CGGR - BACSU - GREMLIN Contacts

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CGGR - Central glycolytic genes regulator

UniProt:	O32253	Sequences: MNQLIQAQKKLLPDLLLVMQKRFEILQYIRLTEPIGRRSLSASLGISERVLRGEVQFLKEQNLVDIKTNGMTLTEEGYELLSVLEDTMKDVLGLTLLEKTLKERLNLKDAIIVSGDSDQSPWVKKEMGRAAVACMKKRFSGKNIVAVTGGTTIEAVAEMMTPDSKNRELLFVPARGGLGEDVKNQANTICAHMAEKASGTYRLLFVPGQLSQGAYSSIIEEPSVKEVLNTIKSASMLVHGIGEAKTMAQRRNTPLEDLKKIDDNDAVTEAFGYYFNADGEVVHKVHSVGMQLDDIDAIPDIIAVAGGSSKAEAIEAYFKKPRNTVLVTDEGAAKKLLRDE	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	340 (294)
Sequences:	2205 (1726)
Seq/√Len:	100.7

ECOLI - YJHU LSRR
BACSU - CGGR DEOR

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
276_N	280_E	7.011	1.00
232_K	294_D	4.157	1.00
146_A	234_A	3.534	1.00
127_M	306_G	3.328	1.00
277_A	312_E	2.966	1.00
314_I	332_A	2.918	1.00
143_N	235_S	2.878	1.00
105_L	318_F	2.861	1.00
105_L	315_E	2.824	1.00
275_F	316_A	2.717	1.00
241_I	303_A	2.706	1.00
134_C	327_V	2.617	1.00
315_E	319_K	2.596	1.00
328_T	332_A	2.504	1.00
215_Y	219_I	2.502	1.00
303_A	323_N	2.494	1.00
58_L	68_T	2.423	1.00
171_F	197_A	2.373	1.00
142_K	168_E	2.348	1.00
131_A	304_V	2.315	1.00
225_K	229_N	2.289	1.00
113_V	130_A	2.252	1.00
235_S	299_P	2.136	1.00
100_T	103_E	2.130	1.00
240_G	303_A	2.125	1.00
268_T	316_A	2.122	1.00
144_I	230_T	2.113	1.00
305_A	314_I	2.093	1.00
311_A	335_K	2.069	1.00
212_Q	216_S	2.067	1.00
311_A	336_L	2.052	1.00
335_K	338_R	2.020	1.00
300_D	325_V	1.958	1.00
131_A	156_V	1.954	1.00
268_T	275_F	1.944	1.00
82_S	86_D	1.932	1.00
101_L	110_A	1.929	1.00
291_Q	294_D	1.919	1.00
173_P	187_N	1.913	1.00
124_K	151_T	1.909	1.00
311_A	332_A	1.892	1.00
156_V	304_V	1.889	1.00
157_A	189_I	1.839	1.00
315_E	336_L	1.816	1.00
170_L	202_R	1.816	1.00
210_L	214_A	1.805	1.00
99_K	102_K	1.797	1.00
301_I	324_T	1.795	1.00
259_K	263_D	1.770	1.00
111_I	130_A	1.761	1.00
144_I	234_A	1.752	1.00
236_M	302_I	1.742	1.00
174_A	237_L	1.738	1.00
231_I	234_A	1.722	1.00
109_D	325_V	1.709	1.00
108_K	300_D	1.690	1.00
234_A	298_I	1.661	1.00
81_L	85_E	1.659	1.00
160_M	193_M	1.658	1.00
275_F	313_A	1.655	1.00
114_S	330_E	1.648	1.00
144_I	233_S	1.610	1.00
239_H	301_I	1.609	1.00
49_R	71_M	1.602	1.00
102_K	110_A	1.591	1.00
49_R	63_L	1.591	1.00
212_Q	285_V	1.576	1.00
239_H	303_A	1.557	1.00
307_G	329_D	1.539	1.00
