LUTC - BACSU - GREMLIN Contacts

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LUTC - Lactate utilization protein C

UniProt:	O32259	Sequences: MTKGTIQNQESFLNRIASSLGRERRTGGVAVPEWAHQPQYKTLEGYSADDLVTVLKNHCVKIHTELIETDSTGLYDALREQVSRFSGGPVIIPKDPRFEEYGLKSLLTKDWPSEGTPVWEWDADKGEENIKKAEQANVGITFSEITLAESGTVVLFSSKDIGRSVSLLPTTYIAIVPKSSIVPRMTQASDIIRQNIANGVTVPSCINYITGPSNSADIEMDLVVGVHGPVKAAYILVSDR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	240 (207)
Sequences:	2861 (1906)
Seq/√Len:	132.5

ECOLI - YKGG YKGF
BACSU - LUTC LUTB
HALSA - Q9HHI3 Q9HHI4
SULSO - Q97U90

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
59_C	64_T	3.673	1.00
80_E	84_R	3.216	1.00
76_D	80_E	3.154	1.00
59_C	234_Y	3.106	1.00
56_K	60_V	2.941	1.00
152_T	208_Y	2.890	1.00
70_D	73_G	2.838	1.00
82_V	138_V	2.730	1.00
146_T	176_V	2.593	1.00
152_T	210_T	2.586	1.00
87_G	138_V	2.583	1.00
138_V	173_I	2.499	1.00
55_L	146_T	2.411	1.00
47_S	50_D	2.337	1.00
141_T	172_Y	2.275	1.00
55_L	234_Y	2.254	1.00
67_I	77_A	2.252	1.00
88_G	137_N	2.230	1.00
55_L	59_C	2.225	1.00
85_F	231_K	2.222	1.00
67_I	233_A	2.107	1.00
184_R	187_Q	2.105	1.00
58_H	61_K	2.066	1.00
64_T	232_A	2.036	1.00
170_T	230_V	2.026	1.00
59_C	232_A	1.999	1.00
143_S	146_T	1.982	1.00
56_K	68_E	1.895	1.00
90_V	140_I	1.793	1.00
73_G	76_D	1.790	1.00
53_T	57_N	1.786	1.00
171_T	231_K	1.741	1.00
137_N	170_T	1.737	1.00
65_E	233_A	1.690	1.00
177_P	180_S	1.687	1.00
143_S	180_S	1.663	1.00
79_R	106_L	1.606	1.00
171_T	233_A	1.594	1.00
57_N	60_V	1.584	1.00
154_V	208_Y	1.576	1.00
54_V	58_H	1.572	1.00
77_A	81_Q	1.559	1.00
54_V	57_N	1.555	1.00
85_F	171_T	1.551	1.00
139_G	169_P	1.541	1.00
175_I	237_V	1.522	1.00
143_S	174_A	1.516	1.00
52_V	181_I	1.499	1.00
89_P	137_N	1.490	1.00
34_W	38_P	1.487	1.00
64_T	234_Y	1.485	1.00
138_V	171_T	1.482	1.00
131_K	135_Q	1.480	1.00
69_T	77_A	1.460	1.00
51_L	183_P	1.449	1.00
98_F	175_I	1.436	1.00
143_S	176_V	1.409	1.00
153_V	174_A	1.394	1.00
69_T	235_I	1.389	1.00
178_K	236_L	1.380	1.00
72_T	76_D	1.377	1.00
87_G	137_N	1.366	1.00
43_L	47_S	1.351	1.00
183_P	187_Q	1.325	1.00
36_H	40_Y	1.285	1.00
91_I	136_A	1.284	1.00
182_V	188_A	1.280	1.00
50_D	53_T	1.276	1.00
33_E	36_H	1.251	1.00
154_V	188_A	1.235	1.00
93_P	161_I	1.234	1.00
56_K	66_L	1.224	1.00
78_L	235_I	1.208	1.00
65_E	231_K	1.206	1.00
213_S	217_D	1.202	0.99
38_P	42_T	1.187	0.99
68_E	178_K	1.187	0.99
67_I	81_Q	1.186	0.99
149_E	184_R	1.186	0.99
82_V	87_G	1.183	0.99
181_I	236_L	1.179	0.99
16_I	20_L	1.171	0.99
176_V	236_L	1.136	0.99
153_V	232_A	1.135	0.99
147_L	188_A	1.128	0.99
145_I	188_A	1.121	0.99
14_N	18_S	1.121	0.99
215_S	218_I	1.117	0.99
39_Q	42_T	1.101	0.99
33_E	37_Q	1.100	0.99
34_W	37_Q	1.083	0.99
53_T	68_E	1.074	0.99
68_E	238_S	1.070	0.99
