SDPI - BACSU - GREMLIN Contacts

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SDPI - Immunity protein SdpI

UniProt:	O32241	Sequences: MKKNIISIIIVCLSFLTSIILYQYLPEEIPIQWSGNKPAAIVSKPLTIFIIPVVMLIYYLTFYMLTIKSTQKNKALLFLASNNMLILLYILQLSTLLISLGYEVNIDLIIGLGVGIFLIIGGNSMQLAEQNHLIGLRTPWTLKDETVWKLGNRFASKVLVVCGFIIAVLSFFTGEYIILIMIVLVLLALVISTLASYHYYKKLNGSR	Download Alignment We filter this alignment to remove sites that have many gaps before running GREMLIN. Date: 2015_01
Length:	207 (198)
Sequences:	556 (492)
Seq/√Len:	35.0

BACSU - SDPI

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:

i	j	Sco	Prob
39_A	44_K	5.073	1.00
41_I	44_K	4.501	1.00
39_A	45_P	4.111	1.00
34_S	38_P	3.879	1.00
130_Q	145_E	3.769	1.00
41_I	45_P	3.559	1.00
40_A	44_K	3.508	1.00
162_C	188_A	3.192	1.00
41_I	47_T	3.053	1.00
40_A	45_P	2.991	1.00
31_I	42_V	2.859	1.00
115_G	166_I	2.636	1.00
195_A	199_Y	2.630	1.00
39_A	42_V	2.597	1.00
18_S	52_P	2.423	1.00
159_L	192_S	2.386	1.00
115_G	167_A	2.333	0.99
155_A	159_L	2.268	0.99
30_P	99_S	2.266	0.99
43_S	47_T	2.199	0.99
31_I	41_I	2.100	0.99
42_V	45_P	2.092	0.99
126_Q	156_S	2.088	0.99
141_T	152_N	2.060	0.99
140_W	196_S	2.054	0.99
123_N	153_R	2.042	0.98
125_M	128_A	1.919	0.98
68_K	132_H	1.901	0.98
115_G	163_G	1.888	0.97
18_S	92_Q	1.851	0.97
39_A	47_T	1.849	0.97
44_K	47_T	1.799	0.97
154_F	191_I	1.792	0.96
123_N	127_L	1.724	0.96
74_K	77_L	1.710	0.95
159_L	188_A	1.624	0.94
68_K	133_L	1.584	0.93
119_I	160_V	1.556	0.92
152_N	159_L	1.552	0.92
69_S	132_H	1.539	0.92
132_H	143_K	1.515	0.91
141_T	151_G	1.488	0.91
39_A	43_S	1.478	0.90
53_V	57_I	1.437	0.89
115_G	170_S	1.428	0.89
159_L	162_C	1.426	0.89
49_F	52_P	1.425	0.89
61_T	65_L	1.413	0.88
32_Q	39_A	1.374	0.87
52_P	127_L	1.350	0.86
31_I	47_T	1.295	0.83
69_S	139_P	1.291	0.83
182_I	186_L	1.275	0.82
31_I	43_S	1.264	0.82
34_S	39_A	1.260	0.81
16_L	20_I	1.258	0.81
141_T	144_D	1.251	0.81
70_T	132_H	1.247	0.81
59_Y	85_L	1.244	0.81
9_I	202_K	1.244	0.81
182_I	189_L	1.234	0.80
9_I	12_C	1.230	0.80
40_A	47_T	1.225	0.79
140_W	197_Y	1.213	0.79
68_K	73_N	1.204	0.78
33_W	95_T	1.179	0.77
52_P	92_Q	1.168	0.76
84_M	87_L	1.134	0.74
125_M	174_G	1.118	0.73
162_C	192_S	1.111	0.72
123_N	129_E	1.104	0.72
131_N	135_G	1.095	0.71
33_W	139_P	1.094	0.71
104_V	109_I	1.092	0.71
146_T	149_K	1.087	0.71
52_P	55_M	1.081	0.70
162_C	184_L	1.076	0.70
18_S	48_I	1.074	0.70
73_N	143_K	1.068	0.69
29_I	99_S	1.050	0.68
136_L	152_N	1.042	0.67
138_T	147_V	1.040	0.67
9_I	172_F	1.034	0.67
135_G	196_S	1.028	0.66
123_N	160_V	1.022	0.66
188_A	192_S	1.016	0.65
151_G	196_S	0.983	0.63
84_M	156_S	0.979	0.63
30_P	39_A	0.972	0.62
43_S	51_I	0.968	0.62
185_V	189_L	0.963	0.61
126_Q	147_V	0.957	0.61
97_L	100_L	0.952	0.60
135_G	148_W	0.951	0.60
