GREMLIN Database
YVBG - UPF0056 membrane protein YvbG
UniProt: O32244 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 211 (195)
Sequences: 2513 (1684)
Seq/√Len: 120.6

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
199_G205_M4.2931.00
34_T37_E3.4121.00
50_F157_I3.3091.00
76_V199_G3.2681.00
53_L129_T3.2081.00
84_G87_Y3.0041.00
73_A196_G2.9211.00
161_F165_H2.7711.00
43_R161_F2.6191.00
72_H204_G2.5551.00
10_F155_A2.5441.00
48_L116_V2.4011.00
196_G200_A2.3651.00
52_I121_I2.3541.00
50_F154_A2.2171.00
6_I152_G2.1411.00
175_G178_E2.1251.00
61_H65_K2.0961.00
9_V152_G2.0461.00
83_F198_I2.0451.00
46_A157_I2.0061.00
47_I51_F1.9871.00
26_F30_T1.9661.00
6_I151_I1.9281.00
10_F159_L1.9151.00
54_A150_M1.8771.00
58_V150_M1.8381.00
49_S157_I1.8151.00
86_A191_A1.8051.00
39_K165_H1.7811.00
72_H75_R1.7501.00
50_F54_A1.7321.00
17_S156_V1.7091.00
88_N93_K1.6871.00
80_I83_F1.6691.00
203_K206_F1.6681.00
18_N21_G1.6481.00
48_L120_S1.6481.00
169_F172_S1.6361.00
76_V205_M1.5931.00
13_L133_V1.5291.00
53_L125_A1.5291.00
75_R200_A1.5141.00
137_S146_Y1.5081.00
80_I198_I1.4981.00
26_F42_A1.4911.00
9_V136_L1.4871.00
52_I125_A1.4501.00
53_L133_V1.4251.00
54_A154_A1.3931.00
83_F194_A1.3671.00
43_R165_H1.3661.00
137_S149_V1.3531.00
73_A199_G1.3421.00
26_F119_L1.3361.00
158_A162_L1.3131.00
46_A160_T1.2771.00
57_L133_V1.2711.00
6_I155_A1.2701.00
89_L187_G1.2701.00
124_I160_T1.2681.00
38_R168_A1.2651.00
76_V202_L1.2500.99
21_G24_P1.2440.99
166_Y169_F1.2430.99
33_Y37_E1.2350.99
40_A44_K1.2170.99
35_A39_K1.2080.99
115_S120_S1.2020.99
79_G198_I1.1810.99
133_V153_I1.1790.99
51_F55_A1.1740.99
46_A161_F1.1710.99
6_I10_F1.1530.99
44_K113_D1.1470.99
190_L194_A1.1460.99
33_Y41_I1.1410.99
75_R204_G1.1350.99
17_S157_I1.1320.99
79_G201_G1.1310.99
89_L186_M1.1310.99
57_L150_M1.1260.99
70_N196_G1.1250.99
59_F63_I1.1220.99
169_F173_K1.1040.99
45_A49_S1.1040.99
22_N164_F1.1020.99
81_F191_A1.1010.99
35_A38_R1.0990.99
13_L153_I1.0960.99
15_A18_N1.0920.99
57_L137_S1.0840.98
199_G202_L1.0790.98
30_T38_R1.0760.98
144_G147_A1.0730.98
15_A67_F1.0700.98
80_I87_Y1.0630.98
89_L183_T1.0530.98
17_S129_T1.0510.98
107_E111_K1.0460.98
129_T133_V1.0370.98
39_K43_R1.0330.98
52_I120_S1.0300.98
24_P27_L1.0300.98
174_L178_E1.0280.98
81_F85_I1.0150.98
76_V198_I0.9990.97
83_F87_Y0.9900.97
16_V128_G0.9860.97
83_F191_A0.9840.97
43_R47_I0.9810.97
16_V132_T0.9700.97
191_A194_A0.9690.97
64_F192_V0.9690.97
162_L166_Y0.9610.97
18_N82_I0.9590.97
55_A59_F0.9490.96
53_L130_I0.9330.96
27_L171_S0.9330.96
57_L146_Y0.9310.96
76_V201_G0.9300.96
147_A151_I0.9160.96
94_E97_V0.9060.95
146_Y150_M0.8980.95
49_S120_S0.8780.95
21_G25_I0.8730.94
48_L115_S0.8570.94
26_F38_R0.8470.93
45_A114_I0.8340.93
130_I134_M0.8330.93
148_A151_I0.8250.92
35_A168_A0.8220.92
63_I130_I0.8220.92
14_F159_L0.8200.92
158_A169_F0.8120.92
21_G160_T0.8050.92
156_V159_L0.8010.91
82_I135_S0.8000.91
26_F167_S0.7980.91
62_L65_K0.7970.91
77_A195_V0.7910.91
14_F163_F0.7780.90
46_A49_S0.7770.90
125_A153_I0.7680.90
74_L157_I0.7640.89
184_R195_V0.7630.89
59_F62_L0.7560.89
18_N186_M0.7500.88
74_L131_A0.7500.88
81_F179_M0.7480.88
12_S132_T0.7470.88
44_K48_L0.7460.88
26_F127_P0.7450.88
18_N24_P0.7370.88