139_G	165_V	1.069	0.99
23_E	27_G	1.060	0.99
79_R	83_S	1.057	0.99
117_P	120_E	1.052	0.99
43_L	51_L	1.050	0.99
52_V	56_K	1.045	0.99
101_Y	175_I	1.044	0.99
105_S	108_T	1.017	0.98
145_I	182_V	1.014	0.98
20_L	24_R	1.007	0.98
94_K	160_D	0.998	0.98
62_I	210_T	0.991	0.98
142_F	177_P	0.985	0.98
213_S	219_E	0.985	0.98
77_A	80_E	0.965	0.98
44_E	51_L	0.961	0.98
178_K	238_S	0.957	0.97
91_I	165_V	0.949	0.97
211_G	228_G	0.946	0.97
35_A	38_P	0.934	0.97
89_P	135_Q	0.930	0.97
141_T	166_S	0.930	0.97
55_L	58_H	0.929	0.97
82_V	173_I	0.925	0.97
119_W	123_A	0.917	0.97
103_L	107_L	0.915	0.97
173_I	235_I	0.914	0.97
214_N	229_P	0.894	0.96
166_S	209_I	0.887	0.96
69_T	73_G	0.886	0.96
89_P	132_K	0.885	0.96
35_A	41_K	0.884	0.96
57_N	61_K	0.882	0.96
69_T	74_L	0.882	0.96
47_S	51_L	0.875	0.96
41_K	192_I	0.874	0.96
217_D	229_P	0.867	0.95
93_P	162_G	0.865	0.95
37_Q	41_K	0.864	0.95
84_R	231_K	0.863	0.95
152_T	185_M	0.860	0.95
20_L	25_R	0.859	0.95
81_Q	171_T	0.858	0.95
24_R	28_G	0.856	0.95
74_L	237_V	0.855	0.95
185_M	208_Y	0.844	0.95
213_S	218_I	0.836	0.95
144_E	161_I	0.835	0.94
60_V	68_E	0.832	0.94
62_I	214_N	0.826	0.94
176_V	234_Y	0.824	0.94
134_E	168_L	0.823	0.94
55_L	181_I	0.822	0.94
36_H	39_Q	0.821	0.94
62_I	211_G	0.818	0.94
121_W	125_K	0.814	0.94
215_S	219_E	0.814	0.94
125_K	129_N	0.812	0.94
97_R	237_V	0.804	0.93
118_V	122_D	0.798	0.93
97_R	176_V	0.794	0.93
90_V	138_V	0.782	0.92
119_W	122_D	0.782	0.92
15_R	64_T	0.782	0.92
142_F	160_D	0.781	0.92
153_V	176_V	0.780	0.92
163_R	166_S	0.777	0.92
60_V	65_E	0.777	0.92
93_P	165_V	0.775	0.92
102_G	105_S	0.770	0.92
73_G	77_A	0.768	0.92
189_S	208_Y	0.767	0.92
77_A	235_I	0.758	0.91
166_S	172_Y	0.756	0.91
87_G	171_T	0.755	0.91
12_F	20_L	0.753	0.91
214_N	217_D	0.752	0.91
133_A	168_L	0.751	0.91
52_V	236_L	0.735	0.90
96_P	99_E	0.727	0.89
213_S	216_A	0.725	0.89
103_L	140_I	0.722	0.89
52_V	68_E	0.721	0.89
71_S	177_P	0.720	0.89
74_L	78_L	0.718	0.89
77_A	233_A	0.714	0.88
218_I	228_G	0.712	0.88
24_R	27_G	0.712	0.88
33_E	41_K	0.712	0.88
144_E	156_F	0.710	0.88
48_A	52_V	0.707	0.88
46_Y	50_D	0.702	0.88
93_P	139_G	0.702	0.88
162_G	205_C	0.700	0.87
156_F	161_I	0.700	0.87
99_E	104_K	0.699	0.87
123_A	127_E	0.696	0.87
120_E	123_A	0.694	0.87
163_R	209_I	0.687	0.86
59_C	146_T	0.681	0.86
163_R	167_L	0.681	0.86
78_L	175_I	0.679	0.86
98_F	140_I	0.677	0.86
78_L	101_Y	0.673	0.85
78_L	173_I	0.661	0.84
140_I	173_I	0.661	0.84
93_P	141_T	0.652	0.83
20_L	23_E	0.651	0.83
17_A	24_R	0.649	0.83
122_D	125_K	0.648	0.83
38_P	41_K	0.646	0.83
48_A	51_L	0.645	0.83
74_L	101_Y	0.645	0.83
82_V	106_L	0.645	0.83
128_E	131_K	0.645	0.83
72_T	75_Y	0.644	0.83
14_N	24_R	0.643	0.83
132_K	135_Q	0.637	0.82
217_D	228_G	0.636	0.82
164_S	167_L	0.632	0.82