134_C	325_V	1.537	1.00
278_D	319_K	1.521	1.00
46_I	79_E	1.520	1.00
194_A	201_Y	1.487	1.00
125_K	159_M	1.471	1.00
254_P	257_D	1.468	1.00
277_A	316_A	1.460	1.00
241_I	313_A	1.458	1.00
139_F	145_V	1.455	1.00
102_K	109_D	1.448	1.00
148_T	271_F	1.432	1.00
141_G	167_R	1.431	1.00
145_V	236_M	1.414	1.00
330_E	334_K	1.414	1.00
128_G	155_A	1.413	1.00
257_D	286_H	1.355	0.99
134_C	138_R	1.342	0.99
314_I	328_T	1.340	0.99
170_L	230_T	1.336	0.99
158_E	192_H	1.329	0.99
308_S	335_K	1.328	0.99
145_V	171_F	1.323	0.99
260_K	264_N	1.316	0.99
146_A	174_A	1.305	0.99
155_A	158_E	1.284	0.99
228_L	231_I	1.277	0.99
276_N	282_V	1.262	0.99
202_R	230_T	1.259	0.99
42_A	82_S	1.241	0.99
132_V	160_M	1.240	0.99
156_V	238_V	1.233	0.99
57_F	84_L	1.222	0.99
210_L	218_I	1.214	0.99
192_H	195_E	1.213	0.99
58_L	62_N	1.212	0.99
157_A	193_M	1.207	0.99
74_T	77_G	1.207	0.99
96_L	100_T	1.198	0.99
101_L	337_L	1.189	0.98
305_A	328_T	1.188	0.98
104_R	336_L	1.183	0.98
229_N	233_S	1.180	0.98
146_A	149_G	1.176	0.98
135_M	236_M	1.174	0.98
49_R	69_N	1.171	0.98
237_L	298_I	1.167	0.98
144_I	235_S	1.148	0.98
99_K	103_E	1.131	0.98
138_R	300_D	1.126	0.98
53_G	73_L	1.122	0.98
104_R	337_L	1.104	0.98
177_G	269_E	1.099	0.97
46_I	88_M	1.090	0.97
54_E	91_V	1.085	0.97
52_R	68_T	1.076	0.97
135_M	238_V	1.075	0.97
45_G	79_E	1.068	0.97
51_L	55_V	1.066	0.97
177_G	185_Q	1.064	0.97
64_V	76_E	1.044	0.97
318_F	323_N	1.041	0.96
101_L	112_I	1.040	0.96
224_V	228_L	1.035	0.96
218_I	288_V	1.034	0.96
216_S	220_E	1.025	0.96
173_P	185_Q	1.022	0.96
49_R	79_E	1.015	0.96
273_Y	289_G	1.010	0.96
273_Y	284_K	1.008	0.96
100_T	104_R	0.994	0.95
101_L	336_L	0.988	0.95
334_K	338_R	0.986	0.95
214_A	221_E	0.986	0.95
157_A	192_H	0.984	0.95
226_E	229_N	0.983	0.95
140_S	143_N	0.977	0.95
148_T	273_Y	0.976	0.95
109_D	137_K	0.969	0.95
275_F	317_Y	0.967	0.95
241_I	314_I	0.965	0.95
46_I	82_S	0.962	0.94
143_N	236_M	0.958	0.94
259_K	262_D	0.950	0.94
260_K	263_D	0.948	0.94
239_H	323_N	0.944	0.94
149_G	273_Y	0.939	0.94
50_V	80_L	0.933	0.94
170_L	200_T	0.931	0.93
145_V	193_M	0.927	0.93
329_D	332_A	0.925	0.93
229_N	232_K	0.922	0.93
190_C	201_Y	0.912	0.93
129_R	159_M	0.908	0.93
292_L	322_R	0.906	0.93
317_Y	320_K	0.906	0.93
108_K	324_T	0.901	0.92
47_S	88_M	0.899	0.92
269_E	272_G	0.899	0.92
247_M	250_R	0.899	0.92
188_T	191_A	0.895	0.92
