GREMLIN Database
LUTC - Lactate utilization protein C
UniProt: O32259 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 240 (207)
Sequences: 2861 (1906)
Seq/√Len: 132.5

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
59_C64_T3.6731.00
80_E84_R3.2161.00
76_D80_E3.1541.00
59_C234_Y3.1061.00
56_K60_V2.9411.00
152_T208_Y2.8901.00
70_D73_G2.8381.00
82_V138_V2.7301.00
146_T176_V2.5931.00
152_T210_T2.5861.00
87_G138_V2.5831.00
138_V173_I2.4991.00
55_L146_T2.4111.00
47_S50_D2.3371.00
141_T172_Y2.2751.00
55_L234_Y2.2541.00
67_I77_A2.2521.00
88_G137_N2.2301.00
55_L59_C2.2251.00
85_F231_K2.2221.00
67_I233_A2.1071.00
184_R187_Q2.1051.00
58_H61_K2.0661.00
64_T232_A2.0361.00
170_T230_V2.0261.00
59_C232_A1.9991.00
143_S146_T1.9821.00
56_K68_E1.8951.00
90_V140_I1.7931.00
73_G76_D1.7901.00
53_T57_N1.7861.00
171_T231_K1.7411.00
137_N170_T1.7371.00
65_E233_A1.6901.00
177_P180_S1.6871.00
143_S180_S1.6631.00
79_R106_L1.6061.00
171_T233_A1.5941.00
57_N60_V1.5841.00
154_V208_Y1.5761.00
54_V58_H1.5721.00
77_A81_Q1.5591.00
54_V57_N1.5551.00
85_F171_T1.5511.00
139_G169_P1.5411.00
175_I237_V1.5221.00
143_S174_A1.5161.00
52_V181_I1.4991.00
89_P137_N1.4901.00
34_W38_P1.4871.00
64_T234_Y1.4851.00
138_V171_T1.4821.00
131_K135_Q1.4801.00
69_T77_A1.4601.00
51_L183_P1.4491.00
98_F175_I1.4361.00
143_S176_V1.4091.00
153_V174_A1.3941.00
69_T235_I1.3891.00
178_K236_L1.3801.00
72_T76_D1.3771.00
87_G137_N1.3661.00
43_L47_S1.3511.00
183_P187_Q1.3251.00
36_H40_Y1.2851.00
91_I136_A1.2841.00
182_V188_A1.2801.00
50_D53_T1.2761.00
33_E36_H1.2511.00
154_V188_A1.2351.00
93_P161_I1.2341.00
56_K66_L1.2241.00
78_L235_I1.2081.00
65_E231_K1.2061.00
213_S217_D1.2020.99
38_P42_T1.1870.99
68_E178_K1.1870.99
67_I81_Q1.1860.99
149_E184_R1.1860.99
82_V87_G1.1830.99
181_I236_L1.1790.99
16_I20_L1.1710.99
176_V236_L1.1360.99
153_V232_A1.1350.99
147_L188_A1.1280.99
145_I188_A1.1210.99
14_N18_S1.1210.99
215_S218_I1.1170.99
39_Q42_T1.1010.99
33_E37_Q1.1000.99
34_W37_Q1.0830.99
53_T68_E1.0740.99
68_E238_S1.0700.99
139_G165_V1.0690.99
23_E27_G1.0600.99
79_R83_S1.0570.99
117_P120_E1.0520.99
43_L51_L1.0500.99
52_V56_K1.0450.99
101_Y175_I1.0440.99
105_S108_T1.0170.98
145_I182_V1.0140.98
20_L24_R1.0070.98
94_K160_D0.9980.98
62_I210_T0.9910.98
142_F177_P0.9850.98
213_S219_E0.9850.98
77_A80_E0.9650.98
44_E51_L0.9610.98
178_K238_S0.9570.97
91_I165_V0.9490.97
211_G228_G0.9460.97
35_A38_P0.9340.97
89_P135_Q0.9300.97
141_T166_S0.9300.97
55_L58_H0.9290.97
82_V173_I0.9250.97
119_W123_A0.9170.97
103_L107_L0.9150.97
173_I235_I0.9140.97
214_N229_P0.8940.96
166_S209_I0.8870.96
69_T73_G0.8860.96
89_P132_K0.8850.96
35_A41_K0.8840.96
57_N61_K0.8820.96
69_T74_L0.8820.96
47_S51_L0.8750.96
41_K192_I0.8740.96
217_D229_P0.8670.95
93_P162_G0.8650.95
37_Q41_K0.8640.95
84_R231_K0.8630.95
152_T185_M0.8600.95
20_L25_R0.8590.95
81_Q171_T0.8580.95
24_R28_G0.8560.95
74_L237_V0.8550.95
185_M208_Y0.8440.95
213_S218_I0.8360.95
144_E161_I0.8350.94
60_V68_E0.8320.94
62_I214_N0.8260.94
176_V234_Y0.8240.94
134_E168_L0.8230.94
55_L181_I0.8220.94
36_H39_Q0.8210.94
62_I211_G0.8180.94
121_W125_K0.8140.94
215_S219_E0.8140.94
125_K129_N0.8120.94
97_R237_V0.8040.93
118_V122_D0.7980.93
97_R176_V0.7940.93
90_V138_V0.7820.92
119_W122_D0.7820.92
15_R64_T0.7820.92
142_F160_D0.7810.92
153_V176_V0.7800.92
163_R166_S0.7770.92
60_V65_E0.7770.92
93_P165_V0.7750.92
102_G105_S0.7700.92
