GREMLIN Database
YVBI - Uncharacterized protein YvbI
UniProt: O32246 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 232 (221)
Sequences: 234 (207)
Seq/√Len: 13.9

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
3_C6_C4.7031.00
46_F75_T4.5501.00
16_C19_C4.1941.00
10_T13_G3.6950.99
3_C19_C3.3460.99
3_C16_C3.3460.99
6_C19_C3.3460.99
6_C16_C3.3460.99
16_C20_G3.2840.99
10_T23_L3.0130.97
73_I77_V2.9080.97
122_I138_S2.8440.96
4_P23_L2.7960.96
84_P104_F2.6920.95
53_V147_I2.6720.95
214_T218_I2.6610.94
15_F20_G2.6540.94
6_C20_G2.4540.92
3_C20_G2.4540.92
104_F108_T2.1820.86
88_Y100_F2.1670.85
100_F143_G2.1290.84
141_R186_M2.0830.83
127_K174_G2.0300.81
113_L201_I1.9920.80
113_L118_L1.9370.78
94_G209_L1.9320.78
7_G15_F1.8640.75
127_K218_I1.8400.74
119_H135_F1.8390.74
117_G124_F1.8370.74
30_Q174_G1.8010.73
10_T17_E1.7550.71
200_F210_I1.7250.69
15_F19_C1.7220.69
49_F53_V1.7220.69
78_L150_T1.6380.65
104_F150_T1.6160.64
134_S172_A1.6010.63
105_L217_L1.5960.63
171_L215_F1.5890.63
127_K216_Q1.5790.62
41_Q44_K1.5630.61
171_L213_V1.5590.61
47_G79_F1.5390.60
117_G128_I1.5370.60
22_P25_G1.5290.60
86_M153_L1.4670.56
173_V205_I1.4640.56
70_I140_S1.4490.55
49_F79_F1.4030.53
26_Q34_Q1.3940.52
142_F171_L1.3900.52
123_F127_K1.3630.51
57_P199_D1.3470.50
72_A140_S1.3310.49
140_S147_I1.3180.48
77_V111_F1.3020.47
75_T150_T1.2700.46
116_F120_A1.2430.44
51_L84_P1.2420.44
109_I220_E1.2260.43
82_L154_I1.2240.43
158_F205_I1.2210.43
54_L151_A1.2160.43
117_G221_H1.1960.42
3_C7_G1.1910.41
140_S143_G1.1550.40
208_Y215_F1.1350.38
66_G224_K1.1200.38
43_A135_F1.1190.38
81_L213_V1.1140.37
109_I161_L1.1120.37
134_S227_F1.1110.37
77_V139_F1.1090.37
6_C15_F1.0940.36
3_C15_F1.0940.36
23_L201_I1.0810.36
158_F217_L1.0800.36
124_F161_L1.0560.35
13_G143_G1.0480.34
136_K151_A1.0460.34
109_I226_I1.0440.34
81_L174_G1.0390.34
49_F144_A1.0370.34
69_L136_K1.0300.33
182_I186_M1.0290.33
53_V138_S1.0280.33
122_I150_T1.0220.33
75_T202_Y1.0200.33
114_F155_L1.0170.33
28_G32_A1.0130.32
123_F138_S1.0110.32
111_F203_S1.0090.32
5_Q8_H1.0020.32
46_F190_Y0.9900.31
12_G18_K0.9890.31
79_F144_A0.9880.31
206_V210_I0.9870.31
30_Q120_A0.9870.31
72_A183_P0.9780.31
40_K43_A0.9750.31
5_Q134_S0.9650.30
151_A221_H0.9650.30
81_L206_V0.9650.30
25_G139_F0.9600.30
78_L125_A0.9430.29
71_S143_G0.9400.29
51_L55_K0.9320.29
151_A154_I0.9310.29
146_L153_L0.9300.29
172_A179_F0.9290.29
155_L178_A0.9260.28
