GREMLIN Database
YVBW - Uncharacterized amino acid permease YvbW
UniProt: O32257 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 447 (419)
Sequences: 24650 (15899)
Seq/√Len: 776.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
136_T340_T4.4491.00
322_V334_F4.2991.00
382_K386_Q3.2741.00
53_G244_V3.2301.00
374_L406_I3.1361.00
325_K334_F3.0571.00
230_K234_K3.0131.00
225_T231_V2.8261.00
13_T226_K2.8091.00
77_R316_D2.7931.00
428_T432_Y2.7231.00
93_D313_Q2.6561.00
432_Y436_T2.6471.00
314_A324_S2.5931.00
18_M238_S2.5611.00
327_S333_M2.5141.00
227_N230_K2.5091.00
129_L344_Y2.5091.00
168_G253_I2.5051.00
223_A315_S2.4721.00
322_V325_K2.4061.00
65_E384_R2.3681.00
282_G286_I2.3601.00
377_G405_A2.3561.00
14_S238_S2.3411.00
81_Q89_A2.2451.00
224_E308_R2.2441.00
337_L341_S2.2301.00
166_I170_L2.1931.00
137_I141_L2.1641.00
136_T336_I2.1351.00
403_W407_V2.1341.00
14_S231_V2.1311.00
311_Y315_S2.1241.00
133_L344_Y2.0991.00
14_S18_M2.0911.00
144_K148_E2.0681.00
17_I225_T2.0441.00
128_A347_V2.0201.00
434_L438_A2.0171.00
426_G430_A2.0111.00
84_L382_K2.0091.00
140_L333_M1.9811.00
273_M276_K1.9761.00
234_K238_S1.9461.00
317_G321_K1.9461.00
18_M242_R1.9451.00
37_A45_V1.9321.00
155_M159_T1.9201.00
13_T16_H1.9161.00
8_L326_L1.9051.00
97_W339_C1.8931.00
323_F338_M1.8871.00
62_G377_G1.8761.00
129_L347_V1.8631.00
54_I58_F1.8421.00
81_Q86_N1.8421.00
84_L378_F1.8051.00
259_P262_Q1.8021.00
327_S331_V1.7921.00
237_R241_T1.7831.00
139_N300_N1.7771.00
80_V92_L1.7321.00
227_N231_V1.7181.00
430_A434_L1.7131.00
133_L340_T1.7071.00
378_F406_I1.7021.00
273_M277_M1.6871.00
16_H151_Y1.6821.00
262_Q277_M1.6811.00
48_A204_A1.6801.00
132_S343_L1.6741.00
92_L375_I1.6631.00
44_S201_L1.6561.00
108_A299_M1.6531.00
400_Y404_F1.6401.00
140_L337_L1.6361.00
12_M16_H1.6241.00
382_K385_K1.6181.00
329_K333_M1.6101.00
21_A239_T1.6041.00
55_I408_A1.5921.00
407_V411_A1.5911.00
241_T245_A1.5891.00
85_G88_A1.5881.00
104_I343_L1.5691.00
159_T163_I1.5471.00
123_P126_V1.5291.00
115_I127_L1.5231.00
432_Y435_I1.5201.00
58_F404_F1.4771.00
73_A223_A1.4701.00
52_G208_V1.4551.00
141_L329_K1.4541.00
108_A132_S1.4531.00
310_L335_A1.4511.00
129_L133_L1.4491.00
221_T304_Y1.4461.00
425_T428_T1.4421.00
160_V290_V1.4401.00
388_T391_P1.4251.00
9_K330_N1.4221.00
8_L311_Y1.4201.00
227_N234_K1.4191.00
306_S339_C1.4061.00
158_I162_I1.4011.00
60_M240_L1.3991.00
311_Y326_L1.3971.00
334_F338_M1.3961.00
80_V375_I1.3871.00
228_P233_P1.3861.00
267_P273_M1.3851.00
435_I439_Y1.3841.00
378_F382_K1.3791.00
111_A292_L1.3701.00
321_K325_K1.3681.00
132_S340_T1.3671.00
169_L253_I1.3521.00
54_I404_F1.3521.00
307_S336_I1.3501.00
321_K324_S1.3471.00