87_L	91_L	0.950	0.60
30_P	41_I	0.947	0.60
30_P	199_Y	0.945	0.60
125_M	159_L	0.938	0.59
40_A	43_S	0.936	0.59
141_T	147_V	0.922	0.58
135_G	152_N	0.917	0.57
178_I	182_I	0.915	0.57
186_L	190_V	0.915	0.57
127_L	149_K	0.901	0.56
56_L	91_L	0.895	0.56
62_F	84_M	0.885	0.55
143_K	147_V	0.884	0.55
142_L	152_N	0.883	0.55
121_G	171_F	0.879	0.54
147_V	199_Y	0.877	0.54
119_I	167_A	0.876	0.54
14_S	89_Y	0.869	0.53
135_G	140_W	0.867	0.53
11_V	59_Y	0.866	0.53
30_P	40_A	0.864	0.53
69_S	151_G	0.848	0.52
161_V	164_F	0.847	0.51
139_P	152_N	0.847	0.51
141_T	155_A	0.843	0.51
32_Q	40_A	0.843	0.51
138_T	193_T	0.837	0.51
138_T	201_K	0.835	0.50
64_M	161_V	0.833	0.50
29_I	48_I	0.827	0.50
14_S	23_Q	0.826	0.50
113_G	126_Q	0.826	0.50
137_R	193_T	0.825	0.50
140_W	151_G	0.824	0.49
119_I	163_G	0.824	0.49
63_Y	81_S	0.824	0.49
59_Y	127_L	0.823	0.49
146_T	150_L	0.813	0.49
136_L	151_G	0.810	0.48
121_G	190_V	0.809	0.48
121_G	125_M	0.807	0.48
57_I	61_T	0.807	0.48
8_I	16_L	0.803	0.48
141_T	158_V	0.799	0.47
59_Y	147_V	0.793	0.47
33_W	132_H	0.789	0.46
144_D	147_V	0.786	0.46
30_P	43_S	0.783	0.46
33_W	101_G	0.780	0.46
53_V	176_Y	0.777	0.45
22_Y	127_L	0.776	0.45
8_I	59_Y	0.772	0.45
69_S	152_N	0.765	0.44
134_I	182_I	0.761	0.44
73_N	100_L	0.757	0.44
28_E	201_K	0.742	0.43
24_Y	64_M	0.741	0.42
80_A	84_M	0.730	0.42
7_S	59_Y	0.726	0.41
59_Y	81_S	0.725	0.41
21_L	24_Y	0.720	0.41
11_V	147_V	0.717	0.40
104_V	125_M	0.712	0.40
97_L	197_Y	0.705	0.39
155_A	192_S	0.705	0.39
7_S	96_L	0.700	0.39
169_L	184_L	0.696	0.39
15_F	33_W	0.691	0.38
69_S	141_T	0.688	0.38
129_E	145_E	0.688	0.38
135_G	151_G	0.687	0.38
156_S	160_V	0.686	0.38
162_C	166_I	0.684	0.38
123_N	126_Q	0.683	0.38
131_N	148_W	0.681	0.38
167_A	202_K	0.680	0.37
79_L	124_S	0.679	0.37
171_F	193_T	0.677	0.37
18_S	59_Y	0.677	0.37
194_L	198_H	0.673	0.37
164_F	168_V	0.668	0.36
21_L	119_I	0.662	0.36
124_S	127_L	0.661	0.36
59_Y	138_T	0.658	0.36
9_I	200_Y	0.657	0.36
14_S	93_L	0.656	0.36
148_W	152_N	0.656	0.36
12_C	22_Y	0.655	0.35
80_A	87_L	0.650	0.35
30_P	98_I	0.647	0.35
29_I	83_N	0.646	0.35
116_I	186_L	0.643	0.35
166_I	181_M	0.642	0.34
85_L	88_L	0.641	0.34
10_I	16_L	0.639	0.34
75_A	83_N	0.638	0.34
68_K	74_K	0.638	0.34
154_F	158_V	0.635	0.34
82_N	85_L	0.634	0.34
87_L	172_F	0.634	0.34
110_I	113_G	0.633	0.34
116_I	167_A	0.625	0.33
68_K	71_Q	0.621	0.33
140_W	148_W	0.618	0.33
17_T	21_L	0.617	0.33
22_Y	29_I	0.615	0.32
107_D	158_V	0.615	0.32
67_I	138_T	0.614	0.32
10_I	114_V	0.614	0.32
72_K	90_I	0.611	0.32
159_L	189_L	0.610	0.32
48_I	96_L	0.607	0.32
29_I	194_L	0.605	0.32
93_L	165_I	0.605	0.32
169_L	180_I	0.605	0.32
105_N	108_L	0.604	0.32
29_I	36_N	0.602	0.31
81_S	159_L	0.602	0.31
130_Q	143_K	0.601	0.31
139_P	154_F	0.600	0.31
