YVBH - BACSU - GREMLIN Contacts

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YVBH - Uncharacterized protein YvbH

UniProt:	O32245	Sequences: MFKKIAADALGLSDIGKIIEPQDYDKTDADDYVMHEDNEKIYFLIKTKADEYCFTNLALIHVDGERATSSKRTLKRYPYSQYKISDVFLETAGKVDLDVEIKFKLGGEQFDIDVHKDQIEKLKDLYKALLRIAETTYENDILINQAEQSLDKAVTILHHTRPEHVNIETQYKELTEFGFTWLTSVRSQYHIKDFGDVFEKYINN	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	204 (203)
Sequences:	129 (103)
Seq/√Len:	7.2

BACSU - YVBH

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
33_V	60_I	4.798	0.99
114_V	122_L	4.411	0.98
84_I	105_L	4.183	0.97
65_E	70_S	3.272	0.89
101_I	125_L	3.034	0.85
130_L	133_A	3.027	0.85
27_T	47_T	2.907	0.82
75_K	110_F	2.711	0.78
27_T	114_V	2.609	0.75
95_V	197_V	2.576	0.74
170_Q	173_E	2.467	0.70
18_I	121_K	2.465	0.70
191_I	196_D	2.314	0.65
15_I	105_L	2.275	0.64
5_I	9_A	2.215	0.61
47_T	175_T	2.204	0.61
115_H	118_Q	2.201	0.61
15_I	191_I	2.063	0.56
118_Q	121_K	2.055	0.55
34_M	186_R	1.968	0.52
102_K	111_D	1.927	0.50
27_T	122_L	1.792	0.45
8_D	78_P	1.689	0.41
8_D	195_G	1.672	0.41
15_I	146_A	1.640	0.39
24_Y	143_I	1.605	0.38
42_Y	119_I	1.577	0.37
32_Y	78_P	1.573	0.37
119_I	197_V	1.561	0.37
18_I	115_H	1.557	0.36
74_L	149_S	1.540	0.36
29_A	53_C	1.500	0.34
80_S	190_H	1.500	0.34
49_A	65_E	1.478	0.34
20_E	176_E	1.477	0.34
154_V	178_G	1.448	0.33
24_Y	122_L	1.432	0.32
83_K	187_S	1.423	0.32
34_M	181_W	1.423	0.32
172_K	176_E	1.422	0.32
29_A	44_L	1.420	0.32
44_L	53_C	1.404	0.31
49_A	70_S	1.400	0.31
27_T	175_T	1.386	0.30
146_A	185_V	1.385	0.30
73_T	99_V	1.385	0.30
173_E	196_D	1.375	0.30
174_L	200_K	1.372	0.30
17_K	118_Q	1.372	0.30
139_N	181_W	1.368	0.30
8_D	181_W	1.357	0.30
46_K	61_H	1.356	0.29
3_K	7_A	1.354	0.29
5_I	109_Q	1.313	0.28
107_G	135_T	1.299	0.28
4_K	202_I	1.297	0.28
154_V	188_Q	1.287	0.27
131_R	175_T	1.284	0.27
18_I	118_Q	1.279	0.27
7_A	142_L	1.275	0.27
20_E	131_R	1.273	0.27
180_T	183_T	1.265	0.27
3_K	58_A	1.263	0.27
68_T	133_A	1.255	0.26
8_D	42_Y	1.252	0.26
163_E	170_Q	1.245	0.26
153_A	157_L	1.239	0.26
38_N	150_L	1.238	0.26
59_L	150_L	1.228	0.26
68_T	141_I	1.211	0.25
136_T	188_Q	1.192	0.24
101_I	149_S	1.190	0.24
21_P	32_Y	1.188	0.24
80_S	141_I	1.182	0.24
144_N	158_H	1.170	0.24
89_L	125_L	1.160	0.24
70_S	187_S	1.152	0.23
108_E	128_A	1.147	0.23
171_Y	178_G	1.138	0.23
3_K	70_S	1.116	0.22
32_Y	184_S	1.097	0.22
69_S	94_K	1.095	0.22
45_I	193_D	1.075	0.21
16_G	30_D	1.073	0.21
17_K	177_F	1.072	0.21
80_S	136_T	1.069	0.21
133_A	150_L	1.067	0.21
3_K	165_V	1.066	0.21
77_Y	133_A	1.056	0.21
62_V	187_S	1.055	0.21
24_Y	140_D	1.047	0.21
18_I	37_D	1.046	0.21
174_L	177_F	1.043	0.20