423_V436_T1.3441.00
16_H147_A1.3331.00
427_I431_I1.3321.00
136_T337_L1.3311.00
12_M17_I1.3231.00
84_L88_A1.3181.00
183_G186_N1.3171.00
276_K284_D1.3151.00
111_A131_I1.3061.00
325_K333_M1.3061.00
285_H289_A1.3051.00
397_W401_T1.2951.00
44_S194_F1.2911.00
428_T435_I1.2861.00
60_M236_V1.2761.00
70_N82_Q1.2711.00
107_E298_S1.2601.00
245_A249_L1.2581.00
69_R391_P1.2551.00
231_V234_K1.2511.00
170_L175_S1.2501.00
83_V379_A1.2421.00
32_K110_V1.2401.00
59_I377_G1.2381.00
165_I249_L1.2361.00
46_I252_F1.2351.00
172_L256_S1.2351.00
12_M147_A1.2311.00
310_L319_L1.2261.00
381_L403_W1.2251.00
430_A433_L1.2191.00
61_Q237_R1.2171.00
14_S234_K1.2131.00
125_W129_L1.2121.00
436_T439_Y1.2121.00
135_V299_M1.2051.00
78_D82_Q1.2031.00
15_R19_M1.1981.00
269_S273_M1.1971.00
97_W310_L1.1961.00
138_V149_T1.1901.00
62_G402_T1.1881.00
94_W432_Y1.1881.00
427_I430_A1.1881.00
168_G257_L1.1841.00
87_Y439_Y1.1731.00
429_A433_L1.1711.00
25_A243_I1.1711.00
63_L76_F1.1641.00
17_I235_A1.1571.00
411_A415_G1.1541.00
226_K231_V1.1471.00
425_T432_Y1.1401.00
169_L173_F1.1391.00
260_W263_V1.1381.00
21_A218_I1.1371.00
374_L410_L1.1341.00
90_Y94_W1.1261.00
126_V130_G1.1231.00
173_F176_F1.1221.00
433_L437_V1.1221.00
149_T153_L1.1211.00
398_F402_T1.1111.00
72_N78_D1.1031.00
197_G200_G1.1001.00
163_I167_L1.0941.00
65_E68_V1.0921.00
11_T226_K1.0881.00
20_M221_T1.0871.00
130_G134_I1.0871.00
77_R312_T1.0871.00
22_L242_R1.0831.00
426_G429_A1.0761.00
150_E300_N1.0741.00
164_F168_G1.0731.00
385_K399_P1.0671.00
326_L330_N1.0661.00
67_A79_L1.0641.00
38_I45_V1.0521.00
80_V88_A1.0511.00
112_A127_L1.0451.00
162_I166_I1.0421.00
417_I420_T1.0391.00
341_S345_I1.0331.00
115_I292_L1.0291.00
410_L414_I1.0271.00
425_T430_A1.0231.00
421_S425_T1.0201.00
334_F337_L1.0191.00
399_P403_W1.0171.00
400_Y403_W1.0111.00
133_L137_I1.0111.00
184_F187_L1.0101.00
267_P270_P1.0101.00
222_L232_V1.0081.00
391_P394_Y1.0071.00
397_W400_Y1.0031.00
22_L243_I1.0031.00
380_H402_T1.0011.00
276_K281_P1.0001.00
428_T436_T0.9981.00
58_F401_T0.9941.00
50_L248_L0.9871.00
430_A435_I0.9801.00
423_V426_G0.9751.00
136_T140_L0.9741.00
429_A432_Y0.9741.00
148_E152_W0.9711.00
112_A128_A0.9651.00
202_I411_A0.9641.00
431_I434_L0.9641.00
72_N82_Q0.9631.00
423_V432_Y0.9611.00
423_V427_I0.9601.00
140_L331_V0.9591.00
216_E220_V0.9591.00
186_N189_D0.9581.00
140_L327_S0.9581.00
406_I410_L0.9581.00
315_S324_S0.9551.00
435_I438_A0.9551.00
143_V304_Y0.9461.00
271_F275_F0.9391.00
279_G283_A0.9351.00
46_I255_V0.9331.00
194_F201_L0.9321.00
153_L297_S0.9321.00
393_Y396_K0.9271.00
158_I246_F0.9271.00
213_G369_V0.9241.00
170_L174_V0.9241.00
26_I31_F0.9201.00
157_K294_A0.9111.00
280_I283_A0.9061.00
