GREMLIN Database
YVBH - Uncharacterized protein YvbH
UniProt: O32245 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 204 (203)
Sequences: 129 (103)
Seq/√Len: 7.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
33_V60_I4.7980.99
114_V122_L4.4110.98
84_I105_L4.1830.97
65_E70_S3.2720.89
101_I125_L3.0340.85
130_L133_A3.0270.85
27_T47_T2.9070.82
75_K110_F2.7110.78
27_T114_V2.6090.75
95_V197_V2.5760.74
170_Q173_E2.4670.70
18_I121_K2.4650.70
191_I196_D2.3140.65
15_I105_L2.2750.64
5_I9_A2.2150.61
47_T175_T2.2040.61
115_H118_Q2.2010.61
15_I191_I2.0630.56
118_Q121_K2.0550.55
34_M186_R1.9680.52
102_K111_D1.9270.50
27_T122_L1.7920.45
8_D78_P1.6890.41
8_D195_G1.6720.41
15_I146_A1.6400.39
24_Y143_I1.6050.38
42_Y119_I1.5770.37
32_Y78_P1.5730.37
119_I197_V1.5610.37
18_I115_H1.5570.36
74_L149_S1.5400.36
29_A53_C1.5000.34
80_S190_H1.5000.34
49_A65_E1.4780.34
20_E176_E1.4770.34
154_V178_G1.4480.33
24_Y122_L1.4320.32
83_K187_S1.4230.32
34_M181_W1.4230.32
172_K176_E1.4220.32
29_A44_L1.4200.32
44_L53_C1.4040.31
49_A70_S1.4000.31
27_T175_T1.3860.30
146_A185_V1.3850.30
73_T99_V1.3850.30
173_E196_D1.3750.30
174_L200_K1.3720.30
17_K118_Q1.3720.30
139_N181_W1.3680.30
8_D181_W1.3570.30
46_K61_H1.3560.29
3_K7_A1.3540.29
5_I109_Q1.3130.28
107_G135_T1.2990.28
4_K202_I1.2970.28
154_V188_Q1.2870.27
131_R175_T1.2840.27
18_I118_Q1.2790.27
7_A142_L1.2750.27
20_E131_R1.2730.27
180_T183_T1.2650.27
3_K58_A1.2630.27
68_T133_A1.2550.26
8_D42_Y1.2520.26
163_E170_Q1.2450.26
153_A157_L1.2390.26
38_N150_L1.2380.26
59_L150_L1.2280.26
68_T141_I1.2110.25
136_T188_Q1.1920.24
101_I149_S1.1900.24
21_P32_Y1.1880.24
80_S141_I1.1820.24
144_N158_H1.1700.24
89_L125_L1.1600.24
70_S187_S1.1520.23
108_E128_A1.1470.23
171_Y178_G1.1380.23
3_K70_S1.1160.22
32_Y184_S1.0970.22
69_S94_K1.0950.22
45_I193_D1.0750.21
16_G30_D1.0730.21
17_K177_F1.0720.21
80_S136_T1.0690.21
133_A150_L1.0670.21
3_K165_V1.0660.21
77_Y133_A1.0560.21
62_V187_S1.0550.21
24_Y140_D1.0470.21
18_I37_D1.0460.21
174_L177_F1.0430.20
19_I85_S1.0350.20
101_I139_N1.0350.20
107_G133_A1.0280.20
7_A28_D1.0260.20
17_K110_F1.0210.20
176_E179_F1.0080.20
38_N180_T1.0010.19
8_D182_L1.0000.19
142_L173_E0.9950.19
170_Q174_L0.9950.19
82_Y108_E0.9940.19
153_A181_W0.9900.19
28_D194_F0.9800.19
47_T66_R0.9790.19
16_G45_I0.9780.19
101_I110_F0.9770.19
22_Q188_Q0.9750.19
157_L174_L0.9670.19
84_I87_V0.9640.19
3_K14_D0.9640.19
37_D114_V0.9620.18
86_D173_E0.9610.18
16_G31_D0.9590.18
115_H121_K0.9570.18
88_F190_H0.9450.18
17_K115_H0.9430.18
13_S72_R0.9380.18
75_K130_L0.9360.18
83_K141_I0.9350.18
7_A189_Y0.9270.18
163_E166_N0.9200.17
57_L78_P0.9180.17
6_A30_D0.9080.17
47_T120_E0.9070.17
29_A123_K0.9040.17
86_D168_E0.8980.17
57_L168_E0.8970.17
52_Y72_R0.8950.17
95_V133_A0.8900.17
50_D63_D0.8880.17
99_V134_E0.8880.17
109_Q144_N0.8850.17
35_H69_S0.8810.17
139_N189_Y0.8740.16
7_A160_T0.8700.16
3_K118_Q0.8700.16
139_N153_A0.8680.16
153_A203_N0.8660.16
32_Y114_V0.8650.16
36_E69_S0.8610.16
30_D36_E0.8550.16
128_A199_E0.8540.16
13_S113_D0.8520.16
101_I181_W0.8500.16
148_Q201_Y0.8490.16
128_A159_H0.8490.16
53_C193_D0.8490.16
32_Y105_L0.8480.16
45_I61_H0.8420.16
106_G146_A0.8390.16
6_A16_G0.8330.16
62_V175_T0.8300.16
33_V181_W0.8300.16
5_I151_D0.8260.15
16_G193_D0.8240.15
52_Y71_K0.8140.15
24_Y114_V0.8010.15
