GREMLIN Database
SDPR - Transcriptional repressor SdpR
UniProt: O32242 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 90 (81)
Sequences: 5437 (3219)
Seq/√Len: 357.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
55_S68_N3.5931.00
24_D57_H3.2581.00
55_S66_S2.7001.00
24_D66_S2.4931.00
56_D63_I2.3141.00
49_K56_D2.1651.00
19_L33_H1.9151.00
46_N50_Q1.8921.00
36_I40_S1.8501.00
7_A51_A1.8371.00
58_R63_I1.8241.00
31_A38_K1.7651.00
37_S40_S1.7021.00
19_L25_M1.5921.00
76_I83_I1.5821.00
76_I80_L1.5481.00
17_L53_V1.5391.00
20_L54_I1.5081.00
16_I30_I1.4841.00
3_N50_Q1.4551.00
40_S43_H1.4061.00
12_T36_I1.3931.00
25_M29_D1.3901.00
16_I41_I1.2991.00
17_L67_L1.2841.00
27_A45_L1.2831.00
8_I75_S1.1991.00
26_T29_D1.1741.00
10_D43_H1.1571.00
71_V74_D1.1461.00
59_K62_F1.1451.00
77_N81_N1.1431.00
43_H61_Q1.1381.00
4_V53_V1.1331.00
52_E68_N1.1131.00
26_T62_F1.1131.00
45_L54_I1.1071.00
34_F41_I1.1001.00
15_K18_D1.0811.00
4_V75_S1.0741.00
47_I51_A1.0621.00
25_M33_H1.0541.00
54_I65_Y1.0331.00
30_I41_I1.0141.00
45_L65_Y0.9891.00
16_I20_L0.9481.00
18_D21_K0.9481.00
31_A41_I0.9371.00
28_G31_A0.9141.00
56_D65_Y0.9131.00
26_T64_Y0.8821.00
45_L49_K0.8691.00
70_T73_Q0.8581.00
77_N80_L0.8571.00
7_A47_I0.8541.00
24_D64_Y0.8521.00
80_L83_I0.8491.00
12_T34_F0.8441.00
29_D32_E0.8391.00
27_A43_H0.8371.00
73_Q77_N0.8211.00
48_L54_I0.8011.00
59_K64_Y0.7971.00
76_I79_M0.7941.00
36_I41_I0.7871.00
27_A42_S0.7821.00
39_P44_H0.7791.00
57_H64_Y0.7691.00
58_R61_Q0.7671.00
14_R17_L0.7611.00
28_G62_F0.7561.00
7_A53_V0.7541.00
41_I45_L0.7531.00
15_K34_F0.7511.00
24_D59_K0.7451.00
5_F8_I0.7421.00
40_S61_Q0.7381.00
19_L30_I0.7271.00
46_N49_K0.7210.99
73_Q76_I0.7160.99
57_H66_S0.7120.99
68_N71_V0.7090.99
20_L23_G0.6910.99
40_S44_H0.6890.99
27_A38_K0.6800.99
18_D82_F0.6780.99
79_M82_F0.6600.99
28_G58_R0.6590.99
8_I17_L0.6570.99
38_K62_F0.6500.99
15_K19_L0.6450.99
46_N58_R0.6290.99
38_K42_S0.6220.98
8_I11_P0.6190.98
6_K9_S0.6180.98
18_D22_G0.6090.98
5_F75_S0.6060.98
6_K14_R0.5810.98
47_I50_Q0.5760.97
49_K65_Y0.5730.97
27_A41_I0.5670.97
62_F65_Y0.5490.97
20_L25_M0.5460.97
35_N38_K0.5460.97
21_K73_Q0.5420.96
69_T72_L0.5420.96
76_I81_N0.5390.96
12_T41_I0.5390.96
28_G32_E0.5360.96
18_D78_W0.5350.96
42_S46_N0.5320.96
25_M30_I0.5270.96
49_K54_I0.5250.96
6_K10_D0.5250.96
78_W81_N0.5230.96
29_D64_Y0.5140.95
7_A48_L0.5130.95
14_R78_W0.5100.95
72_L82_F0.5080.95
43_H58_R0.5060.95
17_L75_S0.5040.95
22_G25_M0.5000.94
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3f6vA 2 1 99.7 0.473 Contact Map
2kkoA 2 1 99.7 0.477 Contact Map
1r1tA 2 0.9556 99.7 0.477 Contact Map
1u2wA 2 0.9667 99.7 0.487 Contact Map
2jscA 2 1 99.6 0.494 Contact Map
4k2eA 2 0.9444 99.6 0.494 Contact Map
2zkzA 2 0.9 99.6 0.499 Contact Map
2qlzA 2 0.9667 99.6 0.503 Contact Map
1r1uA 2 0.9667 99.6 0.504 Contact Map
3pqkA 2 1 99.6 0.505 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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