GREMLIN Database
OPUCC - Glycine betaine/carnitine/choline-binding protein OpuCC
UniProt: O32243 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 303 (271)
Sequences: 4428 (3230)
Seq/√Len: 196.2

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
280_E286_K4.6611.00
143_K227_D4.4661.00
143_K229_K3.5461.00
270_D273_T3.5131.00
155_S234_D3.2361.00
37_G84_I2.9701.00
293_K297_E2.8991.00
152_N229_K2.8791.00
145_F149_E2.7001.00
280_E294_E2.6521.00
140_T216_A2.6331.00
141_V151_I2.6061.00
52_A65_L2.5121.00
109_K113_N2.4151.00
143_K147_E2.4001.00
126_K249_E2.3271.00
33_T62_N2.3101.00
53_Q293_K2.2561.00
294_E298_K2.2501.00
46_I281_V2.1691.00
286_K294_E2.1691.00
273_T277_L2.1571.00
33_T64_A2.1161.00
139_F213_A2.0741.00
35_K64_A2.0521.00
153_T232_K2.0381.00
280_E284_K2.0101.00
273_T299_H1.9671.00
77_Q80_L1.9361.00
224_K276_E1.9141.00
167_G211_M1.9111.00
152_N156_D1.8931.00
36_I86_I1.8561.00
160_N163_Q1.8191.00
268_Q299_H1.8171.00
249_E253_K1.7851.00
49_N53_Q1.7611.00
59_T261_V1.7411.00
203_Y226_Y1.7371.00
182_G237_F1.6801.00
286_K290_V1.6621.00
52_A56_E1.6501.00
153_T234_D1.6431.00
179_G182_G1.6381.00
53_Q56_E1.6131.00
142_T145_F1.6121.00
152_N232_K1.5911.00
211_M214_V1.5881.00
281_V291_V1.5711.00
144_K209_G1.5261.00
54_L261_V1.5251.00
145_F164_Y1.5101.00
163_Q211_M1.4871.00
156_D159_K1.4851.00
125_Y246_V1.4851.00
49_N65_L1.4721.00
279_Y283_G1.4441.00
129_D263_N1.4421.00
251_V255_H1.4321.00
120_Q249_E1.4061.00
287_E290_V1.4031.00
112_L116_Q1.3931.00
18_L21_C1.3911.00
279_Y284_K1.3881.00
151_I160_N1.3851.00
124_S249_E1.3741.00
189_F192_G1.3641.00
54_L265_L1.3581.00
181_K185_S1.3571.00
38_A48_A1.3511.00
53_Q57_H1.3511.00
276_E280_E1.3461.00
141_V145_F1.3281.00
252_L259_E1.3251.00
180_Y183_F1.3181.00
142_T209_G1.3101.00
290_V294_E1.3071.00
13_V16_M1.3041.00
273_T295_F1.2951.00
145_F211_M1.2881.00
14_F17_L1.2851.00
52_A63_T1.2801.00
268_Q295_F1.2771.00
248_P254_E1.2751.00
138_A230_I1.2731.00
56_E63_T1.2731.00
204_D208_N1.2661.00
203_Y207_K1.2511.00
53_Q289_S1.2231.00
160_N164_Y1.2111.00
85_D248_P1.1971.00
155_S235_K1.1821.00
14_F18_L1.1791.00
78_A84_I1.1781.00
13_V17_L1.1731.00
269_I277_L1.1731.00
186_T235_K1.1731.00
34_I61_L1.1651.00
49_N52_A1.1591.00
35_K66_V1.1561.00
272_E275_Q1.1511.00
38_A65_L1.1501.00
76_H123_F1.1501.00
177_G181_K1.1451.00
147_E229_K1.1441.00
50_M295_F1.1391.00
149_E160_N1.1351.00
123_F244_S1.1341.00
202_V214_V1.1331.00
184_V190_E1.1301.00
48_A65_L1.1261.00
51_I261_V1.1191.00
130_S133_F1.1181.00
17_L20_G1.1101.00
260_G264_K1.1101.00
201_L205_A1.0981.00
127_W244_S1.0951.00
102_K118_E1.0921.00
186_T237_F1.0921.00
42_T282_D1.0911.00
53_Q296_L1.0891.00
37_G75_Q1.0831.00
110_K113_N1.0801.00
224_K275_Q1.0771.00
277_L291_V1.0721.00
113_N117_N1.0721.00
34_I258_L1.0711.00
114_I118_E1.0691.00
114_I117_N1.0661.00
145_F151_I1.0641.00
288_P292_A1.0551.00
216_A222_R1.0541.00
49_N289_S1.0481.00
51_I262_I1.0461.00
127_W130_S1.0431.00
