TKRA - BACSU - GREMLIN Contacts

Home
GREMLIN
- Submit - Monomer
- Submit - Complex
Contacts
Metagenomics
- Contacts
- Structures
Structures
- List
Old Projects
- Complexes (2014)
- PFAM (2013)

TKRA - Probable 2-ketogluconate reductase

UniProt:	O32264	Sequences: MLKPFVFITKPIPEEIEAFIGEHCRYEVWQEDTLPSDVLFEKLKEAEGLLTSGTSGPSINRELLEHAPKLKVVSNQSVGYDNFDIEAMKERGVVGTHTPYTLDDTVADLAFSLILSSARRVAELDRFVRAGKWGTVEEEALFGIDVHHQTLGIIGMGRIGEQAARRAKFGFDMEVLYHNRHRKQETEDSIGVKYAELDTLLEQSDFILLITPLTDETYHMIGEREFKLMKNSAIFVNISRGKTVDEKALIRALQEGWIRGAGLDVYEKEPVTQDNPLLQLDNVTLLPHIGSATAKVRFNMCKQAAENMLAAIQGQTPKNLTREFQ	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	325 (286)
Sequences:	19415 (13291)
Seq/√Len:	785.9

ECOLI - SERA GHRB LDHD GHRA PDXB
BACSU - TKRA SERA YOAD
HALSA - Q9HMR0 Q9HSS1 Q9HPW9
SULSO - Q97ZK1 Q97U35

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
222_G	225_E	4.245	1.00
223_E	251_R	3.204	1.00
245_D	248_A	2.941	1.00
151_L	167_A	2.665	1.00
254_Q	280_L	2.504	1.00
150_T	174_E	2.502	1.00
213_L	242_K	2.416	1.00
47_E	71_K	2.392	1.00
198_D	228_L	2.344	1.00
150_T	176_L	2.220	1.00
231_N	257_W	2.167	1.00
201_L	225_E	2.164	1.00
152_G	200_L	2.153	1.00
176_L	203_Q	2.122	1.00
202_E	228_L	2.075	1.00
156_M	177_Y	2.053	1.00
125_D	129_R	2.034	1.00
219_H	267_E	2.000	1.00
61_R	90_E	1.959	1.00
111_F	167_A	1.957	1.00
310_A	315_Q	1.943	1.00
196_E	199_T	1.929	1.00
227_K	257_W	1.910	1.00
120_R	123_E	1.889	1.00
251_R	255_E	1.868	1.00
162_Q	165_R	1.865	1.00
118_A	206_F	1.863	1.00
152_G	204_S	1.847	1.00
72_V	96_T	1.836	1.00
61_R	65_E	1.792	1.00
112_S	121_V	1.786	1.00
219_H	245_D	1.782	1.00
174_E	193_K	1.773	1.00
114_I	206_F	1.766	1.00
233_A	258_I	1.741	1.00
221_I	226_F	1.735	1.00
198_D	225_E	1.729	1.00
234_I	260_G	1.705	1.00
254_Q	276_P	1.704	1.00
250_I	280_L	1.696	1.00
94_V	320_L	1.686	1.00
111_F	171_F	1.680	1.00
223_E	227_K	1.673	1.00
235_F	244_V	1.672	1.00
226_F	252_A	1.666	1.00
45_E	69_K	1.645	1.00
113_L	262_G	1.626	1.00
280_L	283_V	1.625	1.00
87_A	90_E	1.618	1.00
199_T	203_Q	1.592	1.00
116_S	122_A	1.584	1.00
36_S	62_E	1.565	1.00
153_I	160_G	1.562	1.00
104_D	147_H	1.539	1.00
246_E	267_E	1.534	1.00
221_I	225_E	1.532	1.00
151_L	173_M	1.531	1.00
205_D	230_K	1.524	1.00
213_L	218_Y	1.523	1.00