116_V177_T0.7350.87
53_L153_I0.7300.87
76_V195_V0.7260.87
90_L187_G0.7250.87
74_L132_T0.7250.87
142_G145_H0.7220.86
64_F134_M0.7200.86
70_N73_A0.7160.86
23_V27_L0.7080.85
120_S125_A0.7070.85
92_A184_R0.7050.85
125_A187_G0.7000.85
23_V164_F0.6990.85
22_N123_I0.6990.85
23_V163_F0.6980.85
65_K147_A0.6980.85
78_G131_A0.6970.85
51_F143_I0.6950.84
92_A187_G0.6940.84
18_N129_T0.6930.84
56_F134_M0.6910.84
22_N124_I0.6870.84
37_E41_I0.6860.84
88_N91_N0.6810.83
44_K115_S0.6780.83
19_P156_V0.6690.82
26_F70_N0.6690.82
19_P127_P0.6670.82
15_A188_L0.6620.81
30_T33_Y0.6610.81
18_N56_F0.6590.81
73_A77_A0.6570.81
177_T181_V0.6510.80
152_G156_V0.6510.80
22_N81_F0.6480.80
13_L53_L0.6470.80
86_A90_L0.6420.79
202_L206_F0.6340.79
113_D202_L0.6340.79
5_F140_H0.6330.78
39_K161_F0.6330.78
67_F135_S0.6300.78
86_A180_N0.6290.78
81_F133_V0.6290.78
40_A202_L0.6290.78
42_A182_I0.6280.78
95_S98_Q0.6250.78
14_F156_V0.6190.77
10_F14_F0.6190.77
10_F152_G0.6160.77
147_A150_M0.6150.76
52_I166_Y0.6130.76
88_N97_V0.6100.76
64_F78_G0.6080.76
78_G89_L0.6070.75
12_S16_V0.6020.75
86_A194_A0.6010.75
185_L189_I0.5950.74
136_L149_V0.5940.74
72_H199_G0.5920.74
15_A191_A0.5910.74
81_F123_I0.5910.74
108_S111_K0.5900.73
186_M197_M0.5890.73
74_L188_L0.5880.73
155_A173_K0.5860.73
121_I188_L0.5860.73
66_L193_V0.5850.73
128_G184_R0.5790.72
82_I193_V0.5790.72
18_N77_A0.5780.72
117_T190_L0.5770.72
57_L185_L0.5750.71
182_I206_F0.5750.71
41_I45_A0.5740.71
141_S148_A0.5720.71
12_S188_L0.5700.71
123_I126_G0.5700.71
14_F88_N0.5680.71
109_K206_F0.5660.70
176_K180_N0.5640.70
20_I182_I0.5630.70
73_A205_M0.5610.70
92_A186_M0.5600.70
15_A72_H0.5550.69
69_I95_S0.5510.68
16_V193_V0.5500.68
89_L116_V0.5490.68
129_T153_I0.5470.68
148_A152_G0.5470.68
57_L153_I0.5460.68
13_L17_S0.5450.67
8_H11_I0.5440.67
93_K96_H0.5430.67
84_G91_N0.5420.67
128_G190_L0.5390.67
122_P126_G0.5390.67
114_I119_L0.5370.66
12_S68_D0.5370.66
67_F194_A0.5360.66
56_F124_I0.5350.66
37_E40_A0.5340.66
49_S124_I0.5320.66
27_L182_I0.5320.66
13_L174_L0.5310.65
131_A134_M0.5290.65
45_A120_S0.5290.65
64_F70_N0.5280.65
92_A180_N0.5280.65
156_V160_T0.5260.65
36_A39_K0.5240.64
151_I172_S0.5220.64
16_V52_I0.5210.64
27_L119_L0.5210.64
15_A192_V0.5200.64
125_A189_I0.5190.64
179_M188_L0.5180.64
92_A181_V0.5180.64
71_I86_A0.5180.64
24_P124_I0.5170.63
65_K172_S0.5150.63
36_A173_K0.5140.63
181_V185_L0.5140.63
90_L194_A0.5120.63
59_F135_S0.5090.62
152_G155_A0.5080.62
83_F195_V0.5080.62
74_L206_F0.5070.62
60_G126_G0.5070.62
48_L56_F0.5060.62
20_I64_F0.5050.62
128_G175_G0.5040.61
15_A183_T0.5040.61
118_P175_G0.5030.61
64_F74_L0.5030.61
24_P123_I0.5020.61
5_F148_A0.5010.61
29_L114_I0.5000.61
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4j05A 3 0.5118 14.2 0.95 Contact Map
2cfqA 1 0.5024 13.6 0.951 Contact Map
4w6vA 1 0.455 12.9 0.951 Contact Map
1pw4A 1 0.5024 11.5 0.952 Contact Map
4kjrA 3 0.3744 7 0.957 Contact Map
4dx5A 3 0.9384 7 0.957 Contact Map
4wgvA 2 0.3886 6.7 0.957 Contact Map
4cz8A 2 0.7725 6.6 0.957 Contact Map
3w9iA 3 0.9336 5.6 0.959 Contact Map
4xnjA 1 0.9384 5.6 0.959 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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