GREMLIN Database
YVAM - AB hydrolase superfamily protein YvaM
UniProt: O32234 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 256 (238)
Sequences: 61297 (49763)
Seq/√Len: 3225.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
16_E47_R4.7281.00
88_V112_H4.1471.00
54_S74_E3.5471.00
39_Q244_N2.9881.00
76_A102_I2.8321.00
204_G229_E2.7041.00
239_Q242_T2.6621.00
88_V111_S2.6571.00
226_F246_L2.5961.00
117_G206_R2.5911.00
199_L250_F2.5141.00
86_K111_S2.5101.00
116_S243_C2.3431.00
228_L246_L2.2581.00
11_H60_D2.1921.00
102_I106_R2.1081.00
15_E33_R2.1001.00
76_A109_K2.0841.00
76_A106_R2.0501.00
76_A80_D2.0261.00
204_G227_R2.0221.00
79_M87_A2.0111.00
89_L99_A2.0111.00
80_D109_K1.9561.00
96_G118_A1.9411.00
217_R223_A1.9331.00
13_F58_D1.9231.00
14_Y78_F1.8661.00
101_H105_T1.8261.00
45_H248_T1.8121.00
16_E49_I1.8111.00
22_P49_I1.8091.00
21_I88_V1.7941.00
17_Y50_F1.7811.00
73_N105_T1.7671.00
41_L244_N1.7431.00
88_V251_V1.7411.00
231_Q239_Q1.7261.00
22_P84_I1.7251.00
21_I111_S1.7081.00
103_G113_L1.7031.00
22_P47_R1.6751.00
211_T227_R1.6641.00
13_F33_R1.6581.00
88_V114_I1.6441.00
199_L226_F1.6151.00
198_M220_C1.6141.00
27_H53_L1.5961.00
27_H56_H1.5781.00
99_A113_L1.5741.00
246_L249_G1.5681.00
46_F88_V1.5651.00
215_Y219_S1.5261.00
69_S105_T1.5041.00
53_L98_I1.4841.00
72_A101_H1.4691.00
31_M35_V1.4381.00
51_P75_I1.4281.00
26_I53_L1.4251.00
245_E249_G1.4081.00
102_I110_V1.4041.00
106_R109_K1.4031.00
26_I75_I1.3981.00
75_I102_I1.3701.00
202_Y213_A1.3511.00
102_I109_K1.3411.00
41_L248_T1.3321.00
156_D159_L1.3211.00
13_F52_D1.3081.00
114_I247_V1.2881.00
80_D106_R1.2791.00
92_Y236_P1.2751.00
33_R52_D1.2621.00
49_I78_F1.2531.00
190_Q193_R1.2511.00
101_H104_F1.2441.00
30_G56_H1.2401.00
115_L118_A1.2341.00
18_G47_R1.2301.00
10_K54_S1.2261.00
242_T246_L1.2241.00
100_Q115_L1.2211.00
211_T214_G1.1961.00
25_F48_V1.1931.00
21_I46_F1.1911.00
26_I99_A1.1901.00
12_L74_E1.1771.00
220_C223_A1.1741.00
41_L44_K1.1721.00
242_T245_E1.1681.00
25_F90_F1.1671.00
67_S70_Y1.1631.00
114_I199_L1.1601.00
78_F82_L1.1431.00
90_F116_S1.1381.00
33_R58_D1.1351.00
192_P219_S1.1331.00
93_S233_H1.1301.00
84_I87_A1.1141.00
104_F190_Q1.1101.00
214_G218_R1.1071.00
20_G47_R1.1051.00
30_G93_S1.1011.00
217_R225_F1.0921.00
23_I46_F1.0871.00
51_P78_F1.0841.00
24_I79_M1.0821.00
228_L231_Q1.0781.00
173_A177_Q1.0721.00
87_A110_V1.0641.00
202_Y227_R1.0631.00
202_Y225_F1.0581.00
28_P93_S1.0531.00
215_Y218_R1.0431.00
35_V236_P1.0431.00
144_L148_I1.0291.00
41_L241_K1.0191.00
21_I86_K1.0071.00
201_M228_L0.9971.00
14_Y82_L0.9941.00
243_C247_V0.9921.00
