GREMLIN Database
YVBV - Uncharacterized transporter YvbV
UniProt: O32256 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 305 (275)
Sequences: 39578 (29152)
Seq/√Len: 1757.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
89_G156_A3.2991.00
12_L234_T2.9091.00
97_L153_V2.8811.00
234_T238_S2.7771.00
259_S265_E2.6561.00
88_I155_L2.5241.00
41_G195_L2.5011.00
48_G188_T2.4591.00
128_G281_S2.3691.00
85_L158_G2.3201.00
234_T237_G2.2921.00
26_L219_F2.2671.00
108_L160_A2.1661.00
119_E171_K2.1411.00
85_L155_L2.1321.00
99_S255_S2.1091.00
28_K265_E2.0661.00
112_F168_V2.0631.00
27_S87_T1.9891.00
13_L235_L1.9721.00
21_G254_I1.9241.00
46_I221_S1.9121.00
114_W121_M1.8901.00
81_L162_S1.8841.00
45_L191_S1.8631.00
110_G129_L1.8541.00
52_V184_A1.8241.00
122_F125_K1.8191.00
93_L153_V1.7951.00
104_F108_L1.7851.00
113_S119_E1.7831.00
67_T176_R1.7821.00
192_V196_I1.7421.00
92_Y151_I1.7311.00
93_L152_G1.7271.00
109_M245_A1.7031.00
154_L158_G1.6921.00
21_G258_A1.6841.00
178_D181_W1.6691.00
283_C287_T1.6601.00
53_I56_L1.6531.00
240_E243_K1.6461.00
132_G249_F1.6281.00
48_G191_S1.6131.00
268_T271_L1.5961.00
85_L162_S1.5881.00
196_I199_F1.5791.00
221_S226_A1.5761.00
108_L164_A1.5641.00
22_V219_F1.5611.00
18_I254_I1.5471.00
211_A215_T1.5221.00
98_F156_A1.5001.00
88_I92_Y1.4941.00
41_G191_S1.4901.00
128_G285_V1.4811.00
150_V153_V1.4511.00
52_V56_L1.4331.00
70_I169_Y1.4131.00
210_T213_F1.4071.00
108_L161_V1.3831.00
30_A39_F1.3821.00
170_M233_F1.3811.00
135_G274_G1.3671.00
66_E70_I1.3601.00
47_G187_L1.3581.00
16_L235_L1.3511.00
49_L53_I1.3451.00
69_P73_V1.3441.00
65_K69_P1.3411.00
113_S117_L1.3401.00
88_I91_N1.3401.00
112_F116_W1.3381.00
269_L273_A1.3361.00
132_G281_S1.3301.00
258_A262_F1.3201.00
128_G284_L1.3121.00
20_W228_G1.3081.00
94_P97_L1.3061.00
54_V58_R1.3061.00
95_A259_S1.3041.00
29_A216_S1.3041.00
12_L231_V1.2851.00
93_L97_L1.2781.00
123_V127_I1.2771.00
10_A247_Y1.2561.00
96_G256_I1.2551.00
73_V169_Y1.2531.00
254_I258_A1.2481.00
66_E69_P1.2421.00
65_K68_W1.2371.00
53_I57_P1.2371.00
50_L226_A1.2341.00
138_V277_L1.2321.00
92_Y155_L1.2251.00
212_P215_T1.2241.00
35_P38_L1.2211.00
33_Y213_F1.2211.00
172_K176_R1.2171.00
250_L254_I1.2061.00
25_P258_A1.2051.00
72_L189_I1.2031.00
126_V130_I1.2021.00
215_T219_F1.1961.00
150_V154_L1.1951.00
100_A275_L1.1901.00
39_F220_I1.1891.00
272_L276_L1.1861.00
193_F196_I1.1841.00
138_V270_S1.1841.00
276_L280_T1.1831.00
164_A168_V1.1761.00
267_L272_L1.1731.00
124_M284_L1.1491.00
172_K175_S1.1441.00
139_I274_G1.1381.00
151_I155_L1.1311.00
80_T193_F1.1291.00
37_L197_S1.1281.00
90_L98_F1.1251.00
171_K175_S1.1211.00
92_Y152_G1.1191.00
28_K32_A1.1151.00
93_L156_A1.1151.00
171_K240_E1.1151.00
130_I134_A1.1111.00
109_M241_A1.1081.00
112_F165_L1.1061.00
70_I173_T1.1051.00
76_L193_F1.0961.00
11_L15_F1.0951.00
123_V126_V1.0951.00
236_V244_V1.0921.00
92_Y149_S1.0851.00
135_G278_I1.0821.00
34_S213_F1.0791.00
41_G198_G1.0751.00
16_L231_V1.0731.00
