GREMLIN Database
YVBX - Uncharacterized glycosylase YvbX
UniProt: O32258 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 344 (292)
Sequences: 5687 (4175)
Seq/√Len: 244.3

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
116_K156_Y3.3111.00
158_S162_N3.0551.00
189_D192_K2.9451.00
128_K164_K2.9291.00
224_K228_Q2.8831.00
121_D160_A2.8491.00
125_T129_K2.5851.00
170_V197_A2.4981.00
112_N115_A2.4941.00
284_G310_T2.4401.00
120_T156_Y2.4221.00
60_F89_A2.4141.00
224_K314_L2.3411.00
155_Q196_Y2.2741.00
315_A323_V2.2521.00
286_M304_N2.2181.00
286_M307_T2.1561.00
137_I154_I2.1491.00
123_L135_I2.1261.00
107_S146_D2.1021.00
117_K121_D2.0871.00
228_Q318_Y2.0871.00
194_G235_K2.0351.00
236_A319_K2.0281.00
146_D149_A2.0241.00
154_I193_I2.0211.00
277_P304_N1.9721.00
227_L320_I1.9621.00
218_A244_P1.9591.00
202_V227_L1.9241.00
221_N224_K1.9031.00
243_I308_V1.8921.00
33_G52_M1.8611.00
231_V236_A1.8501.00
117_K156_Y1.8071.00
30_M240_I1.8031.00
223_I241_M1.7981.00
313_H317_Q1.7861.00
303_E311_K1.7571.00
194_G200_V1.7521.00
280_N283_S1.7201.00
281_K284_G1.6751.00
86_K133_Y1.6741.00
120_T160_A1.6701.00
120_T157_V1.6651.00
63_E67_Q1.6281.00
30_M321_A1.6221.00
127_A166_I1.6181.00
117_K160_A1.6131.00
309_Q313_H1.6091.00
151_S192_K1.5901.00
310_T313_H1.5901.00
158_S168_T1.5881.00
263_W266_L1.5611.00
251_D298_H1.5521.00
172_V230_S1.5411.00
151_S189_D1.5391.00
110_M153_F1.5351.00
243_I323_V1.5301.00
208_H212_G1.5251.00
79_Y83_K1.5081.00
124_I160_A1.5041.00
207_E219_S1.4741.00
88_W169_M1.4731.00
277_P302_Y1.4651.00
45_L75_K1.4641.00
155_Q192_K1.4461.00
74_T78_T1.4371.00
111_S149_A1.4371.00
73_P77_L1.4341.00
216_S285_S1.4331.00
156_Y160_A1.4321.00
249_D298_H1.4301.00
204_T241_M1.4211.00
240_I321_A1.4021.00
113_K117_K1.3981.00
32_V56_A1.3981.00
88_W167_K1.3941.00
227_L241_M1.3871.00
154_I197_A1.3751.00
148_A189_D1.3241.00
245_A325_V1.3101.00
120_T124_I1.3071.00
279_F307_T1.3001.00
155_Q159_Q1.2991.00
70_G73_P1.2941.00
224_K318_Y1.2941.00
262_E330_N1.2911.00
192_K195_K1.2901.00
229_F233_K1.2901.00
197_A200_V1.2661.00
75_K78_T1.2651.00
279_F310_T1.2621.00
201_Q324_S1.2621.00
228_Q232_K1.2531.00
73_P76_Q1.2501.00
140_E203_M1.2481.00
161_L166_I1.2461.00
194_G238_K1.2431.00
30_M199_F1.2351.00
231_V318_Y1.2301.00
152_N155_Q1.2271.00
171_S203_M1.2261.00
249_D300_V1.2211.00
56_A90_V1.2141.00
170_V193_I1.2121.00
224_K317_Q1.2101.00
279_F306_K1.2091.00
231_V320_I1.1981.00
194_G234_I1.1941.00
89_A126_L1.1891.00
279_F304_N1.1871.00
72_A75_K1.1871.00
128_K166_I1.1801.00
138_D203_M1.1731.00
127_A135_I1.1731.00
71_D74_T1.1701.00
121_D125_T1.1661.00
79_Y85_I1.1631.00
137_I157_V1.1511.00
199_F240_I1.1511.00
43_N46_T1.1491.00
154_I196_Y1.1481.00
116_K152_N1.1451.00
76_Q87_T1.1361.00
67_Q118_R1.1351.00
143_N146_D1.1341.00
275_A288_F1.1301.00
190_Y234_I1.1221.00
54_A88_W1.1201.00
266_L270_I1.1171.00
34_Y171_S1.1171.00
109_V115_A1.1141.00
56_A201_Q1.1081.00
172_V200_V1.1061.00
33_G325_V1.1041.00
205_Y242_G1.1021.00
235_K238_K1.0981.00
74_T77_L1.0951.00
88_W134_G1.0951.00
200_V234_I1.0921.00
199_F321_A1.0891.00
314_L318_Y1.0881.00
207_E223_I1.0861.00
147_R189_D1.0721.00
277_P306_K1.0671.00
