GREMLIN Database
CGGR - Central glycolytic genes regulator
UniProt: O32253 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 340 (294)
Sequences: 2205 (1726)
Seq/√Len: 100.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
276_N280_E7.0111.00
232_K294_D4.1571.00
146_A234_A3.5341.00
127_M306_G3.3281.00
277_A312_E2.9661.00
314_I332_A2.9181.00
143_N235_S2.8781.00
105_L318_F2.8611.00
105_L315_E2.8241.00
275_F316_A2.7171.00
241_I303_A2.7061.00
134_C327_V2.6171.00
315_E319_K2.5961.00
328_T332_A2.5041.00
215_Y219_I2.5021.00
303_A323_N2.4941.00
58_L68_T2.4231.00
171_F197_A2.3731.00
142_K168_E2.3481.00
131_A304_V2.3151.00
225_K229_N2.2891.00
113_V130_A2.2521.00
235_S299_P2.1361.00
100_T103_E2.1301.00
240_G303_A2.1251.00
268_T316_A2.1221.00
144_I230_T2.1131.00
305_A314_I2.0931.00
311_A335_K2.0691.00
212_Q216_S2.0671.00
311_A336_L2.0521.00
335_K338_R2.0201.00
300_D325_V1.9581.00
131_A156_V1.9541.00
268_T275_F1.9441.00
82_S86_D1.9321.00
101_L110_A1.9291.00
291_Q294_D1.9191.00
173_P187_N1.9131.00
124_K151_T1.9091.00
311_A332_A1.8921.00
156_V304_V1.8891.00
157_A189_I1.8391.00
315_E336_L1.8161.00
170_L202_R1.8161.00
210_L214_A1.8051.00
99_K102_K1.7971.00
301_I324_T1.7951.00
259_K263_D1.7701.00
111_I130_A1.7611.00
144_I234_A1.7521.00
236_M302_I1.7421.00
174_A237_L1.7381.00
231_I234_A1.7221.00
109_D325_V1.7091.00
108_K300_D1.6901.00
234_A298_I1.6611.00
81_L85_E1.6591.00
160_M193_M1.6581.00
275_F313_A1.6551.00
114_S330_E1.6481.00
144_I233_S1.6101.00
239_H301_I1.6091.00
49_R71_M1.6021.00
102_K110_A1.5911.00
49_R63_L1.5911.00
212_Q285_V1.5761.00
239_H303_A1.5571.00
307_G329_D1.5391.00
134_C325_V1.5371.00
278_D319_K1.5211.00
46_I79_E1.5201.00
194_A201_Y1.4871.00
125_K159_M1.4711.00
254_P257_D1.4681.00
277_A316_A1.4601.00
241_I313_A1.4581.00
139_F145_V1.4551.00
102_K109_D1.4481.00
148_T271_F1.4321.00
141_G167_R1.4311.00
145_V236_M1.4141.00
330_E334_K1.4141.00
128_G155_A1.4131.00
257_D286_H1.3550.99
134_C138_R1.3420.99
314_I328_T1.3400.99
170_L230_T1.3360.99
158_E192_H1.3290.99
308_S335_K1.3280.99
145_V171_F1.3230.99
260_K264_N1.3160.99
146_A174_A1.3050.99
155_A158_E1.2840.99
228_L231_I1.2770.99
276_N282_V1.2620.99
202_R230_T1.2590.99
42_A82_S1.2410.99
132_V160_M1.2400.99
156_V238_V1.2330.99
57_F84_L1.2220.99
210_L218_I1.2140.99
192_H195_E1.2130.99
58_L62_N1.2120.99
157_A193_M1.2070.99
74_T77_G1.2070.99
96_L100_T1.1980.99
101_L337_L1.1890.98
305_A328_T1.1880.98
104_R336_L1.1830.98
229_N233_S1.1800.98
146_A149_G1.1760.98
135_M236_M1.1740.98
49_R69_N1.1710.98
237_L298_I1.1670.98
144_I235_S1.1480.98
99_K103_E1.1310.98
138_R300_D1.1260.98
53_G73_L1.1220.98
104_R337_L1.1040.98
177_G269_E1.0990.97
46_I88_M1.0900.97
54_E91_V1.0850.97
52_R68_T1.0760.97
135_M238_V1.0750.97
45_G79_E1.0680.97
51_L55_V1.0660.97
177_G185_Q1.0640.97
64_V76_E1.0440.97
318_F323_N1.0410.96
101_L112_I1.0400.96
224_V228_L1.0350.96
218_I288_V1.0340.96
216_S220_E1.0250.96
173_P185_Q1.0220.96
49_R79_E1.0150.96
273_Y289_G1.0100.96
273_Y284_K1.0080.96
100_T104_R0.9940.95
101_L336_L0.9880.95
334_K338_R0.9860.95
214_A221_E0.9860.95
157_A192_H0.9840.95
226_E229_N0.9830.95
140_S143_N0.9770.95
148_T273_Y0.9760.95
109_D137_K0.9690.95
