GREMLIN Database
SECG - Probable protein-export membrane protein SecG
UniProt: O32233 Sequences:
Download Alignment
We filter this alignment to remove sites that have many gaps before running GREMLIN.

Date: 2015_01
Length: 76 (73)
Sequences: 460 (271)
Seq/√Len: 31.7

GREMLIN Results:

Legend: The darker and larger the blue dots, the higher coevolution strength.

Residue pairs sorted by coevolution strength:
i j Sco Prob
41_L49_G2.8661.00
24_S51_D2.6591.00
67_V71_A2.6211.00
9_L69_T2.4940.99
63_V67_V2.3880.99
12_V64_L2.3540.99
60_V64_L2.3380.99
51_D55_H2.1730.99
12_V68_L1.8990.97
53_I57_I1.8780.96
45_Q49_G1.8130.96
42_F49_G1.7920.95
8_L11_I1.6900.93
12_V61_L1.6100.92
34_I43_G1.5300.89
29_G32_G1.5060.89
41_L45_Q1.4680.87
7_T11_I1.4440.87
3_A70_I1.4200.86
31_S34_I1.3220.81
30_L34_I1.3160.81
38_A43_G1.3020.80
16_L62_A1.2640.78
9_L72_L1.2130.75
52_L56_R1.2040.75
40_Q49_G1.2000.74
40_Q45_Q1.1990.74
42_F52_L1.1370.70
15_A61_L1.1360.70
56_R63_V1.1130.69
57_I61_L1.0880.67
2_H72_L1.0730.66
3_A7_T1.0570.64
21_L25_S1.0340.63
2_H6_I1.0280.62
14_I18_I1.0120.61
13_S69_T1.0020.60
20_V61_L1.0020.60
11_I61_L0.9990.60
15_A57_I0.9980.60
23_Q58_T0.9930.60
53_I66_F0.9800.59
46_K67_V0.9790.58
28_A32_G0.9780.58
27_S43_G0.9530.56
56_R60_V0.9500.56
9_L13_S0.9470.56
19_V57_I0.9130.53
26_K33_A0.9010.52
8_L12_V0.8890.51
42_F56_R0.8560.48
22_L55_H0.8420.47
21_L65_F0.8330.47
40_Q43_G0.8140.45
42_F47_A0.8120.45
63_V68_L0.7950.44
42_F45_Q0.7910.43
24_S50_L0.7710.42
19_V54_L0.7690.41
5_L63_V0.7630.41
18_I25_S0.7480.40
17_I42_F0.7370.39
13_S43_G0.7340.39
2_H7_T0.7290.38
68_L72_L0.7280.38
48_R61_L0.7100.37
11_I59_V0.7020.36
64_L68_L0.6880.35
10_V35_S0.6800.35
3_A6_I0.6590.33
21_L30_L0.6580.33
59_V63_V0.6540.33
16_L20_V0.6520.33
20_V57_I0.6510.33
45_Q74_Y0.6500.32
10_V26_K0.6440.32
9_L66_F0.6360.31
53_I62_A0.6360.31
11_I62_A0.6310.31
34_I39_E0.6290.31
62_A70_I0.6280.31
53_I60_V0.6260.31
57_I70_I0.6250.31
18_I22_L0.6190.30
53_I59_V0.6180.30
29_G34_I0.6130.30
35_S56_R0.6100.30
31_S54_L0.6060.29
31_S44_K0.6010.29
15_A19_V0.5990.29
16_L50_L0.5980.29
47_A52_L0.5910.28
6_I51_D0.5890.28
41_L73_A0.5840.28
23_Q72_L0.5790.28
65_F70_I0.5740.27
49_G73_A0.5710.27
43_G50_L0.5700.27
27_S59_V0.5690.27
38_A50_L0.5670.27
4_V68_L0.5650.27
10_V74_Y0.5580.26
13_S72_L0.5580.26
11_I65_F0.5450.25
5_L68_L0.5440.25
34_I54_L0.5290.24
35_S74_Y0.5240.24
3_A14_I0.5060.23
59_V70_I0.5010.23
5_L53_I0.5000.23
Legend: The i and j are positions as given in the UniProt sequence. Only predictions with Prob ≥ 0.7 are listed. For all 3L/2 predictions, click on one of the links below.

Sco = ((raw_sco - min_sco)/(avg_sco - min_sco))/2 + 0.5
Prob = P(contact | Sco, seq80/√len)
seq80 = effective number of sequences, after reducing redundancy to 80% identity

HHsearch Results:
Legend: GREMLIN results (Prob ≥ 0.7) overlaid on top PDB hits. The grey/red filled circles underneath are pdb residue contacts (min distance < 5 Angstroms). The shade of the circles is based on the top 10 (or top 20 if e-value < 1E-20) HHsearch results which uses the overall probability and per-site alignment prob. Inter oligomeric contacts in the pdb are in shades of red.
PDB Chains Cov % HHΔ  
3dinE 1 0.8421 99.7 0.376 Contact Map
3dl8E 1 0.8421 99.7 0.378 Contact Map
2akhX 1 0.9605 99.7 0.384 Contact Map
3j45G 1 0.8421 99.6 0.444 Contact Map
2kz7C 1 0.5132 7.8 0.916 Contact Map
2bg9A 1 0.4211 6.1 0.92 Contact Map
2nwlA 3 0.8947 5.4 0.921 Contact Map
4av3A 2 0.8158 5.1 0.922 Contact Map
3giaA 1 1 5 0.923 Contact Map
1rz2A 1 0.0263 5 0.923 Contact Map

Sequence Conservation (Image Generated using WebLogo v3)
Legend: Color is used to show Hydrophobicity (Blue: Hydrophilic, Green: Neutral and Black: Hydrophobic). Amount of gaps is represented by width.

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