GREMLIN Database
YVBK - Uncharacterized N-acetyltransferase YvbK
UniProt: O32248 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 155 (146)
Sequences: 772 (655)
Seq/√Len: 54.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
52_G71_V3.4511.00
89_I153_L3.3031.00
103_G148_M3.1761.00
139_F144_Q3.1691.00
128_D132_R2.7011.00
89_I100_I2.5281.00
42_Y91_K2.4521.00
64_V97_A2.2931.00
44_A80_F2.2611.00
66_I102_I2.2191.00
129_F148_M2.1831.00
122_I125_I2.1691.00
102_I114_L2.1471.00
24_L76_Q2.1451.00
9_E45_W2.0741.00
29_K33_D2.0521.00
121_R147_D2.0481.00
10_L40_E2.0301.00
112_L151_L1.9441.00
116_Q122_I1.9151.00
45_W50_L1.8910.99
105_G145_C1.8390.99
107_S145_C1.8040.99
106_N145_C1.7600.99
58_K97_A1.7400.99
54_Y66_I1.7180.99
43_T50_L1.6880.99
39_G55_V1.6760.99
85_V118_C1.6330.98
75_L78_K1.5980.98
54_Y88_A1.5620.98
24_L70_A1.5550.98
126_D132_R1.5200.98
19_Y29_K1.5170.98
122_I149_V1.5030.97
62_Q98_D1.5000.97
54_Y87_D1.4390.97
103_G129_F1.4320.96
44_A52_G1.4320.96
17_E36_L1.3900.96
123_Q152_Y1.3620.95
131_L146_R1.3610.95
64_V100_I1.3600.95
110_H113_S1.3590.95
99_T152_Y1.3510.95
128_D146_R1.3430.95
56_L92_A1.3400.95
52_G84_L1.3230.94
69_I114_L1.3210.94
82_K118_C1.3180.94
67_V129_F1.3150.94
131_L144_Q1.3030.94
71_V80_F1.2730.93
46_A78_K1.2470.93
82_K117_K1.2350.92
87_D91_K1.2200.92
108_S111_Q1.2160.92
138_I141_N1.1650.90
59_T63_T1.1530.89
31_I34_E1.1480.89
77_K117_K1.1460.89
101_E150_R1.1450.89
40_E95_L1.1370.89
14_T17_E1.1270.88
56_L88_A1.1220.88
52_G81_G1.1190.88
82_K110_H1.1180.88
126_D148_M1.0840.86
9_E15_N1.0770.86
126_D150_R1.0700.85
38_R60_R1.0680.85
25_A102_I1.0640.85
19_Y33_D1.0410.84
51_A80_F1.0120.82
38_R59_T1.0050.81
107_S149_V1.0030.81
38_R57_L1.0000.81
22_L26_D0.9910.81
46_A51_A0.9890.80
89_I120_F0.9860.80
106_N143_I0.9820.80
16_D33_D0.9820.80
108_S145_C0.9730.79
69_I85_V0.9400.77
107_S110_H0.9340.76
112_L116_Q0.9290.76
116_Q121_R0.9150.75
85_V149_V0.9100.75
91_K94_K0.8920.73
71_V81_G0.8880.73
124_A150_R0.8870.73
106_N116_Q0.8760.72
103_G126_D0.8710.71
42_Y87_D0.8670.71
113_S141_N0.8670.71
8_I84_L0.8640.71
44_A51_A0.8620.71
66_I114_L0.8590.70
35_Y104_T0.8540.70
36_L55_V0.8450.69
16_D49_E0.8380.68
38_R118_C0.8350.68
82_K86_L0.8280.67
30_D135_D0.8230.67
106_N112_L0.8120.66
8_I87_D0.8010.65
123_Q127_H0.7870.63
137_D144_Q0.7810.63
20_D24_L0.7710.62
65_E104_T0.7670.61
66_I85_V0.7660.61
39_G57_L0.7560.60
107_S113_S0.7520.60
15_N18_L0.7500.60
53_V146_R0.7500.60
107_S140_E0.7440.59
108_S140_E0.7430.59
