GREMLIN Database
SDPI - Immunity protein SdpI
UniProt: O32241 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 207 (198)
Sequences: 556 (492)
Seq/√Len: 35.0

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
39_A44_K5.0731.00
41_I44_K4.5011.00
39_A45_P4.1111.00
34_S38_P3.8791.00
130_Q145_E3.7691.00
41_I45_P3.5591.00
40_A44_K3.5081.00
162_C188_A3.1921.00
41_I47_T3.0531.00
40_A45_P2.9911.00
31_I42_V2.8591.00
115_G166_I2.6361.00
195_A199_Y2.6301.00
39_A42_V2.5971.00
18_S52_P2.4231.00
159_L192_S2.3861.00
115_G167_A2.3330.99
155_A159_L2.2680.99
30_P99_S2.2660.99
43_S47_T2.1990.99
31_I41_I2.1000.99
42_V45_P2.0920.99
126_Q156_S2.0880.99
141_T152_N2.0600.99
140_W196_S2.0540.99
123_N153_R2.0420.98
125_M128_A1.9190.98
68_K132_H1.9010.98
115_G163_G1.8880.97
18_S92_Q1.8510.97
39_A47_T1.8490.97
44_K47_T1.7990.97
154_F191_I1.7920.96
123_N127_L1.7240.96
74_K77_L1.7100.95
159_L188_A1.6240.94
68_K133_L1.5840.93
119_I160_V1.5560.92
152_N159_L1.5520.92
69_S132_H1.5390.92
132_H143_K1.5150.91
141_T151_G1.4880.91
39_A43_S1.4780.90
53_V57_I1.4370.89
115_G170_S1.4280.89
159_L162_C1.4260.89
49_F52_P1.4250.89
61_T65_L1.4130.88
32_Q39_A1.3740.87
52_P127_L1.3500.86
31_I47_T1.2950.83
69_S139_P1.2910.83
182_I186_L1.2750.82
31_I43_S1.2640.82
34_S39_A1.2600.81
16_L20_I1.2580.81
141_T144_D1.2510.81
70_T132_H1.2470.81
59_Y85_L1.2440.81
9_I202_K1.2440.81
182_I189_L1.2340.80
9_I12_C1.2300.80
40_A47_T1.2250.79
140_W197_Y1.2130.79
68_K73_N1.2040.78
33_W95_T1.1790.77
52_P92_Q1.1680.76
84_M87_L1.1340.74
125_M174_G1.1180.73
162_C192_S1.1110.72
123_N129_E1.1040.72
131_N135_G1.0950.71
33_W139_P1.0940.71
104_V109_I1.0920.71
146_T149_K1.0870.71
52_P55_M1.0810.70
162_C184_L1.0760.70
18_S48_I1.0740.70
73_N143_K1.0680.69
29_I99_S1.0500.68
136_L152_N1.0420.67
138_T147_V1.0400.67
9_I172_F1.0340.67
135_G196_S1.0280.66
123_N160_V1.0220.66
188_A192_S1.0160.65
151_G196_S0.9830.63
84_M156_S0.9790.63
30_P39_A0.9720.62
43_S51_I0.9680.62
185_V189_L0.9630.61
126_Q147_V0.9570.61
97_L100_L0.9520.60
135_G148_W0.9510.60
87_L91_L0.9500.60
30_P41_I0.9470.60
30_P199_Y0.9450.60
125_M159_L0.9380.59
40_A43_S0.9360.59
141_T147_V0.9220.58
135_G152_N0.9170.57
178_I182_I0.9150.57
186_L190_V0.9150.57
127_L149_K0.9010.56
56_L91_L0.8950.56
62_F84_M0.8850.55
143_K147_V0.8840.55
142_L152_N0.8830.55
121_G171_F0.8790.54
147_V199_Y0.8770.54
119_I167_A0.8760.54
14_S89_Y0.8690.53
135_G140_W0.8670.53
11_V59_Y0.8660.53
30_P40_A0.8640.53
69_S151_G0.8480.52
161_V164_F0.8470.51
139_P152_N0.8470.51
141_T155_A0.8430.51
32_Q40_A0.8430.51
138_T193_T0.8370.51
138_T201_K0.8350.50
64_M161_V0.8330.50
29_I48_I0.8270.50
14_S23_Q0.8260.50
113_G126_Q0.8260.50
137_R193_T0.8250.50
140_W151_G0.8240.49
119_I163_G0.8240.49
63_Y81_S0.8240.49
59_Y127_L0.8230.49
146_T150_L0.8130.49
136_L151_G0.8100.48
121_G190_V0.8090.48
121_G125_M0.8070.48
57_I61_T0.8070.48
8_I16_L0.8030.48
141_T158_V0.7990.47
59_Y147_V0.7930.47
33_W132_H0.7890.46
144_D147_V0.7860.46
30_P43_S0.7830.46
33_W101_G0.7800.46
53_V176_Y0.7770.45
22_Y127_L0.7760.45
8_I59_Y0.7720.45
69_S152_N0.7650.44
134_I182_I0.7610.44
73_N100_L0.7570.44
28_E201_K0.7420.43
24_Y64_M0.7410.42
80_A84_M0.7300.42
7_S59_Y0.7260.41
59_Y81_S0.7250.41
21_L24_Y0.7200.41
11_V147_V0.7170.40
104_V125_M0.7120.40