19_I	85_S	1.035	0.20
101_I	139_N	1.035	0.20
107_G	133_A	1.028	0.20
7_A	28_D	1.026	0.20
17_K	110_F	1.021	0.20
176_E	179_F	1.008	0.20
38_N	180_T	1.001	0.19
8_D	182_L	1.000	0.19
142_L	173_E	0.995	0.19
170_Q	174_L	0.995	0.19
82_Y	108_E	0.994	0.19
153_A	181_W	0.990	0.19
28_D	194_F	0.980	0.19
47_T	66_R	0.979	0.19
16_G	45_I	0.978	0.19
101_I	110_F	0.977	0.19
22_Q	188_Q	0.975	0.19
157_L	174_L	0.967	0.19
84_I	87_V	0.964	0.19
3_K	14_D	0.964	0.19
37_D	114_V	0.962	0.18
86_D	173_E	0.961	0.18
16_G	31_D	0.959	0.18
115_H	121_K	0.957	0.18
88_F	190_H	0.945	0.18
17_K	115_H	0.943	0.18
13_S	72_R	0.938	0.18
75_K	130_L	0.936	0.18
83_K	141_I	0.935	0.18
7_A	189_Y	0.927	0.18
163_E	166_N	0.920	0.17
57_L	78_P	0.918	0.17
6_A	30_D	0.908	0.17
47_T	120_E	0.907	0.17
29_A	123_K	0.904	0.17
86_D	168_E	0.898	0.17
57_L	168_E	0.897	0.17
52_Y	72_R	0.895	0.17
95_V	133_A	0.890	0.17
50_D	63_D	0.888	0.17
99_V	134_E	0.888	0.17
109_Q	144_N	0.885	0.17
35_H	69_S	0.881	0.17
139_N	189_Y	0.874	0.16
7_A	160_T	0.870	0.16
3_K	118_Q	0.870	0.16
139_N	153_A	0.868	0.16
153_A	203_N	0.866	0.16
32_Y	114_V	0.865	0.16
36_E	69_S	0.861	0.16
30_D	36_E	0.855	0.16
128_A	199_E	0.854	0.16
13_S	113_D	0.852	0.16
101_I	181_W	0.850	0.16
148_Q	201_Y	0.849	0.16
128_A	159_H	0.849	0.16
53_C	193_D	0.849	0.16
32_Y	105_L	0.848	0.16
45_I	61_H	0.842	0.16
106_G	146_A	0.839	0.16
6_A	16_G	0.833	0.16
62_V	175_T	0.830	0.16
33_V	181_W	0.830	0.16
5_I	151_D	0.826	0.15
16_G	193_D	0.824	0.15
52_Y	71_K	0.814	0.15
24_Y	114_V	0.801	0.15
125_L	181_W	0.796	0.15
81_Q	137_Y	0.793	0.15
147_E	176_E	0.793	0.15
33_V	59_L	0.792	0.15
59_L	78_P	0.784	0.15
140_D	186_R	0.784	0.15
161_R	200_K	0.781	0.15
82_Y	105_L	0.775	0.14
64_G	67_A	0.770	0.14
42_Y	78_P	0.760	0.14
148_Q	187_S	0.755	0.14
104_K	166_N	0.755	0.14
80_S	146_A	0.744	0.14
122_L	137_Y	0.743	0.14
9_A	95_V	0.742	0.14
45_I	53_C	0.740	0.14
107_G	137_Y	0.738	0.14
30_D	124_D	0.738	0.14
22_Q	142_L	0.737	0.14
47_T	171_Y	0.731	0.14
50_D	61_H	0.722	0.13
61_H	193_D	0.722	0.13
139_N	192_K	0.721	0.13
82_Y	86_D	0.720	0.13
21_P	40_K	0.718	0.13
60_I	105_L	0.715	0.13
5_I	83_K	0.712	0.13
66_R	156_I	0.710	0.13
87_V	126_Y	0.709	0.13
154_V	175_T	0.707	0.13
118_Q	182_L	0.704	0.13
89_L	101_I	0.703	0.13
141_I	144_N	0.702	0.13
79_Y	146_A	0.701	0.13
20_E	95_V	0.699	0.13
15_I	109_Q	0.699	0.13
6_A	41_I	0.696	0.13
128_A	166_N	0.694	0.13
137_Y	140_D	0.693	0.13
29_A	192_K	0.692	0.13
124_D	202_I	0.690	0.13
38_N	95_V	0.689	0.13
66_R	118_Q	0.686	0.13
128_A	203_N	0.683	0.13
43_F	64_G	0.678	0.13
91_T	124_D	0.675	0.13
108_E	164_H	0.674	0.13
47_T	62_V	0.673	0.13
108_E	169_T	0.672	0.13
46_K	63_D	0.669	0.13