70_T	124_S	0.599	0.31
10_I	89_Y	0.597	0.31
89_Y	152_N	0.596	0.31
16_L	90_I	0.594	0.31
77_L	96_L	0.593	0.31
110_I	114_V	0.593	0.31
127_L	130_Q	0.591	0.31
62_F	78_F	0.590	0.31
43_S	46_L	0.590	0.31
33_W	59_Y	0.589	0.30
101_G	104_V	0.587	0.30
44_K	155_A	0.584	0.30
5_I	24_Y	0.584	0.30
90_I	109_I	0.582	0.30
82_N	147_V	0.582	0.30
54_V	80_A	0.580	0.30
132_H	147_V	0.579	0.30
110_I	116_I	0.577	0.30
58_Y	161_V	0.572	0.29
59_Y	80_A	0.571	0.29
109_I	125_M	0.570	0.29
113_G	117_F	0.568	0.29
67_I	193_T	0.567	0.29
69_S	140_W	0.563	0.29
14_S	127_L	0.562	0.29
51_I	104_V	0.561	0.28
145_E	151_G	0.559	0.28
57_I	86_I	0.558	0.28
49_F	177_I	0.557	0.28
33_W	98_I	0.557	0.28
125_M	186_L	0.557	0.28
69_S	142_L	0.556	0.28
198_H	201_K	0.555	0.28
31_I	39_A	0.553	0.28
122_G	159_L	0.552	0.28
149_K	172_F	0.550	0.28
179_L	183_V	0.549	0.28
87_L	117_F	0.549	0.28
95_T	146_T	0.548	0.28
74_K	95_T	0.546	0.27
5_I	34_S	0.543	0.27
12_C	53_V	0.542	0.27
158_V	198_H	0.542	0.27
108_L	136_L	0.541	0.27
118_L	159_L	0.540	0.27
150_L	199_Y	0.540	0.27
103_E	116_I	0.539	0.27
31_I	180_I	0.539	0.27
147_V	151_G	0.538	0.27
129_E	149_K	0.537	0.27
116_I	144_D	0.537	0.27
137_R	148_W	0.536	0.27
137_R	183_V	0.536	0.27
141_T	148_W	0.535	0.27
90_I	171_F	0.534	0.27
23_Q	117_F	0.534	0.27
197_Y	201_K	0.533	0.27
151_G	195_A	0.531	0.26
60_L	90_I	0.530	0.26
146_T	167_A	0.530	0.26
27_E	109_I	0.529	0.26
35_G	182_I	0.526	0.26
48_I	52_P	0.523	0.26
125_M	191_I	0.521	0.26
61_T	173_T	0.520	0.26
52_P	105_N	0.519	0.26
114_V	165_I	0.519	0.26
77_L	138_T	0.518	0.26
73_N	77_L	0.517	0.25
48_I	104_V	0.516	0.25
112_L	167_A	0.516	0.25
19_I	59_Y	0.515	0.25
20_I	57_I	0.514	0.25
79_L	99_S	0.510	0.25
17_T	52_P	0.509	0.25
93_L	134_I	0.508	0.25
33_W	67_I	0.507	0.25
121_G	155_A	0.506	0.25
144_D	148_W	0.504	0.25
30_P	95_T	0.503	0.25
132_H	136_L	0.501	0.24
36_N	180_I	0.501	0.24
60_L	176_Y	0.500	0.24

Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

Text file of predictions (all 3L/2 predictions)
Generate restraints for ROSETTA Structure Modeling
Upload PDB model overlay contacts on the model

HHsearch Results:

Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.

PDB	Chains	Cov	%	HHΔ
4o6yA	2	0.8647	51.9	0.938	Contact Map
4k0jA	3	0.8599	42.5	0.942	Contact Map
2xq2A	2	0.8502	37.3	0.943	Contact Map
3w9iA	3	0.9034	33.8	0.945	Contact Map
3ne5A	3	0.9324	27.4	0.947	Contact Map
4dx5A	3	0.913	24.5	0.948	Contact Map
3v2yA	1	0.8406	22.4	0.949	Contact Map
4httA	1	0.8889	19.6	0.951	Contact Map
4tphA	2	0.8309	15.9	0.953	Contact Map
1fftB	1	0.1836	15.7	0.953	Contact Map

Sequence Conservation (Image Generated using WebLogo v3)

Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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