69_L174_G0.9220.28
76_M202_Y0.9200.28
206_V215_F0.9150.28
11_D130_G0.9080.28
120_A184_P0.9070.28
54_L147_I0.9010.27
77_V201_I0.8940.27
124_F174_G0.8930.27
223_V226_I0.8900.27
175_L214_T0.8870.27
108_T217_L0.8790.26
76_M91_F0.8790.26
128_I134_S0.8710.26
213_V217_L0.8700.26
87_F213_V0.8640.26
8_H77_V0.8630.26
145_F203_S0.8620.26
99_S217_L0.8610.26
143_G199_D0.8600.26
153_L157_L0.8590.26
180_F184_P0.8580.26
49_F140_S0.8550.25
53_V140_S0.8460.25
81_L200_F0.8460.25
75_T143_G0.8440.25
120_A158_F0.8400.25
169_T205_I0.8350.25
129_A159_F0.8310.24
114_F172_A0.8300.24
5_Q11_D0.8250.24
37_A82_L0.8240.24
79_F146_L0.8220.24
155_L176_I0.8200.24
18_K49_F0.8160.24
113_L195_K0.8140.24
71_S144_A0.8120.24
84_P107_P0.8080.24
38_A43_A0.8050.23
88_Y143_G0.8050.23
58_Y143_G0.8000.23
75_T129_A0.7990.23
182_I206_V0.7980.23
101_T112_I0.7980.23
78_L104_F0.7980.23
41_Q187_L0.7970.23
148_P183_P0.7910.23
87_F181_A0.7880.23
189_S207_I0.7880.23
192_H198_V0.7780.22
45_Q219_I0.7780.22
72_A199_D0.7740.22
119_H211_I0.7720.22
46_F49_F0.7720.22
113_L183_P0.7710.22
114_F123_F0.7710.22
31_H222_Y0.7700.22
80_S115_L0.7680.22
162_L223_V0.7600.22
73_I134_S0.7600.22
85_L165_D0.7580.22
167_C177_G0.7560.22
17_E49_F0.7560.22
77_V85_L0.7500.21
137_D141_R0.7490.21
26_Q82_L0.7450.21
73_I102_A0.7420.21
94_G118_L0.7390.21
134_S158_F0.7390.21
5_Q18_K0.7370.21
93_D178_A0.7350.21
4_P10_T0.7300.21
141_R189_S0.7260.21
91_F117_G0.7260.21
36_G81_L0.7250.20
212_C223_V0.7250.20
53_V144_A0.7200.20
50_V219_I0.7170.20
103_I150_T0.7140.20
169_T175_L0.7130.20
49_F146_L0.7110.20
102_A178_A0.7090.20
17_E53_V0.7090.20
192_H208_Y0.7070.20
142_F202_Y0.7050.20
71_S147_I0.7040.20
61_C128_I0.7030.20
135_F226_I0.7020.20
46_F57_P0.7010.20
217_L226_I0.6990.20
12_G226_I0.6970.20
14_N146_L0.6960.19
13_G69_L0.6930.19
34_Q40_K0.6930.19
112_I217_L0.6910.19
58_Y148_P0.6910.19
82_L153_L0.6900.19
7_G25_G0.6870.19
21_S164_T0.6860.19
158_F203_S0.6850.19
141_R191_Q0.6840.19
123_F134_S0.6840.19
8_H12_G0.6830.19
179_F210_I0.6810.19
124_F201_I0.6800.19
117_G215_F0.6750.19
110_Y219_I0.6720.19
99_S114_F0.6700.19
46_F78_L0.6690.19
7_G116_F0.6680.19
71_S186_M0.6670.19
72_A80_S0.6650.18
65_G143_G0.6640.18
112_I226_I0.6640.18
56_R113_L0.6630.18
197_K204_T0.6580.18
47_G71_S0.6570.18
78_L130_G0.6570.18
45_Q56_R0.6560.18
184_P191_Q0.6550.18
199_D220_E0.6520.18
33_A111_F0.6510.18
47_G177_G0.6420.18
80_S161_L0.6400.18