73_G77_A0.7680.92
189_S208_Y0.7670.92
77_A235_I0.7580.91
166_S172_Y0.7560.91
87_G171_T0.7550.91
12_F20_L0.7530.91
214_N217_D0.7520.91
133_A168_L0.7510.91
52_V236_L0.7350.90
96_P99_E0.7270.89
213_S216_A0.7250.89
103_L140_I0.7220.89
52_V68_E0.7210.89
71_S177_P0.7200.89
74_L78_L0.7180.89
77_A233_A0.7140.88
218_I228_G0.7120.88
24_R27_G0.7120.88
33_E41_K0.7120.88
144_E156_F0.7100.88
48_A52_V0.7070.88
46_Y50_D0.7020.88
93_P139_G0.7020.88
162_G205_C0.7000.87
156_F161_I0.7000.87
99_E104_K0.6990.87
123_A127_E0.6960.87
120_E123_A0.6940.87
163_R209_I0.6870.86
59_C146_T0.6810.86
163_R167_L0.6810.86
78_L175_I0.6790.86
98_F140_I0.6770.86
78_L101_Y0.6730.85
78_L173_I0.6610.84
140_I173_I0.6610.84
93_P141_T0.6520.83
20_L23_E0.6510.83
17_A24_R0.6490.83
122_D125_K0.6480.83
38_P41_K0.6460.83
48_A51_L0.6450.83
74_L101_Y0.6450.83
82_V106_L0.6450.83
128_E131_K0.6450.83
72_T75_Y0.6440.83
14_N24_R0.6430.83
132_K135_Q0.6370.82
217_D228_G0.6360.82
164_S167_L0.6320.82
81_Q233_A0.6310.81
22_R26_T0.6280.81
213_S230_V0.6280.81
23_E26_T0.6280.81
118_V121_W0.6270.81
139_G166_S0.6270.81
150_S208_Y0.6270.81
12_F16_I0.6250.81
75_Y78_L0.6200.80
150_S210_T0.6190.80
20_L212_P0.6180.80
26_T29_V0.6170.80
54_V148_A0.6170.80
37_Q40_Y0.6160.80
66_L236_L0.6160.80
52_V178_K0.6160.80
213_S228_G0.6140.80
34_W41_K0.6130.80
16_I19_S0.6070.79
92_I104_K0.6060.79
146_T180_S0.6050.79
56_K236_L0.6040.79
23_E28_G0.6020.78
74_L175_I0.6000.78
169_P216_A0.5980.78
55_L232_A0.5940.77
147_L185_M0.5930.77
69_T173_I0.5910.77
157_S207_N0.5900.77
154_V206_I0.5900.77
27_G31_V0.5870.77
104_K107_L0.5850.76
125_K130_I0.5850.76
126_G129_N0.5840.76
76_D106_L0.5810.76
210_T214_N0.5800.76
167_L217_D0.5800.76
144_E158_S0.5790.76
147_L182_V0.5760.75
158_S161_I0.5720.75
167_L205_C0.5680.74
32_P37_Q0.5670.74
87_G173_I0.5650.74
49_D53_T0.5640.74
166_S169_P0.5630.74
94_K159_K0.5580.73
53_T56_K0.5580.73
117_P122_D0.5580.73
149_E186_T0.5530.72
104_K108_T0.5530.72
209_I213_S0.5530.72
194_Q206_I0.5500.72
131_K134_E0.5410.71
16_I21_G0.5410.71
188_A208_Y0.5390.70
214_N228_G0.5370.70
54_V183_P0.5350.70
34_W39_Q0.5340.70
158_S173_I0.5340.70
50_D54_V0.5340.70
71_S238_S0.5310.69
55_L147_L0.5310.69
67_I80_E0.5300.69
116_T120_E0.5290.69
157_S163_R0.5240.68
79_R82_V0.5230.68
51_L181_I0.5220.68
59_C66_L0.5220.68
54_V149_E0.5210.68
67_I142_F0.5200.68
194_Q199_G0.5200.68
140_I175_I0.5190.67
167_L216_A0.5190.67
44_E47_S0.5180.67
58_H63_H0.5180.67
143_S153_V0.5170.67
83_S86_S0.5170.67
120_E124_D0.5170.67
90_V173_I0.5160.67
155_L166_S0.5130.67
144_E160_D0.5130.67
35_A39_Q0.5130.67
14_N20_L0.5130.67
211_G229_P0.5130.67
53_T60_V0.5120.66
190_D194_Q0.5120.66
212_P217_D0.5100.66
43_L195_N0.5100.66
18_S21_G0.5090.66
214_N218_I0.5050.65
50_D60_V0.5020.65
29_V32_P0.5020.65
145_I189_S0.5020.65
150_S154_V0.5010.65
28_G32_P0.5010.65
192_I206_I0.5000.65
116_T119_W0.5000.65
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2g40A 2 0.6792 100 0.284 Contact Map
3cf4A 2 0.85 97 0.889 Contact Map
1yksA 1 0.3708 41.7 0.947 Contact Map
1q5zA 1 0.4583 27.2 0.952 Contact Map
3brcA 4 0.5958 22.7 0.954 Contact Map
1fuuA 2 0.5333 15.1 0.957 Contact Map
4ct4B 1 0.5167 13.6 0.958 Contact Map
4cbhA 1 0.4083 10.4 0.96 Contact Map
2ocaA 1 0.8208 10.3 0.96 Contact Map
2i4iA 1 0.5625 10.3 0.96 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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