65_E	107_G	0.667	0.13
20_E	68_T	0.666	0.12
128_A	137_Y	0.665	0.12
75_K	200_K	0.664	0.12
57_L	136_T	0.662	0.12
32_Y	35_H	0.661	0.12
10_L	16_G	0.657	0.12
167_I	190_H	0.656	0.12
24_Y	155_T	0.653	0.12
89_L	189_Y	0.650	0.12
3_K	20_E	0.649	0.12
37_D	200_K	0.643	0.12
2_F	91_T	0.642	0.12
155_T	187_S	0.640	0.12
77_Y	147_E	0.632	0.12
4_K	168_E	0.631	0.12
94_K	171_Y	0.631	0.12
148_Q	151_D	0.629	0.12
83_K	166_N	0.625	0.12
119_I	122_L	0.622	0.12
5_I	107_G	0.621	0.12
42_Y	104_K	0.620	0.12
106_G	138_E	0.617	0.12
144_N	196_D	0.613	0.12
53_C	58_A	0.612	0.12
46_K	193_D	0.611	0.12
90_E	113_D	0.611	0.12
32_Y	47_T	0.608	0.12
74_L	89_L	0.608	0.12
33_V	128_A	0.608	0.12
119_I	176_E	0.607	0.12
52_Y	61_H	0.605	0.11
49_A	62_V	0.603	0.11
31_D	45_I	0.602	0.11
96_D	100_E	0.597	0.11
108_E	163_E	0.589	0.11
65_E	175_T	0.588	0.11
102_K	113_D	0.587	0.11
8_D	95_V	0.587	0.11
192_K	202_I	0.587	0.11
21_P	195_G	0.586	0.11
58_A	152_K	0.586	0.11
117_D	201_Y	0.584	0.11
144_N	172_K	0.584	0.11
74_L	134_E	0.583	0.11
160_T	196_D	0.582	0.11
6_A	31_D	0.580	0.11
38_N	148_Q	0.579	0.11
18_I	175_T	0.577	0.11
80_S	170_Q	0.574	0.11
64_G	102_K	0.571	0.11
31_D	52_Y	0.570	0.11
62_V	152_K	0.569	0.11
78_P	134_E	0.568	0.11
33_V	97_L	0.566	0.11
72_R	132_I	0.565	0.11
163_E	167_I	0.564	0.11
18_I	89_L	0.563	0.11
49_A	68_T	0.559	0.11
5_I	135_T	0.557	0.11
163_E	169_T	0.556	0.11
61_H	198_F	0.554	0.11
75_K	186_R	0.553	0.11
158_H	176_E	0.551	0.11
152_K	180_T	0.551	0.11
85_S	107_G	0.551	0.11
57_L	115_H	0.550	0.11
152_K	171_Y	0.546	0.11
15_I	58_A	0.544	0.11
13_S	94_K	0.542	0.11
50_D	198_F	0.542	0.11
52_Y	63_D	0.541	0.11
50_D	193_D	0.536	0.10
86_D	185_V	0.534	0.10
145_Q	150_L	0.533	0.10
114_V	143_I	0.532	0.10
8_D	49_A	0.531	0.10
81_Q	166_N	0.530	0.10
52_Y	69_S	0.529	0.10
1_M	58_A	0.529	0.10
186_R	190_H	0.524	0.10
153_A	186_R	0.524	0.10
85_S	194_F	0.524	0.10
138_E	176_E	0.523	0.10
2_F	99_V	0.522	0.10
20_E	147_E	0.520	0.10
1_M	91_T	0.517	0.10
30_D	45_I	0.512	0.10
141_I	186_R	0.510	0.10
66_R	135_T	0.510	0.10
59_L	136_T	0.508	0.10
63_D	193_D	0.505	0.10
74_L	116_K	0.502	0.10
84_I	188_Q	0.500	0.10

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
3b77A	4	0.9216	100	0.372	Contact Map
3hsaA	3	0.549	99.9	0.731	Contact Map
4k92A	1	0.5098	13.1	0.972	Contact Map
1dp7P	1	0.1324	8.2	0.974	Contact Map
4n78F	1	0.4902	8.1	0.974	Contact Map
3s0rA	3	0.1471	7.8	0.975	Contact Map
4e1pA	2	0.2745	6.6	0.975	Contact Map
1fjrA	1	0.3137	6.5	0.975	Contact Map
4e1rA	2	0.2206	5.8	0.976	Contact Map
3a7rA	1	0.7794	5.6	0.976	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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