80_T194_L1.0721.00
43_R225_I1.0671.00
112_F164_A1.0601.00
95_A263_L1.0571.00
41_G45_L1.0571.00
117_L168_V1.0571.00
86_Q90_L1.0561.00
20_W232_F1.0561.00
115_L118_G1.0551.00
56_L60_H1.0531.00
16_L20_W1.0521.00
15_F231_V1.0461.00
109_M167_T1.0401.00
110_G121_M1.0391.00
48_G184_A1.0391.00
114_W120_S1.0381.00
151_I154_L1.0291.00
75_A189_I1.0271.00
171_K241_A1.0241.00
9_T235_L1.0241.00
121_M126_V1.0231.00
197_S201_T1.0181.00
26_L216_S1.0161.00
22_V258_A1.0111.00
206_A209_W1.0041.00
19_M231_V1.0031.00
124_M288_K1.0001.00
101_I160_A0.9931.00
27_S90_L0.9921.00
119_E125_K0.9901.00
40_A87_T0.9891.00
69_P72_L0.9881.00
19_M223_F0.9841.00
36_P40_A0.9791.00
131_L281_S0.9761.00
60_H178_D0.9721.00
104_F136_V0.9671.00
77_L165_L0.9661.00
50_L222_V0.9661.00
269_L272_L0.9651.00
160_A164_A0.9641.00
45_L195_L0.9641.00
44_T190_G0.9641.00
141_A268_T0.9631.00
68_W189_I0.9621.00
124_M287_T0.9621.00
215_T218_L0.9611.00
137_A141_A0.9611.00
211_A214_I0.9591.00
77_L162_S0.9561.00
196_I200_W0.9551.00
207_I210_T0.9511.00
214_I218_L0.9481.00
9_T238_S0.9471.00
67_T70_I0.9471.00
67_T177_V0.9311.00
37_L84_G0.9311.00
70_I172_K0.9281.00
25_P262_F0.9221.00
109_M164_A0.9221.00
152_G156_A0.9201.00
38_L198_G0.9191.00
101_I153_V0.9151.00
236_V240_E0.9141.00
122_F126_V0.9121.00
212_P216_S0.9111.00
112_F161_V0.9111.00
240_E244_V0.9091.00
30_A216_S0.9081.00
79_I166_G0.9011.00
218_L222_V0.8981.00
218_L221_S0.8911.00
112_F115_L0.8891.00
197_S200_W0.8841.00
120_S124_M0.8721.00
199_F202_E0.8701.00
101_I156_A0.8671.00
239_G244_V0.8671.00
100_A137_A0.8671.00
95_A265_E0.8661.00
17_V254_I0.8631.00
17_V21_G0.8541.00
188_T192_V0.8521.00
149_S153_V0.8471.00
70_I74_S0.8391.00
239_G243_K0.8391.00
84_G88_I0.8351.00
71_Y177_V0.8111.00
56_L59_I0.8051.00
68_W72_L0.8011.00
256_I267_L0.8011.00
235_L244_V0.7981.00
52_V188_T0.7971.00
136_V140_S0.7941.00
156_A160_A0.7921.00
260_S267_L0.7911.00
270_S273_A0.7891.00
77_L169_Y0.7831.00
134_A138_V0.7801.00
114_W118_G0.7801.00
50_L53_I0.7781.00
189_I192_V0.7781.00
165_L169_Y0.7741.00
134_A277_L0.7721.00
275_L279_V0.7721.00
253_L275_L0.7701.00
56_L61_K0.7651.00
48_G52_V0.7631.00
73_V76_L0.7581.00
40_A194_L0.7561.00
107_V132_G0.7551.00
25_P259_S0.7541.00
80_T84_G0.7541.00
184_A188_T0.7531.00
42_I46_I0.7481.00
13_L247_Y0.7471.00
138_V273_A0.7471.00
57_P61_K0.7451.00
260_S266_P0.7431.00
51_L226_A0.7411.00
256_I275_L0.7381.00
217_L221_S0.7331.00
213_F216_S0.7311.00
120_S123_V0.7291.00
110_G125_K0.7261.00
250_L253_L0.7261.00
208_Q211_A0.7251.00
163_W167_T0.7211.00
185_L189_I0.7211.00
216_S219_F0.7181.00
30_A213_F0.7171.00
93_L98_F0.7121.00
273_A277_L0.7101.00
227_L231_V0.7081.00
82_F162_S0.7011.00
198_G202_E0.7011.00
135_G281_S0.6981.00
111_V115_L0.6981.00
267_L271_L0.6981.00
89_G152_G0.6971.00
54_V180_I0.6971.00
246_S285_V0.6961.00
27_S31_L0.6951.00
183_V186_Q0.6941.00
38_L42_I0.6941.00
57_P60_H0.6921.00
79_I229_W0.6921.00
259_S263_L0.6921.00
14_A254_I0.6871.00
121_M125_K0.6851.00