65_E	91_R	1.516	1.00
309_L	313_Q	1.514	1.00
109_L	290_G	1.504	1.00
215_D	218_Y	1.501	1.00
149_Q	295_K	1.500	1.00
229_M	233_A	1.490	1.00
144_I	149_Q	1.485	1.00
224_R	228_L	1.479	1.00
250_I	254_Q	1.471	1.00
249_L	261_A	1.470	1.00
117_S	260_G	1.439	1.00
201_L	221_I	1.437	1.00
35_P	38_V	1.436	1.00
36_S	60_N	1.419	1.00
167_A	173_M	1.400	1.00
126_R	129_R	1.398	1.00
223_E	248_A	1.395	1.00
163_A	210_I	1.392	1.00
218_Y	242_K	1.391	1.00
225_E	228_L	1.386	1.00
108_D	166_R	1.380	1.00
162_Q	166_R	1.377	1.00
145_D	299_N	1.375	1.00
234_I	259_R	1.375	1.00
174_E	203_Q	1.373	1.00
40_F	66_H	1.352	1.00
110_A	163_A	1.350	1.00
176_L	195_A	1.343	1.00
88_M	95_G	1.342	1.00
209_L	243_T	1.339	1.00
310_A	318_K	1.331	1.00
48_G	72_V	1.324	1.00
239_S	243_T	1.318	1.00
104_D	162_Q	1.311	1.00
210_I	238_I	1.293	1.00
126_R	130_A	1.286	1.00
153_I	208_L	1.284	1.00
127_F	132_K	1.274	1.00
43_L	67_A	1.271	1.00
64_L	91_R	1.265	1.00
306_E	310_A	1.259	1.00
60_N	63_L	1.254	1.00
209_L	235_F	1.246	1.00
110_A	238_I	1.243	1.00
61_R	87_A	1.243	1.00
302_K	306_E	1.240	1.00
211_T	243_T	1.238	1.00
47_E	69_K	1.237	1.00
200_L	204_S	1.227	1.00
153_I	164_A	1.226	1.00
117_S	234_I	1.226	1.00
193_K	203_Q	1.218	1.00
165_R	172_D	1.204	1.00
109_L	113_L	1.199	1.00
122_A	125_D	1.187	1.00
266_Y	285_L	1.176	1.00
154_I	211_T	1.172	1.00
86_E	90_E	1.168	1.00
198_D	224_R	1.163	1.00
224_R	227_K	1.155	1.00
311_A	317_P	1.154	1.00
154_I	220_M	1.149	1.00
72_V	311_A	1.140	1.00
156_M	161_E	1.135	1.00
87_A	91_R	1.131	1.00
131_G	279_Q	1.130	1.00
154_I	221_I	1.129	1.00
117_S	262_G	1.124	1.00
176_L	204_S	1.121	1.00
115_L	171_F	1.118	1.00
306_E	318_K	1.117	1.00
64_L	88_M	1.117	1.00
75_N	83_F	1.116	1.00
107_A	166_R	1.113	1.00
206_F	234_I	1.109	1.00
303_Q	319_N	1.105	1.00
83_F	88_M	1.105	1.00
163_A	208_L	1.101	1.00
197_L	225_E	1.100	1.00
230_K	233_A	1.092	1.00
104_D	166_R	1.090	1.00
207_I	229_M	1.083	1.00
247_K	276_P	1.077	1.00
117_S	284_T	1.073	1.00
150_T	203_Q	1.069	1.00
114_I	151_L	1.064	1.00
112_S	115_L	1.062	1.00
220_M	243_T	1.061	1.00
65_E	87_A	1.059	1.00
74_S	307_N	1.056	1.00
86_E	89_K	1.045	1.00
271_V	274_D	1.042	1.00
208_L	238_I	1.040	1.00
109_L	286_L	1.039	1.00
222_G	248_A	1.037	1.00
253_L	283_V	1.037	1.00
102_L	291_S	1.033	1.00
246_E	275_N	1.020	1.00