17_Y43_S0.9901.00
46_F251_V0.9851.00
241_K245_E0.9841.00
224_E246_L0.9831.00
90_F247_V0.9771.00
202_Y211_T0.9731.00
26_I89_L0.9691.00
69_S101_H0.9681.00
79_M84_I0.9681.00
33_R50_F0.9681.00
79_M102_I0.9581.00
52_D57_G0.9521.00
72_A98_I0.9521.00
76_A79_M0.9431.00
232_G238_K0.9401.00
116_S236_P0.9381.00
228_L242_T0.9361.00
92_Y234_Q0.9351.00
199_L224_E0.9331.00
76_A105_T0.9311.00
112_H197_P0.9291.00
214_G225_F0.9201.00
24_I87_A0.9161.00
214_G227_R0.9141.00
231_Q238_K0.9121.00
91_G99_A0.9041.00
43_S48_V0.9021.00
87_A109_K0.9011.00
226_F249_G0.9001.00
214_G217_R0.8941.00
204_G230_Y0.8851.00
10_K60_D0.8821.00
144_L147_K0.8761.00
53_L94_A0.8711.00
162_I166_H0.8711.00
77_Q80_D0.8701.00
161_S164_T0.8661.00
12_L59_S0.8661.00
177_Q180_L0.8641.00
142_P146_M0.8571.00
178_Y181_D0.8531.00
176_H180_L0.8531.00
77_Q81_A0.8501.00
37_Y50_F0.8411.00
231_Q235_L0.8401.00
143_G147_K0.8381.00
40_R43_S0.8291.00
116_S235_L0.8291.00
49_I82_L0.8291.00
133_L137_L0.8231.00
171_D174_H0.8171.00
201_M246_L0.8161.00
113_L198_M0.8141.00
23_I90_F0.8101.00
91_G96_G0.8081.00
200_F223_A0.8011.00
213_A225_F0.7981.00
162_I165_D0.7961.00
175_W179_Y0.7951.00
72_A105_T0.7901.00
160_R164_T0.7891.00
70_Y73_N0.7881.00
21_I112_H0.7881.00
22_P46_F0.7861.00
157_R161_S0.7831.00
112_H250_F0.7811.00
103_G110_V0.7781.00
23_I48_V0.7761.00
26_I51_P0.7701.00
22_P87_A0.7691.00
226_F242_T0.7691.00
101_H190_Q0.7691.00
174_H178_Y0.7651.00
73_N77_Q0.7641.00
175_W178_Y0.7581.00
24_I75_I0.7551.00
73_N76_A0.7541.00
33_R51_P0.7501.00
30_G94_A0.7501.00
40_R44_K0.7491.00
204_G211_T0.7411.00
161_S165_D0.7391.00
36_F39_Q0.7381.00
155_K159_L0.7331.00
203_G235_L0.7301.00
89_L102_I0.7281.00
244_N248_T0.7281.00
114_I251_V0.7271.00
187_C190_Q0.7271.00
71_Y94_A0.7241.00
151_G154_T0.7221.00
150_A153_H0.7211.00
166_H169_K0.7211.00
29_P94_A0.7211.00
174_H177_Q0.7151.00
52_D58_D0.7151.00
117_G235_L0.7131.00
53_L71_Y0.7121.00
180_L183_L0.6991.00
228_L239_Q0.6981.00
19_Q47_R0.6981.00
166_H170_A0.6961.00
132_K136_Y0.6951.00
195_E221_R0.6951.00
117_G202_Y0.6931.00
23_I251_V0.6921.00
153_H156_D0.6911.00
92_Y117_G0.6891.00
89_L110_V0.6881.00
144_L149_L0.6801.00
72_A102_I0.6791.00
83_H86_K0.6771.00
27_H51_P0.6771.00
34_K37_Y0.6751.00
103_G196_M0.6681.00
46_F248_T0.6681.00
164_T168_K0.6681.00
12_L54_S0.6671.00
44_K248_T0.6611.00
112_H251_V0.6611.00
17_Y40_R0.6591.00
131_H134_G0.6571.00
69_S73_N0.6541.00
240_W244_N0.6541.00
114_I250_F0.6531.00
186_N190_Q0.6521.00
180_L184_G0.6521.00
179_Y182_S0.6511.00
156_D160_R0.6481.00
134_G137_L0.6441.00
181_D184_G0.6411.00
87_A111_S0.6411.00