81_L85_L0.6811.00
17_V250_L0.6811.00
24_W86_Q0.6791.00
33_Y210_T0.6781.00
280_T284_L0.6751.00
127_I131_L0.6751.00
70_I73_V0.6731.00
101_I157_L0.6731.00
104_F107_V0.6701.00
25_P95_A0.6691.00
71_Y182_M0.6681.00
13_L239_G0.6641.00
281_S285_V0.6631.00
58_R61_K0.6621.00
82_F166_G0.6591.00
230_L234_T0.6591.00
177_V182_M0.6581.00
24_W99_S0.6571.00
29_A263_L0.6561.00
55_A184_A0.6561.00
189_I193_F0.6511.00
10_A243_K0.6471.00
256_I260_S0.6461.00
109_M168_V0.6411.00
163_W232_F0.6401.00
179_S183_V0.6381.00
89_G98_F0.6321.00
58_R178_D0.6311.00
75_A80_T0.6311.00
219_F223_F0.6311.00
103_F106_P0.6301.00
68_W185_L0.6291.00
50_L221_S0.6271.00
45_L49_L0.6271.00
103_F136_V0.6261.00
119_E242_S0.6251.00
117_L172_K0.6181.00
144_F148_I0.6151.00
108_L157_L0.6141.00
34_S39_F0.6131.00
19_M228_G0.6131.00
110_G114_W0.6111.00
58_R180_I0.6091.00
86_Q159_S0.6091.00
46_I50_L0.6051.00
181_W185_L0.6051.00
191_S195_L0.6041.00
47_G226_A0.6041.00
271_L275_L0.6021.00
266_P270_S0.6001.00
106_P249_F0.5981.00
72_L76_L0.5971.00
70_I176_R0.5961.00
257_V261_I0.5881.00
79_I186_Q0.5871.00
15_F19_M0.5871.00
79_I190_G0.5871.00
23_N224_V0.5871.00
34_S38_L0.5861.00
104_F160_A0.5841.00
9_T239_G0.5821.00
166_G233_F0.5791.00
183_V233_F0.5781.00
86_Q98_F0.5761.00
125_K240_E0.5751.00
282_I285_V0.5751.00
40_A84_G0.5741.00
131_L284_L0.5701.00
209_W214_I0.5701.00
87_T91_N0.5691.00
155_L158_G0.5691.00
192_V195_L0.5671.00
140_S153_V0.5601.00
68_W71_Y0.5601.00
258_A261_I0.5591.00
167_T232_F0.5591.00
135_G277_L0.5581.00
190_G194_L0.5581.00
17_V251_I0.5581.00
268_T272_L0.5571.00
188_T191_S0.5561.00
49_L52_V0.5561.00
249_F282_I0.5561.00
223_F227_L0.5551.00
185_L188_T0.5521.00
24_W28_K0.5511.00
37_L201_T0.5471.00
10_A14_A0.5461.00
193_F197_S0.5441.00
80_T197_S0.5441.00
35_P202_E0.5391.00
210_T214_I0.5381.00
82_F86_Q0.5321.00
100_A139_I0.5321.00
55_A181_W0.5311.00
248_T251_I0.5311.00
55_A59_I0.5281.00
142_A270_S0.5281.00
113_S242_S0.5251.00
167_T245_A0.5231.00
117_L171_K0.5231.00
266_P271_L0.5211.00
166_G170_M0.5201.00
284_L288_K0.5181.00
19_M227_L0.5181.00
79_I83_Y0.5161.00
71_Y75_A0.5151.00
72_L193_F0.5151.00
116_W165_L0.5151.00
183_V187_L0.5141.00
100_A140_S0.5131.00
14_A17_V0.5131.00
31_L91_N0.5121.00
54_V57_P0.5111.00
13_L232_F0.5091.00
85_L159_S0.5071.00
31_L90_L0.5061.00
42_I217_L0.5041.00
235_L239_G0.5031.00
153_V157_L0.5031.00
84_G194_L0.5031.00
203_S208_Q0.5021.00
103_F160_A0.5011.00
67_T71_Y0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2i68A 2 0.2525 98.8 0.771 Contact Map
3b5dA 2 0.3311 98.2 0.804 Contact Map
1pw4A 1 0.9705 66.4 0.916 Contact Map
4he8J 1 0.5049 64.1 0.917 Contact Map
4j05A 3 0.9508 60.2 0.919 Contact Map
4pypA 1 0.9311 54.6 0.922 Contact Map
2cfqA 1 0.6 47.2 0.925 Contact Map
3wdoA 1 0.9508 42.9 0.927 Contact Map
3l1lA 2 0.8754 37.5 0.929 Contact Map
4zw9A 1 0.9672 28.3 0.934 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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