275_F317_Y0.9670.95
241_I314_I0.9650.95
46_I82_S0.9620.94
143_N236_M0.9580.94
259_K262_D0.9500.94
260_K263_D0.9480.94
239_H323_N0.9440.94
149_G273_Y0.9390.94
50_V80_L0.9330.94
170_L200_T0.9310.93
145_V193_M0.9270.93
329_D332_A0.9250.93
229_N232_K0.9220.93
190_C201_Y0.9120.93
129_R159_M0.9080.93
292_L322_R0.9060.93
317_Y320_K0.9060.93
108_K324_T0.9010.92
47_S88_M0.8990.92
269_E272_G0.8990.92
247_M250_R0.8990.92
188_T191_A0.8950.92
179_G185_Q0.8950.92
266_A282_V0.8930.92
255_L259_K0.8920.92
118_D331_G0.8910.92
277_A315_E0.8880.92
105_L110_A0.8870.92
240_G305_A0.8850.92
149_G269_E0.8820.91
311_A315_E0.8810.91
208_G272_G0.8770.91
237_L295_I0.8740.91
51_L77_G0.8700.91
59_K73_L0.8690.91
127_M131_A0.8580.90
261_I266_A0.8560.90
49_R52_R0.8500.90
277_A319_K0.8430.90
206_V288_V0.8300.89
115_G331_G0.8260.89
59_K62_N0.8250.89
148_T173_P0.8250.89
75_E78_Y0.8190.88
111_I134_C0.8150.88
187_N205_F0.8060.87
220_E225_K0.8060.87
49_R76_E0.7980.87
147_V189_I0.7970.87
107_L326_L0.7890.86
147_V193_M0.7890.86
273_Y287_S0.7860.86
136_K163_D0.7850.86
303_A314_I0.7830.86
171_F199_G0.7830.86
94_L98_E0.7820.86
52_R60_E0.7810.86
240_G323_N0.7800.86
238_V302_I0.7740.85
135_M156_V0.7730.85
149_G173_P0.7720.85
144_I172_V0.7720.85
105_L336_L0.7710.85
127_M304_V0.7700.85
307_G310_K0.7700.85
163_D166_N0.7700.85
100_T334_K0.7670.85
46_I83_V0.7660.85
242_G269_E0.7620.84
128_G306_G0.7600.84
139_F197_A0.7600.84
192_H196_K0.7590.84
208_G244_A0.7580.84
217_S221_E0.7560.84
97_L112_I0.7540.84
193_M313_A0.7530.84
209_Q286_H0.7520.83
113_V123_V0.7450.83
134_C302_I0.7450.83
45_G71_M0.7440.83
139_F168_E0.7410.83
293_D296_D0.7410.83
52_R63_L0.7400.82
94_L114_S0.7390.82
305_A310_K0.7380.82
72_T78_Y0.7350.82
316_A319_K0.7340.82
321_P324_T0.7290.82
290_M298_I0.7290.82
54_E63_L0.7290.82
138_R236_M0.7290.82
53_G60_E0.7280.81
136_K197_A0.7270.81
306_G314_I0.7230.81
190_C194_A0.7190.81
209_Q287_S0.7190.81
155_A240_G0.7180.81
49_R75_E0.7170.80
210_L288_V0.7140.80
306_G332_A0.7140.80
174_A271_F0.7130.80
219_I228_L0.7110.80
213_G216_S0.7100.80
134_C137_K0.7070.80
226_E230_T0.7030.79
240_G314_I0.7010.79
261_I274_Y0.6970.79
131_A240_G0.6970.79
316_A320_K0.6970.79
107_L110_A0.6960.78
107_L324_T0.6900.78
210_L224_V0.6890.78
43_S86_D0.6890.78
110_A113_V0.6890.78
172_V227_V0.6890.78
60_E64_V0.6880.78
229_N338_R0.6840.77
173_P221_E0.6840.77
284_K291_Q0.6840.77
48_E51_L0.6830.77
54_E80_L0.6810.77
80_L84_L0.6810.77
46_I49_R0.6810.77
240_G287_S0.6790.77
173_P205_F0.6790.77
113_V127_M0.6790.77
76_E80_L0.6780.77
150_G330_E0.6770.77
141_G168_E0.6750.76
191_A205_F0.6750.76
211_S214_A0.6740.76
175_R208_G0.6730.76
42_A45_G0.6720.76
54_E89_K0.6720.76
229_N312_E0.6710.76
97_L334_K0.6710.76
50_V83_V0.6680.76
235_S298_I0.6670.75
139_F143_N0.6630.75
79_E83_V0.6570.74
284_K287_S0.6560.74
314_I326_L0.6550.74
64_V72_T0.6510.74
62_N67_K0.6480.73
77_G269_E0.6470.73
54_E73_L0.6460.73
270_A317_Y0.6450.73
53_G63_L0.6430.73
99_K308_S0.6430.73
41_S327_V0.6370.72
171_F190_C0.6370.72
104_R319_K0.6360.72
290_M294_D0.6360.72
248_A251_R0.6320.72
306_G329_D0.6320.72
244_A313_A0.6310.71
145_V278_D0.6300.71
127_M328_T0.6280.71
139_F169_L0.6270.71
63_L78_Y0.6240.71
48_E102_K0.6230.70