179_G	185_Q	0.895	0.92
266_A	282_V	0.893	0.92
255_L	259_K	0.892	0.92
118_D	331_G	0.891	0.92
277_A	315_E	0.888	0.92
105_L	110_A	0.887	0.92
240_G	305_A	0.885	0.92
149_G	269_E	0.882	0.91
311_A	315_E	0.881	0.91
208_G	272_G	0.877	0.91
237_L	295_I	0.874	0.91
51_L	77_G	0.870	0.91
59_K	73_L	0.869	0.91
127_M	131_A	0.858	0.90
261_I	266_A	0.856	0.90
49_R	52_R	0.850	0.90
277_A	319_K	0.843	0.90
206_V	288_V	0.830	0.89
115_G	331_G	0.826	0.89
59_K	62_N	0.825	0.89
148_T	173_P	0.825	0.89
75_E	78_Y	0.819	0.88
111_I	134_C	0.815	0.88
187_N	205_F	0.806	0.87
220_E	225_K	0.806	0.87
49_R	76_E	0.798	0.87
147_V	189_I	0.797	0.87
107_L	326_L	0.789	0.86
147_V	193_M	0.789	0.86
273_Y	287_S	0.786	0.86
136_K	163_D	0.785	0.86
303_A	314_I	0.783	0.86
171_F	199_G	0.783	0.86
94_L	98_E	0.782	0.86
52_R	60_E	0.781	0.86
240_G	323_N	0.780	0.86
238_V	302_I	0.774	0.85
135_M	156_V	0.773	0.85
149_G	173_P	0.772	0.85
144_I	172_V	0.772	0.85
105_L	336_L	0.771	0.85
127_M	304_V	0.770	0.85
307_G	310_K	0.770	0.85
163_D	166_N	0.770	0.85
100_T	334_K	0.767	0.85
46_I	83_V	0.766	0.85
242_G	269_E	0.762	0.84
128_G	306_G	0.760	0.84
139_F	197_A	0.760	0.84
192_H	196_K	0.759	0.84
208_G	244_A	0.758	0.84
217_S	221_E	0.756	0.84
97_L	112_I	0.754	0.84
193_M	313_A	0.753	0.84
209_Q	286_H	0.752	0.83
113_V	123_V	0.745	0.83
134_C	302_I	0.745	0.83
45_G	71_M	0.744	0.83
139_F	168_E	0.741	0.83
293_D	296_D	0.741	0.83
52_R	63_L	0.740	0.82
94_L	114_S	0.739	0.82
305_A	310_K	0.738	0.82
72_T	78_Y	0.735	0.82
316_A	319_K	0.734	0.82
321_P	324_T	0.729	0.82
290_M	298_I	0.729	0.82
54_E	63_L	0.729	0.82
138_R	236_M	0.729	0.82
53_G	60_E	0.728	0.81
136_K	197_A	0.727	0.81
306_G	314_I	0.723	0.81
190_C	194_A	0.719	0.81
209_Q	287_S	0.719	0.81
155_A	240_G	0.718	0.81
49_R	75_E	0.717	0.80
210_L	288_V	0.714	0.80
306_G	332_A	0.714	0.80
174_A	271_F	0.713	0.80
219_I	228_L	0.711	0.80
213_G	216_S	0.710	0.80
134_C	137_K	0.707	0.80
226_E	230_T	0.703	0.79
240_G	314_I	0.701	0.79
261_I	274_Y	0.697	0.79
131_A	240_G	0.697	0.79
316_A	320_K	0.697	0.79
107_L	110_A	0.696	0.78
107_L	324_T	0.690	0.78
210_L	224_V	0.689	0.78
43_S	86_D	0.689	0.78
110_A	113_V	0.689	0.78
172_V	227_V	0.689	0.78
60_E	64_V	0.688	0.78
229_N	338_R	0.684	0.77
173_P	221_E	0.684	0.77
284_K	291_Q	0.684	0.77
48_E	51_L	0.683	0.77
54_E	80_L	0.681	0.77
80_L	84_L	0.681	0.77