247_G300_V1.0591.00
312_S323_V1.0551.00
29_G316_K1.0541.00
237_N321_A1.0491.00
33_G328_L1.0461.00
70_G78_T1.0411.00
156_Y159_Q1.0391.00
110_M139_F1.0381.00
151_S196_Y1.0371.00
148_A152_N1.0321.00
113_K152_N1.0321.00
136_N169_M1.0271.00
327_A330_N1.0261.00
191_A195_K1.0241.00
61_A96_D1.0221.00
207_E226_S1.0151.00
206_D248_Y0.9991.00
136_N171_S0.9961.00
263_W267_K0.9931.00
247_G302_Y0.9901.00
79_Y82_K0.9821.00
73_P78_T0.9811.00
108_R115_A0.9801.00
234_I239_V0.9781.00
135_I168_T0.9741.00
72_A77_L0.9641.00
159_Q196_Y0.9611.00
279_F284_G0.9571.00
124_I128_K0.9541.00
241_M315_A0.9321.00
71_D75_K0.9321.00
236_A320_I0.9301.00
304_N307_T0.9301.00
203_M246_Y0.9301.00
229_F232_K0.9261.00
77_L87_T0.9201.00
312_S315_A0.9161.00
217_V301_W0.9151.00
32_V324_S0.9141.00
52_M328_L0.9081.00
54_A167_K0.9041.00
291_V296_H0.9011.00
54_A86_K0.8961.00
313_H316_K0.8951.00
82_K85_I0.8931.00
152_N156_Y0.8921.00
140_E171_S0.8911.00
306_K310_T0.8891.00
265_E268_S0.8891.00
277_P288_F0.8871.00
162_N165_H0.8851.00
147_R187_P0.8821.00
150_Y170_V0.8750.99
153_F157_V0.8750.99
70_G74_T0.8750.99
158_S196_Y0.8750.99
264_N267_K0.8740.99
126_L130_H0.8680.99
303_E307_T0.8670.99
49_H85_I0.8650.99
206_D246_Y0.8590.99
147_R151_S0.8580.99
111_S115_A0.8560.99
87_T133_Y0.8550.99
241_M320_I0.8540.99
227_L239_V0.8530.99
247_G266_L0.8530.99
115_A118_R0.8490.99
109_V119_F0.8450.99
169_M201_Q0.8420.99
104_D108_R0.8380.99
81_K133_Y0.8310.99
49_H82_K0.8310.99
40_A262_E0.8260.99
217_V248_Y0.8250.99
252_V299_V0.8250.99
56_A88_W0.8230.99
201_Q240_I0.8230.99
190_Y230_S0.8230.99
47_K328_L0.8230.99
214_P299_V0.8200.99
175_K183_D0.8170.99
157_V161_L0.8170.99
30_M54_A0.8150.99
208_H215_G0.8130.99
220_T284_G0.8130.99
63_E66_G0.8110.99
89_A132_Y0.8030.99
140_E205_Y0.8010.99
136_N201_Q0.7990.99
203_M326_Y0.7980.99
32_V199_F0.7980.99
248_Y260_I0.7970.99
118_R121_D0.7940.99
184_W187_P0.7920.99
307_T310_T0.7900.99
108_R143_N0.7830.99
124_I164_K0.7790.99
118_R122_Q0.7750.99
193_I200_V0.7730.99
58_D90_V0.7710.99
107_S149_A0.7710.99
160_A163_K0.7690.99
267_K332_S0.7690.99
154_I170_V0.7590.99
161_L168_T0.7580.99
110_M149_A0.7570.98
48_Y51_Y0.7560.98
314_L320_I0.7550.98
138_D246_Y0.7520.98
160_A164_K0.7480.98
261_R265_E0.7480.98
72_A78_T0.7470.98
70_G75_K0.7470.98
109_V112_N0.7440.98
49_H52_M0.7430.98
50_T82_K0.7410.98
107_S111_S0.7390.98
108_R111_S0.7370.98
278_A287_T0.7340.98
266_L302_Y0.7330.98
150_Y154_I0.7310.98
275_A291_V0.7280.98
270_I288_F0.7240.98
249_D261_R0.7240.98
243_I325_V0.7210.98
69_I74_T0.7200.98
86_K167_K0.7200.98
172_V190_Y0.7200.98
108_R112_N0.7190.98
44_S47_K0.7190.98
267_K270_I0.7190.98
228_Q231_V0.7190.98
149_A152_N0.7180.98
259_T269_L0.7140.98
269_L288_F0.7090.98
59_T140_E0.7090.98
58_D326_Y0.7090.98
220_T224_K0.7080.98
290_Y296_H0.7060.98
220_T314_L0.7060.98
193_I197_A0.7060.98
116_K149_A0.7060.98
262_E265_E0.7040.98
70_G77_L0.7040.98
190_Y233_K0.7030.98
245_A308_V0.7030.98
60_F130_H0.7030.98
204_T240_I0.7020.98
240_I324_S0.7000.97
80_A84_K0.6980.97
123_L157_V0.6980.97
261_R266_L0.6950.97
227_L314_L0.6950.97
218_A303_E0.6940.97
29_G319_K0.6920.97
77_L81_K0.6910.97
69_I73_P0.6910.97
256_S299_V0.6900.97
262_E266_L0.6900.97