230_Y239_Q0.6401.00
65_P70_Y0.6391.00
15_E37_Y0.6371.00
104_F193_R0.6371.00
110_V196_M0.6361.00
49_I84_I0.6351.00
142_P145_L0.6351.00
13_F59_S0.6341.00
90_F114_I0.6331.00
117_G203_G0.6321.00
152_S155_K0.6291.00
201_M243_C0.6281.00
177_Q181_D0.6261.00
23_I88_V0.6251.00
115_L200_F0.6221.00
189_E192_P0.6221.00
245_E248_T0.6191.00
100_Q120_P0.6181.00
25_F36_F0.6141.00
92_Y116_S0.6121.00
37_Y40_R0.6101.00
160_R163_L0.6081.00
127_G131_H0.6071.00
157_R160_R0.6061.00
97_L119_Y0.6061.00
167_M170_A0.6051.00
133_L136_Y0.6051.00
205_L230_Y0.6051.00
158_Q162_I0.6051.00
39_Q243_C0.6021.00
163_L167_M0.6021.00
130_L134_G0.6011.00
91_G95_G0.6001.00
152_S156_D0.5981.00
165_D169_K0.5951.00
85_D109_K0.5931.00
53_L56_H0.5921.00
96_G115_L0.5911.00
71_Y98_I0.5891.00
145_L148_I0.5881.00
24_I89_L0.5871.00
131_H135_M0.5851.00
68_I101_H0.5821.00
165_D168_K0.5801.00
87_A102_I0.5731.00
70_Y74_E0.5711.00
213_A217_R0.5691.00
138_L142_P0.5691.00
178_Y182_S0.5691.00
93_S234_Q0.5671.00
200_F225_F0.5661.00
47_R84_I0.5651.00
200_F213_A0.5621.00
163_L166_H0.5611.00
100_Q118_A0.5591.00
15_E50_F0.5591.00
114_I201_M0.5581.00
145_L149_L0.5561.00
16_E82_L0.5541.00
151_G155_K0.5531.00
86_K109_K0.5531.00
24_I51_P0.5521.00
155_K158_Q0.5511.00
188_I219_S0.5511.00
173_A176_H0.5481.00
78_F81_A0.5481.00
25_F50_F0.5481.00
72_A76_A0.5471.00
155_K160_R0.5461.00
194_L220_C0.5441.00
45_H48_V0.5441.00
54_S71_Y0.5431.00
188_I215_Y0.5411.00
29_P93_S0.5411.00
235_L243_C0.5391.00
236_P243_C0.5391.00
159_L163_L0.5371.00
200_F217_R0.5361.00
150_A156_D0.5361.00
201_M226_F0.5351.00
143_G146_M0.5311.00
159_L162_I0.5311.00
73_N106_R0.5311.00
151_G156_D0.5301.00
142_P147_K0.5261.00
31_M234_Q0.5261.00
79_M109_K0.5241.00
216_Y220_C0.5211.00
244_N249_G0.5161.00
26_I98_I0.5141.00
155_K163_L0.5121.00
129_K133_L0.5121.00
112_H199_L0.5111.00
247_V251_V0.5111.00
146_M149_L0.5101.00
132_K135_M0.5091.00
186_N189_E0.5091.00
35_V92_Y0.5091.00
205_L229_E0.5071.00
142_P148_I0.5071.00
53_L75_I0.5051.00
200_F220_C0.5011.00
172_Q176_H0.5001.00
99_A115_L0.5001.00
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
1ehyA 1 0.9531 100 0.176 Contact Map
4inzA 1 0.9844 100 0.184 Contact Map
3oosA 1 0.9766 100 0.184 Contact Map
2pujA 4 0.9883 100 0.185 Contact Map
2xuaA 2 0.9766 100 0.186 Contact Map
1zoiA 3 0.9844 100 0.2 Contact Map
3om8A 4 0.9805 100 0.202 Contact Map
2xmzA 1 0.9688 100 0.211 Contact Map
4psuA 1 0.9766 100 0.212 Contact Map
1iupA 2 0.9766 100 0.213 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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