377_G406_I0.9061.00
434_L437_V0.9051.00
259_P277_M0.9031.00
19_M151_Y0.9011.00
74_R77_R0.8991.00
428_T431_I0.8971.00
303_L340_T0.8951.00
374_L409_L0.8931.00
135_V300_N0.8871.00
106_A362_M0.8871.00
426_G432_Y0.8861.00
414_I418_M0.8861.00
82_Q387_Q0.8801.00
26_I29_G0.8791.00
389_E394_Y0.8791.00
333_M337_L0.8781.00
74_R78_D0.8781.00
8_L308_R0.8771.00
106_A210_Y0.8751.00
431_I435_I0.8741.00
425_T434_L0.8731.00
8_L224_E0.8721.00
165_I253_I0.8721.00
53_G212_Y0.8691.00
374_L378_F0.8681.00
68_V392_A0.8671.00
11_T144_K0.8651.00
170_L173_F0.8651.00
134_I296_I0.8631.00
238_S242_R0.8611.00
50_L54_I0.8601.00
422_I425_T0.8601.00
14_S235_A0.8581.00
244_V248_L0.8571.00
172_L176_F0.8551.00
172_L175_S0.8541.00
94_W319_L0.8511.00
428_T433_L0.8511.00
433_L436_T0.8501.00
16_H148_E0.8471.00
275_F278_V0.8451.00
327_S330_N0.8451.00
323_F334_F0.8421.00
281_P285_H0.8381.00
57_L61_Q0.8371.00
47_I201_L0.8351.00
125_W347_V0.8341.00
127_L130_G0.8331.00
185_S188_T0.8261.00
165_I169_L0.8251.00
15_R151_Y0.8241.00
164_F275_F0.8221.00
425_T436_T0.8221.00
81_Q316_D0.8221.00
340_T344_Y0.8201.00
422_I426_G0.8191.00
432_Y439_Y0.8161.00
198_G201_L0.8151.00
112_A124_I0.8151.00
427_I432_Y0.8121.00
381_L402_T0.8111.00
421_S426_G0.8101.00
364_S368_T0.8011.00
396_K400_Y0.8001.00
319_L323_F0.8001.00
111_A295_I0.7981.00
405_A409_L0.7951.00
432_Y437_V0.7911.00
413_L416_V0.7911.00
115_I119_L0.7901.00
390_T394_Y0.7901.00
57_L237_R0.7901.00
26_I157_K0.7881.00
87_Y91_F0.7831.00
58_F62_G0.7811.00
217_I305_G0.7801.00
27_G31_F0.7781.00
431_I436_T0.7731.00
135_V303_L0.7731.00
252_F256_S0.7721.00
148_E151_Y0.7711.00
432_Y438_A0.7711.00
137_I140_L0.7691.00
381_L385_K0.7681.00
402_T406_I0.7671.00
190_H195_P0.7661.00
109_V361_L0.7631.00
379_A383_S0.7611.00
122_C126_V0.7601.00
227_N233_P0.7591.00
88_A375_I0.7581.00
416_V420_T0.7571.00
213_G373_W0.7551.00
430_A436_T0.7491.00
132_S347_V0.7481.00
25_A239_T0.7481.00
233_P236_V0.7471.00
66_M380_H0.7461.00
191_G194_F0.7461.00
257_L274_V0.7441.00
139_N336_I0.7391.00
96_Y100_W0.7361.00
411_A414_I0.7341.00
103_N365_L0.7341.00
169_L249_L0.7331.00
189_D192_G0.7321.00
11_T143_V0.7301.00
18_M235_A0.7291.00
112_A115_I0.7291.00
431_I438_A0.7291.00
173_F177_G0.7271.00
141_L145_I0.7221.00
30_L250_P0.7211.00
15_R148_E0.7211.00
80_V379_A0.7201.00
409_L412_I0.7191.00
187_L190_H0.7181.00
380_H384_R0.7181.00
421_S436_T0.7181.00
425_T429_A0.7171.00
426_G431_I0.7161.00
303_L307_S0.7151.00
426_G436_T0.7141.00
37_A41_A0.7131.00
203_T207_V0.7131.00
308_R311_Y0.7121.00
184_F256_S0.7081.00
111_A296_I0.7071.00
59_I409_L0.7061.00
66_M79_L0.7051.00
307_S335_A0.7041.00
77_R81_Q0.7021.00
341_S344_Y0.7011.00
