0.962	1.00
129_V	167_A	0.956	1.00
198_G	383_L	0.954	1.00
28_R	380_W	0.949	1.00
305_N	331_T	0.949	1.00
341_E	358_V	0.949	1.00
172_C	177_L	0.948	1.00
335_Q	340_Y	0.945	1.00
302_S	305_N	0.944	1.00
226_F	253_W	0.937	1.00
383_L	387_I	0.936	1.00
25_R	134_S	0.931	1.00
330_S	333_K	0.922	1.00
249_W	359_L	0.921	1.00
239_I	298_P	0.919	1.00
180_E	183_K	0.916	1.00
200_E	203_L	0.916	1.00
20_D	23_R	0.915	1.00
238_M	351_F	0.912	1.00
201_Y	379_D	0.904	1.00
297_M	307_A	0.903	1.00
25_R	132_D	0.899	1.00
295_G	307_A	0.899	1.00
296_I	355_C	0.891	1.00
130_I	171_T	0.891	1.00
313_L	325_G	0.889	1.00
41_E	64_R	0.886	1.00
324_V	343_V	0.886	1.00
30_A	34_A	0.880	1.00
242_A	352_I	0.880	1.00
250_T	273_N	0.880	1.00
260_N	263_V	0.879	1.00
349_I	353_A	0.874	1.00
171_T	195_V	0.872	1.00
26_R	113_T	0.870	1.00
313_L	323_V	0.869	1.00
243_A	273_N	0.869	1.00
193_H	390_Y	0.869	1.00
252_L	291_L	0.868	1.00
225_G	289_M	0.863	1.00
226_F	295_G	0.863	1.00
173_S	303_P	0.859	1.00
385_R	388_M	0.858	1.00
294_I	358_V	0.854	1.00
167_A	170_I	0.853	1.00
24_Y	28_R	0.852	1.00
335_Q	342_Y	0.850	1.00
297_M	331_T	0.847	1.00
313_L	334_M	0.844	1.00
193_H	386_Q	0.842	1.00
109_C	391_T	0.839	1.00
196_E	333_K	0.838	1.00
195_V	390_Y	0.838	1.00
289_M	321_K	0.837	1.00
324_V	354_A	0.836	1.00
226_F	298_P	0.835	1.00
128_Q	168_D	0.835	1.00
379_D	383_L	0.830	1.00
162_R	166_R	0.825	1.00
234_L	302_S	0.825	1.00
197_N	306_Q	0.825	1.00
242_A	348_P	0.823	1.00
234_L	299_Y	0.816	1.00
95_L	99_T	0.815	1.00
218_G	250_T	0.813	1.00
328_L	331_T	0.812	1.00
294_I	355_C	0.809	1.00
263_V	266_Q	0.806	1.00
361_Q	366_T	0.803	1.00
20_D	229_G	0.800	1.00
28_R	200_E	0.799	1.00
207_N	290_E	0.798	1.00
24_Y	282_P	0.797	1.00
260_N	264_S	0.796	1.00
182_D	192_V	0.795	1.00
176_Y	179_K	0.791	1.00
34_A	62_G	0.788	1.00
322_P	358_V	0.785	1.00
324_V	358_V	0.783	1.00
353_A	356_E	0.782	1.00
240_K	265_F	0.777	1.00
367_Y	375_A	0.776	1.00
219_R	222_I	0.773	1.00
200_E	204_F	0.773	1.00
173_S	306_Q	0.772	1.00
224_L	249_W	0.769	1.00
135_D	233_K	0.767	1.00
29_L	387_I	0.766	1.00
25_R	197_N	0.765	1.00
196_E	378_Q	0.765	1.00
134_S	173_S	0.764	1.00
180_E	184_K	0.764	1.00
317_L	374_I	0.759	1.00
232_P	237_K	0.757	1.00
287_H	291_L	0.756	1.00
288_Y	291_L	0.753	1.00
158_S	161_L	0.751	1.00
93_P	97_E	0.750	1.00
34_A	42_V	0.749	1.00
36_Q	381_N	0.745	1.00
113_T	132_D	0.744	1.00
381_N	385_R	0.742	1.00
228_G	236_F	0.742	1.00
95_L	98_L	0.742	1.00
28_R	32_F	0.742	1.00
287_H	290_E	0.741	1.00
109_C	130_I	0.739	1.00
341_E	364_D	0.738	1.00
196_E	386_Q	0.737	1.00