195_Y199_I1.0391.00
43_E274_M1.0361.00
138_A154_V1.0251.00
187_Y191_F1.0201.00
16_M19_G1.0191.00
180_Y184_V1.0081.00
113_N116_Q1.0051.00
117_N120_Q1.0001.00
50_M53_Q0.9981.00
251_V258_L0.9951.00
164_Y213_A0.9891.00
157_L213_A0.9881.00
151_I156_D0.9871.00
96_L99_T0.9851.00
286_K291_V0.9840.99
294_E297_E0.9820.99
269_I274_M0.9790.99
126_K259_E0.9750.99
169_D217_Y0.9710.99
138_A218_S0.9710.99
136_T218_S0.9690.99
55_I61_L0.9680.99
32_D255_H0.9680.99
76_H80_L0.9660.99
247_I252_L0.9510.99
188_G191_F0.9480.99
115_V118_E0.9440.99
50_M296_L0.9420.99
259_E263_N0.9400.99
86_I247_I0.9390.99
10_F14_F0.9330.99
34_I255_H0.9280.99
43_E47_V0.9270.99
50_M54_L0.9240.99
134_D138_A0.9210.99
157_L164_Y0.9200.99
76_H119_F0.9190.99
12_L15_V0.9190.99
128_F247_I0.9120.99
260_G263_N0.9110.99
194_T197_M0.9100.99
271_T275_Q0.9100.99
61_L257_E0.9090.99
179_G183_F0.8960.99
76_H246_V0.8860.99
250_K254_E0.8850.99
45_E288_P0.8840.99
258_L262_I0.8830.99
39_Q87_S0.8800.99
175_R178_D0.8710.99
273_T276_E0.8640.99
289_S293_K0.8520.99
50_M269_I0.8500.99
70_G74_V0.8400.98
142_T212_D0.8350.98
120_Q126_K0.8330.98
56_E65_L0.8310.98
77_Q81_G0.8300.98
134_D271_T0.8200.98
50_M292_A0.8180.98
40_S68_N0.8170.98
15_V21_C0.8170.98
128_F133_F0.8150.98
55_I258_L0.8140.98
158_K161_A0.8080.98
145_F148_K0.8070.98
54_L296_L0.8030.98
129_D132_G0.8000.98
78_A83_D0.7960.98
57_H293_K0.7950.98
154_V189_F0.7940.98
50_M265_L0.7920.98
133_F274_M0.7880.98
21_C25_G0.7870.98
55_I59_T0.7860.98
272_E276_E0.7810.97
131_Y134_D0.7800.97
18_L22_S0.7780.97
169_D199_I0.7770.97
168_V172_W0.7740.97
133_F243_C0.7720.97
12_L16_M0.7690.97
187_Y233_D0.7680.97
225_A283_G0.7660.97
161_A192_G0.7540.97
140_T230_I0.7520.97
51_I245_P0.7520.97
42_T281_V0.7500.97
172_W175_R0.7490.97
100_L118_E0.7480.97
265_L269_I0.7430.97
158_K188_G0.7420.97
202_V215_L0.7420.97
116_Q120_Q0.7400.96
252_L258_L0.7390.96
247_I251_V0.7380.96
141_V149_E0.7370.96
258_L261_V0.7350.96
188_G192_G0.7310.96
39_Q44_S0.7290.96
110_K114_I0.7280.96
154_V231_L0.7280.96
209_G212_D0.7250.96
151_I157_L0.7230.96
19_G22_S0.7220.96
139_F154_V0.7210.96
233_D237_F0.7200.96
119_F123_F0.7200.96
225_A279_Y0.7200.96
218_S230_I0.7190.96
144_K148_K0.7170.96
221_G282_D0.7160.96
140_T228_L0.7150.96
248_P251_V0.7140.96
165_K212_D0.7140.96
86_I258_L0.7130.96
48_A67_K0.7120.96
119_F127_W0.7070.95
21_C27_G0.7040.95
165_K193_T0.7040.95
14_F21_C0.7040.95
261_V265_L0.7030.95
193_T197_M0.7000.95
86_I262_I0.6970.95
40_S217_Y0.6900.95
82_G85_D0.6900.95
11_A15_V0.6870.95
55_I60_D0.6850.95
187_Y192_G0.6850.95
223_I230_I0.6840.95
173_L196_P0.6840.95
51_I96_L0.6830.95
151_I164_Y0.6820.94
116_Q126_K0.6810.94
128_F245_P0.6750.94
56_E62_N0.6720.94
184_V187_Y0.6690.94
182_G186_T0.6690.94
127_W131_Y0.6680.94
128_F131_Y0.6680.94
140_T223_I0.6680.94
124_S130_S0.6670.94
46_I277_L0.6670.94
115_V119_F0.6600.93
34_I251_V0.6560.93
218_S271_T0.6540.93
141_V213_A0.6510.93
38_A44_S0.6480.93