232_S	257_W	1.016	1.00
268_K	272_T	1.009	1.00
114_I	167_A	1.003	1.00
252_A	257_W	0.999	1.00
154_I	207_I	0.998	1.00
226_F	235_F	0.995	1.00
254_Q	279_Q	0.991	1.00
180_R	216_E	0.990	1.00
197_L	201_L	0.989	1.00
36_S	40_F	0.984	1.00
38_V	41_E	0.977	1.00
165_R	168_K	0.974	1.00
154_I	197_L	0.972	1.00
74_S	304_A	0.971	1.00
298_F	302_K	0.969	1.00
109_L	262_G	0.964	1.00
118_A	144_I	0.958	1.00
246_E	268_K	0.952	1.00
168_K	191_G	0.947	1.00
250_I	276_P	0.946	1.00
94_V	317_P	0.945	1.00
252_A	258_I	0.935	1.00
182_R	194_Y	0.933	1.00
84_D	87_A	0.932	1.00
163_A	167_A	0.931	1.00
195_A	199_T	0.923	1.00
85_I	89_K	0.920	1.00
118_A	149_Q	0.920	1.00
29_W	46_A	0.919	1.00
41_E	44_K	0.912	1.00
204_S	207_I	0.911	1.00
182_R	187_E	0.910	1.00
111_F	166_R	0.902	1.00
48_G	308_M	0.901	1.00
179_N	183_K	0.900	1.00
222_G	245_D	0.898	1.00
113_L	284_T	0.898	1.00
221_I	235_F	0.894	1.00
83_F	95_G	0.889	1.00
147_H	172_D	0.888	1.00
161_E	183_K	0.885	1.00
211_T	220_M	0.884	1.00
212_P	217_T	0.884	1.00
75_N	82_N	0.883	1.00
154_I	209_L	0.880	1.00
74_S	96_T	0.877	1.00
151_L	208_L	0.876	1.00
161_E	186_T	0.873	1.00
44_K	66_H	0.865	1.00
307_N	310_A	0.860	1.00
126_R	281_D	0.859	1.00
105_T	145_D	0.853	1.00
116_S	121_V	0.851	1.00
195_A	203_Q	0.850	1.00
226_F	229_M	0.850	1.00
195_A	200_L	0.850	1.00
244_V	249_L	0.846	1.00
48_G	312_I	0.840	1.00
153_I	163_A	0.838	1.00
145_D	293_T	0.838	1.00
122_A	126_R	0.835	1.00
118_A	234_I	0.835	1.00
116_S	284_T	0.834	1.00
77_S	82_N	0.830	1.00
226_F	257_W	0.829	1.00
164_A	175_V	0.825	1.00
209_L	221_I	0.822	1.00
111_F	163_A	0.821	1.00
103_D	162_Q	0.820	1.00
40_F	63_L	0.819	1.00
251_R	254_Q	0.809	1.00
156_M	164_A	0.809	1.00
144_I	295_K	0.807	1.00
183_K	186_T	0.805	1.00
177_Y	192_V	0.802	1.00
201_L	207_I	0.802	1.00
268_K	271_V	0.801	1.00
260_G	284_T	0.800	1.00
247_K	251_R	0.800	1.00
38_V	42_K	0.796	1.00
271_V	275_N	0.795	1.00
50_L	304_A	0.791	1.00
198_D	202_E	0.786	1.00
232_S	259_R	0.782	1.00
106_V	290_G	0.780	1.00
144_I	294_A	0.779	1.00
73_V	88_M	0.777	1.00
72_V	308_M	0.775	1.00
62_E	65_E	0.772	1.00
249_L	258_I	0.768	1.00
64_L	73_V	0.766	1.00
104_D	108_D	0.763	1.00
112_S	116_S	0.761	1.00
261_A	283_V	0.759	1.00
104_D	145_D	0.755	1.00
110_A	210_I	0.755	1.00
246_E	277_L	0.751	1.00
177_Y	194_Y	0.749	1.00