115_Y120_F0.7150.56
45_W49_E0.7150.56
106_N122_I0.7120.56
113_S143_I0.7000.54
110_H141_N0.6980.54
104_T115_Y0.6950.54
121_R146_R0.6920.54
38_R67_V0.6830.53
47_G139_F0.6810.52
73_E76_Q0.6810.52
26_D35_Y0.6790.52
122_I145_C0.6780.52
56_L64_V0.6750.52
41_C55_V0.6640.51
91_K95_L0.6630.51
85_V154_D0.6610.50
145_C149_V0.6580.50
35_Y68_N0.6570.50
31_I129_F0.6560.50
111_Q145_C0.6510.49
12_E17_E0.6490.49
60_R63_T0.6470.49
55_V103_G0.6450.49
86_L94_K0.6440.49
87_D95_L0.6420.48
16_D37_E0.6410.48
69_I81_G0.6410.48
51_A154_D0.6380.48
45_W72_K0.6330.47
45_W48_D0.6300.47
68_N130_F0.6270.47
57_L67_V0.6260.47
76_Q151_L0.6260.47
58_K153_L0.6210.46
57_L63_T0.6190.46
130_F134_Y0.6180.46
105_G111_Q0.6170.46
12_E74_S0.6130.45
82_K113_S0.6110.45
103_G150_R0.6110.45
11_G43_T0.6100.45
104_T130_F0.6050.44
101_E148_M0.6000.44
104_T108_S0.5990.44
144_Q153_L0.5970.44
16_D20_D0.5960.43
49_E72_K0.5950.43
127_H152_Y0.5950.43
86_L95_L0.5940.43
113_S116_Q0.5890.43
41_C53_V0.5870.42
38_R61_P0.5850.42
67_V123_Q0.5800.42
31_I39_G0.5800.42
64_V92_A0.5780.42
27_P136_E0.5770.41
59_T62_Q0.5760.41
81_G115_Y0.5760.41
22_L68_N0.5750.41
67_V150_R0.5720.41
85_V102_I0.5710.41
21_L84_L0.5680.41
70_A115_Y0.5660.40
106_N149_V0.5630.40
30_D37_E0.5590.40
85_V151_L0.5570.39
99_T154_D0.5550.39
131_L135_D0.5520.39
62_Q83_Q0.5520.39
66_I100_I0.5450.38
39_G67_V0.5440.38
60_R67_V0.5430.38
51_A75_L0.5410.38
105_G130_F0.5380.37
147_D150_R0.5360.37
60_R135_D0.5330.37
122_I151_L0.5330.37
121_R125_I0.5310.37
63_T101_E0.5300.37
46_A49_E0.5300.37
40_E100_I0.5290.37
79_G82_K0.5270.36
23_L26_D0.5230.36
77_K118_C0.5230.36
28_S31_I0.5220.36
65_E103_G0.5210.36
48_D137_D0.5200.36
48_D95_L0.5190.36
93_K98_D0.5190.36
69_I100_I0.5160.35
116_Q125_I0.5150.35
111_Q138_I0.5150.35
108_S141_N0.5110.35
13_E47_G0.5080.35
83_Q98_D0.5070.34
11_G18_L0.5060.34
24_L73_E0.5050.34
35_Y134_Y0.5050.34
46_A75_L0.5040.34
30_D74_S0.5020.34
116_Q143_I0.5000.34
27_P145_C0.5000.34
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1y9kA 1 0.9742 99.9 0.44 Contact Map
1yvkA 3 0.9742 99.9 0.466 Contact Map
2oh1A 1 0.871 99.8 0.583 Contact Map
2r7hA 2 0.8968 99.8 0.587 Contact Map
1n71A 4 0.8903 99.8 0.589 Contact Map
3pp9A 2 0.9484 99.8 0.591 Contact Map
3lodA 1 0.8645 99.8 0.591 Contact Map
1gheA 1 0.9161 99.8 0.592 Contact Map
2fiaA 1 0.8968 99.8 0.593 Contact Map
4kvxA 1 0.8839 99.7 0.596 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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