81_Q	233_A	0.631	0.81
22_R	26_T	0.628	0.81
213_S	230_V	0.628	0.81
23_E	26_T	0.628	0.81
118_V	121_W	0.627	0.81
139_G	166_S	0.627	0.81
150_S	208_Y	0.627	0.81
12_F	16_I	0.625	0.81
75_Y	78_L	0.620	0.80
150_S	210_T	0.619	0.80
20_L	212_P	0.618	0.80
26_T	29_V	0.617	0.80
54_V	148_A	0.617	0.80
37_Q	40_Y	0.616	0.80
66_L	236_L	0.616	0.80
52_V	178_K	0.616	0.80
213_S	228_G	0.614	0.80
34_W	41_K	0.613	0.80
16_I	19_S	0.607	0.79
92_I	104_K	0.606	0.79
146_T	180_S	0.605	0.79
56_K	236_L	0.604	0.79
23_E	28_G	0.602	0.78
74_L	175_I	0.600	0.78
169_P	216_A	0.598	0.78
55_L	232_A	0.594	0.77
147_L	185_M	0.593	0.77
69_T	173_I	0.591	0.77
157_S	207_N	0.590	0.77
154_V	206_I	0.590	0.77
27_G	31_V	0.587	0.77
104_K	107_L	0.585	0.76
125_K	130_I	0.585	0.76
126_G	129_N	0.584	0.76
76_D	106_L	0.581	0.76
210_T	214_N	0.580	0.76
167_L	217_D	0.580	0.76
144_E	158_S	0.579	0.76
147_L	182_V	0.576	0.75
158_S	161_I	0.572	0.75
167_L	205_C	0.568	0.74
32_P	37_Q	0.567	0.74
87_G	173_I	0.565	0.74
49_D	53_T	0.564	0.74
166_S	169_P	0.563	0.74
94_K	159_K	0.558	0.73
53_T	56_K	0.558	0.73
117_P	122_D	0.558	0.73
149_E	186_T	0.553	0.72
104_K	108_T	0.553	0.72
209_I	213_S	0.553	0.72
194_Q	206_I	0.550	0.72
131_K	134_E	0.541	0.71
16_I	21_G	0.541	0.71
188_A	208_Y	0.539	0.70
214_N	228_G	0.537	0.70
54_V	183_P	0.535	0.70
34_W	39_Q	0.534	0.70
158_S	173_I	0.534	0.70
50_D	54_V	0.534	0.70
71_S	238_S	0.531	0.69
55_L	147_L	0.531	0.69
67_I	80_E	0.530	0.69
116_T	120_E	0.529	0.69
157_S	163_R	0.524	0.68
79_R	82_V	0.523	0.68
51_L	181_I	0.522	0.68
59_C	66_L	0.522	0.68
54_V	149_E	0.521	0.68
67_I	142_F	0.520	0.68
194_Q	199_G	0.520	0.68
140_I	175_I	0.519	0.67
167_L	216_A	0.519	0.67
44_E	47_S	0.518	0.67
58_H	63_H	0.518	0.67
143_S	153_V	0.517	0.67
83_S	86_S	0.517	0.67
120_E	124_D	0.517	0.67
90_V	173_I	0.516	0.67
155_L	166_S	0.513	0.67
144_E	160_D	0.513	0.67
35_A	39_Q	0.513	0.67
14_N	20_L	0.513	0.67
211_G	229_P	0.513	0.67
53_T	60_V	0.512	0.66
190_D	194_Q	0.512	0.66
212_P	217_D	0.510	0.66
43_L	195_N	0.510	0.66
18_S	21_G	0.509	0.66
214_N	218_I	0.505	0.65
50_D	60_V	0.502	0.65
29_V	32_P	0.502	0.65
145_I	189_S	0.502	0.65
150_S	154_V	0.501	0.65
28_G	32_P	0.501	0.65
192_I	206_I	0.500	0.65
116_T	119_W	0.500	0.65

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2g40A	2	0.6792	100	0.284	Contact Map
3cf4A	2	0.85	97	0.889	Contact Map
1yksA	1	0.3708	41.7	0.947	Contact Map
1q5zA	1	0.4583	27.2	0.952	Contact Map
3brcA	4	0.5958	22.7	0.954	Contact Map
1fuuA	2	0.5333	15.1	0.957	Contact Map
4ct4B	1	0.5167	13.6	0.958	Contact Map
4cbhA	1	0.4083	10.4	0.96	Contact Map
2ocaA	1	0.8208	10.3	0.96	Contact Map
2i4iA	1	0.5625	10.3	0.96	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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