147_A151_Y0.7001.00
322_V338_M0.6991.00
425_T439_Y0.6991.00
140_L329_K0.6981.00
421_S428_T0.6971.00
423_V429_A0.6961.00
83_V382_K0.6961.00
328_S333_M0.6891.00
139_N304_Y0.6881.00
186_N190_H0.6881.00
310_L338_M0.6881.00
165_I250_P0.6861.00
47_I51_L0.6851.00
101_V342_S0.6831.00
102_L364_S0.6791.00
238_S241_T0.6721.00
43_P255_V0.6711.00
23_G154_A0.6711.00
183_G187_L0.6691.00
172_L253_I0.6661.00
116_Q120_P0.6651.00
129_L348_L0.6641.00
426_G433_L0.6641.00
8_L11_T0.6641.00
69_R388_T0.6621.00
314_A323_F0.6621.00
125_W128_A0.6591.00
174_V177_G0.6581.00
114_F291_I0.6561.00
421_S434_L0.6531.00
229_E392_A0.6521.00
132_S344_Y0.6511.00
421_S432_Y0.6511.00
381_L399_P0.6491.00
323_F335_A0.6481.00
11_T15_R0.6471.00
116_Q124_I0.6441.00
425_T431_I0.6431.00
26_I33_G0.6421.00
184_F188_T0.6411.00
15_R18_M0.6371.00
135_V296_I0.6371.00
428_T439_Y0.6361.00
56_L215_T0.6361.00
249_L253_I0.6361.00
84_L379_A0.6351.00
131_I299_M0.6341.00
63_L376_I0.6331.00
34_S251_F0.6331.00
399_P402_T0.6321.00
405_A408_A0.6311.00
232_V236_V0.6311.00
77_R93_D0.6281.00
224_E332_P0.6271.00
99_M369_V0.6271.00
83_V383_S0.6271.00
368_T372_I0.6271.00
47_I50_L0.6261.00
105_A361_L0.6261.00
105_A346_G0.6261.00
202_I415_G0.6251.00
282_G285_H0.6231.00
213_G216_E0.6231.00
140_L336_I0.6221.00
73_A311_Y0.6211.00
65_E393_Y0.6201.00
69_R392_A0.6191.00
49_Y211_S0.6191.00
147_A300_N0.6191.00
85_G89_A0.6191.00
60_M215_T0.6191.00
242_R246_F0.6171.00
189_D193_F0.6161.00
425_T433_L0.6151.00
117_Y288_N0.6141.00
412_I416_V0.6121.00
427_I436_T0.6111.00
156_I290_V0.6111.00
390_T393_Y0.6111.00
27_G247_Y0.6111.00
107_E299_M0.6101.00
46_I50_L0.6081.00
77_R89_A0.6081.00
384_R388_T0.6061.00
67_A232_V0.6051.00
414_I417_I0.6051.00
220_V305_G0.6051.00
167_L280_I0.6041.00
223_A311_Y0.6041.00
429_A436_T0.6031.00
242_R245_A0.6021.00
64_A68_V0.6011.00
61_Q401_T0.6011.00
76_F216_E0.6001.00
423_V437_V0.5981.00
115_I131_I0.5981.00
143_V221_T0.5971.00
145_I148_E0.5961.00
391_P395_V0.5951.00
225_T232_V0.5951.00
62_G405_A0.5941.00
395_V398_F0.5931.00
95_I372_I0.5931.00
357_T360_Y0.5911.00
219_G236_V0.5901.00
51_L205_M0.5901.00
228_P231_V0.5901.00
24_G302_G0.5901.00
332_P335_A0.5881.00
46_I49_Y0.5861.00
130_G133_L0.5861.00
24_G301_S0.5851.00
46_I248_L0.5851.00
133_L136_T0.5841.00
37_A208_V0.5841.00
52_G212_Y0.5831.00
103_N106_A0.5831.00
18_M21_A0.5831.00
45_V251_F0.5821.00
108_A112_A0.5821.00
289_A293_L0.5821.00
60_M64_A0.5821.00
194_F197_G0.5821.00
359_N362_M0.5811.00
422_I432_Y0.5801.00
107_E110_V0.5801.00
407_V410_L0.5781.00
107_E295_I0.5771.00
183_G188_T0.5761.00
65_E396_K0.5761.00
264_N267_P0.5751.00
118_W288_N0.5751.00
142_S145_I0.5751.00