380_W	384_F	0.736	1.00
244_L	270_R	0.734	1.00
187_A	191_K	0.731	1.00
335_Q	339_V	0.731	1.00
158_S	162_R	0.731	1.00
124_Y	127_D	0.731	1.00
389_K	392_G	0.730	1.00
130_I	169_S	0.727	1.00
43_I	47_P	0.727	1.00
25_R	387_I	0.727	1.00
111_W	387_I	0.722	1.00
369_E	373_N	0.721	1.00
195_V	387_I	0.717	1.00
31_E	61_S	0.716	1.00
35_A	381_N	0.716	1.00
237_K	260_N	0.714	1.00
227_I	295_G	0.712	1.00
241_E	245_Q	0.712	1.00
327_N	342_Y	0.709	1.00
282_P	286_P	0.706	1.00
387_I	391_T	0.705	1.00
367_Y	373_N	0.704	1.00
241_E	244_L	0.704	1.00
36_Q	384_F	0.700	1.00
265_F	268_L	0.699	1.00
34_A	40_K	0.698	1.00
130_I	391_T	0.698	1.00
193_H	196_E	0.697	1.00
358_V	365_E	0.694	1.00
154_K	157_K	0.690	1.00
326_T	345_G	0.690	1.00
224_L	359_L	0.689	1.00
104_N	107_R	0.689	1.00
326_T	351_F	0.682	1.00
161_L	165_Q	0.682	1.00
317_L	340_Y	0.680	1.00
24_Y	27_H	0.679	1.00
226_F	251_F	0.679	1.00
296_I	351_F	0.679	1.00
235_D	298_P	0.678	1.00
357_K	360_G	0.676	1.00
280_A	285_V	0.675	1.00
242_A	355_C	0.675	1.00
176_Y	180_E	0.673	1.00
228_G	234_L	0.665	1.00
107_R	110_L	0.665	1.00
314_F	378_Q	0.662	1.00
240_K	274_V	0.657	1.00
349_I	352_I	0.657	1.00
305_N	313_L	0.657	1.00
304_Y	378_Q	0.656	1.00
232_P	300_K	0.655	1.00
247_P	356_E	0.655	1.00
195_V	386_Q	0.654	1.00
338_Y	357_K	0.652	1.00
22_L	114_F	0.647	1.00
30_A	42_V	0.646	1.00
30_A	63_I	0.645	1.00
332_S	342_Y	0.645	1.00
288_Y	292_I	0.644	1.00
172_C	194_T	0.643	1.00
255_G	278_G	0.643	1.00
201_Y	318_A	0.642	1.00
321_K	367_Y	0.640	1.00
374_I	378_Q	0.638	1.00
299_Y	305_N	0.638	1.00
187_A	190_E	0.638	1.00
246_K	359_L	0.635	1.00
94_L	97_E	0.632	1.00
235_D	346_D	0.630	1.00
125_S	128_Q	0.630	1.00
343_V	350_D	0.629	1.00
37_E	42_V	0.629	1.00
230_I	257_D	0.626	1.00
31_E	35_A	0.624	1.00
132_D	387_I	0.624	1.00
248_D	273_N	0.624	1.00
59_V	62_G	0.623	1.00
203_L	282_P	0.622	1.00
202_E	205_S	0.620	1.00
205_S	290_E	0.618	1.00
265_F	271_L	0.618	1.00
40_K	392_G	0.616	1.00
370_M	374_I	0.616	1.00
295_G	323_V	0.614	1.00
46_C	65_Q	0.614	1.00
220_E	248_D	0.614	1.00
246_K	273_N	0.611	1.00
340_Y	374_I	0.611	1.00
132_D	171_T	0.609	1.00
176_Y	332_S	0.609	1.00
238_M	242_A	0.606	1.00
67_A	70_D	0.604	1.00
337_P	341_E	0.604	1.00
174_S	177_L	0.602	1.00
123_L	166_R	0.601	1.00
289_M	307_A	0.601	1.00
94_L	98_L	0.601	1.00
230_I	236_F	0.600	1.00
251_F	274_V	0.599	1.00
222_I	362_N	0.597	1.00
88_R	92_S	0.595	1.00
368_K	375_A	0.595	1.00
134_S	197_N	0.593	1.00
324_V	355_C	0.593	1.00
89_H	92_S	0.593	1.00
229_G	234_L	0.592	1.00
118_P	121_S	0.590	1.00