97_L197_Y0.7050.39
155_A192_S0.7050.39
7_S96_L0.7000.39
169_L184_L0.6960.39
15_F33_W0.6910.38
69_S141_T0.6880.38
129_E145_E0.6880.38
135_G151_G0.6870.38
156_S160_V0.6860.38
162_C166_I0.6840.38
123_N126_Q0.6830.38
131_N148_W0.6810.38
167_A202_K0.6800.37
79_L124_S0.6790.37
171_F193_T0.6770.37
18_S59_Y0.6770.37
194_L198_H0.6730.37
164_F168_V0.6680.36
21_L119_I0.6620.36
124_S127_L0.6610.36
59_Y138_T0.6580.36
9_I200_Y0.6570.36
14_S93_L0.6560.36
148_W152_N0.6560.36
12_C22_Y0.6550.35
80_A87_L0.6500.35
30_P98_I0.6470.35
29_I83_N0.6460.35
116_I186_L0.6430.35
166_I181_M0.6420.34
85_L88_L0.6410.34
10_I16_L0.6390.34
75_A83_N0.6380.34
68_K74_K0.6380.34
154_F158_V0.6350.34
82_N85_L0.6340.34
87_L172_F0.6340.34
110_I113_G0.6330.34
116_I167_A0.6250.33
68_K71_Q0.6210.33
140_W148_W0.6180.33
17_T21_L0.6170.33
22_Y29_I0.6150.32
107_D158_V0.6150.32
67_I138_T0.6140.32
10_I114_V0.6140.32
72_K90_I0.6110.32
159_L189_L0.6100.32
48_I96_L0.6070.32
29_I194_L0.6050.32
93_L165_I0.6050.32
169_L180_I0.6050.32
105_N108_L0.6040.32
29_I36_N0.6020.31
81_S159_L0.6020.31
130_Q143_K0.6010.31
139_P154_F0.6000.31
70_T124_S0.5990.31
10_I89_Y0.5970.31
89_Y152_N0.5960.31
16_L90_I0.5940.31
77_L96_L0.5930.31
110_I114_V0.5930.31
127_L130_Q0.5910.31
62_F78_F0.5900.31
43_S46_L0.5900.31
33_W59_Y0.5890.30
101_G104_V0.5870.30
44_K155_A0.5840.30
5_I24_Y0.5840.30
90_I109_I0.5820.30
82_N147_V0.5820.30
54_V80_A0.5800.30
132_H147_V0.5790.30
110_I116_I0.5770.30
58_Y161_V0.5720.29
59_Y80_A0.5710.29
109_I125_M0.5700.29
113_G117_F0.5680.29
67_I193_T0.5670.29
69_S140_W0.5630.29
14_S127_L0.5620.29
51_I104_V0.5610.28
145_E151_G0.5590.28
57_I86_I0.5580.28
49_F177_I0.5570.28
33_W98_I0.5570.28
125_M186_L0.5570.28
69_S142_L0.5560.28
198_H201_K0.5550.28
31_I39_A0.5530.28
122_G159_L0.5520.28
149_K172_F0.5500.28
179_L183_V0.5490.28
87_L117_F0.5490.28
95_T146_T0.5480.28
74_K95_T0.5460.27
5_I34_S0.5430.27
12_C53_V0.5420.27
158_V198_H0.5420.27
108_L136_L0.5410.27
118_L159_L0.5400.27
150_L199_Y0.5400.27
103_E116_I0.5390.27
31_I180_I0.5390.27
147_V151_G0.5380.27
129_E149_K0.5370.27
116_I144_D0.5370.27
137_R148_W0.5360.27
137_R183_V0.5360.27
141_T148_W0.5350.27
90_I171_F0.5340.27
23_Q117_F0.5340.27
197_Y201_K0.5330.27
151_G195_A0.5310.26
60_L90_I0.5300.26
146_T167_A0.5300.26
27_E109_I0.5290.26
35_G182_I0.5260.26
48_I52_P0.5230.26
125_M191_I0.5210.26
61_T173_T0.5200.26
52_P105_N0.5190.26
114_V165_I0.5190.26
77_L138_T0.5180.26
73_N77_L0.5170.25
48_I104_V0.5160.25
112_L167_A0.5160.25
19_I59_Y0.5150.25
20_I57_I0.5140.25
79_L99_S0.5100.25
17_T52_P0.5090.25
93_L134_I0.5080.25
33_W67_I0.5070.25
121_G155_A0.5060.25
144_D148_W0.5040.25
30_P95_T0.5030.25
132_H136_L0.5010.24
36_N180_I0.5010.24
60_L176_Y0.5000.24
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
4o6yA 2 0.8647 51.9 0.938 Contact Map
4k0jA 3 0.8599 42.5 0.942 Contact Map
2xq2A 2 0.8502 37.3 0.943 Contact Map
3w9iA 3 0.9034 33.8 0.945 Contact Map
3ne5A 3 0.9324 27.4 0.947 Contact Map
4dx5A 3 0.913 24.5 0.948 Contact Map
3v2yA 1 0.8406 22.4 0.949 Contact Map
4httA 1 0.8889 19.6 0.951 Contact Map
4tphA 2 0.8309 15.9 0.953 Contact Map
1fftB 1 0.1836 15.7 0.953 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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