46_I	49_R	0.681	0.77
240_G	287_S	0.679	0.77
173_P	205_F	0.679	0.77
113_V	127_M	0.679	0.77
76_E	80_L	0.678	0.77
150_G	330_E	0.677	0.77
141_G	168_E	0.675	0.76
191_A	205_F	0.675	0.76
211_S	214_A	0.674	0.76
175_R	208_G	0.673	0.76
42_A	45_G	0.672	0.76
54_E	89_K	0.672	0.76
229_N	312_E	0.671	0.76
97_L	334_K	0.671	0.76
50_V	83_V	0.668	0.76
235_S	298_I	0.667	0.75
139_F	143_N	0.663	0.75
79_E	83_V	0.657	0.74
284_K	287_S	0.656	0.74
314_I	326_L	0.655	0.74
64_V	72_T	0.651	0.74
62_N	67_K	0.648	0.73
77_G	269_E	0.647	0.73
54_E	73_L	0.646	0.73
270_A	317_Y	0.645	0.73
53_G	63_L	0.643	0.73
99_K	308_S	0.643	0.73
41_S	327_V	0.637	0.72
171_F	190_C	0.637	0.72
104_R	319_K	0.636	0.72
290_M	294_D	0.636	0.72
248_A	251_R	0.632	0.72
306_G	329_D	0.632	0.72
244_A	313_A	0.631	0.71
145_V	278_D	0.630	0.71
127_M	328_T	0.628	0.71
139_F	169_L	0.627	0.71
63_L	78_Y	0.624	0.71
48_E	102_K	0.623	0.70
214_A	217_S	0.622	0.70
138_R	324_T	0.622	0.70
185_Q	272_G	0.622	0.70
101_L	105_L	0.621	0.70
133_A	136_K	0.620	0.70
42_A	50_V	0.617	0.70
273_Y	291_Q	0.616	0.70
73_L	84_L	0.616	0.70
267_V	316_A	0.616	0.70
107_L	325_V	0.611	0.69
216_S	284_K	0.610	0.69
153_I	189_I	0.609	0.69
139_F	166_N	0.609	0.69
310_K	329_D	0.608	0.69
221_E	272_G	0.607	0.68
245_K	251_R	0.607	0.68
125_K	158_E	0.605	0.68
136_K	161_T	0.605	0.68
94_L	112_I	0.603	0.68
125_K	155_A	0.600	0.68
171_F	193_M	0.600	0.68
116_D	119_Q	0.599	0.67
77_G	186_A	0.598	0.67
267_V	282_V	0.598	0.67
232_K	297_A	0.598	0.67
209_Q	212_Q	0.597	0.67
266_A	274_Y	0.596	0.67
204_L	288_V	0.596	0.67
76_E	295_I	0.596	0.67
207_P	210_L	0.593	0.67
149_G	174_A	0.592	0.67
174_A	231_I	0.592	0.67
231_I	290_M	0.588	0.66
157_A	196_K	0.588	0.66
161_T	196_K	0.585	0.66
131_A	327_V	0.583	0.65
241_I	323_N	0.583	0.65
114_S	130_A	0.582	0.65
154_E	192_H	0.580	0.65
177_G	206_V	0.578	0.65
148_T	202_R	0.576	0.64
44_L	98_E	0.574	0.64
77_G	244_A	0.573	0.64
146_A	153_I	0.570	0.64
94_L	330_E	0.570	0.64
61_Q	67_K	0.570	0.64
150_G	287_S	0.569	0.63
177_G	187_N	0.568	0.63
78_Y	205_F	0.568	0.63
201_Y	221_E	0.568	0.63
313_A	316_A	0.567	0.63
208_G	274_Y	0.565	0.63
218_I	224_V	0.564	0.63
297_A	338_R	0.564	0.63
317_Y	321_P	0.564	0.63
53_G	76_E	0.561	0.62
308_S	332_A	0.560	0.62
44_L	51_L	0.560	0.62
110_A	318_F	0.560	0.62
140_S	235_S	0.559	0.62
152_T	307_G	0.558	0.62