207_I	233_A	0.748	1.00
247_K	267_E	0.747	1.00
103_D	158_R	0.747	1.00
178_H	197_L	0.746	1.00
299_N	302_K	0.745	1.00
199_T	202_E	0.745	1.00
263_L	283_V	0.745	1.00
227_K	255_E	0.744	1.00
146_V	173_M	0.743	1.00
223_E	257_W	0.743	1.00
118_A	122_A	0.741	1.00
187_E	194_Y	0.739	1.00
27_E	46_A	0.736	1.00
110_A	208_L	0.734	1.00
114_I	163_A	0.729	1.00
98_T	303_Q	0.728	1.00
201_L	228_L	0.724	1.00
111_F	114_I	0.720	1.00
49_L	59_I	0.719	1.00
100_Y	158_R	0.717	1.00
27_E	42_K	0.716	1.00
37_D	41_E	0.716	1.00
124_L	289_I	0.714	1.00
166_R	171_F	0.714	1.00
61_R	91_R	0.712	1.00
61_R	84_D	0.711	1.00
75_N	80_Y	0.710	1.00
27_E	30_Q	0.709	1.00
147_H	299_N	0.708	1.00
244_V	261_A	0.706	1.00
150_T	204_S	0.705	1.00
213_L	217_T	0.701	1.00
144_I	232_S	0.701	1.00
43_L	49_L	0.700	1.00
40_F	62_E	0.699	1.00
197_L	220_M	0.699	1.00
80_Y	85_I	0.698	1.00
266_Y	271_V	0.697	1.00
107_A	162_Q	0.694	1.00
251_R	257_W	0.690	1.00
105_T	296_V	0.687	1.00
108_D	119_R	0.685	1.00
253_L	282_N	0.685	1.00
201_L	229_M	0.684	1.00
184_Q	187_E	0.682	1.00
272_T	275_N	0.682	1.00
114_I	146_V	0.680	1.00
209_L	239_S	0.680	1.00
149_Q	206_F	0.674	1.00
173_M	206_F	0.669	1.00
305_A	309_L	0.667	1.00
74_S	308_M	0.665	1.00
316_T	320_L	0.663	1.00
234_I	262_G	0.662	1.00
294_A	298_F	0.661	1.00
192_V	195_A	0.660	1.00
44_K	68_P	0.659	1.00
218_Y	267_E	0.656	1.00
207_I	230_K	0.656	1.00
179_N	182_R	0.653	1.00
98_T	300_M	0.652	1.00
306_E	309_L	0.649	1.00
110_A	113_L	0.648	1.00
128_V	278_L	0.647	1.00
100_Y	303_Q	0.644	1.00
125_D	128_V	0.638	1.00
191_G	195_A	0.635	1.00
150_T	230_K	0.635	1.00
161_E	165_R	0.634	1.00
150_T	205_D	0.633	1.00
232_S	258_I	0.633	1.00
127_F	130_A	0.633	1.00
62_E	66_H	0.632	1.00
71_K	311_A	0.632	1.00
249_L	263_L	0.629	1.00
114_I	208_L	0.629	1.00
51_T	59_I	0.628	1.00
278_L	285_L	0.628	1.00
45_E	68_P	0.627	1.00
310_A	316_T	0.627	1.00
74_S	98_T	0.626	1.00
152_G	178_H	0.626	1.00
67_A	70_L	0.625	1.00
114_I	236_V	0.624	1.00
310_A	317_P	0.621	1.00
105_T	108_D	0.619	1.00
176_L	200_L	0.618	1.00
211_T	239_S	0.615	1.00
223_E	255_E	0.614	1.00
81_D	213_L	0.613	1.00
26_Y	29_W	0.610	1.00
80_Y	97_H	0.610	1.00
100_Y	103_D	0.607	1.00
124_L	287_P	0.605	1.00
214_T	217_T	0.605	1.00
125_D	285_L	0.603	1.00
59_I	64_L	0.602	1.00
271_V	278_L	0.601	1.00