214_A217_S0.6220.70
138_R324_T0.6220.70
185_Q272_G0.6220.70
101_L105_L0.6210.70
133_A136_K0.6200.70
42_A50_V0.6170.70
273_Y291_Q0.6160.70
73_L84_L0.6160.70
267_V316_A0.6160.70
107_L325_V0.6110.69
216_S284_K0.6100.69
153_I189_I0.6090.69
139_F166_N0.6090.69
310_K329_D0.6080.69
221_E272_G0.6070.68
245_K251_R0.6070.68
125_K158_E0.6050.68
136_K161_T0.6050.68
94_L112_I0.6030.68
125_K155_A0.6000.68
171_F193_M0.6000.68
116_D119_Q0.5990.67
77_G186_A0.5980.67
267_V282_V0.5980.67
232_K297_A0.5980.67
209_Q212_Q0.5970.67
266_A274_Y0.5960.67
204_L288_V0.5960.67
76_E295_I0.5960.67
207_P210_L0.5930.67
149_G174_A0.5920.67
174_A231_I0.5920.67
231_I290_M0.5880.66
157_A196_K0.5880.66
161_T196_K0.5850.66
131_A327_V0.5830.65
241_I323_N0.5830.65
114_S130_A0.5820.65
154_E192_H0.5800.65
177_G206_V0.5780.65
148_T202_R0.5760.64
44_L98_E0.5740.64
77_G244_A0.5730.64
146_A153_I0.5700.64
94_L330_E0.5700.64
61_Q67_K0.5700.64
150_G287_S0.5690.63
177_G187_N0.5680.63
78_Y205_F0.5680.63
201_Y221_E0.5680.63
313_A316_A0.5670.63
208_G274_Y0.5650.63
218_I224_V0.5640.63
297_A338_R0.5640.63
317_Y321_P0.5640.63
53_G76_E0.5610.62
308_S332_A0.5600.62
44_L51_L0.5600.62
110_A318_F0.5600.62
140_S235_S0.5590.62
152_T307_G0.5580.62
99_K331_G0.5570.62
308_S331_G0.5570.62
149_G175_R0.5570.62
138_R325_V0.5570.62
77_G81_L0.5560.62
147_V249_Q0.5550.62
147_V186_A0.5540.61
171_F273_Y0.5520.61
131_A134_C0.5510.61
124_K304_V0.5510.61
207_P272_G0.5500.61
206_V210_L0.5500.61
115_G194_A0.5470.60
100_T337_L0.5460.60
256_E259_K0.5450.60
115_G329_D0.5440.60
187_N240_G0.5420.60
228_L288_V0.5410.60
323_N326_L0.5390.59
110_A125_K0.5390.59
175_R289_G0.5390.59
53_G89_K0.5380.59
75_E197_A0.5370.59
119_Q331_G0.5360.59
162_P198_S0.5360.59
231_I272_G0.5350.59
138_R302_I0.5350.59
248_A258_L0.5340.59
80_L269_E0.5340.59
165_K198_S0.5330.59
73_L91_V0.5310.58
140_S297_A0.5310.58
154_E240_G0.5290.58
45_G50_V0.5280.58
175_R246_T0.5280.58
106_N321_P0.5280.58
173_P184_N0.5270.58
302_I324_T0.5270.58
238_V270_A0.5260.58
74_T175_R0.5260.58
138_R145_V0.5250.57
115_G330_E0.5250.57
269_E313_A0.5240.57
58_L275_F0.5220.57
229_N260_K0.5200.57
153_I201_Y0.5190.57
83_V87_T0.5190.57
325_V328_T0.5190.57
114_S173_P0.5180.56
157_A181_D0.5150.56
277_A296_D0.5150.56
281_V292_L0.5140.56
264_N283_H0.5140.56
55_V148_T0.5140.56
44_L48_E0.5130.56
238_V311_A0.5100.55
177_G274_Y0.5100.55
244_A248_A0.5090.55
186_A289_G0.5090.55
272_G289_G0.5090.55
45_G48_E0.5090.55
131_A238_V0.5080.55
210_L295_I0.5070.55
175_R179_G0.5070.55
296_D321_P0.5050.55
74_T173_P0.5040.54
277_A280_E0.5030.54
74_T208_G0.5030.54
100_T106_N0.5010.54
185_Q231_I0.5000.54
147_V190_C0.5000.54
214_A218_I0.5000.54
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
2o0mA 1 0.7176 100 0.462 Contact Map
4l5jA 4 0.8588 100 0.469 Contact Map
2w48A 3 0.8765 100 0.47 Contact Map
2okgA 2 0.7412 100 0.523 Contact Map
4l4yA 2 0.6824 100 0.53 Contact Map
4r9nA 1 0.7059 100 0.53 Contact Map
2gnpA 1 0.7382 100 0.537 Contact Map
3nzeA 2 0.7353 100 0.537 Contact Map
2r5fA 1 0.6294 100 0.539 Contact Map
4oqpA 2 0.7235 100 0.54 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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