99_K	331_G	0.557	0.62
308_S	331_G	0.557	0.62
149_G	175_R	0.557	0.62
138_R	325_V	0.557	0.62
77_G	81_L	0.556	0.62
147_V	249_Q	0.555	0.62
147_V	186_A	0.554	0.61
171_F	273_Y	0.552	0.61
131_A	134_C	0.551	0.61
124_K	304_V	0.551	0.61
207_P	272_G	0.550	0.61
206_V	210_L	0.550	0.61
115_G	194_A	0.547	0.60
100_T	337_L	0.546	0.60
256_E	259_K	0.545	0.60
115_G	329_D	0.544	0.60
187_N	240_G	0.542	0.60
228_L	288_V	0.541	0.60
323_N	326_L	0.539	0.59
110_A	125_K	0.539	0.59
175_R	289_G	0.539	0.59
53_G	89_K	0.538	0.59
75_E	197_A	0.537	0.59
119_Q	331_G	0.536	0.59
162_P	198_S	0.536	0.59
231_I	272_G	0.535	0.59
138_R	302_I	0.535	0.59
248_A	258_L	0.534	0.59
80_L	269_E	0.534	0.59
165_K	198_S	0.533	0.59
73_L	91_V	0.531	0.58
140_S	297_A	0.531	0.58
154_E	240_G	0.529	0.58
45_G	50_V	0.528	0.58
175_R	246_T	0.528	0.58
106_N	321_P	0.528	0.58
173_P	184_N	0.527	0.58
302_I	324_T	0.527	0.58
238_V	270_A	0.526	0.58
74_T	175_R	0.526	0.58
138_R	145_V	0.525	0.57
115_G	330_E	0.525	0.57
269_E	313_A	0.524	0.57
58_L	275_F	0.522	0.57
229_N	260_K	0.520	0.57
153_I	201_Y	0.519	0.57
83_V	87_T	0.519	0.57
325_V	328_T	0.519	0.57
114_S	173_P	0.518	0.56
157_A	181_D	0.515	0.56
277_A	296_D	0.515	0.56
281_V	292_L	0.514	0.56
264_N	283_H	0.514	0.56
55_V	148_T	0.514	0.56
44_L	48_E	0.513	0.56
238_V	311_A	0.510	0.55
177_G	274_Y	0.510	0.55
244_A	248_A	0.509	0.55
186_A	289_G	0.509	0.55
272_G	289_G	0.509	0.55
45_G	48_E	0.509	0.55
131_A	238_V	0.508	0.55
210_L	295_I	0.507	0.55
175_R	179_G	0.507	0.55
296_D	321_P	0.505	0.55
74_T	173_P	0.504	0.54
277_A	280_E	0.503	0.54
74_T	208_G	0.503	0.54
100_T	106_N	0.501	0.54
185_Q	231_I	0.500	0.54
147_V	190_C	0.500	0.54
214_A	218_I	0.500	0.54

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
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HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
2o0mA	1	0.7176	100	0.462	Contact Map
4l5jA	4	0.8588	100	0.469	Contact Map
2w48A	3	0.8765	100	0.47	Contact Map
2okgA	2	0.7412	100	0.523	Contact Map
4l4yA	2	0.6824	100	0.53	Contact Map
4r9nA	1	0.7059	100	0.53	Contact Map
2gnpA	1	0.7382	100	0.537	Contact Map
3nzeA	2	0.7353	100	0.537	Contact Map
2r5fA	1	0.6294	100	0.539	Contact Map
4oqpA	2	0.7235	100	0.54	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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