161_L184_P0.6370.18
158_F187_L0.6350.17
55_K149_F0.6350.17
92_S216_Q0.6320.17
59_Q101_T0.6310.17
69_L100_F0.6300.17
61_C141_R0.6290.17
47_G199_D0.6270.17
95_P154_I0.6260.17
9_Q76_M0.6250.17
161_L206_V0.6250.17
96_G212_C0.6250.17
86_M155_L0.6230.17
161_L176_I0.6210.17
72_A202_Y0.6200.17
153_L209_L0.6200.17
162_L174_G0.6110.17
49_F93_D0.6100.17
155_L217_L0.6050.17
210_I217_L0.6050.17
54_L79_F0.5990.16
209_L217_L0.5970.16
85_L117_G0.5960.16
138_S147_I0.5950.16
44_K80_S0.5930.16
162_L209_L0.5920.16
11_D14_N0.5900.16
67_E143_G0.5900.16
98_V197_K0.5870.16
113_L208_Y0.5850.16
58_Y139_F0.5850.16
82_L160_F0.5810.16
79_F140_S0.5790.16
124_F209_L0.5770.16
93_D173_V0.5750.16
161_L215_F0.5750.16
139_F187_L0.5740.16
157_L161_L0.5730.16
81_L102_A0.5720.16
84_P142_F0.5710.16
182_I227_F0.5690.16
97_S171_L0.5680.15
203_S214_T0.5670.15
35_T64_T0.5650.15
85_L177_G0.5640.15
65_G178_A0.5640.15
172_A194_Y0.5630.15
108_T171_L0.5610.15
29_H157_L0.5600.15
170_I209_L0.5600.15
68_Q141_R0.5570.15
71_S145_F0.5540.15
91_F214_T0.5530.15
84_P91_F0.5520.15
48_S222_Y0.5510.15
49_F147_I0.5510.15
15_F22_P0.5500.15
82_L209_L0.5480.15
69_L72_A0.5480.15
107_P124_F0.5470.15
53_V201_I0.5460.15
158_F207_I0.5460.15
13_G17_E0.5460.15
110_Y214_T0.5450.15
154_I201_I0.5450.15
130_G204_T0.5420.15
41_Q156_A0.5410.15
93_D139_F0.5390.15
28_G222_Y0.5370.15
146_L190_Y0.5330.15
176_I212_C0.5320.15
155_L173_V0.5320.15
70_I119_H0.5310.14
8_H143_G0.5280.14
77_V194_Y0.5270.14
77_V121_C0.5270.14
172_A210_I0.5240.14
37_A103_I0.5240.14
75_T156_A0.5230.14
43_A55_K0.5230.14
137_D207_I0.5220.14
74_I146_L0.5190.14
38_A46_F0.5170.14
59_Q227_F0.5140.14
113_L172_A0.5130.14
37_A152_I0.5110.14
37_A113_L0.5110.14
33_A135_F0.5090.14
135_F166_I0.5090.14
110_Y218_I0.5080.14
158_F170_I0.5060.14
13_G183_P0.5020.14
158_F193_S0.5010.14
84_P114_F0.5010.14
91_F161_L0.5010.14
92_S152_I0.5000.14
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3wwlA 1 0.194 94.5 0.89 Contact Map
2k4xA 1 0.1379 93.8 0.894 Contact Map
1h7bA 2 0.0819 93.7 0.894 Contact Map
3h0gL 1 0.1638 93.5 0.895 Contact Map
1vw4W 1 0.2759 93 0.897 Contact Map
3ga8A 1 0.1983 92.8 0.898 Contact Map
3j21g 1 0.1379 92.7 0.898 Contact Map
3j7y0 1 0.2629 91.8 0.9 Contact Map
3o9xA 2 0.4526 90.6 0.904 Contact Map
4qiwP 1 0.1552 89.7 0.905 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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