125_L181_W0.7960.15
81_Q137_Y0.7930.15
147_E176_E0.7930.15
33_V59_L0.7920.15
59_L78_P0.7840.15
140_D186_R0.7840.15
161_R200_K0.7810.15
82_Y105_L0.7750.14
64_G67_A0.7700.14
42_Y78_P0.7600.14
148_Q187_S0.7550.14
104_K166_N0.7550.14
80_S146_A0.7440.14
122_L137_Y0.7430.14
9_A95_V0.7420.14
45_I53_C0.7400.14
107_G137_Y0.7380.14
30_D124_D0.7380.14
22_Q142_L0.7370.14
47_T171_Y0.7310.14
50_D61_H0.7220.13
61_H193_D0.7220.13
139_N192_K0.7210.13
82_Y86_D0.7200.13
21_P40_K0.7180.13
60_I105_L0.7150.13
5_I83_K0.7120.13
66_R156_I0.7100.13
87_V126_Y0.7090.13
154_V175_T0.7070.13
118_Q182_L0.7040.13
89_L101_I0.7030.13
141_I144_N0.7020.13
79_Y146_A0.7010.13
20_E95_V0.6990.13
15_I109_Q0.6990.13
6_A41_I0.6960.13
128_A166_N0.6940.13
137_Y140_D0.6930.13
29_A192_K0.6920.13
124_D202_I0.6900.13
38_N95_V0.6890.13
66_R118_Q0.6860.13
128_A203_N0.6830.13
43_F64_G0.6780.13
91_T124_D0.6750.13
108_E164_H0.6740.13
47_T62_V0.6730.13
108_E169_T0.6720.13
46_K63_D0.6690.13
65_E107_G0.6670.13
20_E68_T0.6660.12
128_A137_Y0.6650.12
75_K200_K0.6640.12
57_L136_T0.6620.12
32_Y35_H0.6610.12
10_L16_G0.6570.12
167_I190_H0.6560.12
24_Y155_T0.6530.12
89_L189_Y0.6500.12
3_K20_E0.6490.12
37_D200_K0.6430.12
2_F91_T0.6420.12
155_T187_S0.6400.12
77_Y147_E0.6320.12
4_K168_E0.6310.12
94_K171_Y0.6310.12
148_Q151_D0.6290.12
83_K166_N0.6250.12
119_I122_L0.6220.12
5_I107_G0.6210.12
42_Y104_K0.6200.12
106_G138_E0.6170.12
144_N196_D0.6130.12
53_C58_A0.6120.12
46_K193_D0.6110.12
90_E113_D0.6110.12
32_Y47_T0.6080.12
74_L89_L0.6080.12
33_V128_A0.6080.12
119_I176_E0.6070.12
52_Y61_H0.6050.11
49_A62_V0.6030.11
31_D45_I0.6020.11
96_D100_E0.5970.11
108_E163_E0.5890.11
65_E175_T0.5880.11
102_K113_D0.5870.11
8_D95_V0.5870.11
192_K202_I0.5870.11
21_P195_G0.5860.11
58_A152_K0.5860.11
117_D201_Y0.5840.11
144_N172_K0.5840.11
74_L134_E0.5830.11
160_T196_D0.5820.11
6_A31_D0.5800.11
38_N148_Q0.5790.11
18_I175_T0.5770.11
80_S170_Q0.5740.11
64_G102_K0.5710.11
31_D52_Y0.5700.11
62_V152_K0.5690.11
78_P134_E0.5680.11
33_V97_L0.5660.11
72_R132_I0.5650.11
163_E167_I0.5640.11
18_I89_L0.5630.11
49_A68_T0.5590.11
5_I135_T0.5570.11
163_E169_T0.5560.11
61_H198_F0.5540.11
75_K186_R0.5530.11
158_H176_E0.5510.11
152_K180_T0.5510.11
85_S107_G0.5510.11
57_L115_H0.5500.11
152_K171_Y0.5460.11
15_I58_A0.5440.11
13_S94_K0.5420.11
50_D198_F0.5420.11
52_Y63_D0.5410.11
50_D193_D0.5360.10
86_D185_V0.5340.10
145_Q150_L0.5330.10
114_V143_I0.5320.10
8_D49_A0.5310.10
81_Q166_N0.5300.10
52_Y69_S0.5290.10
1_M58_A0.5290.10
186_R190_H0.5240.10
153_A186_R0.5240.10
85_S194_F0.5240.10
138_E176_E0.5230.10
2_F99_V0.5220.10
20_E147_E0.5200.10
1_M91_T0.5170.10
30_D45_I0.5120.10
141_I186_R0.5100.10
66_R135_T0.5100.10
59_L136_T0.5080.10
63_D193_D0.5050.10
74_L116_K0.5020.10
84_I188_Q0.5000.10
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3b77A 4 0.9216 100 0.372 Contact Map
3hsaA 3 0.549 99.9 0.731 Contact Map
4k92A 1 0.5098 13.1 0.972 Contact Map
1dp7P 1 0.1324 8.2 0.974 Contact Map
4n78F 1 0.4902 8.1 0.974 Contact Map
3s0rA 3 0.1471 7.8 0.975 Contact Map
4e1pA 2 0.2745 6.6 0.975 Contact Map
1fjrA 1 0.3137 6.5 0.975 Contact Map
4e1rA 2 0.2206 5.8 0.976 Contact Map
3a7rA 1 0.7794 5.6 0.976 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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