312_S316_K0.6820.97
54_A199_F0.6780.97
148_A192_K0.6770.97
308_V312_S0.6750.97
31_T323_V0.6720.97
71_D76_Q0.6700.97
288_F300_V0.6660.97
56_A199_F0.6650.97
286_M302_Y0.6640.97
174_A226_S0.6640.97
281_K306_K0.6610.96
167_K199_F0.6530.96
124_I166_I0.6520.96
59_T90_V0.6520.96
32_V240_I0.6510.96
145_E149_A0.6500.96
119_F123_L0.6480.96
116_K120_T0.6480.96
254_D257_T0.6470.96
124_I161_L0.6470.96
109_V120_T0.6440.96
200_V230_S0.6430.96
216_S280_N0.6430.96
138_D171_S0.6420.96
125_T128_K0.6400.96
173_P187_P0.6390.96
227_L231_V0.6370.96
127_A131_S0.6350.96
124_I127_A0.6340.96
270_I273_Q0.6340.96
79_Y87_T0.6330.95
251_D296_H0.6330.95
94_Y141_A0.6320.95
135_I161_L0.6320.95
62_F109_V0.6320.95
173_P188_Y0.6300.95
113_K156_Y0.6270.95
120_T152_N0.6270.95
202_V230_S0.6220.95
123_L127_A0.6210.95
291_V297_K0.6200.95
111_S145_E0.6150.95
306_K309_Q0.6130.95
52_M55_I0.6120.95
106_A110_M0.6120.95
231_V239_V0.6100.95
67_Q122_Q0.6090.94
140_E326_Y0.6080.94
169_M199_F0.6070.94
268_S272_K0.6070.94
260_I266_L0.6060.94
167_K198_D0.6060.94
151_S155_Q0.6040.94
42_Y328_L0.6040.94
60_F91_I0.6030.94
279_F286_M0.6000.94
91_I119_F0.5960.94
230_S239_V0.5960.94
55_I328_L0.5950.94
236_A321_A0.5940.94
66_G118_R0.5930.94
248_Y301_W0.5920.94
59_T171_S0.5900.93
35_T44_S0.5880.93
193_I196_Y0.5820.93
117_K159_Q0.5770.93
71_D78_T0.5770.93
260_I265_E0.5770.93
124_I162_N0.5760.93
214_P253_K0.5740.93
183_D187_P0.5730.92
56_A324_S0.5690.92
137_I153_F0.5660.92
171_S205_Y0.5660.92
93_N96_D0.5660.92
62_F105_L0.5630.92
96_D106_A0.5600.92
225_S229_F0.5590.92
191_A194_G0.5580.91
106_A139_F0.5540.91
303_E308_V0.5540.91
216_S283_S0.5540.91
96_D105_L0.5530.91
267_K271_K0.5510.91
155_Q195_K0.5500.91
243_I315_A0.5490.91
176_S185_S0.5450.91
188_Y193_I0.5450.91
325_V328_L0.5440.90
107_S143_N0.5420.90
62_F68_I0.5410.90
173_P185_S0.5400.90
81_K87_T0.5390.90
243_I312_S0.5390.90
208_H217_V0.5380.90
240_I244_P0.5380.90
66_G109_V0.5370.90
154_I158_S0.5370.90
236_A318_Y0.5360.90
288_F302_Y0.5330.90
215_G250_W0.5310.89
203_M206_D0.5300.89
270_I277_P0.5300.89
212_G215_G0.5290.89
35_T57_T0.5290.89
70_G76_Q0.5280.89
116_K153_F0.5260.89
261_R264_N0.5250.89
55_I85_I0.5240.89
121_D124_I0.5240.89
221_N314_L0.5240.89
210_I248_Y0.5210.88
264_N268_S0.5210.88
260_I263_W0.5180.88
192_K196_Y0.5180.88
127_A132_Y0.5170.88
205_Y246_Y0.5170.88
174_A207_E0.5150.88
261_R269_L0.5140.88
112_N149_A0.5130.88
90_V93_N0.5120.88
32_V169_M0.5100.87
135_I157_V0.5100.87
139_F153_F0.5060.87
147_R193_I0.5050.87
81_K84_K0.5050.87
30_M53_N0.5040.87
241_M314_L0.5030.87
69_I75_K0.5030.87
136_N242_G0.5030.87
141_A203_M0.5010.86
60_F126_L0.5000.86
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3w4rA 1 0.8779 100 0.191 Contact Map
4q6tA 1 0.9041 100 0.206 Contact Map
1itxA 1 0.9041 100 0.212 Contact Map
1edqA 1 0.9535 100 0.217 Contact Map
1w9pA 1 0.875 100 0.227 Contact Map
1goiA 2 0.8983 100 0.229 Contact Map
3arxA 1 0.9535 100 0.23 Contact Map
3oa5A 1 0.9535 100 0.234 Contact Map
1vf8A 1 0.8692 100 0.236 Contact Map
3g6mA 1 0.8692 100 0.236 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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