225_G	295_G	0.588	1.00
25_R	113_T	0.587	1.00
254_V	285_V	0.587	1.00
175_D	196_E	0.586	1.00
225_G	321_K	0.584	1.00
373_N	378_Q	0.583	1.00
316_F	323_V	0.583	1.00
367_Y	372_R	0.581	1.00
270_R	273_N	0.581	1.00
297_M	305_N	0.579	1.00
294_I	324_V	0.578	1.00
363_G	366_T	0.575	1.00
91_L	97_E	0.575	1.00
239_I	243_A	0.574	1.00
384_F	388_M	0.572	1.00
178_H	189_R	0.571	1.00
328_L	345_G	0.570	1.00
32_F	380_W	0.570	1.00
242_A	296_I	0.568	1.00
328_L	332_S	0.568	1.00
377_T	382_C	0.567	1.00
90_K	94_L	0.566	1.00
150_E	154_K	0.566	1.00
339_V	369_E	0.565	1.00
154_K	158_S	0.562	1.00
377_T	386_Q	0.561	1.00
294_I	359_L	0.559	1.00
289_M	295_G	0.558	1.00
298_P	326_T	0.556	1.00
129_V	168_D	0.555	1.00
177_L	180_E	0.555	1.00
222_I	225_G	0.553	1.00
177_L	303_P	0.551	1.00
36_Q	40_K	0.551	1.00
247_P	360_G	0.550	1.00
322_P	365_E	0.549	1.00
265_F	274_V	0.541	1.00
136_L	139_A	0.539	1.00
200_E	380_W	0.538	1.00
201_Y	375_A	0.537	1.00
221_G	291_L	0.537	1.00
137_W	140_P	0.536	1.00
222_I	250_T	0.535	1.00
247_P	273_N	0.535	1.00
317_L	367_Y	0.534	1.00
106_E	127_D	0.534	1.00
40_K	108_C	0.533	1.00
58_E	67_A	0.533	1.00
322_P	367_Y	0.532	1.00
87_Y	90_K	0.531	1.00
225_G	252_L	0.531	1.00
26_R	44_W	0.531	1.00
91_L	94_L	0.530	1.00
29_L	32_F	0.530	1.00
176_Y	333_K	0.530	1.00
64_R	105_G	0.530	1.00
89_H	93_P	0.528	1.00
110_L	127_D	0.528	1.00
188_G	192_V	0.527	1.00
352_I	355_C	0.527	1.00
261_G	265_F	0.526	1.00
61_S	64_R	0.525	1.00
162_R	165_Q	0.523	1.00
107_R	127_D	0.521	1.00
317_L	370_M	0.521	1.00
58_E	62_G	0.519	1.00
196_E	383_L	0.517	1.00
235_D	326_T	0.517	1.00
314_F	334_M	0.516	1.00
327_N	345_G	0.515	1.00
305_N	314_F	0.514	1.00
135_D	138_A	0.514	1.00
28_R	306_Q	0.514	1.00
196_E	304_Y	0.513	1.00
28_R	198_G	0.513	1.00
64_R	67_A	0.511	1.00
117_F	120_L	0.507	1.00
19_K	279_P	0.507	1.00
31_E	60_H	0.506	1.00
340_Y	370_M	0.505	1.00
33_L	40_K	0.504	1.00
240_K	270_R	0.504	1.00
320_G	372_R	0.504	1.00
222_I	365_E	0.502	1.00
232_P	259_T	0.501	1.00
199_V	318_A	0.500	1.00
285_V	288_Y	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2r60A	1	0.9521	100	0.235	Contact Map
3c48A	2	0.932	100	0.26	Contact Map
3froA	3	0.9647	100	0.263	Contact Map
1rzuA	1	0.9547	100	0.278	Contact Map
4n9wA	1	0.8539	100	0.285	Contact Map
2jjmA	4	0.8665	100	0.289	Contact Map
2qzsA	1	0.9471	100	0.291	Contact Map
3okpA	1	0.8942	100	0.302	Contact Map
2x0dA	2	0.8463	100	0.308	Contact Map
3s28A	4	0.9773	100	0.309	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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