384_R398_F0.5741.00
40_V203_T0.5731.00
101_V339_C0.5731.00
369_V372_I0.5711.00
388_T392_A0.5711.00
269_S272_V0.5701.00
33_G362_M0.5701.00
52_G209_I0.5691.00
392_A395_V0.5691.00
80_V89_A0.5691.00
145_I149_T0.5681.00
200_G203_T0.5671.00
66_M83_V0.5651.00
250_P254_I0.5641.00
398_F401_T0.5641.00
253_I256_S0.5631.00
194_F198_G0.5611.00
326_L329_K0.5611.00
294_A297_S0.5611.00
409_L413_L0.5591.00
159_T162_I0.5591.00
19_M154_A0.5591.00
76_F220_V0.5571.00
59_I216_E0.5571.00
306_S310_L0.5571.00
100_W302_G0.5551.00
67_A219_G0.5551.00
28_A210_Y0.5541.00
395_V401_T0.5531.00
308_R332_P0.5531.00
136_T303_L0.5511.00
303_L336_I0.5511.00
22_L154_A0.5511.00
13_T144_K0.5491.00
146_F304_Y0.5491.00
310_L314_A0.5481.00
270_P278_V0.5481.00
36_S359_N0.5461.00
26_I246_F0.5451.00
422_I436_T0.5441.00
172_L257_L0.5441.00
397_W402_T0.5441.00
151_Y155_M0.5421.00
119_L122_C0.5421.00
402_T409_L0.5411.00
270_P274_V0.5411.00
43_P260_W0.5411.00
250_P271_F0.5401.00
95_I371_F0.5401.00
345_I348_L0.5401.00
44_S193_F0.5391.00
103_N107_E0.5381.00
150_E297_S0.5381.00
374_L413_L0.5371.00
192_G195_P0.5371.00
31_F157_K0.5371.00
229_E234_K0.5371.00
102_L365_L0.5371.00
229_E390_T0.5351.00
167_L171_L0.5341.00
398_F403_W0.5331.00
58_F405_A0.5311.00
152_W155_M0.5311.00
322_V326_L0.5291.00
265_S268_E0.5281.00
225_T235_A0.5271.00
30_L33_G0.5271.00
24_G217_I0.5261.00
218_I232_V0.5261.00
402_T416_V0.5251.00
198_G202_I0.5241.00
216_E373_W0.5241.00
134_I138_V0.5221.00
270_P275_F0.5221.00
171_L174_V0.5221.00
156_I160_V0.5201.00
168_G172_L0.5191.00
270_P273_M0.5161.00
425_T435_I0.5161.00
423_V430_A0.5151.00
308_R326_L0.5151.00
358_F362_M0.5141.00
65_E69_R0.5141.00
75_T219_G0.5141.00
108_A135_V0.5131.00
154_A157_K0.5121.00
92_L372_I0.5121.00
213_G365_L0.5121.00
110_V114_F0.5111.00
49_Y251_F0.5111.00
333_M336_I0.5111.00
383_S391_P0.5111.00
10_R226_K0.5081.00
431_I439_Y0.5081.00
162_I165_I0.5071.00
62_G395_V0.5071.00
111_A115_I0.5071.00
408_A412_I0.5061.00
32_K35_S0.5041.00
338_M342_S0.5041.00
285_H288_N0.5031.00
230_K233_P0.5031.00
224_E326_L0.5021.00
37_A204_A0.5011.00
143_V147_A0.5011.00
99_M368_T0.5001.00
430_A437_V0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3l1lA 2 0.9217 100 0.27 Contact Map
3giaA 1 0.9329 100 0.335 Contact Map
4djkA 2 0.915 100 0.337 Contact Map
3dh4A 3 0.9306 99 0.85 Contact Map
2xq2A 2 0.9306 98.9 0.854 Contact Map
2jlnA 1 0.9105 98.8 0.86 Contact Map
2a65A 2 0.9329 98.2 0.885 Contact Map
4wgvA 2 0.8277 98.1 0.885 Contact Map
4xp4A 1 0.9441 97.4 0.902 Contact Map
4us3A 1 0.8747 96.8 0.911 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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