187_Y235_K0.6470.93
144_K298_K0.6470.93
276_E279_Y0.6430.93
35_K82_G0.6420.93
75_Q87_S0.6420.93
221_G225_A0.6390.92
128_F263_N0.6380.92
112_L115_V0.6380.92
158_K189_F0.6360.92
120_Q124_S0.6350.92
161_A189_F0.6300.92
145_F160_N0.6300.92
184_V192_G0.6290.92
43_E219_T0.6290.92
188_G235_K0.6270.92
47_V243_C0.6260.92
245_P262_I0.6240.91
172_W215_L0.6210.91
169_D195_Y0.6200.91
203_Y225_A0.6160.91
128_F132_G0.6160.91
131_Y135_N0.6150.91
224_K279_Y0.6140.91
36_I63_T0.6140.91
35_K84_I0.6110.91
32_D61_L0.6100.90
79_M248_P0.6080.90
126_K131_Y0.6020.90
178_D182_G0.6000.90
290_V293_K0.6000.90
36_I65_L0.5990.90
38_A67_K0.5980.90
10_F17_L0.5970.90
201_L212_D0.5960.89
35_K85_D0.5950.89
114_I119_F0.5920.89
171_A175_R0.5910.89
184_V191_F0.5910.89
21_C30_S0.5890.89
51_I265_L0.5890.89
141_V231_L0.5870.89
125_Y131_Y0.5860.89
166_L201_L0.5850.89
125_Y130_S0.5810.88
199_I217_Y0.5810.88
195_Y198_Q0.5790.88
194_T198_Q0.5780.88
45_E68_N0.5770.88
99_T119_F0.5760.88
51_I55_I0.5760.88
187_Y234_D0.5750.88
124_S127_W0.5720.87
218_S275_Q0.5700.87
15_V18_L0.5670.87
147_E232_K0.5660.87
269_I273_T0.5650.87
162_S165_K0.5620.87
214_V222_R0.5610.86
112_L244_S0.5610.86
35_K63_T0.5590.86
148_K152_N0.5580.86
243_C274_M0.5570.86
149_E163_Q0.5560.86
111_A115_V0.5540.86
79_M125_Y0.5530.86
137_Y172_W0.5530.86
216_A230_I0.5520.86
139_F238_F0.5520.86
150_H159_K0.5510.85
165_K195_Y0.5490.85
155_S158_K0.5480.85
137_Y174_K0.5480.85
112_L130_S0.5460.85
28_G31_D0.5450.85
36_I51_I0.5450.85
257_E260_G0.5450.85
120_Q252_L0.5450.85
205_A210_K0.5440.85
291_V294_E0.5440.85
250_K253_K0.5410.84
127_W133_F0.5400.84
168_V194_T0.5390.84
145_F229_K0.5370.84
125_Y128_F0.5360.84
202_V222_R0.5360.84
99_T103_E0.5350.84
45_E49_N0.5340.84
41_M171_A0.5340.84
280_E298_K0.5340.84
57_H297_E0.5310.83
46_I50_M0.5310.83
178_D183_F0.5280.83
49_N292_A0.5280.83
44_S47_V0.5270.83
129_D133_F0.5270.83
96_L245_P0.5260.83
152_N159_K0.5230.82
51_I54_L0.5230.82
36_I48_A0.5220.82
179_G238_F0.5210.82
193_T200_G0.5210.82
111_A114_I0.5200.82
13_V19_G0.5200.82
130_S134_D0.5200.82
216_A223_I0.5200.82
165_K192_G0.5190.82
131_Y243_C0.5170.82
33_T63_T0.5160.82
72_N98_S0.5140.81
11_A14_F0.5120.81
169_D202_V0.5120.81
76_H98_S0.5110.81
197_M211_M0.5100.81
196_P200_G0.5100.81
34_I86_I0.5100.81
180_Y191_F0.5060.80
196_P199_I0.5060.80
182_G185_S0.5050.80
120_Q123_F0.5040.80
9_A13_V0.5030.80
13_V21_C0.5020.80
36_I55_I0.5020.80
154_V234_D0.5000.80
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3o66A 1 0.8944 100 0.235 Contact Map
4ne4A 1 0.8878 100 0.275 Contact Map
3r6uA 1 0.8911 100 0.297 Contact Map
1sw5A 1 0.8845 100 0.36 Contact Map
1r9lA 1 0.8416 100 0.44 Contact Map
2rinA 1 0.8284 100 0.525 Contact Map
3tmgA 1 0.8053 100 0.565 Contact Map
3l6gA 1 0.802 100 0.575 Contact Map
2b4lA 1 0.4851 100 0.583 Contact Map
3un6A 1 0.7888 99.7 0.76 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

Page generated in 0.0092 seconds.