223_E	252_A	0.600	1.00
262_G	284_T	0.600	1.00
68_P	91_R	0.599	1.00
25_R	30_Q	0.599	1.00
166_R	170_G	0.599	1.00
151_L	163_A	0.598	1.00
253_L	261_A	0.597	1.00
156_M	194_Y	0.596	1.00
246_E	250_I	0.595	1.00
25_R	29_W	0.595	1.00
242_K	267_E	0.591	1.00
185_E	189_S	0.589	1.00
113_L	116_S	0.587	1.00
252_A	255_E	0.587	1.00
109_L	119_R	0.587	1.00
177_Y	187_E	0.584	1.00
219_H	242_K	0.582	1.00
104_D	172_D	0.582	1.00
168_K	175_V	0.581	1.00
292_A	297_R	0.580	1.00
132_K	135_T	0.576	1.00
48_G	74_S	0.571	1.00
317_P	320_L	0.570	1.00
105_T	293_T	0.569	1.00
219_H	222_G	0.569	1.00
149_Q	173_M	0.568	1.00
254_Q	281_D	0.566	1.00
146_V	171_F	0.565	1.00
207_I	221_I	0.557	1.00
109_L	112_S	0.557	1.00
37_D	62_E	0.552	1.00
76_Q	300_M	0.551	1.00
156_M	179_N	0.551	1.00
274_D	278_L	0.549	1.00
101_T	303_Q	0.549	1.00
127_F	141_L	0.547	1.00
113_L	117_S	0.546	1.00
184_Q	194_Y	0.546	1.00
106_V	110_A	0.546	1.00
123_E	127_F	0.543	1.00
91_R	94_V	0.543	1.00
176_L	193_K	0.542	1.00
302_K	305_A	0.541	1.00
274_D	279_Q	0.540	1.00
116_S	125_D	0.539	1.00
118_A	173_M	0.537	1.00
211_T	217_T	0.536	1.00
40_F	67_A	0.533	1.00
64_L	93_V	0.529	1.00
165_R	170_G	0.528	1.00
102_L	105_T	0.527	1.00
303_Q	307_N	0.527	1.00
122_A	284_T	0.527	1.00
201_L	220_M	0.525	1.00
240_R	288_H	0.525	1.00
101_T	291_S	0.525	1.00
309_L	315_Q	0.524	1.00
154_I	200_L	0.524	1.00
127_F	134_G	0.524	1.00
144_I	259_R	0.523	1.00
101_T	300_M	0.523	1.00
51_T	75_N	0.523	1.00
118_A	146_V	0.522	1.00
164_A	177_Y	0.521	1.00
129_R	279_Q	0.518	1.00
42_K	46_A	0.517	1.00
304_A	307_N	0.516	1.00
303_Q	306_E	0.514	1.00
127_F	140_A	0.514	1.00
128_V	266_Y	0.513	1.00
34_L	38_V	0.513	1.00
149_Q	205_D	0.508	1.00
217_T	243_T	0.508	1.00
81_D	242_K	0.506	1.00
231_N	252_A	0.501	1.00
128_V	285_L	0.500	1.00

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
1ygyA	4	0.9692	100	0.192	Contact Map
2g76A	2	0.9292	100	0.198	Contact Map
3ba1A	2	0.96	100	0.198	Contact Map
2d0iA	2	0.9754	100	0.199	Contact Map
4g2nA	3	0.9723	100	0.202	Contact Map
3wwyA	4	0.9723	100	0.207	Contact Map
3k5pA	3	0.9569	100	0.207	Contact Map
4lswA	2	0.9723	100	0.211	Contact Map
1sc6A	4	0.9323	100	0.212	Contact Map
2gcgA	2	0.9815	100	0.213	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.01 seconds.